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( Jeong-hoon Lee ),( Joon Hyeok Lee ),( Young-suk Lim ),( Jong Eun Yeon ),( Tae-jin Song ),( Su Jong Yu ),( Geum-youn Gwak ),( Kang Mo Kim ),( Young Youn Cho ),( Eun Ju Cho ),( Yoon Jun Kim ),( Jae Wo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: A previous randomized controlled trial demonstrated that adjuvant immunotherapy with cytokine-induced killer (CIK) cells prolonged both recurrence-free and overall survivals of patients with hepatocellular carcinoma (HCC) receiving curative treatment. We investigated whether the efficacy of CIK cell immunotherapy might be sustained after cessation of repeated transfer of CIK cells. Methods: We performed a follow-up study of our multicenter, randomized trial reported in 2015. We included 226 patients: 114 patients in the immunotherapy group (injection of 6.4 ×10<sup>9</sup> CIK cells, 16 times during 60 weeks) and 112 patients in the control group (no treatment) after potentially curative treatments for HCC. Among them, 162 patients (89 of the immunotherapy group and 73 of controls) underwent extended follow-up until 60 months after randomization of the last patient. The primary endpoint was recurrence-free survival (RFS); secondary endpoints included overall survival and cancer- specific survival. Results: The median follow-up duration was 68.5 (interquartile range, 45.0-82.2) months. During follow-up, the immunotherapy group maintained a significantly lower risk of recurrence or death (hazard ratio [HR] with immunotherapy was 0.67; 95% confidence interval [CI], 0.48-0.94; P=.009 by one-sided log-rank test). The 5-year RFS rate was 44.8% in the immunotherapy group and 33.1% in the control group (Figure 1). HRs were also lower in the immunotherapy than control group for all-cause death (0.33; 95% CI, 0.15-0.76; P=.006) and cancer-related death (0.33; 95% CI, 0.13-0.86; P=.02). Conclusions: In patients who underwent curative treatment for HCC, significant gain in recurrence-free and overall survival by adjuvant CIK cell immunotherapy was maintained for over 5 years. Clinical- Trials.gov number: NCT01890291.
Su Jeong Song,Kyung Seek Choi,Jong Chul Han,Donghyun Jee,Jin Wook Jeoung,Young Joon Jo,Jae Yong Kim,Ko Eun Kim,Seong Taeck Kim,Ji Woong Lee,Tae Eun Lee,Dong Hui Lim,Chan Yun Kim,Hyun Woong Kim,Sang Wo 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.4
This report provides a detailed description of the methodology for ophthalmic examinations according to the Korea National Health and Nutrition Examination Survey (KNHANES) VII and VIII (from 2017 to 2021). The KNHANES is a nationwide survey which has been performed since 1998 in representatives of whole Korean population. During the KNHANES VII and VIII, in addition to the ophthalmic questionnaire, intraocular pressure measurement, visual field test, auto refractometry, axial length and optical coherence tomography measurements were included. This new survey will provide not only provide normative and pathologic ophthalmic data including intraocular pressure, refractive error, axial length, visual field and precise measurement of anterior segment, macula and optic nerve with optical coherence tomography, but also a more accurate diagnosis for major adult blindness diseases, including age-related macular degeneration, diabetic retinopathy, glaucoma, and other ocular diseases, for the national Korean population.
현정환 ( Hyeon Jeong Hwan ),박정현 ( Jeong Hyeon Bak ),이홍우 ( Hong Wo Lee ),안광준 ( Gwang Jun An ),김태상 ( Tae Sang Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
Meconium peritonitis is the chemical inflammation or foreign body reaction of peritoneum resulted from the prenatal bowel perforation associated with or without obstructive lesion during late intrauterine or early neonatal periods. Prenatal ultrasonograph
Array comparative genomic hybridization analysis of cervical intraepithelial neoplasia and cancer
유희정 ( Hee Jeong Yu ),( Jeong Hoon Bae ),( Hae Nam Lee ),( Yong Wook Kim ),( Guo Hwa Ding ),( Su Mi Bae ),( Yong Wan Kim ),( Tae Chul Park ),( Jang Heub Kim ),( Joon Mo Lee ),( Sung Eun Namkoong ),( Wo 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-
임태균(Lim, Tae Kyu),정석우(Jeong, Seok Wo),정남철(Jung, Nam Chu) 한국회계정보학회 2016 한국회계정보학회 학술대회발표집 Vol.2016 No.2
본 연구는 사외이사를 공무원 등 출신 집단별로 8가지 분류기준으로 분류하여 그 출신 집단별 선임 여부 및 전체 사외이사에서 해당 출신 집단이 차지하는 비율과 기업가치와의 관련성이 존재하는지 조사한다. 2000년부터 2010년까지(11년간) 유가증권 시장에 상장된 4,572개-연도 표본을 대상으로 한 실증 분석결과는 다음과 같다. 첫째, 각 사외이사의 출신 집단에 따른 기업가치 평균에 대한 t-test 및 Wilcoxon‘s rank sum test 결과, 공무원, 교수 및 시민단체 출신 사외이사를 선임시 미선임시보다 1% 유의수준 이하에서 기업가치가 더 높게 나타났고, 정치인과 기업인의 경우에는 선임시의 기업가치가 미선임시의 기업가치보다 유의하게 낮았다. 둘째, 출신별 더미변수를 이용한 회귀분석 결과, 공무원, 교수 및 시민단체 출신 사외이사를 선임중인 기업의 기업가치가 유의하게 높게 나타났고, 반대로 정치인 출신 사외이사의 선임은 기업가치와 유의한 음의 관계를 보였다. 셋째, 사외이사 총수 중 출신별 사외이사 비율에 대한 회귀분석 결과, 사외이사 중 교수 출신 사외이사의 비율이 높을수록 기업가치가 높게 나타났고, 정치인과 기업인의 비율이 높을수록 기업가치는 낮았다. 한편, 법조인, 언론인 및 연구원의 선임 여부 및 비율은 기업가치와는 유의한 관련성이 나타나지 않았다. 이상의 분석 결과는 상대적으로 기업 경영과 독립적인 위치에서 전문지식과 경험을 활용하기 용이한 교수 및 시민단체 출신 사외이사가 기업가치에 도움이 되며, 공무원 출신 사외이사 역시 공공기관에서의 근무경험 및 유관지식을 영리기업에 일정부분 효과적으로 활용하고 있음을 시사하고 있다. 반면, 정치인 출신 사외이사는 낮은 업무 관련성과 정치적 목적으로 인한 업무 무관 활동의 가능성이 존재하고, 기업인 출신 사외이사는 대주주 전횡 방지 등 기업 외부의 독립적인 감시 목적을 위한 사외이사의 도입 취지와 기업인 출신의 역할이 부합하지 않아, 기업가치에 오히려 악영향을 주는 것으로 해석된다. This study examines the association between the appointment (proportion) of outside directors by background group which is classified by 8 criteria and firm value. Tests include 4,572 firm-year samples covered from 2000~2000 listed in KSE(Korea Stock Exchange) and findings are as follows: first, the results using t-test and Wilcoxon’s rank sum test show that the firm value of appointment of outsided director with public servant, professor and civil organization background outsided director is higher than that of non-appointment sample. And, the firm value of appointment of outsided director with politician and businessman is lower than that of non-appointment sample. Second, using multivariate model analyzing dummy variables by background group of outside directors, the study finds that the appointment of public servant, professor and civil organization is positively related with firm value. However, the appointment of politician is negatively associated with firm value. Third, using multivariate model analyzing the appointment portion by background group, we find that positive relation with the proportion of professor based outside directors and negative relation with politician and businessman based outside directors and firm value. On the other hand, there is no significant relation between lawyer, journalist and researcher based outside directors and firm value. This results have implication that outside directors based by professor and civil organization could be helpful to firm value as they could take advantage of their professional knowledge and experience independently. And, outside director of public servant also helpful because of their experience in public sector. However, outside director of politician and businessman could have negative effect on firm value as politicians often act as their political objective irrelevant to business purpose and as businessman could not accord with outside directors system requesting independent monitoring function.
LEE, JAE-CHUL,TAE, HYUN-JIN,CHO, GEUM-SIL,KIM, IN HYE,AHN, JI HYEON,PARK, JOON HA,CHEN, BAI HUI,CHO, JEONG-HWI,SHIN, BICH NA,CHO, JUN HWI,BAE, EUN JOO,PARK, JINSEU,KIM, YOUNG-MYEONG,CHOI, SOO YOUNG,WO D.A. Spandidos 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.6
<P>Pyramidal neurons in region I of hippocampus proper (CA1) are particularly vulnerable to excitotoxic processes following transient forebrain ischemia. Kynurenic acid (KYNA) is a small molecule derived from tryptophan when this amino acid is metabolized through the kynurenine pathway. In the present study, we examined the effects of ischemic preconditioning (IPC) on the immunoreactivity and protein levels of KYNA following 5 min of transient forebrain ischemia in gerbils. The animals were randomly assigned to 4 groups (sham-operated group, ischemia-operated group, IPC + sham-operated group and IPC + ischemia-operated group). IPC was induced by subjecting the gerbils to 2 min of ischemia followed by 1 day of recovery. In the ischemia-operated group, we observed a significant loss of pyramidal neurons in the CA1 stratum pyramidale (SP) at 5 days post-ischemia; however, in the IPC + ischemia-operated group, the pyramidal neurons were well protected. KYNA immunoreactivity in the SP of the ischemia-operated group was significantly altered following ischemia-reperfusion and was very low 5 days following ischemia-reperfusion. In the IPC + ischemia-operated group, however, KYNA immunoreactivity was constitutively detected in the SP of the CA1 region after the ischemic insult. We also found that the alteration pattern of the KYNA protein level in the CA1 region following ischemia was generally similar to the immunohistochemical changes observed. In brief, our findings demonstrated that IPC maintained and even increased KYNA immunoreactivity in the SP of the CA1 region following ischemia-reperfusion. The data from the present study thus indicate that the enhancement of KYNA expression by IPC may be necessary for neuronal survival following transient ischemic injury.</P>
Park, Chul-Kee,Kim, Jeong Hoon,Nam, Do-Hyun,Kim, Chae-Yong,Chung, Sang-Bong,Kim, Young-Hoon,Seol, Ho Jun,Kim, Tae Min,Choi, Seung Hong,Lee, Se-Hoon,Heo, Dae Seog,Kim, Il Han,Kim, Dong Gyu,Jung, Hee-Wo Oxford University Press 2013 Neuro-oncology Vol.15 No.8
<P><B>Background</B></P><P>To determine the benefit of surgical management in recurrent glioblastoma, we analyzed a series of patients with recurrent glioblastoma who had undergone surgery, and we devised a new scale to predict their survival.</P><P><B>Methods</B></P><P>Clinical data from 55 consecutive patients with recurrent glioblastoma were evaluated after surgical management. Kaplan–Meier survival analysis and Cox proportional hazards regression modeling were used to identify prognostic variables for the development of a predictive scale. After the multivariate analysis, performance status (<I>P</I> = .078) and ependymal involvement (<I>P</I> = .025) were selected for inclusion in the new prognostic scale. The devised scale was validated with a separate set of 96 patients from 3 different institutes.</P><P><B>Results</B></P><P>A 3-tier scale (scoring range, 0–2 points) composed of additive scores for the Karnofsky performance status (KPS) (0 for KPS ≥ 70 and 1 for KPS < 70) and ependymal involvement (0 for no enhancement and 1 for enhancement of the ventricle wall in the magnetic resonance imaging) significantly distinguished groups with good (0 points; median survival, 18.0 months), intermediate (1 point; median survival, 10.0 months), and poor prognoses (2 points; median survival, 4.0 months). The new scale was successfully applied to the validation cohort of patients showing distinct prognosis among the groups (median survivals of 11.0, 9.0, and 4.0 months for the 0-, 1-, and 2-point groups, respectively).</P><P><B>Conclusions</B></P><P>We developed a practical scale to facilitate deciding whether to proceed with surgical management in patients with recurrent glioblastoma. This scale was useful for the diagnosis of prognostic groups and can be used to develop guidelines for patient treatment.</P>