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내인성 N1- methylnicotinamide 를 이용한 신혈장유량측정
심창구 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
Renal plasma flow (RPF) was estimated from the extraction ratio (E.R.) and renal plasma clearance of the endogenous N¹-methylnicotinamide(NMN) in the experimental renal failure (ERF) rat, and was compared with that of healthy rats. PRE of ERF-rats was not different from that of the healthy rat significantly and dependened upon E. R, or intrinsic clearance of the kidney. This NMN method seemed to be superior to the conventional p-aminohippuric acid (PAH) method clinically.
피막법에 의한 경구투여용 제어방출 제제의 개발-II-사람에 있어서 아세트아미노겐 혈장 중 농도와 타액 중 농도와의 상관성-
심창구,김미애,이민화,김신근,Shim, Chang-Koo,Kim, Mi-Ae,Lee, Min-Hwa,Kim, Shin-Keun 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.1
Plasma and saliva concentrations of acetaminophen (AAP) were determined at various time points by HPLC after oral administration of AAP tablets (AAP 500 mg) to four healthy male Korean subjects. Saliva concentrations (S) of AAP were significantly correlated with plasma AAP concentrations (P). The S/P ratio of AAP was calculated to be 1.05 (r =0.944, $p<10^{-6}$) for all the data points from the subjects. It showed a little intersubject variation and ranged from 0.89 to 1.46 in each subject. Bioavailability parameters such as AUC, $C_{max}$ and $T_{max}$ which are usually obtained from the plasma concentration data will be predictable approximately by saliva concentration data. Saliva seems to be very convinient and useful samples for the preliminary studies of bioavailability and bioequivalence of AAP preparations, since it can be collected frequently without any painful venipuncture to the subjects, that is inevitable in plasma sampling. Evaluation of the bioavailability of a preparation by saliva samples will reduce the cost, time and safety risk greatly in developing a new drug delivery system for AAP.
심창구,김대덕,정인환,김현수,유무영,Shim, Chang-Koo,Kim, Dae-Duk,Jung, In-Whoan,Kim, Hyun-Su,Yoon, Moo-Yung 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.3
Time-concentration curves of recombinant human interferon alpha$(rIFN-{\alpha}A)$ in the skin and serum of nude mice or rats were studied after topical application of IFN ointment. IFN appeared in the skin and serum in less than 30 minutes and lasted for more than 10-12 hours at high concentration level after the application to nude mice at a dose of $9.0{\times}10^5\;IU/g$ mouse. But in the rats, IFN was not detected in the serum even 7 hours after the application at a dose of $6.0{\times}10^5\;IU/g$ rat. Topical application of IFN might be useful for the topical and systemic treatment if the human skin resembles that of nude mouse in respect to transport characteristics.
심창구 대한약학회 1983 약학회지 Vol.27 No.1
Distribution volume (Vd$_{ss}$ ) of a model basic drug, tetraethylammonium bromide (TEA) at a steady-state decreased sinificantly in glycerol and uranium-renal failure rats. Assuming carrier-mediated transport of TEA into tissues, the theoretical $Vd_{ss}$ of TEA decreases in an exponential way as the plasmal concentration of TEA increases. The relationship between $Vd_{ss}$ and plasma concentration of TEA in the experimental renal failure (ERF)-rats was similar. Therefore, the decrease in $Vd_{ss}$ of TEA in the ERF-rats seemed to be due to the saturation of the carrier system that are responsible for the tissue distribution of TEA, by the elevated plasma concentration of TEA in the ERF-rats. ERF was induced to rats with glycerol, folate, salicylate, uranium and gentamicin, respectively..