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( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2
Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)
Polymorphisms of GSTM1,GSTT1,GSTP1,NATII and CYP1A1 and the Susceptibility to Asthma
Chung, Hai Won,Ahn, Tai Hui,Kim, Su Young,Kim, Tae Yon,Paek, Domyung 한국유전학회 2002 Genes & Genomics Vol.24 No.3
The associations of asthma with genetic polymorphisms remains unclear. The purpose of this study is to find the association of NA72, GSTM1, GS7T1, GS7P1 and CYP1A1 polymorphism with asthma in Koreans. The genetic polymorphisms of GS7M1, GS7T1, GS7P1, NA7II and CYP1A1 genes among 33 asthma patients and 66 controls were investigated to find the association of the polymorphism with the risk of asthma. The frequency of the GS7Tl null genotype was slightly higher in asthma patients than that in controls, but this difference was not statistically significant. No difference in the frequencies of GS7T1 and GS7Pl was found between patients and controls. Excess risk for the combined GS7T1 and GS7M1 null genotype was found (O.R = 7.62, 95% CI: 1.13-51.46). There was no association with asthma risk by NA72 genotypes. The presence of the homozygous variant type (M/M of CYP1A1 led to the increased risk (O.R = 4.40, 95% CI:1.01-19.29) for asthma compared to wild type (WT) and heterozygous variant type (W/M). An increased risk of asthma for the combined GS7T1 null genotype (MM and CYP1A1 homozygous variant genotype (M/M) was also found (O.R. = 11.61, 95% CI: 1.14 - 118.43). The CYP1AI genotype, combined GS7M1 and GS7T1 genotypes as well as the combination of CYP1A1 and GS7T1 genotypes may be used as susceptible markers for asthma.
Update of aristolochic acid nephropathy in Korea
( Tae Hyun Ban ),( Ji-won Min ),( Changhwan Seo ),( Da Rae Kim ),( Yu Ho Lee ),( Byung Ha Chung ),( Kyung-hwan Jeong ),( Jae Wook Lee ),( Beom Seok Kim ),( Sang-ho Lee ),( Bum Soon Choi ),( Jin Suk Ha 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.5
Background/Aims: The true incidence of aristolochic acid nephropathy (AAN) is thought to be underestimated because numerous ingredients known or suspected to contain aristolochic acid (AA) are used in traditional medicine in Korea. Methods: We collected data on cases of AAN since 1996 via a database in Korea. We evaluated the year of AAN development, route to obtaining AA-containing herbal medicine, gender, reason for taking AA-containing herbal medicine, clinical manifestations, histological findings, phytochemical analysis, and prognosis of patients with AAN. Results: Data on 16 cases of AAN were collected. Thirteen cases developed AAN before and three cases after the prohibition of AA-containing herbal medicine by the Korea Food and Drug Administration. Patients were prescribed AA-containing herbal medicine from oriental clinics or had purchased it from traditional markets. AAN was distributed in all age groups. Young females were most commonly exposed to AA-containing herbal medicine for slimming purposes and postpartum health promotion, while older adults took AA-containing compounds for the treatment of chronic diseases. The most common symptoms presented at hospitalization were nausea and vomiting, and acute kidney injury was accompanied by Fanconi syndrome in almost half of the patients. Phytochemical analysis of AA in herbal medicine was available in six cases. Progression to end stage renal disease (ESRD) was observed in seven patients (43.8%), and five patients (31.3%) had progressed to ESRD within 6 months of diagnosis. Conclusions: Our report shows that patients were still exposed to AA-containing herbal medicine and that there is a possibility of underdiagnosis of AAN in Korea. A stronger national supervision system of herbal ingredients and remedies in oriental medicine is needed to prevent AAN.
Tae Joung Ha,Myoung-Hee Lee,Chang-Hwan Park,Suk-Bok Pae,Kang-Bo Shim,Chung-Dong Hwang,Young-Sil Kim,Byeong-Won Lee,Keum-Yong Park 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
The influenza neuraminidase (E.C. 3.2.1.18) is an antiviral target of high pharmaceutical interest because of its essential role in cleaving sialic acid residues from surface glycoproteins and facilitating release of virions from infected cell. In this context, polyphenolic compounds including luteolin, rosmarinic acid, and apigenin from Perilla frutescens were evaluated for their inhibitory effect on recombinant virus H1N1 neuraminidase. Among the test compounds, luteolin and rosmarinic acid inhibited the rvH1N1 neuraminidase with an IC50 of 8.4 and 46.7 μM, respectively. The inhibition kinetics analyzed by Dixon plots indicates that luteolin and rosmarinic acid are noncompetitive inhibitor and inhibition constant, Ki, were established as 14.3 and 43.9 μM, respectively. Subsequently, we also analyzed the rosmarinic acid and luteolin contents of 383 accessions of perilla seed germplasms by high performance liquid chromatography (HPLC). The rosmarinic acid and luteolin contents of perilla seeds were ranged from 15.7 μg/g to 2,894.9 μg/g and from 1.6 μg/g to 949.1 μg/g, respectively.
( Won Gu Kim ),( Tae Yong Kim ),( Tae Hyuk Kim ),( Hye Won Jang ),( Young Suk Jo ),( Young Joo Park ),( Sun Wook Kim ),( Won Bae Kim ),( Min Ho Shong ),( Do Joon Park ),( Jae Hoon Chung ),( Young Kee 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.3
Background/Aims: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma(HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine-sufficient areas. In this study we evaluated the clinical behavior, prognosticfactors and treatment outcomes of FTC and HCC in Korea. Methods: This multicenter study included 483 patients with FTC and 80 patientswith HCC who underwent an initial surgery between 1995 and 2006 in one of thefour tertiary referral hospitals in Korea. We evaluated clinicopathological factorsassociated with distant metastases and recurrence during a median of 6 years offollow-up. Results: HCC patients were significantly older (49 years vs. 43 years; p < 0.001) andhad more lymphovascular invasions (22% vs. 14%; p = 0.03) compared with FTCpatients. Distant metastases were confirmed in 40 patients (8%) in the FTC groupand in two patients (3%) in the HCC group (p = 0.07). Distant metastases weresignificantly associated with older age, widely invasive cancer and extrathyroidalinvasion. Only 14 patients (3%) had recurrent disease and there was no significantdifference between FTC and HCC groups (p = 0.38). Recurrence was associatedwith larger tumor size and cervical lymph node metastasis. Conclusions: HCC patients were older and had more lymphovascular invasionsthan FTC patients. However, FTC and HCC patients had similar initial clinicopathologicalfeatures. Older age, wide invasiveness and extrathyroidal invasionwere independent risk factors for predicting distant metastases in FTC and HCCpatients.
Chung, Yeon-Choon,Kang, Tae-Won,Park, Dong-Chul The Korean Institute of Electrical Engineers 1997 Journal of Electrical Engineering and Information Vol.2 No.5
The design process and construction method of a strip line is described for measuring radiated susceptibility of vehicular components having electrical cables more than 2 min length. he characteristic impedance of the trip line was determined 90$\Omega$ to obtain the field uniformity of $\leq$${\pm}$3 dB in the frequency range from 100 kHz to 500 MHz. Tapered coaxial lines were used instead of the traditional lumped circuit element for the impedence matching units, therefore, the strip line has high power capability. Using these techniques, the field uniformity and power capability of a strip line could be considerably improved.
Filtration and Dust Cake Experiment by Ceramic Candle Filter in High Temperature Conditions
Chung, Jin-Do,Hwang, Tae-Won,Park, So-Jin 한국화학공학회 2003 Korean Journal of Chemical Engineering Vol.20 No.6
Particulate collection at high temperature and high pressure (HTHP) is important in an advanced coal power genemion system not only to improve the thermal efficiency of the system, but also to prevent the gas turbine from erosion and to meet the emission limit? of the effluent gas. The specifications for particulate collection in those systems such as Integrated Gasification Combined Cycle (IGCC) and Pressmized Fluidized Bed Combustion (PFBC) require absolutely high collection efficiency and reliability. Advanced cyclone, granular bed fdter, elechostatic precipitator, and ceramic filter have been developed for particulate collection in the advanced coal power generation system. However, rigid ceramic filters and granular bed filters among them show the best potential. The problems experienced of these systems on performance, materials, and mechanical design were investigated. Ceramic candle filters have the best potential for IGCC at this moment because they have nearly the highest efficiency compared with other filtering systems and have accumulated many reliable design data from many field experiences. The purpose of this study was to investigate the efficiency of ceramic filters and stability of material against high temperature and long-term operation condition by applying fly ash on the surface of the filter and relation of pressure drop and dust cake thickness. Experimental conditions were 50 hours at 450 ℃, 650 ℃ and 850 ℃.