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Seo, Changhwan,Kim, Seonghun,Lee, Misol,Cha, Min-Uk,Kim, Hyoungnae,Park, Seohyun,Yun, Hae-Ryong,Jhee, Jong Hyun,Kee, Youn Kyung,Han, Seung Hyeok,Yoo, Tae-Hyun,Kang, Shin-Wook,Park, Jung Tak American Association of Clinical Endocrinologists 2018 Endocrine practice Vol.24 No.3
<P>Conclusion: THRT may decrease the risk of CVD in DMN patients with SCH. Randomized trials are needed to verify this finding.</P>
S-455 Periostin-binding DNA aptamer ameliorates peritoneal dialysis-induced peritoneal fibrosis
( Changhwan Seo ),( Bo Young Nam ),( Meiyan Wu ),( Ji Min Park ),( Jae Eun Um ),( Seonghun Kim ),( Hye-young Kang ),( Seohyun Park ),( Su-young Jung ),( Jong Hyun Jhee ),( Hae-ryong Yun ),( Hyoungnae 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Peritoneal fibrosis (PF) is a major complication in patients on peritoneal dialysis (PD). In PD-related PF, the protein expressions of various extracellular matrix including periostin are known to be increased via the transforming growth factor-β1 (TGF-β1) pathway. This study was undertaken to evaluate the impact of periostin inhibition by novel aptamer-based inhibitor on TGF-β1-induced epithelial-mesenchymal transition (EMT). Methods: In vitro, primary HPMCs were exposed to TGF-β1 (2 ng/ml) to induce EMT and fibrosis with or without periostin siRNA (100 nM) or periostin-binding DNA aptamer (200 nM). In vivo, PD catheters were inserted into 48 C57BL/6 mice, and saline (C group, N=24) or 4.25% PD solution (PD group, N=24) was infused for 4 weeks. Twelve mice from each group were treated with periostin-binding DNA aptamer (500 μg/kg/d) (PA). mRNA and protein expressions of periostin, fibronectin, α-smooth muscle actin (α-SMA), snail, and E-cadherin in HPMCs and mouse peritoneum were evaluated by quantitative real-time polymerase chain reaction and western blot analysis, respectively. PF was also assessed by Masson’s trichrome (MT) staining. Results: In vitro, TGF-β1 treatment significantly up-regulated periostin, fibronectin, α-SMA, and snail expressions, while E-cadherin expression was significantly decreased by TGF-β1 in cultured HPMCs (p<0.01). Not only periostin siRNA but also periostin-binding DNA aptamer significantly attenuated TGF-β1-induced periostin, fibronectin, α-SMA, and snail expressions and significantly restored E-cadherin expression in HPMCs (p<0.05). In vivo, the expressions of periostin, fibronectin, α-SMA, and snail were significantly increased, whereas E-cadherin expression was significantly decreased in the peritoneum of PD mice (p<0.05). The thickness of the submesothelial layer and the intensity of MT staining in the peritoneum were significantly higher in PD mice compared to C mice (p<0.05). These changes in the PD group were significantly abrogated by PA treatment (p<0.05). Conclusions: These findings suggest that PA can be a potential therapeutic strategy for PF in PD patients.
한국형 발사체 7톤급 엔진 연소시험 시 엔진작동점 제어에 대한 연구
황창환(Changhwan Hwang),이광진(Kwangjin Lee),김승한(Seunghan Kim),우성필(Seongphil Woo),임지혁(Ji-Hyuk Im),전준수(Junsu Jeon),김채형(Chae-Hyoung Kim),서대반(Daeban Seo),이정호(Jungho Lee),김성혁(Sunghyuk Kim),소윤석(Younseok So),이승재( 한국추진공학회 2016 한국추진공학회 학술대회논문집 Vol.2016 No.12
한국항공우주연구원 나로우주센터 내의 3단 엔진 연소 시험설비에서 7톤 액체로켓엔진 580초 연소시험 중 4개의 엔진작동점 제어를 수행하였다. 시험결과 세 개의 유량제어밸브 모두 제어목표에 따라 정상작동하여 다중 엔진작동점 제어를 성공적으로 수행하였다. 1회 시험 중 다중 엔진작동점 제어가 가능해짐에 따라 시간과 비용의 절약이 가능하며 발사체의 비행 상황에 따라 엔진작동점의 제어 가능성을 확인하였다. For the KSLV-II development, the four operating point engine control during 580 second combustion test of 7 tonf liquid rocket engine has been performed at upper stage engine test facility in NARO space center. The three flow control valve was successfully controlled for the multi operating point control. This multi operating point combustion test result show that the saving of time and cost is possible at each test. Furthermore the possibility of the engine operating control during the launch vehicle flight is verified.
Fighting the COVID-19 pandemic: onsite mass workplace testing for COVID-19 in the Republic of Korea
Eunhye Seo,Eunchan Mun,Wonsool Kim,Changhwan Lee 대한직업환경의학회 2020 대한직업환경의학회지 Vol.32 No.-
The ongoing coronavirus disease 2019 (COVID-19) pandemic is causing tremendous damage globally. The Republic of Korea (ROK), a highly export-dependent nation, is a leader in the fight against the COVID-19 pandemic and coping well with the disaster. Like the drive-through COVID-19 testing, which reflects the brilliant flexibility of the Korean medical system, onsite mass workplace testing for COVID-19, which our hospital has been performing over the past few months, is a unique and valuable countermeasure. We believe it is time that the current health examination system for workers in the ROK considered the risk of transmissible diseases.
최창환(Changhwan Choi),이종환(Jonghwan Lee),김태성(Tae-Sung Kim),윤상한(Sanghan Yoon),박광희(Kwanghee Park),이희천(Heechun Lee),서영복(Yeongbok Seo) 한국산업경영시스템학회 2011 한국산업경영시스템학회지 Vol.34 No.1
This study looks at a company which introduced SAP program, one type of ERP systems, and how the firm copes with the problems which happen in business process. The research tried to solve the problem by IDEAL method of process software improvement methodology. As a result, receipt account program for credit sales could be developed; the program was applied to the actual business work and operated.