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      • 개에서 관찰된 모기질세포종의 증례보고

        조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-

        Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.

      • 아젭틴 정(염산아젤라스틴 1 mg)에 대한 아젤라 정의 생물학적 동등성

        조혜영,윤지훈,서유리,오인준,이성관,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

        Azelastine, a phthalazinone derivative, is an antiallergic agent which demonstrates histamine H_1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. Thus, azelastine may be useful in the management of both asthma and allergic disorders. The purpose of the present study was to evaluate the bioequivalence of two azelastine hydrochloride tablets, Azeptin^TM (Bu Kwang Pharmaceutical Co., Ltd.) and Azela^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 22.44±2.01 years in age and 61.99±6.18㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 1㎎ of azelastine hydrochloride per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of azelastine in serum were determined using HPLC with fluorescence detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -6.45%, -2.60% and -7.14%, respectively, when calculated against the Azeptin^TM tablet. The powers (1-β) for AUC_t and C_max were 96.65% and 88.47%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.40% and 17.65% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -14.87∼1.97 and -12.92∼7.72 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Azela^TM tablet is bioequivalent to Azeptin^TM tablet.

      • 중·고등학교 체육 교과서의 활용성

        윤해철,조성호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

        The purpose of this study is to investigate whether the text book is used effectively in the practical physical education and, if not, to reveal the reason and find the direction and remedy to reform the school physical education curriculum. The subjects of this survey were 182 of teachers and 1,671 of students and the results were analyzed by using SAS package program. The main results obtained can be summarized as following: First, although students are interested in the class of physical education, there is no variety in the class of both theory and practice. Second, the text book is unsystematically used in the class of the physical education theory. Although students recognized the text book to be used in the class, the contents of the text book did not satisfy students. From the result of this study, we can find that teachers and students relatively want to use the text book in the class of physical education. However, there are many problems in the contents and the practicability of the text book is very low.

      • 디자인에 있어서 모듈러 시스템구축의 유효성에 관한 연구 : 중성펜 디자인개발 사례를 중심으로 concentrated on the Jelly Pen Design

        조창연,이성남 한국디자인과학학회 1998 디자인과학연구 Vol.1 No.-

        오늘날 디자인의 문제인식과 해결의 방법은 빠르게 전개되는 기술적 진보와. 문화적 분기에 따라 다양하게 시도되고 있다. 특히 컴퓨터를 응용한 디자인 작업은 제품정보의 통합적인 관리와 효과적인 처리를 할 수 있으므로 생산성 향상을 위한 방법으로 널리 사용되고 있다. 본 연구는 이러한 컴퓨터 응용기술을 A사의 중성펜 디자인 개발에 적용한 사례로서, "중성펜의 부품모들(Module)을 제품개념에 맞도록 최적화 시킨다'는 재발이념을 실천하며 추출한 8개 모델의 개발과정과 방법을 제시하였다. According to the development of technology and cultural divergence progressing rapidly, the critical recognition and the means of solution of Design are trying to realize diversely. Especially, since the Computer Aided Design work can manage the product information and process it effectively, it has been used for the method of higher productivity. This study is a example of the application of Computer Aided Design for the development of"Neutral-Pen" that is produced by "A" Co. producing stationery. This study shows the process and the method of the product development defined by "To be most suitable the parts module of the product according to the product concept" for eight models of Neutral-Pen.

      • 한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석

        조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-

        Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.

      • CBT를 이용한 안전한 멀티캐스트 그룹 관리

        윤성현,장주만,조원환 高麗大學校附設 컴퓨터科學技術硏究所 1999 JOURNAL OF COMPUTER SCIENCE & ENGINEERING TECHNOLO Vol.2 No.-

        보다 높은 대역폭에서 안전한 멀티캐스트 통신을 하고자 욕구는 기업, 정부, 그리고 인터넷을 사용하는 모든 단체에서의 고조되고 있고 또한 주요 관심사이다. 멀티캐스트 환경에서 보안성을 제공하기 위해 최근까지 진행되어 오고 있는 연구는 주로 그룹 키 관리 기법에 관한 것들이다. 본 논문에서는 화장성이 우수한 CBT 멀티캐스트 라우팅 프로토콜을 기반으로 안전한 인터넷 멀티캐스트를 위한 CBT기반 그룹 관리 시스템을 제안한다. 본 논문에서 제안하는 기법은 핵심라우터가 키 생성, 키 재구성, 그룹 가입, 탈퇴 등 그룹 관리 뿐 아니라 여러 가지 보안사항을 고려한 기능도 제공해 준다. The need for high bandwidth, very dynamic secure internet multicast communications is increasingly evident in a wide variety of commercial, government, and Internet communities. One of the most recently researches is mainly about the group key management schemes. In this paper, We'll propose a CBT-based group management system with scalable CBT multicast routing protocol. The benefits of this proposed technique are that it offers not only key generation, rekey, group join and leaving but also many functions lated security of multicast group.

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