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중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향
최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.
Sung Yeoul Yoon,Da Young Lee,On You Kim,Seung Yun Lee,Sun Jin Hur 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.4
The purpose of this study was to develop a commercially viable method for synthesis of conjugated linoleic acid (CLA) using the linoleic acid fraction obtained from six pork by-products (liver, lung, heart, stomach, small intestine, and large intestine). The workflow of CLA synthesis from each by-product was as follows: washing→crude fat extraction→fractionation into saturated and unsaturated fatty acids→repeat unsaturated fatty acid fractionation→CLA synthesis. Cis-9, trans-11, and trans-10, cis-12 CLA was synthesized from pork by-products. The yield of CLA synthesis of pork by-products ranged from 1.55 to 11.18 g per 100 g of by-products. The amount of synthesized CLA was the highest in the small intestine and large intestine by-products. Fractionation of pork by-products nearly doubled the yield of CLA. We suggest that commercial fractionation methods could increase the yield of CLA at low cost, reduce waste, and improve the efficiency of by-product utilization.
Koh, Yoon-Seok,Jung, Hae-Ok,Park, Mahn-Won,Baek, Joo-Yeoul,Yoon, Sung-Gyu,Kim, Pum-Joon,Ihm, Sang-Hyun,Chang, Kiyuk,Oh, Yong-Seog,Youn, Ho-Joong,Baek, Sang Hong,Chung, Wook-Sung,Seung, Ki-Bae,Kim, Jae Korean Society of Echocardiography 2009 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.17 No.4
<P>Left ventricular hypertrophy (LVH) has been known as an important predictor of prognosis of cardiovascular disease. Carboxy-terminal propeptide of procollagen type I (PIP) is related with myocardial fibrosis. We sought to analyze the differences in the characteristics of LVH, myocardial fibrosis, and LV functions among hypertension (HBP), diabetes mellitus (DM) and chronic renal failure (CRF).</P>
흰쥐에서 Nitric Oxide 합성 억제가 Bradykinin의 승압 및 감압효과에 미치는 영향
윤평진,이종은,문성호,염철호,전제열,양민준,김재훈 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.5
Bradykinin has been known to elicit a pressor effect when administered centrally, and a depressor effect when administered peripherally. The present study was aimed at investigating whether the blood pressure response to bradykinin is dependent on the endogenous generation of nitric oxide (NO). Effects of NG-nitro-L-arginine methyl ester (L-NAME) on the pressor and depressor responses to intracerebroventricularly and intravenously injected bradykinin (5nmol/rat), respectively, were examined in anesthetized rats. Neither the pressor response nor the depressor response was affected by acute parenteral treatment with L-NAME. The pressor and depressor effects of bradykinin were also noted in rats chronically supplemented with L-NAME in drinking water for 4 weeks. Bradykinin caused a relaxation of the isolated thoracic aorta in vitro, which was not affected in the presence of L-NAME. However, bradykinin failed to cause a relaxation of the aorta isolated from rats chronically treated with L-NAME. These findings suggest that endogenous generation of NO may not completely account for the blood pressure responses to bradykinin in rats.
배상철(Sang Cheol Bae),김동욱(Dong Yook Kim),김태환(Tae Hwan Kim),전재범(Jae Bum Jun),정성수(Sung Soo Jung),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),이은영(Eun Young Lee),장성렬(Sung Yeoul Chang) 대한내과학회 1997 대한내과학회지 Vol.52 No.1
N/A Objectives: Nitric Oxide(NO) is a toxic, inorganic, gaseous free radical produced during the metabolism of L-Arginine by NO synthase(NOS). It has been implicated in a rapidly growing number of physiological and pathophysiological processes such as cytotoxic effects against microbes and tumor cells, blood vessel dilation and neurotransmitter. Recently there is growing evidence implicating NO in immune regulation, inflammation, autoimmunity, and arthritis. We performed this study to determine a role for nitric oxide in inflammatory arthritis especially rheumatoid arthritis(RA). Methods: We measured (D the concentrations of nitrite, a breakdown product of nitric oxide, in serum and synovial fluid from patients with RA and osteoarthritis(OA) and in the serum of controls ② the concentrations of nitrite in the supernatant of cultured synovial tissue with RA and OA and ③ determined whether human chondrocytes and synoviocytes can synthesize nitric oxide and if so, how production is regulated by cytokines and antirheumatic drugs. Results: 1) Serum nitrite concentrations in patients with RA and OA were higher than in controls. In both disease groups synovial fluid nitrite was higher than serum nitrite. Serum and synovial fluid nitrite concenrations in RA were higher than those in OA. However, those findings are not statistically significant. 2) Although these findings are not statistically significant, the concentration of nitrite in the supernatant of cultured synavial tissue with RA was higher than that in OA. 3) IL-l5 and TNF-a induced the biosynthesis of NO by chondrocytes and synoviocytes. IGF-1 and TGF-5 failed to provoke the production of NO. The biosynthesis of NO required an induction period of approximately 6 hours and was inhibited by L- NMMA and cycloheximide. Dexamethasone, indomethacin, gold sodium thiomalate and methotrexate had no effect on the induction of NO biosynthesis. Conclusion: These results suggest a role for nitric oxide as an inflommatory mediator in inflammatory arthritis.
이승호,이재열,김미숙,박윤기,이미나 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.1
저자들은 본 병원 산부인과에 입원하여 수술 후 조직학적으로 진단된 난소 임신 3례를 경험하였기에 이에 문헌고찰과 함께 보고하는 바이다. Primarty ovarian pregnancy is one of the rerest types of extrauterine pregnancy. But an increase in the reported prevalence of ovarian pregnancies was published in recent years. Three cases of ovarian pregnancy which have Spiegelberg criteria are presented with a brief review of literatures.
개의 출생 후 중추신경계통 발달에서 Platelet-derived growth factor α-receptor (PDGF-αR)의 발현
윤상필(Sang-Pil Yoon),전제열(Jae-Yeoul Jun),유호진(Ho-Jin You),김주영(Joo-Young Kim),양경철(Kyung-Chul Yang),안병수(Byung-Soo Ahn),장인엽(In-Youb Chang) 대한해부학회 2003 Anatomy & Cell Biology Vol.36 No.1
Platelet-derived growth factor (PDGF)는 민무늬근육세포, 섬유모세포, 아교세포 등의 분열능력에 상당한 영향을 미치고, 세포의 분열 및 분화의 유도, 조직손상의 복구, 염증, 종양형성 등에 관여하며, 신경계통에서는 주로 아교세포계열의 발생에 중요한 기능을 수행하는 것으로 알려져 왔다. 배자의 출생 후 발달중인 신경원에는 PDGF-αR가 존재하지 않는다는 주장들이 대부분이고, 또 PDGF-αR이 성숙한 신경원에 존재한다는 최근 보고는 생쥐의 신경원에서 밝혀냈을 뿐이다. 따라서 고등포유동물인 개의 중추신경계통에서 출생 후 발달에 따른 PDGF-αR양성신경원의 존재 양상을 밝혀내고자 면역조직화학염색을 실시하여 다음과 같은 결과를 얻었다. 대뇌겉질의 속피라밋층, 해마와 치아이랑의 피라밋세포 및 과립세포, 줄무늬체의 창백핵, 조가비핵, 꼬리핵, 시상의 배쪽앞쪽핵, 그물핵, 가쪽무릎체, 뒤쪽시상하부핵, 흑색질, 얼굴신경핵, 안뜰핵, 삼차신경핵 등의 뇌줄기핵, 소뇌의 조롱박세포와 과립세포, 척수의 뒤뿔과 앞뿔 등 여러 부위에서 출생 0일부터 PDGF-αR의 염색반응을 보이는 신경원들을 관찰할 수 있었는데, 이들은 출생 후 6개월까지 지속적으로 관찰되었다. PDGF-αR의 염색반응양상은 대체로 출생 후 1개월까지 세포의 가지돌기 및 축삭에 잘 표지되었지만, 그 이후 신경세포의 염색성과 숫자가 감소되는 경향을 보이며, 출생 후 6개월까지 발현을 확인할 수 있었다. 이상의 실험결과로 미루어 출생 후 6개월까지 발달과정동안 개 중추신경계통에서 PDGF-αR양성신경원이 지속적으로 존재한다는 것을 알 수 있었으며, 이로서 PDGF가 중추신경계의 특정부위에 있는 신경원의 성숙에 관여한다고 사료된다. Platelet-derived growth factor (PDGF) was initially described for its mitogenic activity on smooth muscle cells, fibroblast, and glial cells. The biological activities of PDGF include stimulation of mitogenesis, differentiation, wound healing, inflammation, and tumor formation. The localization of platelet-derived growth factor-α receptor (PDGF-αR) in central nervous system was commonly restricted to oligodendrocyte progenitors during late embryonic and postnatal development. However, several studies recently demonstrated that postnatal neurons could also synthesize PDGF-αR in rodents. In the present study, to analyze the distributional pattern of PDGF-αR during postnatal development of the canine CNS, we used immunohistochemical method on sections of canine brain tissue. We found that neurons of various CNS regions, including cerebral cortex, striatum, diencephalon, nuclei of brain stem, cerebellum, spinal cord, exhibited the immunoreactivity to PDGF-αR as early as postnatal day 0. Generally PDGF-αR immunoreactivity was well localized in the dendrites and axons of neuron during the postnatal day 14 and postnatal day 28, and then showed diminished pattern. But neuronal immunoreactivity to PDGF-αR were maintained postnatal 6 month. These results suggest that the localization of PDGF-αR in postnatal developing neurons supports the several roles of PDGF for neurons including maturation and survival.
A Central Pressor Response to Endogenous Nitric Oxide Synthesis Inhibition in Anesthetized Rats
Moon, Sung-Ho,Yang, Min-Joon,Oh, Seung-Ho,Kim, Mi-Won,Yoo, Kwang-Jay,Lee, Jong-Eun,Jun, Jae-Yeoul,Yeum, Cheol-Ho,Yoon, Pyung-Jin The Korean Physiological Society 1994 대한생리학회지 Vol.28 No.2
The present study was aimed to determine if endogenous L-arginine-nitric oxide (NO) pathway has central, rather than peripheral, mechanisms in blood pressure regulation. Arterial blood pressure and heart rate responses to acute inhibition of the t-arginine-NO pathway were examined in rats anesthetized with thiopental (50 mg/kg, IP). An intracerebroventricular (ICV) cannula was placed in the left lateral ventricle. The right femoral artery was cannulated to measure arterial blood pressure and the vein to serve as an infusion route. $N^G-nitro-L-arginine$ methyl ester (L-NAME) was infused either intracerebroventricularly or intravenously. ICV infusion $(1.25\;{\mu}L/min)$ of L-NAME $(20\;or\;100\;{\mu}g/kg)$ per minute for 60 min) increased the mean arterial pressure and heart rate. Plasma renin concentrations(PRC) were significantly lower in L-NAME-infused group than in the control. L-Arginine $(60\;{\mu}g/min,\;ICV)$ prevented the pressor response to ICV L-NAME. The pressor response was not affected by simultaneous intravenous infusion of saralasin, but was abolished by hexamethonium treatment. Intravenous infusion $(40\;{\mu}L/min,\;10{\sim}100\;{\mu}g/kg\;per\;minute\;for\;60\;min)$ also increased blood pressure, while it decreased heart rate. These results indicate that endogenous L-arginine-NO pathway has separate central and peripheral mechanisms in regulating the cardiovascular function. The central effect may not be mediated via activation of renin-angiotensin system, but via, at least in part, activation of the sympathetic outflow.