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- 저자 : Sung Gyu Im (검색결과 361 건)
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당뇨병환자에서 게이트심장혈액풀신티그라피를 이용한 심기능 평가
윤상임,송치운,이진홍,안미애,성기양,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Major cardiovascular complications of diabetes are coronary atherosclerosis, diabetic dilated cardiomyopathy, autonomic neuropathy and those are major causes of morbidity and mortality in diabetic patients. Gated blood pool heart scan is noninvasive and useful method for evaluation of functional status of heart in diabetics. We evaluated 52 patients with diabetes and divided 3 groups. Group 1 were 11 patients without proteinuria or with proteinuria less than 550mng during 24 hours. Group 2 were 9 patients with proteinuria more than 550mg during 24 hours and group 3 were 32 patients with endstage renal diasese due to diabetes. We performed 99mTc-HSA cardiac gated blood pool scan and used left ventricular ejection fraction(LVEF), peak ejection rate(PEF) to indices of LV systolic function and peak filling rate(PER) to index of LV diastolic function. The results were follows : 1) LVEF, PER were significantly lower in diabetics with ESRD than diabetics without ESRD, but there were no significant difference between normal controls and diabetics without ESRD 2) PFR was significantly lower in diabetics than normal controls, but there were no significant differences in diabetics with or without nephropathy. 3) There were negative correlation between PER, PFR and duration of diabetes. On the basis of results, PFR is a LV functional index of GBPS which can disclose early change of LV dysfunction in patients with diabetes.
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文九,林圭庠,崔賢 圓光大學校 漢醫科大學 1989 圓光漢醫大論文集 Vol.- No.6
After finding out cure-all method by analyzing and synthesizing of Peon-Zheng-Shi-Chi(辨證施治) and clinical character of peptic ulcer, forming a cure-all prescription, attempting to conform the modificatory method of Kun(monarch). Shin(minister). Zhoa(assistant). Sha(guide) of forming drugs by Peon-Zheng(辨證) and modificatory drugs with Peon-Zheng-Shi-Chi(辨證施治) of Oriental medicine and pharmacologic effect of Western medicine, the author obtained conclusion as below. 1. The cure-all method based on the method of Peon-Zheng-Shi-Chi(辨證施治) are So-Kan-Hai-Wul (疏肝解鬱), Hoa-Wei (和胃), Hoal-Heol-Sang-ki (活血生肌), Hai-Keong-Zhin-Tong (解痙鎭痛), Jhei-San(制酸)(antacid). 2. The forming drugs of cure-all prescripiton are Radix paeoniae, Radix Glycyrrhizae, Rhizoma Cyperi, Radix Aucklandiae, Radix Linderae, Rhizoma Atracyodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Os Sepiae, Rhizoma Corydalis, Resina Myrrhae, Radix Astragali, Radix Adenophorae, Ramulus Cinnamomi. 3. The main durgs of each Peon-Zheng(辨證) are Rhizoma Cyperi, Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Radix Aucklandiae, Radix Linderae in the symptoms of Ki-Chei(氣滯) Caused by Kan-Ki-Hoing-Yeog(肝氣橫逆) ; Radix Astrageli, Ramulus Cinnamomi, Radix Paeoniae Alba in the symptoms of Ki-Chei(氣滯) of Mog-Pul-So-To (木不疏土) caused by Kan-Ki-Her (肝氣虛) ; Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae in the symptoms of Her-Han(虛寒);Radix Adenophorae, Radix Paeoniae Alba in the symptoms of Wei-Yeum-Her(胃陰虛) and Wul-Yeol(鬱熱) ; Rhizoma Cyperi, Rhizoma cotydalis, Resina Myrrhae in the symptoms of Yer-Heol(瘀血) ; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis in the symptoms od Tam-Kuel(痰厥). On the other hand, classifying and using the modification and utility method by the character of drug in order to coinside with Peon-Zheng (辨證) and pharmacologic effect, and finding out the therapeutic methods and prescriptions to protect the sideaction, it is considered that the better therapeutic effect will gain.
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( Sung Gyu Im ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic hepatitis C (CHC) is a major comorbidity in patients with hemophilia. We assessed the safety and efficacy of new direct acting antiviral agents for CHC in hemophilia. Methods: Patients (n=30) were enrolled between September 2015 and April 2016. Twenty-six patients were genotype 1 (1b, n=21; 1a, n=5) and 4 patients were genotype 2a/2b. Among 21 patients with genotype 1b, Y93H resistance-associated variants (RAVs) were detected in 3 patients (14.3%). We evaluated rapid virologic responses (RVRs), end-of-treatment response (ETRs), sustained virologic response (SVRs) at 24 weeks, relapse and safety. Results: According to medical insurance system in Korea, 5 patients with genotype 1a and 3 patients with genotype 1b (RAV positive) received ledipasvir/sofosbuvir for 12 weeks. RVRs, ETRs, and SVR24 rates were 100% (8/8). Eleven patients with genotype 1b were treatment-naive and received daclatasvir plus asunaprevir for 24 weeks. ETRs, and SVR24 rates were 91% (10/11). One patient experienced viral breakthrough without RAV at 12 weeks. Seven treatment-experienced patients with genotype 1b received daclatasvir plus asunaprevir for 24 weeks. ETRs, and SVR24 rates were 85.7% (6/7). One patient experienced viral breakthrough with RAV (L31M, Y93H) at 12 weeks. Four patients with genotype 2a/2b (treatment- naive, n=2, treatment-experienced, n=2) received sofosbuvir plus ribavirin for 12 weeks. RVR, ETRs, and SVR24 rates were 100% (4/4). No serious adverse event-related discontinuations or dose interruptions were noted. Conclusions: New oral direct acting antiviral treatment achieved high sustained virological response rates at 24 weeks in CHC patients with hemophilia without serious adverse events.
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( Sung Gyu Im ),( Sun Hong Yoo ),( Young Min Park ),( Sang Jin Lee ),( Sun Kyung Jang ),( Dong Ok Jeon ),( Hyo Jin Cho ),( Mi Jung Oh ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33 yearold male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine. (Clin Mol Hepatol 2015;21:180-182)
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( Sung Gyu Im ),( Hyung Joon Kim ),( Hyun Woong Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Interleukin 6(IL-6) has a context-dependent pro- and anti-inflammatory properties. Here we evaluate the impact of IL-6 levels according to the natural history of chronic hepatitis B (CHB) infection. Methods: Patients (n=71) with hepatitis B virus (HBV) were enrolled between September 2015 and April 2016. Treatment-naïve chronic HBV carries were recruited. We examined serum levels of IFN-γ, TNF-α, IL-2, IL-6, and IL-17A were measured by a cytometric bead assay (CBA; BD biosciences). Soluble PD-1 and soluble CD14 were made by the enzyme linked immunosorbent assay (ELISA) technique using the kit supplied from R&D systems (catalogue number, sPD-1: DY1086, sCD14: DC140). We studied patients with inactive CHB phase (HBV DNA< 1,000 copies/ml, anti-HBeAg + and normal ALT, n=22), immune tolerant phase (HBV DNA > 10,000 copies/ml, HBeAg + and normal ALT, n=36), and immune active phase (eleavated ALT and HBV DNA>10,000 copies/ml, n=13). Results: Serum IL-6 level was significantly higher in patients with immune active phase compared with immune tolerant phase and inactive CHB phase (IL-6: 1,815±2,896 vs. 620.2±1,247 pg/mL vs. 267.3±1,152 pg/mL) (Kruskal-Wallis test, p=0.0017). Serum IL-2, IL-17A, IFN-γ, Tumor necrosis factor-alpha (TNF-α), sCD14, and sPD-1 levels appeared not to be correlated with the leading cause to liver damage. Conclusions: We found the impact of IL-6 levels to activate immune system as pro-inflammatory properties in patients with CHB infection.
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Chelidonium majus-Induced Acute Hepatitis
Im, Sung Gyu,Yoo, Sun Hong,Jeon, Dong Ok,Cho, Hyo Jin,Choi, Jin Young,Paik, Soya,Park, Young Min Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1
The use of traditional folk remedies is increasing throughout Asia. Chelidonium majus, a popular herbal remedy, is used to treat abdominal pain caused by various gastrointestinal disorders, including gastric ulcer, gastritis, and biliary tract disease, because of its morphine-like effect. We encountered a 62-year-old woman with acute hepatitis, in which C. majus was suspected to be the etiological factor. The patient had taken high dose of C. majus extract for the preceding 60 days. The clinical context and the temporal association between the start of the herbal medicine treatment and her liver injury allowed us to attribute a causative role to C. majus. The diagnosis was confirmed by liver biopsy and the Council for International Organizations of Medical Sciences/Roussel Uclaf Causality Assessment Method (CIOMS/RUCAM) scale. After C. majus was discontinued, the liver function was restored to normal. In conclusion, because the use of phytotherapy is increasing, we wish to raise awareness of the potential adverse effects of C. majus.
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Clinical Efficacy of Daclatasvir and Asunaprevir for Chronic Hepatitis C Patients with Genotype 1b
( Sung Gyu Im ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We assessed the safety and efficacy of daclatasvir plus asunaprevir for chronic hepatitis C patients with Genotype 1b. Methods: Patients (n=60) were enrolled between August 2015 and October 2016. Sixty patients were genotype 1b. Resistance-associated variants (RAVs) were not detected. We evaluated end-of-treatment response (ETRs), sustained virologic response (SVRs) at 24 weeks, relapse and safety. Results: Thirty nine patients were treatment-naive and received daclatasvir plus asunaprevir for 24 weeks. ETRs, and SVR24 rates were 97.4% (38/39). One patient experienced viral breakthrough at 12 weeks. Twenty one treatment-experienced patients received daclatasvir plus asunaprevir for 24 weeks. ETRs, and SVR24 rates were 95.2% (20/21). One patient experienced viral breakthrough at 16 weeks. Adverse treatment-related events were reported in 8 (13.3%) patients. Transient aminotransferase increase >10-fold was noted in one (1.7%) patient. This patient stopped the medication at 16 weeks but achieved SVR24. Transient aminotransferase increase <5-fold was noted five (8.3%) patients. However, they did not discontinue the medication and achieved SVR24. Two (3.3%) patients complained of mild headache. Conclusions: Daclatasvir plus asunaprevir treatment achieved high sustained virological response rates (96.7%) at 24 weeks in chronic hepatitis C patients with genotype 1b without serious adverse events.
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Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report
Sung Gyu Im,유선홍,Young Min Park,Sang Jin Lee,Sun Kyung Jang,Dong Ok Jeon,Hyo Jin Cho,Mi Jung Oh 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine. (Clin Mol Hepatol 2015;21:180-182)
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