Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Flexural Responses of Prestressed Hybrid Wide Flange Composite Girders

Sun?Jin Han,Deuck Hang Lee,Jae?Yuel Oh,Seung?Ho Choi,Kang Su Kim 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.5

In this study, prestressed hybrid wide flange (PHWF) composite girders were proposed, and full-scale flexural tests were conducted to evaluate their structural performances. This new proposed girder system was developed and designed to effectively resist external loads considering the actual construction sequences. Two specimens with and without shear connectors were fabricated and tested to examine the effect of the shear connectors for achieving the fully-composite behaviors between a cast-in-place (CIP) concrete and the prefabricated prestressed steel–concrete composite girder. The test results showed that sufficient flexural strengths and deformation capacities can be obtained in both types of PHWF composite girders with and without shear connectors. To reflect the actual construction stages of the proposed PHWF composite girder, nonlinear flexural analyses were proposed considering the prestress effect and segmental effect before and after composite with the CIP concrete, respectively. The observed and analysis results of strain behaviors of the PHWF girder specimens were also compared and discussed in detail.

유아기 자녀를 둔 부모의 자녀교육관 및 양육태도 조사연구

박홍선,박경란 인제대학교 아동ㆍ가족복지연구소 1998 아동ㆍ가족복지연구 Vol.2 No.-

As the nuclear and double income families are increasing resecently, the role of parents for their children is recognized to be very important. In this context, this study examined educational views and child-rearing attitudes of parents with preschool children specially with focuses on : First, general trend of parents' educational views and child-rearing attitudes. Second, parents' educational views and child-rearing attitudes according to their individual background(such as age, education, and family's income level). Third, differences in educational views and child-rearing attitudes between fathers and mothers.

발포 유기질 단열재의 경시특성에 관한 연구

조항선,김우식,염경호,남궁식 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.1

The aging properties of cellular plastic insulations(EPS,PUF and UFF) were investigated by varying temperature, relative humidity and time. The time aging properties were changed with in 10 - 12% of initial properties at high temperature(above 318K) and relative humidity (above 90%). The amount of HCHO gas release from UFF was increased as temperature and relative humidity increased, and HCHO release rate was decreased exponentially with time.

하악 제1대구치의 치근 만곡에 영향을 주는 요인

최항문,이원진,허민석,이삼선,김정화,최순철,박태원 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To find the cause of root curvature by use of panoramic and lateral cephalometric radiograph. Materials and Methods : Twenty six 1st graders whose mandibular 1st molars just emerged into the mouth were selected. Panoramic and lateral cephalometric radiograph were taken at grade 1 and 6, longitudinally. In cephalometric radio graph, mandibular plane angle, ramus-occlusal plane angle, gonial angle, and gonion-gnathion distance (Go-Gn distance) were measured. In panoramic radio graph, elongated root length and root angle were measured by means of digital subtraction radiography. Occlusal plane-tooth axis angle was measured, too. Pearson correlations were used to evaluate the relationships between root curvature and elongated length and longitudinal variations of all variables. Multiple regression equation using related variables was computed. Results : The Pearson correlation coefficient between curved angle and longitudinal variations of occlusal plane-tooth axis angle and ramus-occlusal plane angle was 0.350 and 0.401, respectively (p<0.05). There was no significant correlation between elongated root length and longitudinal variations of all variables. The resulting regression equation was Y=10.209+0.208X_(1)+0.745X_(2) (Y: root angle, X_(1): variation of occlusal plane-tooth axis angle, X_(2): variation of ramus-occlusal plane angle). Conclusion: It was suspected that the reasons of root curvature were change of tooth axis caused by contact with 2nd deciduous tooth and amount of mesial and superior movement related to change of occlusal plane. (Korean J Oral Maxillofac Radiol 2006; 36 : 55-62)

系統分類學에 있어서 形質評價方法

고흥선 全北大學校 生物學硏究所 1981 生物學硏究年報 Vol.2 No.-

Recently, the wide use of computers, the refiniment of methods for chromosomal analyses, and new techniques for electrophoretic studies have enabled systematists to interpret evolution through different lines of research, i. e., phenetic, chromosomal, and molecular. Computer applicat'ons are closely related to the methods of 'numerical taxonomy, and the basic tenets of 'numerical taxonomy' are; (1) acceptance of equal weightings for each character; and (2) use of resemblance rather than key characters to compare taxa (Sneath and Sokal, 1962).

特性 부가 文法에 依한 類似 標的의 區分

김항준,홍순목,박민호 경북대학교 공과대학 1983 工大硏究誌 Vol.12 No.-

syntactic method is a general tool for pattern recognition but it's not good at distinguishing similar object. In this paper, we use attributed grammar to distinguish long nose plier from diagonal cutter, and good experimental results are obtained.

산 촉매에 의한 N- (3,4-Dimethoxybenzyl)sulfonamide 유도체의 C-N 결합의 분해

金善嬉,鄭起源,李英行,李寀浩 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.2

Cleavage reaction of N-(3,4-dimethoxybenzyl)sulfonamides has been examined. Treatment of these compounds with trifluoroacetic acid afforded sulfonamides which 3,4-dimethoxybenzyl group was removed.

일산화탄소 중독시 과산화수소 관장에 의한 혈액가스의 변동

윤경선,고응린,박항배 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

The administration of hydrogen peroxide as the means of correcting tissue hypoxia has been studied by many researchers since early 1920's. The purpose of this study is to investigate the validity of clinical application of H₂O₂ enema for the treatment of carbon monoxide poisoning which, in Korea, is one of the most serious life threatening maladies. Sixty rabbits were exposed to carbon monoxide (7,000 ppm) for fifty minutes and the arterial blood gas pictures before and after the exposure were observed. Immediately after the exposure, half of the animals were given with 10ml of 0.5% H₂O₂ solution per kg plus 1 ml of human whole blood by enema and the other half(control) simply with 10 ml of physiologic saline per kg by the same route. A series of blood sampling and gas analysis in every thirty minutes (up to 2 hours) following the enema were carried out and comparison was made between the two groups. The conclusions were as follows: 1) The arterial blood gas picture after the exposure(poisoning) to carbon monoxide was suggestive of partially compensated metabolic acidosis which is interpreted as the result of lactic acid formation by anaerobic tissue metabolism. 2) Immediately after the exposur, extreme reduction of arterial PaCO₂ was observed. The reduced tissue metabolism through aerobic pathway and hyperventilation to overcome the hypoxic condition, both are considered to be the cause of this drop in arterial CO₂ tension. 3) Arterial PaO₂ of the experimental group at 30 minutes after the enema with 0.5% H₂O₂ solution was 19.5 mmHg higher than that of control group and this difference decreased gradually to 10.3 mmHg at 120 minutes. Even though the result of tissue oxygenation by H₂O₂ enema is far less satisfactory than that of 100% oxygen inhalation, the application of this method may be considered as substitute of (or supplement to) oxygen treatment in some particular situations when oxygen equipment is not available or pulmonary function is significantly inhibited (e.g. burn to the respiratory tract, pneumonia etc).

정신병환자의 통합치료를 위한 낮병원 모델

함웅,김선재,윤성철,성상경,이규항,이후경 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

본 연구는 통합치료를 위한 낮병원 모델을 소개하고, 이 모델의 낮병원 치료를 시행하여 그 결과를 평가하고 시행과정 중에 나타난 특징을 분석하며, 우리 실정에 맞는 낮병원 모델을 발전시켜. 정신병환자를 효과적으로 돕고 사회 재적응을 촉진시키기 위한 목적으로 실시되었다. 본 모델의 낮병원 치료를 1996년 5월부터 12월까지 총 25명의 환자를 대상으로 실시하였다. BPRS. 삶의 만족 척도, 프로그램 유익성 척도, 13가지 치료요인 척도, 가장 중요한 사건 설문지를 낮병원 치료초기와 말기에 시행하여 그 결과를 중심으로 낮병원 모델에 대한 평가를 하였다. 본 연구결과는 다음과 같다. 1) 본 낮병원 모델은 나이, 입원횟수, 유병기간. 기능수준에 있어 다양한 환자들에게 광범위한 치료를 제공할 수 있었다. 2)본 낮병원 모델은 치료효과라는 측면에서 볼 때 주로 음상증상을 호전시키고 주관적인 삶의 만족도를 높여주는데 기여하였다. 3) 상위기능집단과 하위기능집단으로 나누었을 때 상위기능집단에서는 집단정신치료, 싸이코드라마등 비구조적이고 자신의 내면을 깊이 있게 탐구를 할 수 있는 치료를 높이 평가하였으나 하위기능집단에서는 그렇지 않았다. 그러므로 두 집단으로 나누어 낮병원 치료를 진행하는 것이 더 효과적일 수 있다. 4) 치료요인의 결과를 살펴보면 상위기능집단과 하위기능집단 모두 치료가 진행됨에 따라 작용하는 치료요인에 차이가 있었으며. 상위기능집단은 말기에 대인관계학습을 더 중요시하였고. 하위기능집단은 말기에 사회화 기술의 발달을 더 중요시하였다 그러므로 상위기능집단은 낮병원 종결 후 장기외래환자 집단정신치료에. 하위기능집단은 사회복귀시설에 참여하는 것이 타당할 것으로 생각된다. 5) 본 낮병원 모델은 전체적으로 운영하기가 편하였고, 치료인력을 최대한 효율적으로 사용 할 수 있게 하였다. Objects : The purpose of this study was to present a day hospital model(hereinafter called as "this model" ) for integrated therapy, to evaluate the result of performing this model, and thus to develop day hospital model for helping psychotic patients effectively and promoting social re-adaptation. Methods : The authors performed this day hospital model from 1996, May to December. A total of 25 psychotic patients participated in this study. BPRS, Life Satisfaction Se1f-Rating Scale, Program Helpfulness Scale, 13 Therapeutic Factors Scale, and Most Important Event Questionnaire were used at the start of day hospital treatment and at the end. Results : The results were as fo11ows : 1) In this model, It was possible to offer the wide treatment to heterogeneous patients who varied in age, number of admission, duration of illness, and functional level. 2) In the aspect of therapeutic effect, this model contributed for improving negative symptoms and increasing subjective life satisfaction 3) When the patients were divided into the higher functional level group and the lower functional level group, the higher functional level group set a high value on group psycho-therapy and psychodrama that were unstructured and could make patients explore their inner side deeply. But the lower functional level group did not so. Therefore dividing into two groups by functional level may be more effective for day hospital treatment. 4) Therapeutic factors were different between the periods of der hospital treatment. And in the higher functional level group, 'interpersonal learning' was important at the last period, but in the lower functional level group, 'socializing technique' was important at the last period. So long-term group psychotherapy may be more suitable for the artier-care of the higher functional level group, and day care or other psychosocial rehabilitation programs may be more suitable for the after-care of the lower functional level group. 5) This model was easy to apply to Korean day hospital setting, and made staffs treat patients efficiently. Conclusion: This day hospital model would be used effectively and efficiently in Korean day hospital setting.