알코올중독의 약물치료

성상경,Sung, Sang Kyung 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

This review focused on the pharmacological treatment of alcoholism, especially alcoholism-related mental disorder. The pharmacological agent for alcoholism can be divided into the following categories : anticraving agent, aversive agent, agent to treat acute alcohol withdrawal, agent to diminish drinking by treating associated psychiatric pathology, agent to induce sobriety in intoxicated individuals. Following trends are included in new trends of pharmacological treatment of alcoholism. What are precise conditions amenable to pharmacological intervention? ; How can psychosocial and behavioral intervention be integrated with pharmacotherapy to enhance treatment outcome? ; Is the concept of "matching" specific pharmacotherapy treatment to different aspect of alcoholism more efficacious than a more generalized medicational approach to treatment? One of the most important factors for alcoholics treatment is good and proper therapeutic relationship with patients and setting up individually specialized treatment program is also important.

공진형 가속도계를 위한 제어루프의 설계

성상경,이장규,강태삼 제어로봇시스템학회 2000 제어로봇시스템학회 합동학술대회 논문집 Vol.2000 No.3

한국인 알코올중독 환자의 예후인자에 관한 연구 : 심리적, 사회적, 생물학적 요인을 중심으로

성상경,장환일,Sung, Sang-Kyung,Chang, Hwan-Il 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

The author studied prognostic indicators of sixty Korean male alcoholics in psychological, social and biological aspects who were divided into abstinent and drinking groups. Thirty patients were assigned to each group. They were controlled in age and sex. Both groups were compared in terms of the demographic characteristics, past drinking history, treatment history, famaily history, ego strength and personality factors differences and distribution of dopamine $D_2$ receptor gene Al allele. Also the author studied relation of clinical course, alcoholic family history and dopamine $D_2$ receptor gene Al allele in both groups. The results were as follows; 1) The abstinent group had higher rate of married state, higher economic status, longer education years and maintained more stable job than the drinking group. But made no differences in occupation and religion. 2) The abstinent group showed higher rate of living with family members than the drinking group, and wives and fellows of the alcoholics anonymous were important factors for maintenance of abstinence. Family loading and parent's characters were not different. 3) The abstinent group had longer maximal length of abstinence but mean amount of alcohol consumption per day were larger than the drinking group. But there were no differences in duration of past drinking, drinking pattern, main drinking time, first drinking age and preference of the kind of alcoholic beverage in the past drinking history. 4) The abstinent group showed stronger treatment motivation, absolute abstinence in treatment goal, more voluntary adimission and maintained longer therapeutic relationship otter discharge than the drinking group. But both groups showed negative attitude toward antabuse therapy. 5) The abstinent group had higher mean score in ego strength scale than the drinking group. 6) In the personality factor questionnaire, the abstinent group showed strong laugh poise and the trait of praxernia, conservatism personality but the drinking group showed tough poise, the trait of weak ego strength(unstableness) and tough mindedness personality. 7) In comparision of dopamine $D_2$ receptor gene A1 allele, the prevalence of A1 allele was seventy percent and the frequency was 0.38 in the abstinent group. The prevalence of A1 allele was sixty percent and the frequency was 0.42 in the drinking group. Both groups were not significantly different in A1 allele prevalence and frequency. 8) In comparision of dopamine $D_2$ receptor gene A1 allele according to alcoholic family history, the prevalence of A1 allele was seventy percent and the frequency was 0.43 in the family history positive group. The prevalence of A1 allele was sixty-one percent and the frequency was 0.38 in the family history negative group. Both groups were not significantly different in A1 allele prevalence and frequency. In comparision of past drinking history according to alcoholic family history, the family history positive group showed earlier first drinking and problem drinking, but the family history negative group hod longer duration of past drinking. The mean amount of alcohol consumption per day, the longest duration of abstinence and Alcoholism Screening Test of Seoul Natoinal Mental Hospital(NAST) results were not significant. In conclusion, the results suggest that successful prognostic indicators of Korean alcoholics are married state, higher economic status, longer education years, stable job, living with family members, longer abstinence during past drinking history, strong treatment motivation, absolute abstinence in treatment goal, voluntary adimission, maintained therapeufic relationship, strong ego strength and the trait of praxernia, conservatism personality. But occupation, religion, alcoholic family history, parent's characters, duration of past drinking, drinking pattern, main drinking time, first drinking age, preference of the kind of alcoholic beverage, attitude to an

Oscillation Amplitude-controlled Resonant Accelerometer Design Using a Reference Tracking Automatic Gain Control

성상경,김창주,이영재,박정근,박준구 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.2

In this paper, it is presented a novel approach for the self-sustained resonant accelerometer design, which takes advantages of an automatic gain control in achieving stabilized oscillation dynamics. Through the proposed system modeling and loop transformation, the feedback controller is designed to maintain uniform oscillation amplitude under dynamic input accelerations. The fabrication process for the mechanical structure is illustrated in brief. Computer simulation and experimental results show the feasibility of the proposed accelerometer design, which is applicable to a control grade inertial sense system.

공진형 가속도계를 위한 폐루프 제어시스템의 설계

성상경,이장규,강태삼 제어로봇시스템학회 1999 제어로봇시스템학회 국내학술대회 논문집 Vol.3 No.10

A Novel Control Loop Design and Its Application to the Force Balance of Vibratory Rate Sensor

성상경,윤석창,김창주,이영재,성운탁 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.4

This paper investigates a new loop design approach of force balance control for the vibratory rate sensor application. The proposed force balance control design takes advantages of the modified automatic gain control configuration in controlling the system’s oscillating dynamics at the sense mode. The adapted automatic gain control scheme and force balance strategy, which maintains a constant oscillation magnitude in the sense mode, have several advantages. First it is possible to analyze a complicated nonlinear feedback system using a linear control theory, which resulted in straightforward prediction of closed loop performance. Moreover the control system to achieve the design goals can be implemented using a relatively simple feedback configuration. An application to the vibratory rate sen-sor using the proposed automatic gain control configuration witnessed that the force balance control can be validated in a practical design process. Experiments using an actual micromachined rate sensor verified the feasibility of the proposed control scheme with demonstration of enhanced performance.

미세먼지의 영향을 고려한 머신러닝 기반태양광 발전량 예측

성상경,조영상 한국환경경제학회 2019 자원·환경경제연구 Vol.28 No.4

Uncertainty of renewable energy such as photovoltaic(PV) power is detrimental to the flexibility of the power system. Therefore, precise prediction of PV power generation is important to make the power system stable. The purpose of this study is to forecast PV power generation using meteorological data including particulate matter(PM). In this study, PV power generation is predicted by support vector machine using RBF kernel function based on machine learning. Comparing the forecasting performances by including or excluding PM variable in predictor variables, we find that the forecasting model considering PM is better. Forecasting models considering PM variable show error reduction of 1.43%, 3.60%, and 3.88% in forecasting power generation between 6am~8pm, between 12pm~2pm, and at 1pm, respectively. Especially, the accuracy of the forecasting model including PM variable is increased in daytime when PV power generation is high. 태양광 발전과 같은 신재생에너지의 불확실성은 전력계통의 유연성을 저해하며, 이를 방지하기 위해서는 정확한 발전량의 사전 예측이 중요하다. 본 연구는 미세먼지 농도를 포함한 기상자료를 이용하여 태양광 발전량을 예측하는 것을 목적으로 한다. 본 연구에서는 2016년 1월 1일부터 2018년 9월 30일까지의 발전량, 기상자료, 미세먼지 농도 자료를 이용하고 머신러닝 기반의 RBF 커널 함수를 사용한 서포트 벡터 머신을 적용하여 태양광 발전량을 예측하였다. 예측변수에 미세먼지 농도 반영 유무에 따른 태양광 발전량 예측 모델의 성능을 비교한 결과 미세먼지 농도를 반영한 발전량 예측 모델의 성능이 더 우수한 것으로 나타났다. 미세먼지를 고려한 예측 모형은 미세먼지를 고려하지 않은 예측 모형 대비 6~20시 예측 모형에서는 1.43%, 12~14시 예측 모형에서는 3.60%, 13시 예측 모형에서는 3.88%만큼 오차가 감소하였다. 특히 발전량이 많은 주간 시간대에 미세먼지 농도를 반영하는 모형의 예측 정확도가 더 뛰어난 것으로 나타났다.

정신분열증환자에서 Nemonapride와 Haloperidol의 치료결과 및 내약성에 대한 비교분석

성상경,홍광화,Sung, Sang Kyung,Hong, Kwang Wha 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

A single-blind comparative study was performed using haloperidol as a reference drug in order to evaluate the efficacy and safety of nemonapride, a new benzamide derivative, in sixty-nine Korean schizophrenic patients. the total period of the study was 8 weeks, maximum dosage of nemonapride was 36mg and that of haloperidol was 24mg. Psychopathology and extrapyramidal symptoms were assessed every week or four weeks until the end of the 8th week using the PANSS, BPRS, and 4 point general side effect check list, The drug safety was assessed every week until the end of the 8th week using vital sign, body weight, EEG, EKG, and blood chemistry. In total. one patient discontinued nemonapride treatment and seven patients discontinued haloperidol treatment before the end of the study. Therefore sixty-one patients(88 %) completed the study. PNASS and BPRS scores of the two groups on the end study point demonstrated a significant improvement compared with baseline score. The number of patients who had a clinical improvement of at least 20% in baseline score was similiar in both treatment groups. The difference of Simpson's rating scale socres were significant in both groups, and mean scores were more high in the haloperidol group than in nemonapride group. No significant EKG, EEG changes were induced, no relevant change in body weight or clinical laboratory parameters were observed in the sixty-one patients during 8 weeks and no Significant difference in the both groups. From these results, nemonapride is considered to be a clinically useful drug having a wide range of antipsychotic effect in schzophrenic patients.

새로운 구조를 갖는 실리콘 가속도계의 재평형 루프 설계

성상경,이장규,강태삼,하병주 제어로봇시스템학회 1997 제어로봇시스템학회 국내학술대회 논문집 Vol.1997 No.10

알코올중독 환자의 예후 예측에 관한 연구(Ⅱ) : 가족력 및 DRD₂와의 관계를 중심으로

성상경,차성조,이규항,이정균 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

알코올중독 환자의 예후인자를 알아보기 위해 나이와 성별을 통제하여 음주군과 단주군 남자환자 각각 30명을 대상으로 비교 연구하였다. 양군간의 인구통계학적 특성, 음주력, 가족력, 자아강도 등의 차이 및 도파민 D2수용체 유전자 분포를 비교하였으며, 질병경과, 가족력 및 도파민 D2수용체 유전자와의 관련성을 알아보았다. 그 결과는 다음과 같다. 1) 단주군은 음주군에 비해 기혼율이 높았으며, 높은 경제상태, 높은 학력 등이 중요한 요소였으나 직업의 종류 및 종교에 있어서는 차이가 없었다. 2) 단주군은 음주군에 비해 과거 음주력상 최대 단주기간이 길었으나 평균 음주량이 더 많았다. 또한 음주군은 단주군에 비해 사회경제적 스트레스 및 정신적 불안정이 주된 음주 이유인 경우가 많았으나 음주기간, 음주양상, 음주시기, 음주시작 연령, 술의 종류에 있어서는 차이가 없었다. 3) 알코올중독의 가족력에 따른 비교에서 단주군과 음주군 사이에 유의한 차이는 없었다. 4) 단주군은 음주군에 비해 자아강도의 평균점수가 더 높았다. 5) 도파민 D2수용체 유전자의 A1 대립유전자 비교에서 단주군에서 A1 대립유전자의 이환율은 70%, 음주군에서는 60%였다. A1 대립유전자의 빈도는 각각 0.38과 0.42로 양군간에 차이는 없었다. 6) 알코올중독 가족력에 따른 도파민 D2 수용체 유전자분포 비교에서 가족력이 있는 군에 A1 대립유전자의 이환율은 70%, 빈도는 0.43이었고, 가족력이 없는 군에서는 이환율이 61%, 빈도는 0.38로 양군간에 유의한 차이는 없었다. 가족력이 있는 경우에 음주시작의 연령이 더 낮았으며 문제음주도 보다 일찍 나타났다. 그러나 평균 음주기간은 가족력이 없는 경우에 더 길었으며, 평균 음주량, 최고 단주기간 및 NAST 비교에서는 차이가 없었다. 결론적으로 알코올중독 환자의 긍정적 예후인자로 기혼, 높은 학력 및 경제상태, 과거 음주력상 보다 긴 단주 기간 및 강한 자아강도를 들 수 있었다. 반면에 직업, 종교, 알코올중독 가족력 유무, 음주기간, 음주양상, 음주시작 연령, 술의 종류 및 도파민 D2수용체 유전자 A1 대립유전자 분포 등에서는 알코올중독의 예후의 의미 있는 상관관계가 없었다. Objectives : The purpose of the study was to identify the prognosis-predicting indicators is alcoholics by the correlation between prognosis and demographic characteristics, ego strength, family history and distribution of dopamine D2 receptor gene A1 allele. Methods : The subjects were composed of 60 alcoholics including 30 psychiatric inpatients(drinking group) and 30 alcoholics abstinent for 6 months or more after discharge(abstinent group). They were investigated with interview, questionnaire, blood sample and review of their charts. Results : The results were as follows ; 1) The abstinent group had higher rate of married state, higher economic status and longer education years than the drinking group. There were no differences in occupation and religion between the two groups. 2) There were no differences between the abstinent group and drinking group according to alcoholic family history. 3) The abstinent group had higher mean score in ego strength scale than the drinking group. 4) In comparision of dopamine D2 receptor gene A1 allele, the prevalence of A1 allele was seventy percent and the frequency was 0.38 in the abstinent group. The prevalence of A1 allele was sixty percent and the frequency was 0.42 in the drinking group. Both groups were not significantly different in A1 allele prevalence and frequency. 5) In comparision of dopamine D2 receptor gene A1 allele according to alcoholic family history, the prevalence of A1 allele was seventy percent and the frequency was 0.43 in the family history positive group. The prevalence of A1 allele was sixty-one percent and the frequency was 0.38 in the family history negative group. Both groups were not significantly different in A1 allele prevalence and frequency. Conclusions : With the above results, the authors think that successful prognostic indicators of alcoholics are married state, higher economic status, longer education years, longer abstinenence period in past history, and strong ego strength. But family history and distribution of dopamine D2 receptor A1 allele were not significantly related to the prognositc indicators of alcoholics.