Comparison of the pharmacokinetics and pharmacodynamics of YH4808 in healthy subjects for defning an appropriate dosing regimen

Sukyong Yoon,오은실,박민수,장성복,변해미,Hyeonsoo Park,Heeyoung Kim,김춘옥 대한임상약리학회 2021 Translational and Clinical Pharmacology Vol.29 No.3

YH4808 is a novel potassium-competitive acid blocker developed for gastric acid-related disorders. Previous studies indicate its potential to improve symptoms of gastric acid-related disorders. The current study was aimed to find the optimal regimen of YH4808 for night time pH control. This study was performed in two parts. Each was a randomized, open-label, active-controlled, multiple-doses, two-treatment, two-period crossover study conducted in 20 healthy Korean volunteers. Subjects were randomly assigned to one of the four groups. The three groups received different dosage regimens of YH4808 (100 mg twice a day, 200 mg once a day, or 200 mg twice a day), and the fourth group received esomeprazole 40 mg twice a day. The pharmacokinetic parameters demonstrated that the systemic exposure of YH4808 increased in a dose-proportional manner. The difference in the proportion of time above pH 4 over 24 h from the baseline was the greatest in the group receiving YH4808 200 mg twice a day. The values of the area under the effect curve at night time (12 A.M.–7 A.M.) were higher in all YH4808 groups than in the esomeprazole group. However, the differences among the YH4808 groups were not statistically significant (p > 0.05). YH4808 exhibited potential for better pH control during the night in comparison to esomeprazole. The optimal regimen for night time pH control among all the YH4808 regimens was 200 mg twice a day.

언어유형론적 관점에서 본 현대중국어 ‘S+很+A+O’ 구문의 문법 제약과 발전 기제

유수경 ( Yu¸ Sukyong ),곡효여 ( Qu¸ Xiaoru ),윤애경 ( Yoon¸ Aekyoung ),박정구 ( Park¸ Jungku ) 한국중국언어학회 2023 중국언어연구 Vol.- No.108

The ‘S+hen(很)+A+O’ structure of modern Chinese is a transitive construction with an adjective as a main predicate, and is distinguished from general adjective-predicate sentences in that it accompanies an object. According to this study, the predicate used in the phrase ‘S+hen+A+O’ is a disyllabic adjective and represents the speaker’s mental state. Compared to other adjectives, it shows a relatively high willingness. In the construction ‘S+hen+A+O’, O can be a VP object or a clausal object, and in many cases it can accompany both forms, but in some cases it can only take one of the two forms. This difference in object form is related to the objectivity of the proposition expressed by the object clause, and ultimately affects the degree of transitivity of the construction. The construction ‘S+hen+A+O’ has a higher transitivity than general adjective-predicate construction in terms of the number of participants, willingness, and agency, but the properties of adjective predicates are still the same in that the degree adverb ‘很’ needs to be modified. The construction ‘S+hen+A+O’ occupies an intermediate position between psychological verbal predicates and adjective predicates in the continuum of transitivity. The psychological adjective construction ‘S+hen+A+O’ exists universally across languages, and in particular, there are many cases in which the form is realized through a transitive structure, which is a result of the productivity and economy of the transitive structure.

Pharmacodynamic evaluation of YH4808 for Helicobacter pylori eradication in healthy subjects

Hyeonsoo Park,김춘옥,Mikyung Kim,Yeji Lim,이우열,Sukyong Yoon,박민수 대한임상약리학회 2020 Translational and Clinical Pharmacology Vol.28 No.3

YH4808 is a novel selective potassium-competitive acid blocker demonstrated to be safe andto have inhibitory effects against gastric acid secretion in previous studies. A randomized,open-label, multiple-dose, 3-treatment, 1-period, parallel design study was conducted tocompare the Helicobacter pylori eradication rates and acid suppression capacities of threeregimens in 60 healthy subjects with H. pylori-positive, and the potential of YH4808 toreplace proton-pump inhibitors (PPIs) in standard regimens for H. pylori eradication. Group1 received YH4808, amoxicillin, and clarithromycin as a novel triple regimen, while Group2 received YH4808 and amoxicillin only, and Group 3 received esomeprazole, amoxicillin,and clarithromycin, as the standard triple regimen. H. pylori eradication rates were 85.0% forGroup 1, 25.0% for Group 2, and 83.3% for Group 3. Relative response rate between Group 1and 3 was 1.02 (0.50–2.07; 95% CI, χ2test p = 0.8881). Furthermore, the novel triple regimen,YH4808, amoxicillin, and clarithromycin, stably inhibited acid secretion and maintaineda gastric pH greater than 4 or 5 for 24 hours, which was comparable to the pH range in thestandard triple regimen. However, the onset times of the YH4808 regimens were earlier thanthat for the regimens using esomeprazole. There were no differences in the incidences orseverity of adverse events among the three groups. Overall, the novel triple regimen was safeand well-tolerated. YH4808 could replace PPIs in standard triple regimens used for H. pylorieradication.

Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects

이우열,오은실,Mengqi Cui,김춘옥,Yeji Lim,Hunam Kim,Hyeonsoo Park,Sukyong Yoon,박민수,홍태곤 대한임상약리학회 2020 Translational and Clinical Pharmacology Vol.28 No.1

YH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination with amoxicillin and clarithromycin for Helicobacter pylori eradication. We compared the pharmacokinetic (PK) profiles and safety of amoxicillin, clarithromycin, and YH4808 used as monotherapies or in combination for evaluating potential drug interactions. An open-label, randomized, single-dose, Latin-square (4 × 4) crossover study was conducted in 32 healthy Korean volunteers. Subjects were randomly assigned to one of the 4 treatment sequences that consisted of 4 periods separated by 21-day washout intervals. PK parameters of YH4808, amoxicillin and clarithromycin administered in combination were compared with those of the respective monotherapies. The geometric mean ratios of the maximum concentration (Cmax) and the area under the time-concentration curve from time zero to time of the last quantifiable concentration (AUClast) of YH4808 increased during the triple therapy by 48.6% and 29.1%, respectively. Similarly, the Cmax and AUClast of M3 (active metabolite of YH4808) increased by 23.3% and 16.0%, respectively. The Cmax and AUClast of clarithromycin increased by 27.4% and 30.5%, and those of 14-hydroxyclarithromycin were increased by 23.1% and 32.4%, respectively. The corresponding amoxicillin values decreased during the triple therapy by 21.5% and 15.6%, respectively. There was no clinically significant change in safety assessment related to either monotherapies or triple therapy. In conclusion, amoxicillin, clarithromycin and YH4808 administered as triple therapy did not exhibit significant PK interactions and were not associated with safety issues.

대한인간공학회지 게재 논문: 읽기 매체의 종류와 읽는 글의 길이에 따른 대학원생의 논문 가독성 및 이해도 비교

강요한(Yohan Kang),박동건(Donggun Park),이경준(Kyungjun Lee),김누리(Nuri Kim),김수경(Sukyong Kim),김현용(Hyunyong Kim),임세호(Seho Yim),윤명환(Myunghwan Yoon) 대한인간공학회 2018 대한인간공학회 학술대회논문집 Vol.2018 No.11

20세기 후반에 컴퓨터와 인터넷의 발달로 사람들이 문자를 디지털의 형태로 읽는 것이 가능해졌다. 이는 읽기 매체를 선정하는 데 있어 종이만이 아닌 PC나 태블릿도 고려의 대상이 될 수 있다는 것을 뜻한다. 기존에 태블릿 PC의 E-book을 이용할 때의 피드백에 관한 선행 연구는 존재했으나, 사용자를 대학원생으로, 읽는 대상을 논문으로 삼고 읽기 매체의 종류에 따른 대학원생의 논문 가독성 및 이해도에 대한 연구는 미미하다. 본 연구는 대학원생이 논문을 읽을 때, 종이, 모니터, 태블릿 중 어떤 매체를 사용할 때 가장 논문에 대한 가독성 및 이해도가 효과적이며, 글의 길이와 각 매체간 읽기능력의 상관관계를 살펴보고자 하였다. 실험대상은 대학원생 13명을 대상으로 실시하였다. 연구 결과, 반페이지 분량의 경우 가독성과 이해도에서 큰 차이를 확인할 수 없었고, 한 페이지 분량의 경우 가독성면에서 PC와 종이매체가 이해도면에서 종이매체가 좀 더 나은 결과를 보였다. 이를 통하여 단문길이의 글을 보는 경우 어떠한 읽기매체를 활용하여도 큰 차이가 없겠지만, 장문의 경우 신속함을 필요로하는 경우엔 PC를 정확도와 이해도를 필요로 하는 경우에는 종이 매체를 선택하는 것이 추천되겠다.