수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향

김미경 ( Kim¸ Mikyung ),한혜숙 ( Han¸ Hyesook ) 한국수학교육학회 2021 수학교육논문집 Vol.35 No.3

본 연구는 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향을 파악하기 위하여 대학 연계 자유학기제 융합수학탐구 수업에 신청한 49명의 학생들을 대상으로 단일집단 사전-사후 검사 설계를 통해 한 학기동안 이루어졌다. 본 연구의 주요 결과는 다음과 같다. 첫째, 사전, 사후 수학적 모델링 능력 검사 결과에 의하면, 사전 검사에 비해서 사후 수학적 모델링 검사의 평균 점수가 향상되었고, 사전, 사후 검사 간에 통계적으로 유의미한 차이가 있는 것으로 나타나 본 연구에서 제공한 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력을 향상시키는데 긍정적인 영향을 준다는 것을 확인하였다. 둘째, 각 문항별 분석 결과에 의하면 STEAM 수업 경험은 학생들의 창의적 사고 및 열린 사고를 요구하는 개방성이 높은 수학적 모델링 문항의 해결에 더욱 효과적인 것으로 나타났다. 셋째, 하위문항별 학생 응답 내용 분석 결과에 의하면, STEAM 수업 경험이 특히 학생들의 수학적 모델 구성 및 결과에 대한 타당성 검토 과정을 더욱 활성화시킨 것으로 나타났다. This study was conducted for one semester through one group pretest-posttest design with 49 first-year middle school students to explore the effects of mathematics-centered STEAM class experiences on students’ mathematical modeling abilities. The main results of this study are as follows: First, the results of the pre and post-mathematical modeling ability tests showed that the average score of posttest was improved compared to the pretest, and that the experiences of mathematics-centered STEAM classes provided in this study had a positive effect on improving the mathematical modeling ability of first-year middle school students. Second, STEAM classes were more effective in solving mathematical modeling problems that require students’ creative and divergent thinking. Third, the content analysis of student responses for each subquestion showed that STEAM classes were especially more helpful in activating students' mathematical model construction and validating steps.

Effect of fermented porcine placenta on physical fatigue in mice

Kim, Hee-Yun,Han, Na-Ra,Kim, Na-Rae,Lee, Mikyung,Kim, Jongbae,Kim, Chang-Ju,Jeong, Hyun-Ja,Kim, Hyung-Min SAGE Publications 2016 Experimental biology and medicine Vol.241 No.17

<P>The fatigue spreads among the people who live under stressful life and brings about a negative impact on physical function. Here we evaluated the anti-fatigue effects of fermented porcine placenta (FPP) and main constituents, lysine (Lys) and leucine (Leu) with treadmill stress test and forced swimming test (FST) in animal models. The mice were administrated with FPP, Lys, and Leu for 21 days. After treadmill exercise, FPP, Lys, and Leu significantly reduced fatigue-related biochemical parameters, including lactate, lactate dehydrogenase, glucose, creatine kinase, urea nitrogen, cortisol, and pro-inflammatory cytokines, whereas superoxide dismutase activity and glycogen levels were significantly increased by FPP, Lys, and Leu. In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain. Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-kappa B, interleukin (IL)-6, IL-1, and IL-4 through blockade of caspase-1/nuclear factor-B pathway in stimulated splenocytes. In addition, FPP, Lys, and Leu significantly promoted proliferation of splenocytes. In conclusion, these findings suggest the potential of FPP as a novel functional food for the regulation of fatigue.</P>

A Profile of Serum Mineral Parameters in Korean CKD Patients on Maintenance Hemodialysis

( Gheunho Kim ),( Bumsoon Choi ),( Daeryong Cha ),( Eunah Hwang ),( Hyungwuk Kim ),( Jaehyun Chang ),( Joohak Lee ),( Joongkyung Kim ),( Kwonwook Joo ),( Mikyung Kim ),( Sangchoel Lee ),( Sangwoong Ha 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

Efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes: A double‐blind randomized controlled trial ( INICOM study)

Lim, Soo,Han, Kyung Ah,Yu, JaeMyung,Chamnan, Parinya,Kim, Eun Sook,Yoon, Kun‐,Ho,Kwon, Sam,Moon, Min Kyong,Lee, Kwan Woo,Kim, Dong‐,Jun,Kim, Mikyung,Wongtanate, Manaj,Kim, Eun Young,Kim, S Blackwell Publishing Ltd 2017 Diabetes, obesity & metabolism Vol.19 No.1

<P><B>Background</B></P><P>Gemigliptin is a new dipeptidyl peptidase‐IV inhibitor. We investigated the efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes (T2D).</P><P><B>Methods</B></P><P>A total of 433 T2D patients with a glycosylated haemoglobin (HbA1c) level of 7.5% to 11.0% and a fasting plasma glucose (FPG) concentration <270 mg/dL were randomly assigned to 3 groups: (1) gemigliptin 50 mg qd + metformin 1000 to 2000 mg qd (titrated individually), (2) gemigliptin 50 mg qd, or (3) metformin 1000 to 2000 mg qd. The primary end‐point was the change in HbA1c level after 24 weeks. Secondary end‐points were the changes in FPG, insulin, proinsulin and C‐peptide levels. The percentages of responders who achieved an HbA1c level <7% (or <6.5%) were compared between treatment groups.</P><P><B>Results</B></P><P>Baseline HbA1c levels were 8.7% in all groups. The mean changes in HbA1c level from baseline to week 24 were −2.06%, −1.24% and −1.47% in the combination, gemigliptin monotherapy and metformin monotherapy groups, respectively. The 95% confidence intervals for between‐group differences in HbA1c changes were −1.02 to −0.63 in the combination group vs the gemigliptin group and −0.82 to −0.41 vs the metformin group, which confirmed the superiority of combination therapy. A significantly higher percentage of patients in the combination therapy group reached the target HbA1c level <7% (or <6.5%) compared with the monotherapy groups. No severe side effects were observed.</P><P><B>Conclusions</B></P><P>In T2D patients, the initial combination of gemigliptin and metformin had superior efficacy without safety concerns compared with monotherapy with either drug.</P>

NADPH Oxidase and the Cardiovascular Toxicity Associated with Smoking

Mikyung Kim,Chang-ho Han,Moo-Yeol Lee 한국독성학회 2014 Toxicological Research Vol.30 No.3

Smoking is one of the most serious but preventable causes of cardiovascular disease (CVD). Key aspects of pathological process associated with smoking include endothelial dysfunction, a prothrombotic state, inflammation, altered lipid metabolism, and hypoxia. Multiple molecular events are involved in smokinginduced CVD. However, the dysregulations of reactive oxygen species (ROS) generation and metabolism mainly contribute to the development of diverse CVDs, and NADPH oxidase (NOX) has been established as a source of ROS responsible for the pathogenesis of CVD. NOX activation and resultant ROS production by cigarette smoke (CS) treatment have been widely observed in isolated blood vessels and cultured vascular cells, including endothelial and smooth muscle cells. NOX-mediated oxidative stress has also been demonstrated in animal studies. Of the various NOX isoforms, NOX2 has been reported to mediate ROS generation by CS, but other isoforms were not tested thoroughly. Of the many CS constituents, nicotine, methyl vinyl ketone, and α,β-unsaturated aldehydes, such as, acrolein and crotonaldehyde, appear to be primarily responsible for NOX-mediated cytotoxicity, but additional validation will be needed. Human epidemiological studies have reported relationships between polymorphisms in the CYBA gene encoding p22phox, a catalytic subunit of NOX and susceptibility to smoking-related CVDs. In particular, G allele carriers of A640G and -930<SUP>A/G</SUP> polymorphisms were found to be vulnerable to smoking-induced cardiovascular toxicity, but results for C242T studies are conflicting. On the whole, evidence implicates the etiological role of NOX in smoking-induced CVD, but the clinical relevance of NOX activation by smoking and its contribution to CVD require further validation in human studies. A detailed understanding of the role of NOX would be helpful to assess the risk of smoking to human health, to define high-risk subgroups, and to develop strategies to prevent or treat smoking-induced CVD.

NADPH Oxidase and the Cardiovascular Toxicity Associated with Smoking

Kim, Mikyung,Han, Chang-Ho,Lee, Moo-Yeol Korean Society of ToxicologyKorea Environmental Mu 2014 Toxicological Research Vol.30 No.3

Smoking is one of the most serious but preventable causes of cardiovascular disease (CVD). Key aspects of pathological process associated with smoking include endothelial dysfunction, a prothrombotic state, inflammation, altered lipid metabolism, and hypoxia. Multiple molecular events are involved in smoking-induced CVD. However, the dysregulations of reactive oxygen species (ROS) generation and metabolism mainly contribute to the development of diverse CVDs, and NADPH oxidase (NOX) has been established as a source of ROS responsible for the pathogenesis of CVD. NOX activation and resultant ROS production by cigarette smoke (CS) treatment have been widely observed in isolated blood vessels and cultured vascular cells, including endothelial and smooth muscle cells. NOX-mediated oxidative stress has also been demonstrated in animal studies. Of the various NOX isoforms, NOX2 has been reported to mediate ROS generation by CS, but other isoforms were not tested thoroughly. Of the many CS constituents, nicotine, methyl vinyl ketone, and ${\alpha}$,${\beta}$-unsaturated aldehydes, such as, acrolein and crotonaldehyde, appear to be primarily responsible for NOX-mediated cytotoxicity, but additional validation will be needed. Human epidemiological studies have reported relationships between polymorphisms in the CYBA gene encoding p22phox, a catalytic subunit of NOX and susceptibility to smoking-related CVDs. In particular, G allele carriers of A640G and $-930^{A/G}$ polymorphisms were found to be vulnerable to smoking-induced cardiovascular toxicity, but results for C242T studies are conflicting. On the whole, evidence implicates the etiological role of NOX in smoking-induced CVD, but the clinical relevance of NOX activation by smoking and its contribution to CVD require further validation in human studies. A detailed understanding of the role of NOX would be helpful to assess the risk of smoking to human health, to define high-risk subgroups, and to develop strategies to prevent or treat smoking-induced CVD.

Retinopathy of Prematurity in Anencephaly : Pathological and Iminunohistochemical Studies of Six Eyes from Three Female Stillborn Holoanencephalic Infants

Kim, Mikyung,Chi, Je G. Seoul National University 1992 The seoul journal of medicine Vol.33 No.4

Gene Expression Profi ling in the Striatum of Per2 KO Mice Exhibiting More Vulnerable Responses against Methamphetamine

( Mikyung Kim ),( Se Jin Jeon ),( Raly James Custodio ),( Hyun Jun Lee ),( Leandro Val Sayson ),( Darlene Mae D. Ortiz ),( Jae Hoon Cheong ),( Hee Jin Kim ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.2

Drug addiction influences most communities directly or indirectly. Increasing studies have reported the relationship between circadian- related genes and drug addiction. Per2 disrupted mice exhibited more vulnerable behavioral responses against some drugs including methamphetamine (METH). However, its roles and mechanisms are still not clear. Transcriptional profiling analysis in Per2 knockout (KO) mice may provide a valuable tool to identify potential genetic involvement and pathways in enhanced behavioral responses against drugs. To explore the potential genetic involvement, we examined common differentially expressed genes (DEGs) in the striatum of drug naïve Per2 KO/wild-type (WT) mice, and before/after METH treatment in Per2 KO mice, but not in WT mice. We selected 9 common DEGs (Ncald, Cpa6, Pklr, Ttc29, Cbr2, Egr2, Prg4, Lcn2, and Camsap2) based on literature research. Among the common DEGs, Ncald, Cpa6, Pklr, and Ttc29 showed higher expression levels in drug naïve Per2 KO mice than in WT mice, while they were downregulated in Per2 KO mice after METH treatment. In contrast, Cbr2, Egr2, Prg4, Lcn2, and Camsap2 exhibited lower expression levels in drug naïve Per2 KO mice than in WT mice, while they were upregulated after METH treatment in Per2 KO mice. qRT-PCR analyses validated the expression patterns of 9 target genes before/after METH treatment in Per2 KO and WT mice. Although further research is required to deeply understand the relationship and roles of the 9 target genes in drug addiction, the findings from the present study indicate that the target genes might play important roles in drug addiction.

Effects of Dysphagia Treatment Applied to Infants with Pierre Robin Syndrome – Single Subject Research Design

Mikyung Kim,Deokju Kim 국제문화기술진흥원 2020 International Journal of Advanced Culture Technolo Vol.8 No.1

Pierre Robin syndrome is characterized by micrognathia, glossoptosis, and cleft palate. Infants with Pierre Robin syndrome causes feeding difficulty, upper airway obstruction, and other symptoms. This study aims to examine the effects of applying dysphagia treatment to infants with Pierre Robin syndrome. The study participant was an infant who was born four weeks premature and referred for dysphagia treatment approximately 100 days after birth. At the initial assessment, the infant showed oral sensory sensitivity, a high level of facial and masticatory muscle tension, and a low stability of the chin and cheeks with almost no normal “sucking-swallowing-breathing” pattern. We set the baseline period and intervention period using the AB design. During the baseline period, non-nutritive sucking training using a rubber nipple was conducted without implementing an oral stimulation intervention. During the intervention period, non-nutritive sucking training and an oral stimulation intervention were performed. After the intervention period, the infant’s daily oral intake and oral intake per time significantly increased compared to that during the baseline period. We observed that the oral intake time of the infant decreased during the intervention period compared to that in the baseline period, which indicated an improvement in control over the chin, tongue, and lip movements, a change in muscular tension, and stabilization of the “sucking-swallowing-breathing” pattern. We provided dysphagia treatment before breastfeeding, it was positive effects such as normal development of the infant, transition from tube feeding to bottle feeding, and enhancement of overall oral motor function.

OVERVIEW OF KSTAR INTEGRATED CONTROL SYSTEM

MIKYUNG PARK,KUKHEE KIM,TAEGU LEE,MYUNGKYU KIM,JAESIC HONG,SULHEE BAEK,SANG-IL LEE,JIN-SEOP PARK,YONG CHU,YOUNG-OK KIM,SANG-HEE HAHN,YEONG-KOOK OH,JOO-SHIK BAK 한국원자력학회 2008 Nuclear Engineering and Technology Vol.40 No.6

After more than 10 years construction, KSTAR (Korea Superconducting Tokamak Advanced Research) had finally completed its assembly in June 2007, and then achieved the goal of first-plasma in July 2008 through the four month’s commissioning. KSTAR was constructed with fully superconducting magnets with material of Nb3Sn and NbTi, and their operation temperatures are maintained below 4.5K by the help of Helium Refrigerator System. During the first-plasma operation, plasmas of maximum current of 133kA and maximum pulse width of 865ms were obtained. The KSTAR Integrated Control System (KICS) has successfully fulfilled its missions of surveillance, device operation, machine protection interlock, and data acquisition and management. These and more were all KSTAR commissioning requirements. For reliable and safe operation of KSTAR, 17 local control systems were developed. Those systems must be integrated into the logically single control system, and operate regardless of their platforms and location installed. In order to meet these requirements, KICS was developed as a network-based distributed system and adopted a new framework, named as EPICS (Experimental Physics and Industrial Control System). Also, KICS has some features in KSTAR operation. It performs not only 24 hour continuous plant operation, but the shot-based real-time feedback control by exchanging the initiatives of operation between a central controller and a plasma control system in accordance with the operation sequence. For the diagnosis and analysis of plasma, 11 types of diagnostic system were implemented in KSTAR, and the acquired data from them were archived using MDSplus (Model Driven System), which is widely used in data management of fusion control systems. This paper will cover the design and implementation of the KSTAR integrated control system and the data management and visualization systems. Commissioning results will be introduced in brief.