인진쑥이 사염화탄소 투여로 유발된 개의 간 손상 회복에 미치는 영향

이우열,이성동,손상익,장혜숙,김영홍,오태호,엄기동,장광호,박승춘 한국임상수의학회 2003 한국임상수의학회지 Vol.20 No.3

Artemisia is a major edible vegetable in Korea and it has traditionally been used as a herbal medicine for the treatment of coughing, abdominal pain, indigestion, bleeding, jaundice, chronic liver disease and diabetes. However the biological and pharmacological actions of the herb have not been studied well. Recently it is known to possess antibacterial, antihelmintic and antifertility activities. But the effect of Artemisia capillaris extract on carbon tetrachloride($CCl_4$) induced liver damage in dogs have not been reported yet. This study was designed to investigate the effect .of Artemisia capillaris crude juice extract on $CCl_4$ induced liver damage in dogs. 30 clinically healthy dogs were divided into 2 groups: crude Artemisia capillaris juice treated group(CEC group) and carbon tetrachloride($CCl_4$) administerd group. The results are as follows: I. The degree of increase in AST activity and ALT activity in CEC group was lower than that in $CCl_4$ group and the recovery in CEC group was faster than that in $CCl_4$ group. 2. Changes of ALP concentration in CEC group were significant(P < 0.05) but changes of Total-bilirubin concentration were not significant(P < 0.05) in both groups. 3. The recovery of GGT concentration in CEC group was faster than that in $CCl_4$ group. 4. Hematological changes other than MCHC were significant(P < 0.05) in CEC group only and changes of GSH and Met-Hb concentration were significant(P < 0.05) in $CCl_4$ group.

실험자료를 위한 선형 혼합효과 모형에서 무선효과 분포를 잘못 지정할 때의 영향

이우열 한국데이터정보과학회 2023 한국데이터정보과학회지 Vol.34 No.5

본 연구는 실험자료 분석을 위한 교차 무선효과 구조를 가진 선형 혼합효과 모형을 사용함에 있어서 무선효과 분포가 잘못 설정되는 것이 무선효과와 고정효과에 대한 추론에 미치는 영향을 조사하였다. 모의실험에서 참가자 무선효과의 종류와 분산의 크기를 조작하였으며, 무선효과 공분산행렬의 편향, 고정효과와 그 표준오차의 편향과 고정효과의 탐지율을 관찰하였다. 그 결과, 선형 혼합효과 모형은 무선효과의 분포가 정규분포를 따르지 않을 때도 고정효과에 대한 추정값의 편향이 발견되지 않아 분포적 가정에 대한 강건성을 보여주었다. 반면, 일부 조건에서 무선효과에 대한 추정값의 편향, 고정효과의 표준오차 추정의 정밀성 저하, 고정효과의 탐지율의 저하가 발견되었다. 실증 연구자를 위한 연구결과의 함의를 논의하고 추후 연구를 제안하였다. This study examined the consequences of misspecifying the distribution of random effects on inferences about random and fixed effects when a linear mixed-effects model with crossed random effects is used to analyze experimental data. In a simulation study, we manipulated the type and magnitude of the variance of the participant random effects and observed the biases in the covariance matrix of the random effects and fixed effects coefficients and the detection rate of the fixed effects. The results showed that the linear mixed-effects model is robust to the distributional assumptions, as no bias was found in the estimates of the fixed effects when the distribution of the random effects was not normally distributed. In contrast, biases in the estimates of the covariance of the random effects, decreases in the precision of the standard error estimates of the fixed effects, and reductions in the power of the fixed effects were found under certain circumstances. The implications of our findings for empirical researchers were discussed.

Protective Effects of Blue Honeysuckle on Rat Hypothyroidism Induced by Propylthiouracil

이우열,이성준,윤성호,임미경,이근우 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.5

The objective of the present study is to determine whether blue honeysuckle lyophilized concentrated powder(BH) has favorable effects on hypothyroidism and related reproductive organ damage. Hypothyroidism was inducedby 9 subcutaneous administration of propylthiouracil (PTU) for 28 days. Levothyroxine (LT4)-treated group wasintraperitoneally injected with LT4 for the same period, while for BH (125, 250, and 500 mg/kg) or Flos Loniceraelyophilized aqueous extract (LF, 250 mg/kg)-treated groups, the test materials were orally administrated for 42 days:two weeks before PTU injection and during PTU administration. The changes in serum thyroid hormone levels, serummale sex hormone levels, and testis antioxidant defense system were observed by histopathology of the thyroid gland,epididymis, prostate, and testis. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effectscompared to LF on hypothyroidism and related damages of reproductive organs through augmentation of the antioxidantdefense system in the testis. In conclusion, BH is a promising new potent thyroid gland protecting agent.

Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects

이우열,오은실,Mengqi Cui,김춘옥,Yeji Lim,Hunam Kim,Hyeonsoo Park,Sukyong Yoon,박민수,홍태곤 대한임상약리학회 2020 Translational and Clinical Pharmacology Vol.28 No.1

YH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination with amoxicillin and clarithromycin for Helicobacter pylori eradication. We compared the pharmacokinetic (PK) profiles and safety of amoxicillin, clarithromycin, and YH4808 used as monotherapies or in combination for evaluating potential drug interactions. An open-label, randomized, single-dose, Latin-square (4 × 4) crossover study was conducted in 32 healthy Korean volunteers. Subjects were randomly assigned to one of the 4 treatment sequences that consisted of 4 periods separated by 21-day washout intervals. PK parameters of YH4808, amoxicillin and clarithromycin administered in combination were compared with those of the respective monotherapies. The geometric mean ratios of the maximum concentration (Cmax) and the area under the time-concentration curve from time zero to time of the last quantifiable concentration (AUClast) of YH4808 increased during the triple therapy by 48.6% and 29.1%, respectively. Similarly, the Cmax and AUClast of M3 (active metabolite of YH4808) increased by 23.3% and 16.0%, respectively. The Cmax and AUClast of clarithromycin increased by 27.4% and 30.5%, and those of 14-hydroxyclarithromycin were increased by 23.1% and 32.4%, respectively. The corresponding amoxicillin values decreased during the triple therapy by 21.5% and 15.6%, respectively. There was no clinically significant change in safety assessment related to either monotherapies or triple therapy. In conclusion, amoxicillin, clarithromycin and YH4808 administered as triple therapy did not exhibit significant PK interactions and were not associated with safety issues.

Comparison of the clinical results between endoscopically assisted transoral approach and retromandibular approach for surgical treatment of mandibular subcondyle fracture

이우열,조진용,양성원 대한치과의사협회 2016 대한치과의사협회지 Vol.54 No.12

Purpose : Aim of this study is to describe and compare clinical results and complications epending on the surgical approaches for the mandibular subcondyle fracture Materials and methods : The patients who had been diagnosed as the mandibular subcondyle fracture and underwent open reduction and internal fixation from May 2009 to December 2014 were included. They were divided into two groups depending on the surgical approaches; endoscopically assisted transoral approach and retromandibular approach. Association between the preoperative fracture classification and post-operative results was reviewed depending on the surgical approaches. Results : The number of patients selected in this study was 33. Eighteen patients (male 7, female 11) underwent open reduction and internal fixation via retromandibular approach and fifteen patients (male 12, female 3) underwent open reduction and internal fixation via endoscopically assisted transoral approach. The mean age, follow up period, and operation time were 44.29 15.19 years, 9.97 7.82 months, and 161 89.44 minutes. Post-operative results were all “good” state in the retromandibular approach group regardless of the fracture classification but two patients in the endoscopically assisted transoral approach group underwent re-operation due to “poor” results. The fracture types of two were classified as displacement and lateral override at the same time. There was no statistically significant difference between two groups. Three patients in the retromandibular approach group had experienced facial nerve palsy (17%) temporarily. No one showed malocclusion in this study. There was no significant difference on the complications such as temporomandibular disorder, local infection, and condyle resorption depending on the surgical approaches. Conclusion : In this study, there was no significant difference on the complications between the two groups but retromandibular approach has advantage over endoscopically assisted transoral approach in case of the severely displaced subcondyle fracture.

Hepatoprotective Effect of Blue Honeysuckle on Rat Hypothyroidism

이우열,이성준,윤성호,오태호,김홍태,이근우,임미경 한국임상수의학회 2017 한국임상수의학회지 Vol.34 No.6

This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.

근로자주택 건설 · 공급제도의 문제점 및 개선방향

이우열 한국규제학회 1992 규제연구 Vol.- No.1

`93년도 직업훈련 비율의 문제점과 개선방안

이우열 한국규제학회 1992 규제연구 Vol.- No.2

자동차 혼류 생산에서 최적 자원 할당을 위한 제조 복잡도 분석

이우열,김남훈 대한산업공학회 2015 대한산업공학회 추계학술대회논문집 Vol.2015 No.11

제품의 다양성이 지속적으로 증가함에 따라, 자동차 제조사들은 다양한 옵션과 모델을 혼류 생산하고 있으며, 혼류 생산에 따른 제조 복잡도는 제조 간접비용 상승과 생산성 저하를 야기하고 있다. 이에 옵션과 모델에 따른 부품 및 공정의 복잡도가 일반 조립공정이나 차체공장에서의 경제성을 평가하는데 중요한 기준이 되고 있다. 그러나 고려해야 하는 부품의 수가 너무 많고, 공정시스템과 공정 내 작업자의 보편적 특성을 규정하기 어렵기 때문에 단위와 수식을 이용하여 복잡도를 정량적으로 나타내고 경제성으로 재평가하기 위한 연구가 미미한 실정이다. 본 연구에서는 이러한 어려움을 보완하고자 정보 엔트로피와 신뢰성을 이용하여 정량적인 제조 복잡도를 평가하고, 실제 제조 공정 데이터 기반으로 평가 결과를 검증한다.

실험데이터 분석을 위한 선형 혼합효과 모형

이우열 한국인지및생물심리학회 2020 한국심리학회지 인지 및 생물 Vol.32 No.2

This paper introduces a linear mixed-effects model with crossed random effects as an alternative to repeated measures analysis of variance (RM-ANOVA). With lmer function in the lme4 package, one of the R packages, two kinds of the linear mixed-effects model are described regarding the model specification, an estimation method, model comparison criteria, and an inference method. The use of the linear mixed-effects model is illustrated through an empirical example data. The performance of hypothesis testing is compared via a Monte Carlo simulation study between the mixed-effects model and variance of analysis framework. 본 논문은 반복측정 변량분석의 대안으로서 교차 무선효과를 가진 선형 혼합효과 모형을 소개한다. 두 종류의 선형 혼합효과 모형의 설정, 추정방법, 모형 비교방법, 추론방법에 관해 R패키지 중 하나인 lme4 패키지의 lmer 함수를 가지고 설명한다. 예제데이터를 통해 선형 혼합효과 모형의 용례를 보인다. 또한, 몬테카를로 시뮬레이션 실험을 통해 특정 상황에서 선형 혼합효과 모형과 변량분석 사이에서 가설검정 수행을 비교한다.