당뇨병성 신증 환자 20예에서 복합한약전탕액이 신기능에 미치는 영향

최우정,김동웅,신선호,이언정,최진영,신학수,조권일,이광석 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2

Diabetic Nephropathy is one of the major causes of chronic renal failure. It is a common microvascular complication and clinically defined as the presence of persistent Proteinuria. We studied the effects and change of the renal function of Complex Herbal medication of the 20Diabetic Nephropathy patients. We measured the initial levels of Total Protein, Creatinine Clearance Rate(Ccr), Serum Creatinine(Serum-Cr), Urine Creatinine(Urine-Cr) and HbA1C on admission and followed up the level changes of Total Protein, Ccr, Serum-Cr and Urine-Cr on discharge. The results are following : Complex Herbal Medication does not cause the renal toxicity. The longer hypertension period is, the higher Serum-Cr level and Urine-Cr level. In an older age group, Urine-Cr is lower. 4.From the "Deficiency in Origin and Excess in Superficiality(本虛表實)“points of view, Complex Herbal Medication improves the Serum-Cr in Diabetic Nephropathy patients. According to this results, it could be suggested that Complex Herbal Medication does not cause the renal toxicity in Diabetic Nephropathy patients and intensive controls of blood sugar, blood pressure and Complex Herbal Medication prevent the renal failure in Diabetic Nephropathy patients with early stage of Microalbumiuria.

마취중 체온변화에 관한 연구

손수창,이정은,김익수,최세진 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

To study the temperature change and the degree of heat loss during general anesthesia, skin temperature, tympanic temperature and rectal temperature were measured in 21 patients. Mean skin temperature was calculated from four probes situated on the lateral aspect of the mid-calf, the ventral surface of the mid-thigh, the nipple and the lateral aspect of the upper arm, using the formula of Ramanathan, and the heat loss can be calculated by Burton's formula. the result are as follows. 1. Mean skin temperature increased higher than control value at 20 minute, not significantly. thereafter remained high. 2. Tympanic temperature decreased significantly at 20 minute (p<0.005), esophageal temperature decreased at 60minute, and rectal temperature decreased at 90 minute significantly (p<0.05). 3. There was continuous loss of total body heat during general anesthesia. 4. In the recovery room, the aural temperature increased progressively.

'광물의 감정' 멀티미디어 학습 프로그램의 개발

양은진,최석원,김희수 공주대학교 사범대학 과학교육연구소 1999 과학교육연구 Vol.30 No.1

고등학교 지구과학 '광물의 감정' 내용에 대한 컴퓨터 보조학습 프로그램이 16 bit IBM-PC 기종에서 학습할 수 있도록 한국형 저작도구(KAS)로 개발되었다. 이 프로그램은 하이퍼텍스트 및 인터럽트 기능 등을 이용하여 만들어 졌으며 학습자가 혼자서 학습할 수 있는 반복 연습형이다. 그리고 이 프로그램은 학습자와 컴퓨터와의 상호작용 효과를 고려하여 제작되었다. 'Judgememt of Minerals' Muitimedia program is developed as an helping tool for the content of high school earth science with 16 bit IBM-PC compatible computer using 'KAS(Korea Authoring System) Ver.3.0'. This program is Drill and Practice type for individual study through, hypertext, interupt functions. And the program is considered to the reciprocal action effect between learner and computer.

상악 전치부 후방 견인 시 이동 양상과 응력 분포에 관한 삼차원 유한요소법적 연구

정애진,김운수,이수행,강성수,최희인,조진형,김상철 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.2

상악 전치부 후방 견인 시의 이동 양상 및 응력 분포를 건조 두개골을 전산화 단층 촬영에 의해 3차원 영상화한 유한 요소 모델 상에서 알아보고자 하였다. 피질골 절단술의 시행 여부와 고정원, 힘의 작용점을 각기 달리 설정하여 8개의 실험군을 구성하여 비교하였다. 통상적인 T-loop을 이용하여 공간폐쇄를 하는 경우 전치부는 후하방으로 경사이동 하였으며, 구치부에서도 약간 전방 이동하였다. 피질골 절단술을 동반하여 전치부를 견인한 경우, 전치부 골편에서의 응력 분포가 전반적으로 넓게 분포되었으며, 전치부 경사의 정도가 적은 반면에 변위량은 훨씬 더 많았다. 협측에서의 견인 시 상악 협측에 식립된 미니 임플랜트와 견치 power arm간에 견인력을 가한 경우가 미니 임플랜트로 고정원이 강화된 제2소구치와 견치 브라켓 간에 견인력을 가한 경우보다 전치부의 후하방 경사 정도가 적었다. 구개측에서 power arm에 대한 견인 시 정중구개봉합 부위에 식립한 미니 임플랜트로부터 견인력을 가한 경우가 상악 제1, 2대구치 간 구개면에 식립된 미니 임플랜트로부터 견인력을 가한 경우보다 전치부의 후하방 경사 정도가 컸다. 이러한 결과로써 치아이동 시 피질골 절단술의 효과와 저항중심에 대한 교정력 벡터 조정의 의미를 확인할 수 있었다. Objective: The purpose of this study was to evaluate the displacement pattern and the stress distribution shown on a finite element model 3-D visualization of a dry human skull using CT during the retraction of upper anterior teeth. Methods: Experimental groups were differentiated into 8 groups according to corticotomy, anchorage (buccal: mini implant between the maxillary second premolar and first molar and second premolar reinforced with a mini implant, palatal: mini implant between the maxillary first molar and second molar and mini implant on the midpalatal suture) and force application point (use of a power arm or not). Results: In cases where anterior teeth were retracted by a conventional T-loop arch wire, the anterior teeth tipped more postero-inferiorly and the posterior teeth moved slightly in a mesial direction. In cases where anterior teeth were retracted with corticotomy, the stress at the anterior bone segment was distributed widely and showed a smaller degree of tipping movement of the anterior teeth, but with a greater amount of displacement. In cases where anterior teeth were retracted from the buccal side with force applied to the mini implant placed between the maxillary second premolar and the first molar to the canine power arm, it showed that a smaller degree of tipping movement was generated than when force was applied to the second premolar reinforced with a mini implant from the canine bracket. In cases where anterior teeth were retracted from the palatal side with force applied to the mini implant on the midpalatal suture, it resulted in a greater degree of tipping movement than when force was applied to the mini implant between the maxillary first and second molars. Conclusion: The results of this study verifies the effects of corticotomies and the effects of controlling orthodontic force vectors during tooth movement.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

중 고등학교 수학교육 개선을 위한 연구

邊龍聖,金東碩,邊東壽,崔雲行,洪慶和,鄭寶鉉 弘益大學校 1991 弘大論叢 Vol.23 No.2

A great many students are working for their mathematics learning in secondary schools and nevertheless its learning effect is rather low. This phenomenon is largely due to a biased social recognition. Furthermore the educational environment including big class size and ability differences enlarge such a difficulty. This study aims at seeking an improving device to enhance learning efficiency under the circumstances. Questionaires about problem finding of teachers educational activity and mathematics teaching were distributed and collected. Data were analyzed to establish a desirable mathematics education and teaching. Devices for individualized instruction and learning tasks and evaluation methods were proposed. This recommendations are supposed to be an improving way for students' mathematics learning. In relation to this result, a further study is strongly required and adminstrative supports by government are badly needed to achieve such a goal.

Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats

Choi, Ji Soo,Leem, Joong Woo,Lee, Kyung Hee,Kim, Sung-Soo,SuhKim, Haeyoung,Jung, Se Jung,Kim, Un Jeng,Lee, Bae Hwan The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6

The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration that avoids the ethical issues associated with embryonic stem cell transplantation. As SCI is a complex pathological entity, the treatment of SCI requires a multipronged approach. The purpose of the present study was to investigate the functional recovery and therapeutic potential of human MSCs (hMSCs) and polymer in a spinal cord hemisection injury model. Rats were subjected to hemisection injuries and then divided into three groups. Two groups of rats underwent partial thoracic hemisection injury followed by implantation of either polymer only or polymer with hMSCs. Another hemisection-only group was used as a control. Behavioral, electrophysiological and immunohistochemical studies were performed on all rats. The functional recovery was significantly improved in the polymer with hMSC-transplanted group as compared with control at five weeks after transplantation. The results of electrophysiologic study demonstrated that the latency of somatosensory-evoked potentials (SSEPs) in the polymer with hMSC-transplanted group was significantly shorter than in the hemisection-only control group. In the results of immunohistochemical study, ${\beta}$-gal-positive cells were observed in the injured and adjacent sites after hMSC transplantation. Surviving hMSCs differentiated into various cell types such as neurons, astrocytes and oligodendrocytes. These data suggest that hMSC transplantation with polymer may play an important role in functional recovery and axonal regeneration after SCI, and may be a potential therapeutic strategy for SCI.

Lysophosphatidic acid‐induced expression of periostin in stromal cells: Prognoistic relevance of periostin expression in epithelial ovarian cancer

Choi, Kyung Un,Yun, Jeong Sup,Lee, Il Hwan,Heo, Soon Chul,Shin, Sang Hun,Jeon, Eun Su,Choi, Yoon Ji,Suh, Dong‐,Soo,Yoon, Man‐,Soo,Kim, Jae Ho Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.2

<P><B>Abstract</B></P><P>Lysophosphatidic acid (LPA) is a bioactive lipid crucial for the initiation and progression of ovarian cancer. Identification of LPA‐induced biomarkers is necessary for predicting prognosis of ovarian cancer patients. Here we report periostin, an extracellular matrix protein, as an LPA‐induced protein in stromal cells and as a prognostic marker in patients with epithelial ovarian cancer (EOC). In human EOC tissues, periostin was mainly expressed in cancer‐associated stromal fibroblasts, but not in cancer cells. The expression levels of periostin highly correlated with poor survival and tumor recurrence of ovarian cancer patients. Treatment of human adipose tissue‐derived stromal cells with LPA or conditioned media from human ovarian adenocarcinoma cell lines, such as SK‐OV‐3 and OVCAR‐3, induced expression of periostin. The periostin expression induced by cancer‐conditioned media was abrogated by silencing of the LPA receptor 1 expression using small hairpin RNA lentivirus. Recombinant periostin stimulated adhesion and invasion of SK‐OV‐3 human ovarian adenocarcinoma cells and induced expression of matrix metalloprotease‐2 in the cancer cells. These results suggest that LPA is associated with the expression of periostin in cancer‐associated fibroblasts of EOC.</P>

Cytotoxicity of Two Novel Cisplatin Analogues, $(CPA)_2Pt[DOLYM]$ and (DACH)Pt[DOLYM], to Human Cancer Cells In Vitro

Choi, Sang-Un,Kim, Kwang-Hee,Choi, Eun-Jung,Park, Sung-Hee,Kim, Kwan-Mook,Shon, Youn-Soo,Lee, Chong-Ock The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.2

Despite the impressive antitumor activity of cisplatin, two major limitations of the drug, that is severe side effects and drug-resistance of cancer cells, make its use difficult of r cancer therapy. These limitations have resulted in a greate deal of effort having been expended into structural modifications of cisplatin. In this study, we tested two novel cisplatin analogues, (CPA)2 Pt[DOLYM] (COMP-I) and (DACH)Pt[DOLYM] (CoMP-II), for the mode of cytotoxic action against human tumor cells comparing with cisplatin and carboplatin in vitro. These two novel analogues had considerable cytotoxic activities against five kinds of human solid tumor cells, and especially COMP-II was more effective on HCT15 colon cancer cells than other compounds. In addition, COMP-II had cytostatic activity at low concentrations (10~0.3${\mu}g/ml$), but other compounds revealed little effect on tumor growth at the low concentration.

진행된 장액성 상피성 난소암 환자의 혈청 CA 125 측정의 예후인자로서의 의의

이지수 ( Ji Soo Lee ),김지운 ( Ji Un Kim ),문성오 ( Sung O Moon ),최중섭 ( Joong Sub Choi ),이선주 ( Sun Joo Lee ),이정원 ( Jeong Won Lee ),박창수 ( Chang Soo Park ),김병기 ( Byoung Gie Kim ),이제호 ( Je Ho Lee ),배덕수 ( Duk Soo 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6

목적 : 난소암의 예후인자로 알려진 환자의 병기, 조직학적 유형 (histologic type), 조직학적 분화도 (histologic differentiation), 수술 후 잔여종양 (residual tumor)외에 환자의 치료반응성을 좀더 역동적으로 추적할 수 있는 혈청 CA-125를 이용한 기존에 발표되었던 방법을 비교하여 환자의 예후를 예측해 보고자 하였다. 연구 방법 : 1995년 8월부터 2000년 7월까지 삼성서울병원 산부인과에서 난소암으로 수술 및 보조적 항암 화학요법을 시행 받은 병기 3기 이상의 장액성 난소암 환자 57명을 대상으로 하였다. 의무기록을 근거로 수술 3개월 후의 CA-125수치의 정상여부 및 CA-125의 반감기, 2차례의 항암 화학요법 시행 후의 CA-125의 regression을 조사, 환자의 생존기간과의 연관성을 조사하였다. 결과 : 1. 전체 환자의 평균 연령은 54.2세 (S.D. 13.4세) 이었으며 FIGO 수술적 병기 제3기가 77.2%, 제4기가 22.8%를 나타내었다. 대상 환자 중 세포 분화도는 grade III가 73.7%로 대부분을 차지하였다. 수술 후 잔류 종괴의 용적은 2 cm 미만이 37예 (64.9%), 2 cm 이상이 20예 (35.1%)이었다. 수술당시 예측된 복수양이 500mL 미만인 경우가 24예 (42.1%), 500mL 이상인 경우가 33예 (57.9%)를 나타냈다. 2. 전체 57명 환자의 회계적 (actuarial) 5년 생존율은 35.2%로 나타났다. 단변량 분석에 의한 예후 인자 분석에서는 연령 (p=0.487), FIGO 수술적 병기 (p=0.952), 세포의 분화도 (p=0.910), 일차 수술 후 잔류 종괴 용적 (p=0.938), 수술시 복수량 (p=0.487) 모두 생존율에는 통계적으로 유의하게 영향을 미치지 못하는 결과를 보였다. 3. 장액성 난소암 환자의 예후 인자로서 CA 125를 평가하는 다섯 가지 방법 중에서 세 번째 항암 화학요법 후 CA 125 수치의 정상화 여부를 보는 방법만이 통계적 유의성을 나타냈다 (p=0.026). 세 번째 항암 화학요법 후 정상화 된 군의 5년 생존율은 40.8%, 정상화되지 않은 군의 경우 23.9%로 의미있는 차이를 보였다. 결론 : 삼성서울병원의 FIGO stage III/IV인 장액성 상피성 난소암 환자의 5년 생존율은 35.2%였다. 난소암의 예후 인자로서 혈청 CA 125를 평가하는 다섯 가지 방법 중 3번째 항암 화학요법 후 정상화 여부를 보는 방법만이 5년 생존율과 통계적으로 유의한 관계를 보였다. Objective : In this retrospective study, we analyzed the clinicopathologic characteristics of advanced serous epithelial ovarian cancer and evaluated the prognostic factors which have an impact on survival of patients with epithelial ovarian cancer. We also compared several analyzing methods of Ca 125 for predicting prognosis of advanced serous epithelial ovarian cancer. Methods : a total of 57 patients with advanced serous epithelial ovarian cancer who were treated at Samsung Medical Center between Aug. 1995 and Jul. 2000 were included. Medical records including pathologic reports were reviewed to identify clinicopathologic characteristics and serum levels of CA 125. Five different methods of analyzing serum CA 125 were compared for predicting the prognosis of advanced serous epithelial ovarian cancer. Survival curves were analyzed by Kaplan-Meier method and Cox proportional hazards model. Results : the median age of all patients was 54.2 years. In univariate analysis, age, FIGO stage, grade, residual tumor and ascites showed no significant correlation with prognosis. Among five different analyzing methods of serum CA 125 levels, normalization after 3^rd chemotherapy was correlated with improved 5-year survival rate (p=0.026). Conclusion : this study showed that normalization of serum levels of CA 125 after 3^rd chemotherapy is useful for predicting prognosis of advanced serous epithelial ovarian cancer patients.