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      • KCI등재

        Response Surface Methodology for Optimizing the Preparation Process of Cellulose Acetate/Polylactic Acid Nonwoven Surgical Gown Material

        Shujie Zhang,Lisong Fu,Zhaowei Yang,Mengke Jing,Ziwei Zhang,Shijian Xiang,Rui Wang 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4

        In view of the problems that traditional woven surgical gowns are prone to cross infection in blocking blood andliquid spillage, cellulose acetate (CA)/polylactic acid (PLA) nonwoven materials were prepared to improve the functionalrequirements of surgical materials in combination with the rapidly developing green fibers. Fiber mixing ratio, fiber webareal weight and water jet pressure were selected to optimize the preparation process of cellulose acetate/polylactic acid (CA/PLA) nonwoven materials with moisture permeability and filtration efficiency. The results showed that the fiber mixing ratiowas 49:51, and the fiber web areal weight was 130 g/m2, and the water jet pressure was 7 MPa. Under this process, moisturepermeability is 5240.86 g/(m2·h), and the filtration efficiency is 38.12 %, which is close to the theoretical value. It shows thatthe response surface method has practical application value, indicating that the response surface method has practicalapplication value, and can provide a theoretical basis for the preparation process parameters of barrier and comfort nonwovensurgical gowns at the same time.

      • KCI등재

        Numerical optimization of transmission bremsstrahlung target for intense pulsed electron beam

        Xiao Yu,Jie Shen,Shijian Zhang,Jie Zhang,Nan Zhang,Ivan Sergeevich Egorov,Sha Yan,Chang Tan,Gennady Efimovich Remnev,Xiaoyun Le 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.2

        The optimization of a transmission type bremsstrahlung conversion target was carried out with MonteCarlo code FLUKA for intense pulsed electron beams with electron energy of several hundred keV formaximum photon fluence. The photon emission intensity from electrons with energy ranging from300 keV to 1 MeV on tungsten, tantalum and molybdenum targets was calculated with varied targetthicknesses. The research revealed that higher target material element number and electron energy leadsto increased photon fluence. For a certain target material, the target thickness with maximum photonemission fluence exhibits a linear relationship with the electron energy. With certain electron energy andtarget material, the thickness of the target plays a dominant role in increasing the transmission photonintensity, with small target thickness the photon flux is largely restricted by low energy loss of electronsfor photon generation while thick targets may impose extra absorption for the generated photons. Thespatial distribution of bremsstrahlung photon density was analyzed and the optimal target thicknessesfor maximum bremsstrahlung photon fluence were derived versus electron energy on three targetmaterials for a quick determination of optimal target design

      • KCI등재

        Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/ Akt signaling pathway

        Shijian Luo,Huiqing Li,Zhihuai Mo,Junjie Lei,Lingjuan Zhu,Yanxia Huang,Ruying Fu,Chunyi Li,Yihuan Huang,Kejia Liu,Wenli Chen,Lei Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

        This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluated by flow cytometry and an MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2-H-tetrazolium bromide) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis were used to test the expression of MMP9 and the PI3K/Akt signaling pathway-related proteins in human brain microvascular endothelial cells (HBMECs) and tissues. Additionally, the infarct volume after middle cerebral artery occlusion (MCAO) was determined by a TTC (2,3,5-triphenyltetrazolium chloride) assay. The microarray and CMap analyses identified luteolin as a promising compound for future therapies for ischemic stroke. Cytoscape and GSEA showed that the PI3K/Akt signaling pathway was crucial in ischemic stroke. Cell experiments revealed that luteolin enhanced cell viability and downregulated apoptosis via inhibiting MMP9 and activating the PI3K/Akt signaling pathway. Experiments performed in vivo also demonstrated that luteolin reduced the infarct volume. These results suggest that luteolin has potential in the treatment of ischemic stroke through inhibiting MMP9 and activating PI3K/ Akt signaling pathway.

      • KCI등재

        Influence mechanism of the compositions in coal-fired flue gas on Hg0 oxidation over commercial SCR catalyst

        Jian Mei,Pengxiang Sun,Xin Xiao,Qi Zhang,Hui Zhao,Yongfu Guo,Shijian Yang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.75 No.-

        Optimizing the performance of commercial SCR catalyst (i.e., V2O5–WO3/TiO2) for Hg0 oxidationremained stagnant as the influence mechanism of the compositions offlue gas on Hg0 oxidation wasunclear. In this work, the mechanism of Hg0 oxidation and the influence mechanism of the compositionsofflue gas on Hg0 oxidation over V2O5–WO3/TiO2 were investigated. The reaction orders of Hg0 oxidationover V2O5–WO3/TiO2 in regard to both the concentrations of Hg0 and HCl in gas phase wereapproximately 0. Hence, Hg0 oxidation over V2O5–WO3/TiO2 primarily followed the Langmuir–Hinshelwood mechanism, and the elementary reactions of Hg0 oxidation primarily involved the physicaladsorption of Hg0, the formation of Cl* radial, and the reaction of physically adsorbed Hg0 and Cl* radial. SO2, NO, H2O, and NH3 not only restrained the Cl* radial formation but also disturbed the reaction ofphysically adsorbed Hg0 and Cl* radial. Meanwhile, the physical adsorption of Hg0 was restrained by bothH2O and NH3. Hence, Hg0 oxidation over V2O5–WO3/TiO2 was obviously restrained when SO2, NO, H2O,and NH3 were present influe gas.

      • KCI등재

        Aramid Nanofibers Reinforced Polyacrylonitrile Nanocomposite Films with High Transparency and High Mechanical Properties

        Xue Bai,Yinghui Zhao,Zhenhu Song,Hui Chen,Sihang Zhang,Yonghui Luo,YingChun Gu,Shijian Tu,Guo Yao,Sheng Chen 한국섬유공학회 2022 Fibers and polymers Vol.23 No.3

        The preparation of polymer nanocomposites combined with high strength, toughness, and high transparencyremains a challenge. Aramid fibers are often used as fiber-reinforced materials for their superior mechanical and thermalproperties, but the weak interfacial force between aramid fibers and matrix polymer limits the application in compositematerials. In this work, aramid nanofibers were prepared by a two-step process, which included deprotonation and acidhydrothermal treatment to obtain better dispersions in general solvents. The hydrothermal aramid nanofibers (HANFs) wereused as reinforcing materials and blended with polyacrylonitrile (PAN) to prepare polyacrylonitrile/aramid nanofibers (PAN/HANFs) composite films with different mass fractions of HANFs. The morphologies of HANFs and the thermal, optical, andmechanical properties of composite films were investigated. Interestingly, when the mass fraction of aramid nanofibers wasless than 1.0 %, the composite films were synchronously strengthened and toughened. When the mass fraction of HANFswas 0.5 %, the tensile strength and toughness of the PAN/HANFs composite film reached 62.04 MPa and 22.56 MJ/m3,which were 74.23 % and 162.31 % higher than the pure PAN film, respectively. Besides, its average transmittance in thevisible light region remained 76.34 %. This work may offer a novel and facile strategy for high transparent reinforcedpolymer composites, which have potential applications in high strength fiber or optical film.

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