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RISS 인기검색어
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- 저자 : Yanxia Huang (검색결과 4 건)
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Yanxia Luo,Rui Yin,Wei Ji,Qingjie Huang,Zisu Gong,Jingyao Li 한국광학회 2020 Current Optics and Photonics Vol.4 No.6
A wavelength-independent optical sensor based on an asymmetric Mach-Zehnder interferometer (AMZI) is proposed. The optical sensor based on an AMZI is very sensitive to wavelength, and wavelength drift will lead to measurement error. The optical sensor is compensated to reduce its dependence on wavelength. The insensitivity of the optical sensor to wavelength mainly depends on the compensation structure, which is composed of an AMZI cascaded with another AMZI and can compensate the wavelength drift. The influence of wavelength drift on the optical sensor can be counteracted by carefully designing the size parameters of the compensation structure. When the wavelength changes from 1549.9 nm to 1550.1 nm, the error after compensation can be lower than 0.066%. Furthermore, the effect of fabrication tolerance on compensation results is analyzed. The proposed compensation method can also be used to compensate the drift of other parameters such as temperature, and can be applied to the compensation of other interference-based optical devices.
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Robust Design Optimization of Hydrodynamic Characteristics of Airfoil 791
Chenghu ZHANG,Binjuan ZHAO,Zhongfu HUANG,Yanxia FU,Qi LIU,Huilong CHEN 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.3
In this paper, the influence of the continuous random variation of the flow velocity on hydrodynamic characteristics of airfoil 791 was discussed, and a robust design optimization method was proposed to reduce the influence of uncertain factors on the stability of hydrodynamic performance. Firstly, Bezier curve was used to parameterize the suction side of the airfoil, and its thickness was controlled by four points, which was then taken as the optimization variables. Secondly, the criterion of robustness was given, and then a robust mathematical model was established. Finally, two objective functions of robust optimization were gained on the basis of uncertainty analysis with surrogate model. Combined with multi-objective genetic algorithm, a robust optimal solution with better hydrodynamic characteristics was obtained. The results showed that compared with original case, the thickness near trailing edge altered more smoothly, the resistance and surface wave intensity were obviously decreased, and the maximum reduction of drag-lift ratio and wake unevenness were 6.89% and 25.04% respectively, which contributed to the improvement of wake quality. The change of surface pressure and resistance coefficients were also more stable under the variable inlet flow velocity conditions, and then the robustness was strengthened accordingly. In conclusion, the robust design optimization can obviously improve the hydrodynamic characteristics of the airfoil while reducing the sensitivity to uncertain factors, meanwhile, it can provide better stability during the operating process.
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Shijian Luo,Huiqing Li,Zhihuai Mo,Junjie Lei,Lingjuan Zhu,Yanxia Huang,Ruying Fu,Chunyi Li,Yihuan Huang,Kejia Liu,Wenli Chen,Lei Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluated by flow cytometry and an MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2-H-tetrazolium bromide) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis were used to test the expression of MMP9 and the PI3K/Akt signaling pathway-related proteins in human brain microvascular endothelial cells (HBMECs) and tissues. Additionally, the infarct volume after middle cerebral artery occlusion (MCAO) was determined by a TTC (2,3,5-triphenyltetrazolium chloride) assay. The microarray and CMap analyses identified luteolin as a promising compound for future therapies for ischemic stroke. Cytoscape and GSEA showed that the PI3K/Akt signaling pathway was crucial in ischemic stroke. Cell experiments revealed that luteolin enhanced cell viability and downregulated apoptosis via inhibiting MMP9 and activating the PI3K/Akt signaling pathway. Experiments performed in vivo also demonstrated that luteolin reduced the infarct volume. These results suggest that luteolin has potential in the treatment of ischemic stroke through inhibiting MMP9 and activating PI3K/ Akt signaling pathway.
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Kuikui Jiang,Ruoxi Hong,Wen Xia,Qianyi Lu,Liang Li,Jianhao Huang,Yanxia Shi,Zhongyu Yuan,Qiufan Zheng,Xin An,Cong Xue,Jiajia Huang,Xiwen Bi,Meiting Chen,Jingmin Zhang,Fei Xu,Shusen Wang 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2
Purpose This study aims to evaluate the efficacy and safety of a new combination treatment of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer (MBC) and provide higher level evidence for clinical practice. Materials and Methods This was a prospective, single-arm, phase 2 trial conducted at three institutions in China. Patients with HER2-positive MBC, who had previously been treated with trastuzumab plus a taxane or trastuzumab plus pertuzumab combined with a chemotherapeutic agent, were enrolled between March 2020 and December 2021. All patients received pyrotinib 400 mg orally once daily plus vinorelbine 25 mg/m2 intravenously or 60-80 mg/m2 orally on day 1 and day 8 of 21-day cycle. The primary endpoint was progression-free survival (PFS), and the secondary endpoints included the objective response rate (ORR), disease control rate (DCR), overall survival, and safety. Results A total of 39 patients were enrolled. All patients had been pretreated with trastuzumab and 23.1% (n=9) of them had accepted trastuzumab plus pertuzumab. The median follow-up time was 16.3 months (95% confidence interval [CI], 5.3 to 27.2), and the median PFS was 6.4 months (95% CI, 4.0 to 8.8). The ORR was 43.6% (95% CI, 27.8% to 60.4%) and the DCR was 84.6% (95% CI, 69.5% to 94.1%). The median PFS of patients with versus without prior pertuzumab treatment was 4.6 and 8.3 months (p=0.017). The most common grade 3/4 adverse events were diarrhea (28.2%), neutrophil count decreased (15.4%), white blood cell count decreased (7.7%), vomiting (5.1%), and anemia (2.6%). Conclusion Pyrotinib plus vinorelbine showed promising efficacy and tolerable toxicity as second-line treatment in patients with HER2-positive MBC.
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