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RISS 인기검색어
- 검색키워드
- 저자 : YingChun Gu (검색결과 3 건)
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Xu Xu,Jia Song,Ke Wang,YingChun Gu,Feng Luo,XiaoHai Tang,Ping Xie,ZhiYong Qian 한국고분자학회 2013 Macromolecular Research Vol.21 No.8
In this paper, a novel biodegradable and pH/thermo-sensitive hydrogel based on poly(ε-caprolactone),methoxyl poly(ethylene glycol), methylacrylic acid and N-isopropylacrylamide was prepared by UV-initiated free radical polymerization. The hydrogels were characterized by Fourier transforms infrared ray. The thermal responsibility was investigated with the help of differential scanning calorimetry. Swelling behavior in aqueous medium with different pH value was studied in detail. When the pH value of the aqueous medium was increased from 1.2 to 7.2,the swelling ratio of the hydrogels increased accordingly. The morphology was observed by scanning electron microscopy, and the hydrolytic degradation behavior in different aqueous media (pH 1.2 and pH 7.2) was also investigated in detail. The prepared biodegradable pH/thermo-sensitive hydrogel based on poly(ε-caprolactone), methoxyl poly(ethylene glycol), methylacrylic acid and N-isopropylacrylamide hold great promise in the development of a smart drug delivery system.
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Tizoxanide induces autophagy by inhibiting PI3K/Akt/ mTOR pathway in RAW264.7 macrophage cells
Jiaoqin Shou,Mi Wang,Xiaolei Cheng,Xiaoyang Wang,Lifang Zhang,Yingchun Liu,Chenzhong Fei,Chunmei Wang,Feng Gu,Feiqun Xue,Juan Li,Keyu Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
As the main metabolite of nitazoxanide, tizoxanide(TIZ) has a broad-spectrum anti-infective effect againstparasites, bacteria, and virus. In this study, we investigatedthe effects of TIZ on autophagy by regulating the PI3K/Akt/mTOR signaling pathway. RAW264.7 macrophage cellswere treated with various TIZ concentrations. Cell viabilityassay, transmission electron microscope, and immunofluorescencestaining were used to detect the biological functionof the macrophage cells, and the expression levels of theautophagy pathway-related proteins were measured by Westernblot. Results revealed that TIZ promoted the conversionof LC3-I to LC3-II, the formation of autophagy vacuoles,and the degradation of SQSTM1/p62 in a concentration- andtime-dependent manner in RAW264.7 cells. Treatment withTIZ increased the Beclin-1 expression level and inhibitedPI3K, Akt, mTOR, and ULK1 activation. These effects wereenhanced by pretreatment with rapamycin but attenuated bypretreatment with LY294002. In addition, the conversion ofLC3-I to LC3-II was observed in Vero, 293T, and HepG2cells treated with TIZ. These data suggested that TIZ mayinduce autophagy by inhibiting the Akt/mTOR/ULK1 signalingpathway in macrophages and other cells.
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Xue Bai,Yinghui Zhao,Zhenhu Song,Hui Chen,Sihang Zhang,Yonghui Luo,YingChun Gu,Shijian Tu,Guo Yao,Sheng Chen 한국섬유공학회 2022 Fibers and polymers Vol.23 No.3
The preparation of polymer nanocomposites combined with high strength, toughness, and high transparencyremains a challenge. Aramid fibers are often used as fiber-reinforced materials for their superior mechanical and thermalproperties, but the weak interfacial force between aramid fibers and matrix polymer limits the application in compositematerials. In this work, aramid nanofibers were prepared by a two-step process, which included deprotonation and acidhydrothermal treatment to obtain better dispersions in general solvents. The hydrothermal aramid nanofibers (HANFs) wereused as reinforcing materials and blended with polyacrylonitrile (PAN) to prepare polyacrylonitrile/aramid nanofibers (PAN/HANFs) composite films with different mass fractions of HANFs. The morphologies of HANFs and the thermal, optical, andmechanical properties of composite films were investigated. Interestingly, when the mass fraction of aramid nanofibers wasless than 1.0 %, the composite films were synchronously strengthened and toughened. When the mass fraction of HANFswas 0.5 %, the tensile strength and toughness of the PAN/HANFs composite film reached 62.04 MPa and 22.56 MJ/m3,which were 74.23 % and 162.31 % higher than the pure PAN film, respectively. Besides, its average transmittance in thevisible light region remained 76.34 %. This work may offer a novel and facile strategy for high transparent reinforcedpolymer composites, which have potential applications in high strength fiber or optical film.
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