Fuzzy C-means Clustering Analysis Based on Quantum Particle Swarm Optimization Algorithm for the Grouping of Rock Discontinuity Sets

Shengyuan Song,Qing Wang,Jianping Chen,Yanyan Li,Wen Zhang,Yunkai Ruan 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.4

Rock discontinuities significantly influence the deformation as well as strength of rock masses. One of the basic analyses for rock engineering is categorizing discontinuities with similar orientations into groups. In this study, an improved FCM method is proposed to identify rock discontinuity sets automatically. The method is established on account of quantum particle swarm optimization, which could achieve the global optimization as well as becomes insensitive to the initial cluster centers. Benchmark case with artificial data and discontinuity data exposed from the Songta dam area are utilized to test the validity of the new algorithm. The test results demonstrate that the new algorithm could well divide discontinuity data. The grouping results acquired by the new algorithm are similar to those of several other methods, which are commonly used to divide discontinuity sets. The main advantage of this method is that achieves a global optimum without selecting proper initial cluster centers.

Delay-Dependent Guaranteed Cost Control for Uncertain Neutral Systems with Distributed Delays

Yongmin Li,Shengyuan Xu,Baoyong Zhang,Yuming Chu 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.1

This paper considers the problem of delay-dependent guaranteed cost controller design for uncertain neutral systems with distributed delays. The system under consideration is subject to norm-bounded time-varying parametric uncertainty appearing in all the matrices of the state-space model. By constructing appropriate Lyapunov functionals and using matrix inequality techniques, a state feedback controller is designed such that the resulting closed-loop system is not only robustly stable but also guarantees an adequate level of performance for all admissible uncertainties. Furthermore, a convex optimization problem is introduced to minimize a specified cost bound. By matrix transformation techniques, the corresponding optimal guaranteed controller can be obtained by solving a linear matrix inequality. Finally, a simulation example is presented to demonstrate the effectiveness of the proposed approach.

SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis

Liu Shengyuan,Huang Feng,Ye Qing,Li Yangming,Chen Jinhu,Huang Hong 한국통합생물학회 2020 Animal cells and systems Vol.24 No.4

Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmental processes. LncRNA-SPRY4-IT1 (GenBank ID AK024556) is derived from an intron of the SPRY4 gene, which was highly expressed in melanoma cells and affected the progression of multiple types of cancers. However, the mechanism of SPRY4-IT1 in CRC progression remains unclear. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients’ prognosis. We further noticed that SPRY4-IT1 regulated CRC cell growth and glycolysis, and promoting PDK1 expression. Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. We therefore thought SPRY4-IT1 could serve as a promising molecular target for the treatment of CRC.

Investigation of Terahertz Generation from Bulk and Periodically Poled LiTaO3 Crystal with a Cherenkov Phase Matching Scheme

Zhongyang Li,Pibin Bing,Shengyuan Xu,Degang Xu,Jianquan Yao 한국광학회 2015 Current Optics and Photonics Vol.19 No.3

Terahertz (THz) wave generation from bulk and periodically poled LiTaO3 (PPLT) with a Cherenkovphase matching scheme is numerically investigated. It is shown that by using the crystal birefringenceof bulk LiTaO3 and a grating vector of PPLT, THz waves can be efficiently generated by differencefrequency generation (DFG) with a Cherenkov phase matching scheme. The frequency tuning characteristicsof the THz wave via varying wavelength of difference frequency waves, phase matching angle, polingperiod of PPLT and working temperature are theoretically analyzed. The parametric gain coefficient inthe low-loss limit and the absorption coefficient of the THz wave during the DFG process in the vicinityof polariton resonances are numerically analyzed. A THz wave can be efficiently generated by utilizingthe giant second order nonlinearities of LiTaO3 in the vicinity of polariton resonances

Investigation of the effect of cavitation and journal whirl on static and dynamic characteristics of journal bearing

Dan Sun,Shengyuan Li,Chengwei Fei,Yanting Ai,Rhea. P Liem 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1

The cavitation phenomenon in journal bearing and journal whirl are considered to evaluate the static and dynamic characteristics of journal bearing, to be more consistent with the actual operating conditions of journal bearing. With a 3D CFD method, the cavitation and journal whirl are simulated by adopting mesh deformation technique and mixture phase-change model. By comparing the results with those of the traditional Reynolds equation, we observe that first, the phenomena of cavitation and journal whirl are very consistent with the actual operating conditions of journal bearing. Moreover, for single-phase and two-phase flow models, the distribution features of oil film pressure are similar in convergent wedge zone while largely different in divergent part of the gap. The oil film pressure and vapor phase volume fraction notably vary on different whirl positions of the journal. We also observe that as whirl frequency increases, the oil film force gradually increases and the stability of journal bearing decreases rapidly before reaching a plateau. The efforts of this paper provide an efficient method to accurately evaluate the static and dynamic characteristics of journal bearing and offer a useful insight into the accurate analysis and design of journal bearing.

Pirfenidone ameliorated AGE-induced EMT and attenuated peritoneal fibrosis in peritoneal mesothelial cells

Fenglin Xiao,Shengyuan Wang,Zhiyong Zhang,Hai Yu,Mingxu Li 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.3

Background Peritoneal dialysis has greatly improved patient survival for patients with chronic kidney disease. However, peritoneal fibrosis is a progressive fibrotic peritoneal disease caused by dialysis, which may lead to ineffective dialysis or dialysis failure. It is well known that the EMT of peritoneal mesenchymal cells has been known to contribute to peritoneal fibrosis. Therefore, at present, inhibiting the formation and development of EMT has become the focus of peritoneal fibrosis. Objectives Pirfenidone has shown clinically relevant benefits in patients with pulmonary fibrosis, however, there is no research on peritoneal fibrosis. Thus, we examined the effect of pirfenidone on AGE-driven EMT in peritoneal mesenchymal cells and assessed its efficacy in inhibiting peritoneal fibrosis. Results AGEs were added with or without pirfenidone to the culture medium of HMrSV5 cells and we detected the changes of EMT and the signaling pathways involved. AGEs greatly reduced the E-cadherin level and augmented the α–SMA and vimentin expression. However, these effects were dramatically suppressed by pirfenidone treatment. Meanwhile, the reactive oxygen species (ROS) induced by AGEs were suppressed by pirfenidone. Furthermore, under the action of AGEs, pirfenidone activated the nuclear transport of Nrf2, and accelerated the production of antioxidant factors. Conclusion Pirfenidone could attenuate AGE-mediated EMT in HPMCs and might be a promising therapeutic drug to antagonize peritoneal fibrosis.

Evaluation of surface texture of dried Hami Jujube using optimized support vector machine based on visual features fusion

Xiuzhi Luo,Benxue Ma,Wenxia Wang,Shengyuan Lei,Yangyang Hu,Guowei Yu,Xiaozhan Li 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.4

The surface texture of dried jujube fruits is a significant quality grading criterion. This paper introduced a novel visual feature fusion based on connected region density, texture features, and color features. The singlescale Two-Dimensional Discrete Wavelet Transform was used to perform single-scale decomposition and reconstruction of dried Hami jujube image before visual features extraction. The connected region density was extracted by the two different algorithms, whereas the texture features were extracted by Gray Level Co-occurrence Matrix and the color features were extracted by image processing algorithms. Based on selected features which obtained by correlation analysis of visual features, the accuracy rate of the optimized Support Vector Machine classification model was 96.67%. In comparing with Extreme Learning Machine classification model and other fusion methods, the optimized Support Vector Machine based on selected visual features fusion was better.

New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study

Zhang Mengru,Morice Alyn H.,Si Fengli,Zhang Li,Chen Qiang,Wang Shengyuan,Zhu Yiqing,Xu Xianghuai,Yu Li,Qiu Zhongmin 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6

Purpose: Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real-world clinical experience. Methods: Retrospective baseline information was obtained from Clinical Research Database (January 2016 to May 2021). At least 6 months after the last clinic visit, included subjects were prospectively followed up. Results: Three hundred and sixty-nine RCC and UCC patients (199 females, 53.9%) were analyzed. The median cough duration was 24.0 (12.0–72.0) months. Laryngeal symptoms were reported in 95.9% of the patients. The common triggers for coughing were talking (74.9%), pungent odors (47.3%), eating (45.5%), and cold air (42.8%). RCC was considered in 38.2%, and the remainder of 228 patients had UCC, with an equal sex distribution (P = 0.66). Among the 141 RCCs, 90.8% (128) had refractory reflux cough, which was more responsive to current treatments (P < 0.01). Although most features and test results between RCC and UCC were similar, UCC was more commonly inappropriately treated (P < 0.01). Nineteen (7.7–41.1) months after the final clinic visit, 31.2% still coughed persistently, while 68.8% reported cough improvement or remission. RCC reported more favorable treatment outcomes (including cough improvement, control, and spontaneous remission) than UCC (P < 0.01). Coughs with long duration before the initial cough clinic visit (P < 0.01), frequent urinary incontinence (P < 0.01), and being sensitive to “talking” (P < 0.01) or “cold air” (P < 0.01) were less likely to be solved. Conclusions: The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to “talking” or “cold air.”

Optical Encryption Scheme with Multiple Users Based on Computational Ghost Imaging and Orthogonal Modulation

Sheng Yuan,Xuemei Liu,Xin Zhou,Zhongyang Li 한국광학회 2016 Current Optics and Photonics Vol.20 No.4

For the application of multiusers, the arrangement and distribution of the keys is a much concerningproblem in a cryptosystem. In this paper, we propose an optical encryption scheme with multiple usersbased on computational ghost imaging (CGI) and orthogonal modulation. The CGI encrypts the secret imageinto an intensity vector rather than a complex-valued matrix. This will bring convenience for post-processingand transmission of the ciphertext. The orthogonal vectors are taken as the address codes to distinguishusers and avoid cross-talk. Only the decryption key and the address code owned by an authorized userare matched, the secret image belonging to him/her could be extracted from the ciphertext. Therefore, thereare two security levels in the encryption scheme. The feasibility and property are verified by numericalsimulations.