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- 저자 : Shengyuan Song (검색결과 4 건)
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Shengyuan Song,Qing Wang,Jianping Chen,Yanyan Li,Wen Zhang,Yunkai Ruan 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.4
Rock discontinuities significantly influence the deformation as well as strength of rock masses. One of the basic analyses for rock engineering is categorizing discontinuities with similar orientations into groups. In this study, an improved FCM method is proposed to identify rock discontinuity sets automatically. The method is established on account of quantum particle swarm optimization, which could achieve the global optimization as well as becomes insensitive to the initial cluster centers. Benchmark case with artificial data and discontinuity data exposed from the Songta dam area are utilized to test the validity of the new algorithm. The test results demonstrate that the new algorithm could well divide discontinuity data. The grouping results acquired by the new algorithm are similar to those of several other methods, which are commonly used to divide discontinuity sets. The main advantage of this method is that achieves a global optimum without selecting proper initial cluster centers.
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Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma
Song Zou,Chen Wang,Jiansheng Liu,Qun Wang,Dongdong Zhang,Shengnan Zhu,Shengyuan Xu,Mafei Kang,Shaozhong He 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.11
Recent studies on molecular carcinogenesis suggest that the chemo-resistance of some cancers is largely due to presence of cancer stem cells (CSCs), which affect the chemotherapy outcome for hepatocellular carcinoma (HCC). However, currently no consensus on a CSC phenotype in HCC has been obtained. Here, we examined Sox12 as a novel CSC marker in HCC. Sox12+ versus Sox12- cells were purified from HCC cell lines. The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis. We found that compared to Sox12- HCC cells, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently. Moreover, Sox12 ap-peared to functionally contribute to the stemness of HCC cells. Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
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Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma
Zou, Song,Wang, Chen,Liu, Jiansheng,Wang, Qun,Zhang, Dongdong,Zhu, Shengnan,Xu, Shengyuan,Kang, Mafei,He, Shaozhong Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.11
Recent studies on molecular carcinogenesis suggest that the chemo-resistance of some cancers is largely due to presence of cancer stem cells (CSCs), which affect the chemotherapy outcome for hepatocellular carcinoma (HCC). However, currently no consensus on a CSC phenotype in HCC has been obtained. Here, we examined Sox12 as a novel CSC marker in HCC. Sox12+ versus Sox12- cells were purified from HCC cell lines. The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis. We found that compared to Sox12- HCC cells, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently. Moreover, Sox12 appeared to functionally contribute to the stemness of HCC cells. Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
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Zhanping Song,Qiang Zhang,Yuwei Zhang,Junbao Wang,Shengyuan Fan,Guannan Zhou 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.11
To study the abnormal precursory information of rock before failure, uniaxial compression tests were carried out on sandstone specimens; meanwhile, the infrared thermal camera was utilized to monitor the infrared radiation temperature (IRT) variation of the specimen surface synchronously during failure process. The test results show that with the increases of strain, the average infrared radiation temperature (AIRT) decreased gradually; when strain raises to a certain degree, the AIRT increased abruptly; thereafter, the AIRT decreased gradually with increasing strain. Therefore, the mutation point of AIRT can be regarded as the abnormal precursory information of sandstone before failure. Through analysis, the average stress at the abnormal point was 79.93% of the uniaxial compression strength of the sandstone specimens tested in this paper, and the average strain at this point was 0.9%. In addition, due to the end effect, the IRT field distribution of the sandstone specimen surface presented a decreasing tendency from top to bottom at the initial loading stage. As strain increases, the IRT field distribution tended to be high in middle and low in two ends. Closing to failure, a Y-shaped high-temperature band caused by the shear failure of the specimen appeared in the infrared thermal image. After comparison, the position of the Y-sharped high-temperature band is basically corresponding to the actually failure position of the specimen. With the increases of strain, the IRT distribution ranges decreased and the IRT frequency distribution histogram form gradually approached to the normal distribution.
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