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Design and applications of fluorescent detectors for peroxynitrite
Wang, Shan,Chen, Liyan,Jangili, Paramesh,Sharma, Amit,Li, Wei,Hou, Ji-Ting,Qin, Caiqin,Yoon, Juyoung,Kim, Jong Seung Elsevier 2018 Coordination chemistry reviews Vol.374 No.-
<P><B>Abstract</B></P> <P>Peroxynitrite (ONOO<SUP>−</SUP>) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the <I>in vivo</I> applications. Thus, the development of more sensitive and selective techniques for detecting ONOO<SUP>−</SUP>, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO<SUP>−</SUP> and their biological applications in diverse living systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The general significance of ONOO<SUP>−</SUP> detection. </LI> <LI> The design strategies of functional ONOO<SUP>−</SUP> probes. </LI> <LI> The diverse platforms to design ONOO<SUP>−</SUP> probes, including small molecules, proteins and nanocarriers. </LI> <LI> The diverse biological applications of fluorescent ONOO<SUP>−</SUP> probes. </LI> <LI> Perspectives and potential future directions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>In this review, the development of fluorescent probes for peroxynitrite detection since 2013 is described. The chemical sensor’s designs has been classified by their reaction based sensing patterns.</P> <P>[DISPLAY OMISSION]</P>
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Release dynamics of As, Co, and Mo in a biochar treated soil under pre-definite redox conditions
El-Naggar, Ali,Shaheen, Sabry M.,Hseu, Zeng-Yei,Wang, Shan-Li,Ok, Yong Sik,Rinklebe, Jö,rg Elsevier 2019 The Science of the total environment Vol.657 No.-
<P><B>Abstract</B></P> <P>This study assessed the impact of pre-definite redox potential (E<SUB>H</SUB>) on the release dynamics and distribution of As, Co, and Mo between the dissolved and colloidal phases as well as their potential mobility and phytoavailability in the sediment phase of a mining soil treated with rice hull biochar (BC). The experiment was conducted from controlled moderately-reducing to oxidizing conditions using an automated biogeochemical microcosm system. Arsenic and Mo were more abundant in the dissolved phase due to their predominant in potential mobile fractions, while Co was more abundant in the colloidal phase due to its association with Fe-(hydr)oxides. Biochar increased the dissolved and colloidal concentrations of As, the dissolved concentration of Co, and the colloidal concentration of Mo under oxidizing condition. On the other hand, the application of BC decreased the dissolved concentration of Mo and the colloidal concentration of Co in the first redox cycle under reducing-acidic condition, due to lower pH values, and chemistry of sulfide-sulfate and Fe/Mn oxides. The phytoavailability of As and Co were higher than their potential mobility in the sediment phase, while the same trend was not discerned for Mo. The potential mobility and phytoavailability of As and Co were high under oxic-acidic conditions. The potential mobility and phytoavailability of Mo might be increased under oxic condition due to the dissolution of Fe and Mn oxides under lower pH conditions, especially in the BC treated soil. Application of such rice hull BC to soil might stimulate the release of As, Co, and Mo under flooding conditions, which might increase the environmental and health risks in such wetland ecosystems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The E<SUB>H</SUB> showed a converse relation with pH in biochar treated and non-treated soils. </LI> <LI> Arsenic and Mo were abundant in the dissolved phase, but Co in the colloidal phase. </LI> <LI> Biochar increased the dissolved As and Co under oxidizing conditions. </LI> <LI> Biochar decreased the dissolved Mo under acidic conditions in the first redox cycle. </LI> <LI> Potential mobility and phytoavailability were higher under low pH and high E<SUB>H</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Wang, Chao,Xiao, Qian,Li, Yu-Wen,Zhao, Chao,Jia, Na,Li, Rui-Li,Cao, Shan-Shan,Cui, Jia,Wang, Lu,Wu, Yin,Wen, Ai-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.
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Elevated Mean Platelet Volume is Associated with Presence of Colon Cancer
Li, Jia-Ying,Li, Ying,Jiang, Zheng,Wang, Rui-Tao,Wang, Xi-Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: Colon cancer is the second most common cancer in developed countries. Activated platelets play a key role in inflammation and atherothrombosis, with mean platelet volume (MPV) is an early marker of platelet activation. The aim of the study was to clarify the relevance of MPV in patients with colon cancer. Materials and Methods: We measured MPV levels in 128 patients with colon cancer before and after surgery, and 128 controls matched for age, gender, body mass index (BMI) and smoking status. The odds ratios (ORs) and 95% confidence intervals (CIs) for colon cancer were calculated using multivariate logistic regression analyses across MPV quartiles. Results: Patients with colon cancer had higher MPV compared with controls. Surgical tumor resection resulted in a significant decrease in MPV levels (11.4 fL vs 10.7 fL; p<0.001). A positive correlation between MPV and tumor-nodule-metastases (TNM) stage was found. Furthermore, after adjusting for other risk factors, the ORs (95%CIs) for colon cancer according to MPV quartiles were 1.000, 2.238 (1.014-4.943), 3.410 (1.528-7.613), and 5.379 (2.372-12.198), respectively. Conclusions: The findings show that patients with colon cancer have higher MPV levels compared with controls, and these are reduced after surgery. In addition, MPV was found to be independently associated with the presence of colon cancer. Further studies are warranted to assess the utility of MPV as a novel diagnostic screening tool for colon cancer.
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Li-Jun Zuo,Shu-Yang Yu,Fang Wang,Yanghui Xia,Ying-Shan Piao,Yang Du,Teng-Hong Lian,Rui-Dan Wang,Qiu-Jin Yu,Ya-Jie Wang,Xiao-Min Wang,Piu Chan,Sheng-Di Chen,Yongjun Wang,Wei Zhang 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2
Background and Purpose The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson’s disease (PD) patients who experience fatigue. Methods PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins—α-synuclein oligomer, β-amyloid (Aβ)1-42, and tau—were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients. Results The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders. Conclusions PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF
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Enhancing the Robustness and Efficiency of Scale-free Network with Limited Link Addition
( Li Li ),( Qing-shan Jia ),( Xiaohong Guan ),( Hengtao Wang ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.5
The robustness of a network is usually measured by error tolerance and attack vulnerability. Significant research effort has been devoted to determining the network design with optimal robustness. However, little attention has been paid to the problem of how to improve the robustness of existing networks. In this paper, we investigate how to optimize attack tolerance and communication efficiency of an existing network under the limited link addition. A survival fitness metric is defined to measure both the attack tolerance and the communication efficiency of the network. We show that network topology reconfiguration optimization with limited link addition (NTRLA) problem is NP-hard. Two approximate solution methods are developed. First, we present a degree-fitness parameter to guide degree-based link addition method. Second, a preferential configuration node-protecting cycle (PCNC) method is developed to do trade-off between network robustness and efficiency. The performance of PCNC method is demonstrated by numerical experiments.
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Flowering and flowering genes: from model plants to orchids
Shan-Li Wang,Hye Ryun An,Chii-Gong Tong,Seonghoe Jang 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.2
Floral transition in model plants including Arabidopsis and rice has been studied extensively through molecular geneticapproaches. Many genetic factors in diff erent fl owering pathways, which depend mainly on photoperiod, vernalization,autonomous and ambient temperature are regulated coordinately to control fl oral induction. However, for the ornamentalplants orchids, the molecular mechanisms underlying the fl oral transition are still unclear. Recently, genes with potentialfl owering-related functions have been identifi ed in diff erent orchid species and their functional roles have also been characterized/examined using homologous or heterologous systems. In this review, we summarize the molecular networks offl owering genes and their regulation as revealed in model plants such as Arabidopsis and rice, and also describe the recentdiscoveries/studies on fl owering genes in several commercially representative orchid species providing a perspective onorchid fl owering research. In addition, our recent results through transgenic approaches with ectopic expression of Hd3a , arice fl origen gene for the induction of precocious fl owering in Phalaenopsis orchids are also discussed.
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The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study
Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2
This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.
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