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RISS 인기검색어
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- 저자 : Jangili, Paramesh (검색결과 2 건)
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Design and applications of fluorescent detectors for peroxynitrite
Wang, Shan,Chen, Liyan,Jangili, Paramesh,Sharma, Amit,Li, Wei,Hou, Ji-Ting,Qin, Caiqin,Yoon, Juyoung,Kim, Jong Seung Elsevier 2018 Coordination chemistry reviews Vol.374 No.-
<P><B>Abstract</B></P> <P>Peroxynitrite (ONOO<SUP>−</SUP>) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the <I>in vivo</I> applications. Thus, the development of more sensitive and selective techniques for detecting ONOO<SUP>−</SUP>, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO<SUP>−</SUP> and their biological applications in diverse living systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The general significance of ONOO<SUP>−</SUP> detection. </LI> <LI> The design strategies of functional ONOO<SUP>−</SUP> probes. </LI> <LI> The diverse platforms to design ONOO<SUP>−</SUP> probes, including small molecules, proteins and nanocarriers. </LI> <LI> The diverse biological applications of fluorescent ONOO<SUP>−</SUP> probes. </LI> <LI> Perspectives and potential future directions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>In this review, the development of fluorescent probes for peroxynitrite detection since 2013 is described. The chemical sensor’s designs has been classified by their reaction based sensing patterns.</P> <P>[DISPLAY OMISSION]</P>
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Rathore, Bhowmira,Sunwoo, Kyoung,Jangili, Paramesh,Kim, Jiseon,Kim, Ji Hyeon,Huang, Meina,Xiong, Jia,Sharma, Amit,Yang, Zhigang,Qu, Junle,Kim, Jong Seung Elsevier 2019 Biomaterials Vol.211 No.-
<P><B>Abstract</B></P> <P>Lysosomes, an important organelle of eukaryotic cells, are covered with the cell membrane and contain an array of degradative enzymes. The disrupt in lysosomal functions may lead to the development of severe diseases. In nanotechnology, nanomaterials working mechanism and its biomedical output are highly dependent on the lysosomes as it plays a crucial role in intracellular transport. Several nanomaterials specifically designed for lysosome-related actions are highly advantageous in trafficking and delivering the loaded imaging/therapeutic agents. But for other applications, especially gene-based therapeutic delivery into the sub-organelles such as mitochondria and nucleus, lysosomal related degradation could be an obstacle to achieve a maximal therapeutic index. In order to understand the relationship between lysosomes and designed nanomaterials for kind of desired application in biomedical research, complete knowledge of their various designing strategies, size dependent or ligand supportive cellular uptake mechanisms, trafficking, and localizations in eukaryotic cells is highly desired. In this review, we intended to discuss various nanomaterial types that have been applied in biomedical applications based on lysosomal internalization and escape from endo/lysosomes and explored their related advantages/disadvantages. Additionally, we also deliberated nanomaterials direct translocation mechanism, their autophagic accumulation and the underlying mechanism to induced autophagy. Finally, some challenges and critical issues in current research from clinical application perspective has also been addressed. Great understanding of these factors will help in understanding and facilitating the development of safe and effective lysosomal related nanomaterial-based imaging/therapeutic systems for future applications.</P>
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