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Multimodal Composite Iron Oxide Nanoparticles for Biomedical Applications
Shameer Pillarisetti,Saji Uthaman,Kang Moo Huh,Yang Seok Koh,Sangjoon Lee,In-Kyu Park 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.6
BACKGROUND: Iron oxide nanoparticles (IONPs) are excellent candidates for biomedical imaging because of unique characteristics like enhanced colloidal stability and excellent in vivo biocompatibility. Over the last decade, material scientists have developed IONPs with better imaging and enhanced optical absorbance properties by tuning their sizes, shape, phases, and surface characterizations. Since IONPs could be detected with magnetic resonance imaging, various attempts have been made to combine other imaging modalities, thereby creating a high-resolution imaging platform. Composite IONPs (CIONPs) comprising IONP cores with polymeric or inorganic coatings have recently been documented as a promising modality for therapeutic applications. METHODS: In this review, we provide an overview of the recent advances in CIONPs for multimodal imaging and focus on the therapeutic applications of CIONPs. RESULT: CIONPs with phototherapeutics, IONP-based nanoparticles are used for theranostic application via imaging guided photothermal therapy. CONCLUSION: CIONP-based nanoparticles are known for theranostic application, longstanding effects of composite NPs in in vivo systems should also be studied. Once such issues are fixed, multifunctional CIONP-based applications can be extended for theranostics of diverse medical diseases in the future.
A multi-stimuli responsive alginate nanogel for anticancer chemo-photodynamic therapy
Shameer Pillarisetti,Veena Vijayan,Jayakumar Rangasamy,Rizia Bardhan,Saji Uthaman,In-Kyu Park 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Stimuli-responsive nanosystems enable highly effective targeting and therapeutic functions, includingchemotherapy and photodynamic therapy (PDT). Traditional PDT alone cannot effectively eradicate thetumor burden; combined with chemotherapy, this combination presents a powerful treatment modalityto modulate the tumor microenvironment (TME). Herein, we report a multi-stimulus responsive alginatenanogel that responds to the change in pH and redox potential in the TME. We coupled oxidized alginatewith 4-mercapto phenylboronic acid and pheophorbide-A (a hydrophobic photosensitizer) and conjugatedwith adipic acid dihydrazide to design the nanogels. Further, we encapsulated doxorubicin, a cytotoxicagent, in the nanogel to enable chemotherapy. The alginate nanogel exhibited the pH-sensitiverelease of both pheophorbide-Aand doxorubicin and simultaneously reduced the redox potential thatenhanced PDT by increasing reactive oxygen species production. Our results demonstrate that themulti-stimuli responsive alginate nanogel enhances toxicity in breast cancer and melanoma.
Saji Uthaman,Shameer Pillarisetti,허강무,Chong-SuCho,박인규 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
Tumor metastasis is associated with high mortality in breast cancer patients. Although photothermaltherapy (PTT) has arisen as a promising anticancer treatment approach, PTT-based monotherapies stillfail to eradicate advanced cancers due to the immunosuppressive microenvironment. Herein, wesynthesized drug-dye-lipid-like micelles composed of thermoresponsive poloxamer conjugated withlinoleic acid (PCLA) loaded with a chemotherapeutic drug doxorubicin (DOX) and a near-infrared dye IR-780 (PCLA-ID) to enhance antitumor immunity against progressive metastatic breast cancers. Intravenous administration of sub-100 nm sized PCLA-ID in breast tumor-bearing mice followed bylocal laser irradiation eliminated not only primary tumors, but also untreated distant tumors (abscopaleffect). The combinatorial treatment of apoptosis-inducing PCLA-ID, which contained DOX at asubtherapeutic dose, and PTT augmented the maturation of tumor-draining lymph nodes, theupregulation of cytotoxic T lymphocytes, and the suppression of regulatory T cells in untreatedsecondary tumors. These events prevented lung metastasis in tumor-bearing mice after re-challengingwith a second injection of breast cancer cells. We conclude that PCLA-ID nanoparticles can enhanceimmunogenic cell death, representing a promising strategy for triggering immune responses againstadvanced metastatic breast cancers.
Tumor intracellular microenvironment-responsive nanoparticles for magnetically targeted chemotherapy
Kangmin Noh,Saji Uthaman,이충성,Yugyeong Kim,Shameer Pillarisetti,Hee Sook Hwang,In-Kyu Park,Kang Moo Huh 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
Nanoparticles (NPs) with responsive modalities in biological microenvironments and external stimulihave received great attention as highly efficient and precise cancer therapy agents. In this study, tumorintracellular microenvironment-responsive NPs co-assembled from poly(ethylene glycol)-poly(asparticacid) [PEG-P(Asp)] copolymer, doxorubicin (DOX), and superparamagnetic iron oxide NPs (SPIONs), termedas PEG-P(Asp)/DOX/SPIONs, were prepared for tumor intracellular microenvironment (enzyme andpH)-responsive and magnetically targeted chemotherapy. The NPs exhibited not only enzyme-responsivedegradation in the presence of protease, but also triggered release of DOX at pH 5, which is an aciditysimilar to endolysosomal microenvironments in tumor cells. Furthermore, the PEG-P(Asp)/DOX/SPIONsshowed a contrast effect in magnetic resonance imaging. In vitro viability assays showed that PEG-P(Asp)/DOX/SPIONs could effectively augment the cytocompatibility of DOX compared to free DOX withouta change in magnetic forces. Fluorescence microscopy images indicated that the fabricated NPs efficientlyincreased the targeted uptake and release of DOX within cells. Overall, this hybrid NP systemcould be a favorable biomedical agent for effective tumor-targeted anti-cancer therapy.