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A multi-stimuli responsive alginate nanogel for anticancer chemo-photodynamic therapy
Shameer Pillarisetti,Veena Vijayan,Jayakumar Rangasamy,Rizia Bardhan,Saji Uthaman,In-Kyu Park 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Stimuli-responsive nanosystems enable highly effective targeting and therapeutic functions, includingchemotherapy and photodynamic therapy (PDT). Traditional PDT alone cannot effectively eradicate thetumor burden; combined with chemotherapy, this combination presents a powerful treatment modalityto modulate the tumor microenvironment (TME). Herein, we report a multi-stimulus responsive alginatenanogel that responds to the change in pH and redox potential in the TME. We coupled oxidized alginatewith 4-mercapto phenylboronic acid and pheophorbide-A (a hydrophobic photosensitizer) and conjugatedwith adipic acid dihydrazide to design the nanogels. Further, we encapsulated doxorubicin, a cytotoxicagent, in the nanogel to enable chemotherapy. The alginate nanogel exhibited the pH-sensitiverelease of both pheophorbide-Aand doxorubicin and simultaneously reduced the redox potential thatenhanced PDT by increasing reactive oxygen species production. Our results demonstrate that themulti-stimuli responsive alginate nanogel enhances toxicity in breast cancer and melanoma.
Role of Immunosuppressive Microenvironment in Acquiring Immunotolerance Post-Photothermal Therapy
Kondareddy Cherukula,박명숙,Adonijah Graham Sontyana,Ansuja Pulickal Mathew,Veena Vijayan,배우균,박인규 대한의학회 2019 Journal of Korean medical science Vol.34 No.44
Background: Nanoparticle-mediated photothermal therapy (PTT) has been well studied as a treatment for cancer. However, the therapeutic outcome of PTT is often hindered by the penetration depth of laser light. In the tumor margin beyond the laser penetration limit, tumor recurrence often occurs, bypassing the immune response of the host. Accumulating evidence suggests the prominent role of tumor microenvironment (TME) and its interactions with the immune components contribute to an immunosuppressive milieu during the post- therapy period. Here, we explored the immunosuppressive cascade generated after PTT, which is responsible for tumor recurrence, and identified the potential targets to achieve an effective PTT period. Methods: Here, we investigated the immunosuppressive cascade generated after PTT in a CT26 tumor bearing mouse. The liposomal system loaded with the indocyanine green (ICG) was utilized for the generation of PTT with high efficiency. Immunological factors such as cytokines and protein expressions post-therapy were investigated through enzyme-linked immunosorbent assay, flow cytometry and western blot analysis. Results: Our results suggested that PTT with ICG-loaded liposomes (Lipo-ICG) was effective for the first 5 days after treatment, resulting in tumor suppression. However, an immunosuppressive and pro-inflammatory environment developed thereafter, causing the recruitment and upregulation of the immune evasion factors of heat shock protein 70, programmed death ligand 1, indoleamine-dioxygenase, interleukin-6, transforming growth factor-β, regulatory T-cells, and myeloid-derived suppressor cells, to develop immunotolerance. Conclusion: Collectively, these findings have determined potential therapeutic targets to modulate the TME during PTT and achieve tumor ablation without remission.
Photocatalytic treatment of detergent-contaminated wastewater: A short review on current progress
Collin Glen Joseph,Yun Hin Taufiq-Yap,Nur Ammarah Affandi,Janice Lay Hui Nga,Veena Vijayan 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.3
Detergents are emerging contaminants in water that require immediate attention due to their widespread use industrially and domestically. However, review articles on detergent treatment methods are not readily available in the literature as this topic is often overlooked. Various oxidation techniques have been applied to eliminate surfactants from the effluents completely. The photocatalytic treatment method is one of the most promising environmentalfriendly oxidation technologies to degrade organic pollutants. Photocatalysis using TiO2 as a catalyst shows outstanding properties, including excellent thermal and chemical stability, nontoxicity, and high photocatalytic degradation ability towards most of the organic compounds present in the wastewater. This paper reviews the research on photocatalytic degradation of detergent contaminated wastewater and the parameters that affect the semiconductor's photocatalytic activity. Lastly, critical remarks are also presented on the photodegradation treatment of laundry detergent wastewater, the economic feasibility of photodegradation treatment on an industrial scale, and suggestions for future work.
Rajendrakumar, Santhosh Kalash,Venu, Akhil,Revuri, Vishnu,George Thomas, Reju,Thirunavukkarasu, Guru Karthikeyan,Zhang, Jun,Vijayan, Veena,Choi, Seok-Yong,Lee, Jae Young,Lee, Yong-Kyu,Jeong, Yong Yeon American Chemical Society 2019 MOLECULAR PHARMACEUTICS Vol.16 No.5
<P>Tailoring combinatorial therapies along with real-time monitoring strategies has been the major focus of overcoming multidrug resistance in cancer. However, attempting to develop a multifunctional nanoplatform in a single construct leads to compromising therapeutic outcomes. Herein, we developed a simple, theranostic nanoassembly containing a hyaluronic acid-stabilized redox-sensitive (HART) polyethylenimine polyplex composed of a doxorubicin (DOX) intercalated Bcl-2 shRNA encoded plasmid along with a green-synthesized hausmannite (Mn<SUB>3</SUB>O<SUB>4</SUB>) and hematite (Fe<SUB>3</SUB>O<SUB>4</SUB>) nanoparticle (GMF). The highly stable HART nanoassembly has enhanced CD44-mediated intracellular uptake along with hyaluronidase (hylase) and redox-responsive drug-gene release. With Bcl-2 gene silencing induced by the successful delivery of HART in multidrug-resistant MCF7 breast cancer cells, the synergistic cytotoxic effect of Bcl-2 silencing and DOX was achieved. In addition, the HART nanoassembly containing GMF exhibited excellent dual MRI contrast (T1/T2) by reducing artifact signals. Overall, the HART nanoassembly with its enhanced theranostic properties has the potential to improve the therapeutic efficacy in future preclinical and clinical trials.</P> [FIG OMISSION]</BR>