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A multi-stimuli responsive alginate nanogel for anticancer chemo-photodynamic therapy
Shameer Pillarisetti,Veena Vijayan,Jayakumar Rangasamy,Rizia Bardhan,Saji Uthaman,In-Kyu Park 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Stimuli-responsive nanosystems enable highly effective targeting and therapeutic functions, includingchemotherapy and photodynamic therapy (PDT). Traditional PDT alone cannot effectively eradicate thetumor burden; combined with chemotherapy, this combination presents a powerful treatment modalityto modulate the tumor microenvironment (TME). Herein, we report a multi-stimulus responsive alginatenanogel that responds to the change in pH and redox potential in the TME. We coupled oxidized alginatewith 4-mercapto phenylboronic acid and pheophorbide-A (a hydrophobic photosensitizer) and conjugatedwith adipic acid dihydrazide to design the nanogels. Further, we encapsulated doxorubicin, a cytotoxicagent, in the nanogel to enable chemotherapy. The alginate nanogel exhibited the pH-sensitiverelease of both pheophorbide-Aand doxorubicin and simultaneously reduced the redox potential thatenhanced PDT by increasing reactive oxygen species production. Our results demonstrate that themulti-stimuli responsive alginate nanogel enhances toxicity in breast cancer and melanoma.
Zhang, Xiaobo,Pint, Cary L.,Lee, Min Hyung,Schubert, Bryan Edward,Jamshidi, Arash,Takei, Kuniharu,Ko, Hyunhyub,Gillies, Andrew,Bardhan, Rizia,Urban, Jeffrey J.,Wu, Ming,Fearing, Ronald,Javey, Ali American Chemical Society 2011 NANO LETTERS Vol.11 No.8
<P>A simple approach is described to fabricate reversible, thermally- and optically responsive actuators utilizing composites of poly(<I>N</I>-isopropylacrylamide) (pNIPAM) loaded with single-walled carbon nanotubes. With nanotube loading at concentrations of 0.75 mg/mL, we demonstrate up to 5 times enhancement to the thermal response time of the nanotube-pNIPAM hydrogel actuators caused by the enhanced mass transport of water molecules. Additionally, we demonstrate the ability to obtain ultrafast near-infrared optical response in nanotube-pNIPAM hydrogels under laser excitation enabled by the strong absorption properties of nanotubes. The work opens the framework to design complex and programmable self-folding materials, such as cubes and flowers, with advanced built-in features, including tunable response time as determined by the nanotube loading.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-8/nl201503e/production/images/medium/nl-2011-01503e_0002.gif'></P>