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Saji Uthaman,Shameer Pillarisetti,허강무,Chong-SuCho,박인규 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
Tumor metastasis is associated with high mortality in breast cancer patients. Although photothermaltherapy (PTT) has arisen as a promising anticancer treatment approach, PTT-based monotherapies stillfail to eradicate advanced cancers due to the immunosuppressive microenvironment. Herein, wesynthesized drug-dye-lipid-like micelles composed of thermoresponsive poloxamer conjugated withlinoleic acid (PCLA) loaded with a chemotherapeutic drug doxorubicin (DOX) and a near-infrared dye IR-780 (PCLA-ID) to enhance antitumor immunity against progressive metastatic breast cancers. Intravenous administration of sub-100 nm sized PCLA-ID in breast tumor-bearing mice followed bylocal laser irradiation eliminated not only primary tumors, but also untreated distant tumors (abscopaleffect). The combinatorial treatment of apoptosis-inducing PCLA-ID, which contained DOX at asubtherapeutic dose, and PTT augmented the maturation of tumor-draining lymph nodes, theupregulation of cytotoxic T lymphocytes, and the suppression of regulatory T cells in untreatedsecondary tumors. These events prevented lung metastasis in tumor-bearing mice after re-challengingwith a second injection of breast cancer cells. We conclude that PCLA-ID nanoparticles can enhanceimmunogenic cell death, representing a promising strategy for triggering immune responses againstadvanced metastatic breast cancers.
In-KyuPark,Seog-JinSeo,MitsuruAkashi,ToshihuroAkaike,Chong-SuCho 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.8
Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed monodispersity and good water-dispersibility. The loading content of EGF to the nanoparticles was very high due to electrostatic interaction between EGF and nanoparticles. EGF was released as a pseudo-zero order pattern after initial burst effect. The nanoparticles were sufficient for A431 cells proliferation.
윤소연,Sang-Kee Kang,이호빈,오서호,김휘수,Hui-Shan Li,복진덕,Chong-SuCho,YUN JAIE CHOI 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.1
BACKGROUND: Despite the many advantages of recombinant subunit vaccines, they have critical weaknesses that include a low efficacy for promoting cellular and humoral immune responses against antigens because of their poor immunogenicity, and a rapidly cleared properties as a result of proteolytic enzymes in the body. To circumvent these problems, we developed mannan-decorated inulin acetate microparticles (M-IA MPs) that functioned as carriers and adjuvants for immunization with the recombinant foot-and-mouth disease multi-epitope subunit vaccine (M5BT). METHODS: The M5BT-loaded M-IA MPs were obtained by a double-emulsion solvent-evaporation method. Their properties including morphology, size and release ability were determined by field emission scanning electron microscope, dynamic light-scattering spectrophotometer and spectrophotometer. To assess the immunization efficacy of the MPs, mice were immunized with MPs and their sera were analyzed by ELISA. RESULTS: The M-IA MPs obtained by a double-emulsion solvent-evaporation method were spherical and approximately 2–3 lm, and M5BT was encapsulated in the M-IA MPs. The M5BT-loaded M-IA MPs showed higher antigen-specific IgG, IgG1, IgG2a and anti-FMDV antibodies than the M5BT-loaded IA MPs and the Freund’s adjuvant as a control. CONCLUSION: The M-IA MPs showed a powerful and multifunctional polymeric system that combined two toll-like receptor agonists compared to the conventional adjuvant.