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Eudragit으로 코팅된 초다공성 하이드로젤의 제조 및 pH 의존형 팽윤거동
허강무(Kang Moo Huh),김보아(Bo A Kim),백은정(Eun Jung Baek) 한국고분자학회 2011 폴리머 Vol.35 No.6
초다공성 하이드로젤은 다공성 공극구조를 이용하여 기존 수화젤의 팽윤성을 획기적으로 향상시킨 것으로, 빠른 팽윤거동과 높은 흡수율로 다양한 의약용 응용분야에 유용한 재료이다. 본 연구에서는 장용 코팅제인 Eudragit 계열 고분자들을 사용하여 poly(acrylic acid-co-acrylamide)계 초다공성 하이드로젤을 코팅함으로써 pH 의존성 팽윤거동을 보이는 초다공성 하이드로젤을 제조하고자 하였다. 서로 다른 pH 영역에서 작용하는 Eudragit L100과 S100을 이용하여 딥 코팅에 의해 표면을 코팅한 후 SEM을 이용해 공극구조를 관찰하고 pH에 따른 초다공성 하이 드로젤의 팽윤거동을 관찰하였다. Eudragit 계열 고분자들로 코팅된 하이드로젤은 낮은 pH 환경하에서는 팽윤이 억 제되다가, 특정 pH 이상에서 팽윤성이 향상되는 pH 의존성 팽윤거동을 보였고, 이러한 pH 의존성은 사용한 장용 코팅제용 고분자들의 pH 특성에 의존하였다. Superporous hydrogels (SPHs) with fast swelling and superabsorbent properties are useful materials in various biomedical fields, by improving the swelling properties of conventional hydrogels based on their unique porous structure. In this study, Eudragit polymers were used as coating materials to control the swelling properties of poly(acrylic acid-co-acrylamide) based SPHs by environmental pH. The SPHs were coated with Eudragit L100 and S100 that have different pH characteristics as enteric coating materials by a dip coating method, and their pH dependent swelling behaviors were observed in various pH environments. The swelling of SPHs was inhibited at a low pH range, but significantly enhanced above a characteristic pH of Eudragit polymers. This pH dependent swelling behavior of hydrogels could be modulated by the characteristics of the enteric coating polymers.
강진무,서은숙,허상명,백태원 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.4
We experienced a case of alobar type holoprosencephaly without extracranial abnormalities except microcephaly in a 8 months old male infant. The diagnosis was made by brain CT scan, which showed the findings compatible to alobar type of holoprosencephaly. The patient is living up to the age 18 months with severe mental retardation. A brief review of literature was made.
초음파와 내시경적 역행성 담췌관 조영술로 경험한 담낭선근종증 (adenomyomatosis) 1예
강대환,양웅석,조몽,백태현,이수걸,문한규,허윤,김무영,황병욱 대한소화기내시경학회 1991 Clinical Endoscopy Vol.11 No.2
Adenomyomatosis of the gallbladder is Characterized by hyperplastic changes including overgrowth of the mucosa, thickening of the muscle wall, and intramural diverticula, crypts, or sinus tracts(Rokitaasky-Aschoff sinuses). The main diagnostic test for the detection of this disease is oral cholecystography but it's use is being decreased. Recently, Ultrasound, ERCP, and CT have been used for diagnosis. We present a report of case in whom ademomyomatosis of gallbladder was disgnosed on ultrasound and ERCP and confirmed by surgery. The essential feactures of ultrasound and ERCP diagnosis are discussed.
실험적 중대뇌동맥 폐쇄로 인한 급성 뇌경색에 대한 Thiopental 효과
강준기,김문찬,윤석훈,허춘웅,송진언,김선무 대한신경외과학회 1981 Journal of Korean neurosurgical society Vol.10 No.1
An experimental ischemic model in cats is described in which we have attempted to produce acute cerebral ischemia by occlusion of the middle cerebral artery (MCA) through the orbit. The main objectives of this experiment were: to observe the effect of thiopental in the tophographic distribution of infarct; the size of the infarct; histological changes of ischemic nerve ceils following occlusion of a major cerebral artery; to investigate the best timing of the administration and dosage of thiopental after the occlusion. 80 adult cats weighing 2.7 to 4.0kg, were used in this study. The components of the pathophysiological responses, systemic changes, cerebral infarct size and histopathological ischemic neuronal changes were studied in these groups of animals. We observed the permanent effect of the thiopental on acute focal cerebral ischemia in 40 cats by effecting permanent occlusion of MCA. The EEG was monitored continously using bifrontal electrodes from the time of administration of thiopental (10mg/kg). The animals were divided into 4 groups of 20 cats each. The 4 different groups were used to investgate the effects of thiopental on focal ischemia according to different time interval. The time intervals were 6hours, 24hours, 48hours, and 72hours after occlusion of MCA. Each animal group were divided into two groups, which one was control (n=10) the other, thiopental treated group (n=10). The results obtained were as follows: 1) Blood gases, artrial pressure, body temperature, and intracranial preosure differed among groups only a s fllows: (a) Normal blood pressure was maintained but pulse rate was slightly fast in each control group. (b) Blood pressure and pulse rate in the thiopental treated groups were significantly lower than in the control groups. In the thiopental treated groups, the value of PaO₂ was significantly higher than control groups, however, PaCO₂, was not significantly higher in the thiopental treated groups as compared to the control group. 2) In the control groups, severe contralateral hemiplegia (grade Ⅲ) developed in the early stage of MCA occlusion, however the neurological deficit progressively improved to the state of abnormal climbing (neurological grade Ⅱ) 48 hours to 72 hours after the occlusion. In the thiopental treated groups, minimum to mild neurological deficit significantly developed in the early stage of MCA occlusion and in one case walking ability was regained. 3) The size and distribution of the infarct significantly decreased to 60% in the thiopental treated groups (P<0.01). The vale of the size of the size of the infarct in the thiopental treated groups 72hours after occlusion was minimized to 0.3±0.6% (P<0. 01). In 80 percent of the control group cases severe extensive ischemic neuronal damage (score 3 or 4), was observed, 70 percent in the thiopental treated groups showed mild ischemic nerve cell changes (score 1 or 2) when the histological examination was given. Although the severity of the ischemic neuronal damage was gradually improved from 6 hours to 72 hours after occlusion of the MCA in the control, the thiopental treated group was not significantly affected to the time factor. 4) Significant reduction of experimentally induced acute focal cerebral ischemia was associated in the cat model with the administration of thiopental at 5 minute, 30 minute. and one hour postocclusion. Also we have defined the best barbiturate, best does, and best timing of administration to protect the acute focal ischemia.