금은화 추출물의 세포독성에 관한 연구

한종현,백승화,김일광,한두석 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1

In order to investigate the cytotoxicity of Lonicerae Flos extract, their extracts were dissolved in distilled water and methanol. All material diluted from 10^-3to 10^-7(㎎/㎖) with distilled water putted in each well of 24 multidish cultured rat fibroblast for 48hours. The cell number was calculated at 2 days and cell shape takes photographed by inverted microscope at same day. The results were as follows: 1. The rate of cell multiplication was the lowest in water extract from 10^-3 to 10^-7(㎎/㎖) concentration and the highest in ether and hexane extract at 10^-7(㎎/㎖) concentration. 2. Index of cytotoxicity was the highest with 3 score in water extract at 10^-3(㎎/㎖) concentration and the lowest with 1 score in ether, ethyl acetate or hexane extract at same concentration. 3. The degeneration of cell shape and number was the severest in water extract of 10&-4(㎎/㎖) concentration, but ether and hexane extracts in same concentration were weaker than water extract. These results indicate that the cytotoxicity of extracts by ether and hexane from same Lonicerae Flos was weaker then water extract.

시민참여와 정부신뢰

정수현,강한솔,황은진,이정주,노승용 서울여자대학교 사회과학연구소 2012 사회과학논총 Vol.19 No.-

이 연구는 시민참여와 정부신뢰와의 관계를 분석하는데 그 목적이 있다. 이를 위하여, 이 연구에서는 시민참여를 전통적인 오프라인 시민참여와 디지털 방식인 온라인 시민참여로 그 유형을 분류하고, 오프라인 시민참여와 온라인 시민참여의 경험이 정부신뢰와 어떤 관계가 있는지를 분석하였다. 2차 자료를 활용하여 빈도분석, 교차분석, t-test, 분산분석, 회귀분석 등을 실시한 결과 먼저, 우리나라 시민참여 경험자는 약 22% 정도이며, 오프라인 시민참여 경험자는 약 12%, 온라인 시민참여 경험자는 약 15%, 그리고 온라인과 오프라인 시민참여를 모두 경험한 시민은 약 5% 정도인 것으로 나타났다. 또한, 시민참여와 정부신뢰와는 관계를 분석한 결과 통계적으로 유의미한 관계가 없는 것으로 나타났다. 오히려, t-test 및 분산분석 결과 오프라인 및 온라인 시민참여 경험자에 비하여 무경험자의 정부신뢰 수준이 상대적으로 약간 더 높은 것으로 나타났다. 시민참여의 경험 유무 만으로 정부신뢰를 설명하는데는 한계가 있음을 보여 주는 결과일 뿐만 아니라 시민참여를 제도적으로 보장하는 것에서 나아가서 시민참여가 실질적 효과를 높일 수 있도록 시민참여과정에서 정부와 시민의 보다 적극적인 노력이 필요함을 보여주는 결과라 하겠다. Trust in government adds legitimacy to political system, provides social stability, and helps government to work effectively. In addition it increases cooperation between governments and citizens, and improves effectiveness of government affairs. However, citizens' trust in government has been quite low sine 1990s. In Korea, citizens' trust in government dropped after financial crisis in late 1990s. Various literatures indicated that citizen participation is one of the best ways to increase citizens' trust in governments. Especially as information technology increases, it is expected that citizens acquire information about different policy areas, and actively participate in surveys, discussion, and policy evaluation through internet. This research attempts to prove the relationship between citizen participation and trust in government by comparing online and offline citizen participation. The research utilized 2nd dataset from 'the influence of information on citizens' participation in policy-making.' With various statistical techniques such as frequency analysis, cross tabulation, ANOVA, and regression analysis, the characteristics of offline and online policy participants are examined. The results showed that citizens, who participate in policy-making processes more actively both online and offline, trust in government less. Comparing online and offline participation, online participants distrusted government more than offline participants. Such variables as policy competitiveness, democracy in government, quality of government, and transparency in government have direct influences on trust in government. However, citizen participation is not statistically significant. Key Words:Citizen Participation, Traditional Citizen Pariticipation, Digital Citizen Participation, Trust in Government.

우리나라 農村 保健支所에서 高血壓患者의 追求管理 方案 및 그 效果에 關한 硏究

韓聖鉉,金琅昊,李成秀 순천향대학교 1987 논문집 Vol.10 No.2

As a follow-up of the case-control study of some risk factors and status of hypertension control in rural community undertaken in May 1985, a brief assessment survey was carried out in May 1987 in order to evaluate the effectiveness of a special hypertension clinic set up at a health sub-center in Eumseong community for one year period, beginning from April 1986. The objectives of this paper were : (1) To describe a hypertension control model designed for primary care at health sub-center level (2) To present the results of follow-게 care of 39% of hypertension for one year in terms of the change in health indicator(BP level) and the factors related to compliance & non-compliance with prescribed regimen. For this study, data was obtained from 24 hypertension patients diagnosed in the previous study, dividing them into two groups : 42% as the compliance group(C-group) and 58% as the noncomplance group(NC-group). In comparing the two groups, the following results were obtained : 1. There were some difference between the two groups. In their characteristics : For example, (a) in sex composition, C-group was consisted of more female than NC-group(60% vs 50%) (b) C-group had shorter history of hypertension than NC group : the proportion of patients under 4 years group(60% vs 36%) 2. During one year period, 24 sessions of special hypertension clinics were operated at HSC. But the mean number of visits of C-group was 21.9, while NC group had 5.3 visits. 3. Knowledge & attitude toward the needs of hypertension treatment were not different between both groups. Also there were less appreciation on the prescribed duration of care to comply in both groups. 4. C-group had expressed their reliance on the treatment at the special clinic services at HSC, but NC-group *) This investiation was surpported by 1986 research grant of Soonchunhyang University. O.K. also partially sup ported by the GTZ grant. had less relied on the special clinic services at HSC and more prefered to the clinic services of the hospital. But there patients attended hospital were not referred back to HSC. 5. Main reason for compliance of C-group was their concern to prevent from stroke attack and other CV diseases. The reasons for NC-group were mainly due to (1) Geographical in accessibility, (2) Economic problems to pay, (3) Less satisfaction on progress in treatment. 6. As a results of this program in average level of BP, it was found that an average BP of C-group were decreased from 187.6㎜Hg in systolic BP and from 112.2㎜Hg to 103.4㎜Hg in diastolic BP. But, the same of NC-group increased from 169.1㎜Hg to 176.0㎜Hg in systolic & form 100.0㎜Hg to 102.3㎜Hg in diastolic BP. While it is too early to claim the success of special clinic program for hypertension control at primary care(HSC) level, this assessment survey led us a tentative conclusion that public doctor assigned at health sub-center can reasonably manage the hypetension control program if there are some support to overcome clients problems in economic & geographic accessibility and if patients adequately comply with the each special clinic sessions at HSC. In order to further strengthen the hypertension control program at primary care level, the following recommendation can be made ; (1) A set of portable EKG instrument should be equipped at health sub-center when public physicians wish to initate the community-based hypetension control program. (2) Taking into account the size of population & geographical area of each health sub-center(or township), and their work load, the HSC can inititate the H.C. program, starting from the accesible villages near HSC where & when their villages wish to participate in the program. (3) To formulate an effective community-based hypertension control program, there is a need of systematic referral system between HSC(primary) & Hospital(secondary), linking the available health resources in the community(e.g. VHW-CHP-HSC-GP-Hospital) as now being developed by the Eumseong CH project.

당뇨병성 말초신경병의 평가에 대한 전류감지검사의 임상적 유용성

김승현,심충섭,김주한,김명호 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

기어의 자동설계와 검증에 관한 연구

한민식,김승현,송호봉,전언찬 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Gear is main machine element which is used for the power transmit device when it si short in the gear. We use a standard goods in the case of the gear. But in case of special purpose, we need to manufacture the gear that have different angles. In this paper, we manufactured standard gears using W-EDM and Hobbing machine. We got a 3D shape doing reverse engineering manufactured gears. And then compared CAD data and measured data. Finally we verified ADS through comparing ADS data and KISSsoft data.

Carboxymethyl-chitin 제조공정의 단순화

한상문,안병제,김용우,김용범,유국현,이승진 대한화학회 2001 대한화학회지 Vol.45 No.4

CM-chitin은 화장품 분야에서 보습제, 유연제, 피부관리를 위한 세포활성제 및 미백제등으로 다양하게 이용되고 있는 것으로 알려져 있다. 본 연구에서는 CM-chitin제조공정을 기존의 방법에서 몇가지 절차를 배재하여 단순화 하였다. Chitin분말을 NaOH와 혼합하고 16hrs 동안 동결 및 교반을 통해 CICH_(2)COONa와 isopropyl alcohol혼합액을 첨가하였다. 그 결과 높은 치환도의 CM-chitin을 얻을 수 있었다. The water soluble carboxymethyl-chitin(CM-chitin) has been well known to be very useful to the cosmetic field as a moisturizer, a smoothener, a cell activater and a cleaner for face skin conditioning. In this study, the preparation process of CM-chitin was simplified with elimination of some procedures in the conventional method. The chitin powder was mixed with sodium hydroxide solution. And then a mixture of sodium monochloroacetate(or monochloroacetic acid) and isopropyl alcohol(or a mixed solution with water and isopropyl alcohol) was added to thorough the agitation and the freezing during 16 hours. The CM-chitin with a high degree of substitution by the improved process was obtained.

Thiamine결핍 유도후 쥐 전뇌의 성상교세포 Glial Fibrillary Acidic Protein(GFAP) 면역화학 활성도에 대한 변화

김승현,김희태,김주한,김명호,황세진,김명권,백태경 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

Simplified Effective Compressive Strengths of Columns with Intervening Floor Slabs

Seung?Ho Choi,Jin?Ha Hwang,Sun?Jin Han,Hae?Chang Cho,Jae Hyun Kim,Kang Su Kim 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.5

The current design codes discuss the effective compressive strengths of columns, which reflect a decrease in load transfer performance that can occur when columns and slabs have different concrete compressive strengths. The effective compressive strength of a column increases as it is confined by the slab, and the design codes mandate three different effective compressive strengths for interior columns (confinement on four sides), exterior columns (confinement on three sides), and corner columns (confinement on two sides). For both corner and exterior columns, the confinement effect of the slab is significantly smaller than that for the interior column, and there is a more marked decrease in load transfer performance. However, there is still a lack of theoretical studies investigating the effective compressive strengths of the corner and exterior columns. Therefore, based on the analysis model established in previous research, this study has proposed an equation for calculating the effective compressive strengths of the corner, exterior and isolated columns without any confinement effects of the slab. In addition, axial loading tests of isolated columns were conducted and the proposed equation was verified.

외이경혈 미세전류신경근 자극과 체성경혈 미세전류신경근 자극이 압통역치에 미치는 효과

한승수,고현철,조원호 한국전문물리치료학회 1997 한국전문물리치료학회지 Vol.4 No.2

甘草의 有效性分 含量에 關한 硏究

韓宗鉉,白承和,康成溶,宋昊埈 한국전통의학연구소 1997 한국전통의학지 Vol.7 No.2

시중에 유통되고 있는 4종류의 감초(특감초,원감초,일호감초,이호감초)에 대하여 유효약리성분 glycyrrhizin, 18α-glycyrrhetinic acid 및 glycyrrhizic ammonium salt의 함량을 대한약전의 규격기준에 준하여 검토한 결과는 다음과 같았다. 1. 감초의 수분함량은 7.00-10.16%범위 였다. 2. 감초의 회분 및 산불용성 회분 함량은 3.03-4.09%, 0.02-0.11 % 범위 였다. 3. 감초 품질의 지표성분인 glycyrrhizin,18α-glycyrrhetinic acid 및 glycyrrhizic ammonium sait 을 TLC로 각각 Rt값 0.399,0.932,0.394 위치에서 암자색의 반점을 확인할 수 있었는데 특 감초,원 감초,1호 감초,2호 감초 모두 같은 위치에서 뚜렷한 암자색 반점을 확인할 수 있었고,확인되지 않은 3종 화합 물의 Rt 값은 0.28,0.66,0.78 였다. 4. 감초품질의 지표성분인 glycyrrhizin,18 α-glycyrrhetinic acid 및 glycyrrhizic ammonium salt을 HPLC로 정량한 결과 glycyrrhizin은 4종류 감초에서 분석되어 2.93-4.48g% 범위였고, 18 α-glycyrrhetinic acid는 특감초 및 일호감초에서만 13.64,3.52 g% 함유되었다. 그러나 glycyrrhizic ammonium salt 분석되지 않았다. 5. 문헌상에 기록된 감초의 종류는 16종이었고 이들에서 분리된 화학물질은 약 170여 가지였다. This study was carried out to investigate the content of glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt, moisture, ash, residue ash in four kinds(teuk-gamcho, won-gamcho, IIho-gamcho, Eho-gamcho) in Glycyrrhizae Radix(Glycyrrhiza sp.) used in Korea. The result were as follows ; The moisture content in four kinds of gamcho was ranged from 7.00-10.16%. The ash and ash of acid residue in all gamcho types ranged from 3.03-4.09% and from 0.02-0.11 %, respectivly. The glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt in Teuk-gamcho, Won-gamcho, IIhogamcho, Eho-gamcho verified from line of dark purplue color by TLC and Rf value of glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt were 0.399, 0.932, O. 394, respectivly, and the Rf value unknown compoud were 0.28, 0.66, 0.78. The glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt content of all gamcho by HPLC were ranged from 2.93-4.48g%, 3.52-13.64g%, and trace, respectively. The 16 kinds of Glycyrrhiza (Licorice) were dassified, and that the identification about 170 chemicals were phamacology action substrate by reported references.