체중감량이 유도선수의 Renin, 면역기능 및 유·무산소 운동능력에 미치는 영향

권영우,전승훈,김진해,민경선,민진아 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

The purpose of this study was to investigate the effect of short terms weight reduction period on body composition and body fluid. Seven Judo athletes (21±1.21 yrs) were matched and randomly placed. Body weight reduction period consists of 7 day. Each groups reduced body weight by 3%(2th day from pre weight reduction), 5%(4th day from pre weight reduction, 7%(7th day) and investigated the recovery period on 3 hour after breakfast, lunch, and 1day, 2day after 7% body reduction. Weight reduction reduced weight during weight reduction period then returned to baseline during recovery(p<.05) and decreased LBM, electrolyte, and immune function and then increased in recovery period to baseline. In conclusion, weight reduction of Judo athletes caused the change biological variable and performance and STWR may detrimental effects body' homeostasis.

다공질 TiNi 형상기억합금의 고온자전합성에 관한 연구 : A Study on the Self-propagating High-tempaerature Synthesis of Porous TiNi shape Memory Alloy

이승해,김지순,권영순 울산대학교 1999 공학연구논문집 Vol.30 No.2

고온자전합성법을 이용하여 다공질 TiNi 금속간화합물을 제조하였다. 합성반응에 미치는 원료분말의 특성과 성형체 밀도, 점화온도 등의 영향을 생성물의 미세조직 관찰과 상분석, 기공도 및 기공구조 분석을 통하여 조사하였다. 다양한 원료분말을 사용하여 이들의 조합을 달리하여 준비한 혼합분말에 대한 반응 결과, 반응을 일으키는 최소점화온도는 280-500℃의 넓은 온도 범위로 확인되었으며, Hunter법으로 제조된 Ti 원료분말과 카르보닐 Ni 원료분말을 혼합한 경우에 가장 안정된 반응거동과 양호한 기공구조를 나타내었다. 제조된 반응생성물의 상분석 결과 단상의 TiNi와 제2상으로Ti₂Ni, TiNI₃등이 관찰되었으며, 제2상은 점화온도가 높아짐에 따라 감소하였다. 점화온도의 증가에 따라 기공의 크기도 감소하였으며 그 분포가 균일하여짐을 확인하였다. Porous TiNi intermetallic compound was produced by SHS(Self-propagating High-temperature Synthesis). Effects of starting powder characteristics, green density and ignition temperature on synthesis reaction were investigated through microstructural observation, phase analysis, porosity and pore structure of reacted specimens. Minimum ignition temperature for a propagation of thermal wave front ranged from 280 to 500℃ which varied according to starting powder characteristics. Mixtures of Ti produced by Hunter process and carbonyl Ni powders showed a stable reaction behavior and a good pore structure. From the results of XRD phase analysis TiNi was confirmed as a major phase. Additionally, Ti₂Ni and TiNi₃phases were also detected as second phases. The amount of teh second phases decreased with increasing ignition temperature which resulted also in a decrease of pore size and uniform distribution of pores.

폐경기 여성에서 1년간 호르몬 대치 요법이 혈청 지질에 미치는 영향

이해혁,남계현,김승형,이임순,이권해,최승도 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Cardiovascular disease is one of the most common cause of death in postmenopausal women. After the onset of menopause, the risk of cardiovascular disease is increased. Several risk factors of cardiovascular disease are well known to us. Among the risk factors, the changes of lipid profiles are roles for cardiovascular disease. Estrogen appears to protect the development of cardiovascular disease, by several mechanism. Especially the protective effect is believed to be mediated by the changes of lipid profiles. Decreased high-density lipoprotein (HDL)-cholesterol and increased low density lipoprotein (LDL)-cholesterol are important factors for development of cardiovascular disease. The purpose of this study was to evaluate the effect of hormone replacement therapy on the lipid profiles to include total cholesterol (TC), high density lipoprotein(HDL)-cholesterol, low density lipoprotein(LDL)-cholesterol, and triglycerides. We measured lipid profiles in 31 postmenopausal women and gave each conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12) for 12months. The levels of serum TC, LDL-cholesterol, and triglycerides were decreased significantly (p<0.05) and HDL-cholesterol was increased significantly (p<0.05) after 12months of hormone replacement therapy. These data suggest that hormone replacement therapy appears to protect agianst the development of cardiovascular disease by the changes of lipid profiles.

일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.

장기투석을 받은 만성 신부전 환자에서 발생한 종양에 관한 고찰

황정화,이혜경,홍현숙,박재성,김대호,권귀향,최득린,황승덕,이희발 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

The authors tried to evaluate tumor occurrence in long-term dialysis patients with chronic renal failure. Among 359 patients, 20 patients (about 5.6%) were diagnosed with malignancy during long-term dialysis from the period of 1983 to 1995 at our nephrology department. The ultrasonographic and computed tomographic findings including the clinical features of 20 patients that were retrospectively reviewed. The mean age of the patients was 53 (37-75)years old and the ratio of male to female was 9:1. Among the 20 cases, 7 cases of hepatoma (35%) were developed. Among them, urinary tract tumors such as renal and bladder cancer were developed in 4 (20%) and 2 (10%) of the cases. Other malignant tumors were lymphoma, stomach cancer, uterine cervical cancer, cholangiocarcinoma, lung cancer, meningioma, and acoustic neuroma one case of each (each of 5.3%). The most common tumor in patients with chronic renal failure, who were receiving long-term dialysis, was hepatoma and the second most common tumor was cancer of the urinary tract such as kidney and bladder.

수용성 Polymer-metal Complex의 형성과 중합 개시제로서의 활용성에 관한 연구(Ⅰ)

맹기석,송해영,권오승,황명천,황택성 충남대학교 공업교육연구소 1983 論文集 Vol.6 No.2(B)

The formation of Water-Soluble Poly(Methacrylic acid) (PMA) and poly (acrylamide) (PAAm)-Cu(II) complexes was achieved at various PH. The structures and the optimum conditions for the formation of complexes have been determined through UV, IR and viscosity measurements. In addition, it was found that they can be used as an initiator for vinyl type monomers. Formed polymer-metal complexes are the most stable at around PH=7 and therefore give rise to maximum absorbance in UV spectrum. As PH is increased the conformation of polymer-metal complexes has become more compact. This can be explained in terms of decreasing viscosity with increasing PH. It was also observed that the function as an initiator of the polymer-metal complexes is very active at around PH=7 and the complexes can polymerize vinyl type monomers up to 10% Conversion. These results can explain the fact that the stable complexes were formed at around PH=7 and the formed complexes can be used as good initiators.

갱년기 여성의 호르몬 대치 요법에 대한 수용율

이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.

HBV : Reactivation of Hepatitis B Virus Following Anti- TNFα Treatment

( Seung Jun Jang ),( Young Kul Jung ),( Hae Lim Baek ),( Hyun Hwa Yoon,),( Seung Kak Shin ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Joo Choi ),( Ju Hyun Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Tumor necrosis factor-α (TNF-α), one of the most important pro-inflammatory cytokines, plays a key role in the immune or inflammatory responses to infectious disease. TNF-α inhibitors have been increasingly in the treatment of several rheumatic diseases or inflammatory bowel diseases. Treatment with TNF-α inhibitors in patients with concurrent HBV or HCV infection can promote viral reactivation and potentially fatal liver failure. The aim of our study is to evaluate the predictive factors of HBV reactivation after TNF-α treatment. Methods: We retrospectively analyzed medical records of the patients who were treated with TNF-α inhibitors(infliximab, etenercept, adalimumab) at Gachon University Gil Medical Center. From January 2010 to April 2013, one hundred seventy- six patients were treated with TNF-α inhibitors and followed up. We determined status of HBsAg, HBcAb, HBVDNA, anti-HCV, ALT. Results: A total of 114 of 176(64.8%) in the study population was tested status for HBsAg at baseline. 6 patients (6/114,5.2%) were HBsAg positive and 109 patients (109/114,94.8%) were negative. Only 10 patient of the HBsAg negative patients (10/109,9.2%) were checked HBcAb. 91 patients were check anti-HCV and 2 patients (2/91,2.2%) were positive. After TNF-α inhibitor treatment, total 3 patients were confirmed reactivation of HBV. All of them was HBsAg positive patients and one of them was treated with entecarvir. Conclusions: Reactivation of HBV after TNF-α inhibitor treatment was observed in HBsAg positive patients. For prevent of reactivation of HBV, screening of HBV infection status and close follow-up is needed. Especially, in HBsAg positive patients should be treated anti viral agent before TNF-α inhibitor inhibitor treatment.

Spontaneous keloid or keloidal scleroderma; 3 cases of scar like lesions on breast

( Seung Hwi Kwon ),( Jung Woo Lee ),( Jiehyun Jeon ),( Hae Jun Song ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Although spontaneous keloids have been reported, most of hypertrophic or keloidal lesions are developed after certain kinds of traumatic events on predisposing sites. 3 women showing very similar clinical findings presented with erythematous linear hypertrophic scar/keloid-like plaques on medial aspect of their left breast near the areolar area. Itching was noted in 2 women. Trauma histories related with lesion formation were not revealed in all cases. Lesions were developed in their early 40s in 2 patients and late 50s in the other. One patient had a history of ovarian cancer and hypothyroidism, and one patient had asthma and polyneuropathy. No specific abnormal findings were noted in routine laboratory tests. On histologic examination, mild acanthotic epidermal hyperplasia and perivascular lymphohistiocytic inflammatory cell infiltrates were seen in the dermis. Thickened and hyalinized collagen bundles were intermingled with increased numbers of fibrous spindle cells in the dermis of 2 patients. In other patient’s specimen, who has been treated for a long time with intralesional injection of steroid, thickening of collagen bundles were minimal. Although they were thought as hypertrophic scar or keloids at the start, after extensive review of literature, keloidal scleroderma was suspected. We herein report interesting 3 cases of suspected keloidal scleroderma showing unique common clinical features.

HBV : Efficacy of Entecavir and Adefovir Combination Therapy in Patients with Multi-antiviraldrug resistant Hepatitis B Virus

( Seung Kak Shin ),( Young Kul Jung ),( Seung Jun Jang ),( Hae Lim Baek ),( Hyun Hwa Yoon ),( Soo Yong Park ),( Min Young Rim ),( Hyeonsu Park ),( In Ku Yo ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Jo 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Multi-antiviral drug resistance is a major problem in the treatment of patients with chronic hepatitis B (CHB). Tenofovir disoproxil fumarate (TDF) is recommended for ADV or entecavir (ETV). However, until recently TDF was not available in Korea. ADV and ETV combination therapy may be a viable alternative to TDF in patients with either ADV or ETV resistance. This study investigated the efficacy of ADV and ETV combination therapy in patients with multidrug resistance. Methods: Forty-one patients were enrolled and were administered ADV and ETV combination therapy for at least 12 months. Blood was drawn at baseline and at 12, 24, 36, 48, and 60 months after commencing treatment, and virological response was analyzed. Results: After ADV and ETV combination therapy, ALT normalization was 68%, 73%, 80% 90%, and 93% in 12wks, 24wks, 36wks, 48wks, and 60 wks, respectively. HBV DNA reduction was -1.5, -1.8, -1.9, -1.8, and -1.9 log10IU/mL in 12wks, 24wks, 36wks, 48wks, and 60 wks, respectively. 29 of HBeAg positive patients showed the following low HBeAg seroconversion rate: 3%, 7%, and 10% in 24wks, 48wks, and 60wks, respectively. In addition, virological response group showed lower initial HBV DNA level (P=0.014) and lower HBeAg positive rate (P=0.016) compared with non-virological response group. Conclusions: ADV and ETV combination therapy could be considered in selected chronic hepatitis B patients who have low initial HBV DNA level and HBeAg negative status.