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Kim, Shin-Hyun,Park, Hyo Sung,Choi, Jae Hoon,Shim, Jae Won,Yang, Seung-Man WILEY-VCH Verlag 2010 Advanced materials Vol.22 No.9
<B>Graphic Abstract</B> <P>The cover shows a schematic illustration of patterned colloidal photonic crystals with different bandgap positions. When an unknown light source impinges on the patterned photonic crystals, the light information can be identified from the reflection intensity profile of the constituent photonic crystals. The two optical microscopy images and background image display integrated photonic crystals with 20 different bandgaps spanning the entire visible range, and the SEM image shows the cross-section of the photonic crystal stripes, as reported by Shin-Hyun Kim, Seung-Man Yang, and co-workers on p. 946. <img src='wiley_img_2010/09359648-2010-22-9-ADMA201090022-content.gif' alt='wiley_img_2010/09359648-2010-22-9-ADMA201090022-content'> </P>
이승복,배귀남,진현철,김영성,문길주,심상규 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.1
Air pollutants were measured eight times from June 1999 to June 2002 on regular ferries cruising across the Yellow Sea between Incheon in Korea and Qingdao or Tianjin in China. PM_(10) and PM_(2.5_ were measured as particulate matters and SO₂, CO, and NOx were measured as gaseous pollutants. On each route, sampling was made, starting two hour after departure and ending two hour before arrival. Low concentrations of gaseous pollutants that were not much varied according to sampling period and location revealed that atmosphere over the sea was not directly affected by anthropogenic emissions. However, concentrations of fine particles were generally higher than those measured at Deokjeok Island. 50 km west of the western seashore, at similar periods. It was believed that considerable influence of China in the form of secondary pollutants was exerted over the sea.
한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고
최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.
Shim, Hyun-Woo,Jin, Yun-Ho,Seo, Seung-Deok,Lee, Seung-Hun,Kim, Dong-Wan American Chemical Society 2011 ACS NANO Vol.5 No.1
<P>In this work, a simple, high-yield biomineralization process is reported for cobalt oxide nanostructures using Gram-positive bacteria, <named-content content-type='genus-species' xlink:type='simple'>Bacillus subtilis</named-content>, as the soft templates. Rod-type cobalt oxide is prepared at room temperature through an electrostatic interaction between the functional surface structures of the bacteria and the cobalt ions in an aqueous solution. Additionally, porous Co<SUB>3</SUB>O<SUB>4</SUB> hollow rods are formed through a subsequent heat treatment at 300 °C. These rods have a high surface area and exhibited an excellent electrochemical performance for rechargeable Li-ion batteries. This facile, inexpensive, and environmentally benign synthesis for transition metal oxides with unique nanostructures can be used for several practical applications, such as batteries, catalysts, sensors, and supercapacitors.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-1/nn1021605/production/images/medium/nn-2010-021605_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn1021605'>ACS Electronic Supporting Info</A></P>
( Seung Kak Shin ),( Yun Soo Kim ),( Young Sup Shim ),( Seung Joon Choi ),( So Hyun Park ),( Dong Hae Jung ),( Oh Sang Kwon ),( Duck Joo Choi ),( Ju Hyun Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Vascular invasion is the most important predictive factor of tumor recurrence after resection in hepatocellular carcinoma (HCC). Recently, it has been suggested that the peritumoral decreased uptake area (PDUA) on hepatobiliary phase of gadoxetic acid-enhanced MRI could be shown in cases of the impaired hepatocyte function induced by decreased portal flow, and was associated with vascular invasion in HCC. The aims of our study were to clarify the clinicopathological characteristics of PDUA on hepatobiliary phase and to elucidate the predictability of the PDUA on tumor recurrence after resection. Methods: We retrospectively analyzed the clinicopathological and radiological data from 194 consecutive HCC patients who underwent preoperative gadoxetic acid-enhanced MRI and surgical resection between January 2008 and January 2016. The presence of a faint and hypointense area around the tumor in the hepatobiliary phase was defined as PDUA. Results: Of 194 HCCs, PDUA on hepatobiliary phase was observed in 25 cases (12.9%). Of 42 HCCs with microvascular invasion, PDUA was observed in 16 cases (38.1%) and of 16 HCCs with macrovascular invasion, PDUA was observed in 8 cases (50.0%). In multivariate analysis, tumor size (>5 cm) and microvascular invasion were significantly associated with PDUA. After a median follow-up period of 17.5 months, 17 of the 25 patients with PDUA (68.0%) suffered from tumor recurrence. The recurrent-free survival in group with PDUA after resection by Kaplan-Meier method with the log-rank test was significantly worse than that in group without PDUA (P=0.003). In addition, multivariate survival analysis using Cox``s regression identified that PDUA (HR =4.2; 95% CI 1.8-9.7; P=0.001) was an independent risk factor for recurrence after resection of HCCs less than 5 cm. Conclusions: PDUA on hepatobiliary phase of gadoxetic acid-enhanced MRI could be a useful preoperative predictor of microvascular invasion and prognosis factor after surgical resection in HCC.
( Seung-On Lee ),( Sang Hoon Joo ),( Ah-won Kwak ),( Mee-hyun Lee ),( Ji-hye Seo ),( Seung-sik Cho ),( Goo Yoon ),( Jung-il Chae ),( Jung-hyun Shim ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.6
Podophyllotoxin (PT), a lignan compound from the roots and rhizomes of Podophyllum peltatum, has diverse pharmacological activities including anticancer effect in several types of cancer. The molecular mechanism of the anticancer effects of PT on colorectal cancer cells has not been reported yet. In this study, we sought to evaluate the anticancer effect of PT on human colorectal cancer HCT116 cells and identify the detailed molecular mechanism. PT inhibited the growth of cells and colony formation in a concentration-dependent manner and induced apoptosis as determined by the annexin V/7-aminoactinomycin D double staining assay. PT-induced apoptosis was accompanied by cell cycle arrest in the G2/M phase and an increase in the generation of reactive oxygen species (ROS). The effects of PT on the induction of ROS and apoptosis were prevented by pretreatment with N-acetyl-L-cysteine (NAC), indicating that an increase in ROS generation mediates the apoptosis of HCT116 cells induced by PT. Furthermore, Western blot analysis showed that PT upregulated the level of phospho (p)-p38 mitogen-activated protein kinase (MAPK). The treatment of SB203580, a p38 inhibitor, strongly prevented the apoptosis induced by PT, suggesting that PT-induced apoptosis involved the p38 MAPK signaling pathway. In addition, PT induced the loss of mitochondrial membrane potential and multi-caspase activation. The results suggested that PT induced cell cycle arrest in the G2/M phase and apoptosis through the p38 MAPK signaling pathway by upregulating ROS in HCT116 cells.
Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin
( Seung-on Lee ),( Sang Hoon Joo ),( Jin-young Lee ),( Ah-won Kwak ),( Ki-taek Kim ),( Seung-sik Cho ),( Goo Yoon ),( Yung Hyun Choi ),( Jin Woo Park ),( Jung-hyun Shim ) 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.1
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. However, the therapeutic potential of LCC in treating colorectal cancer (CRC) and its underlying molecular mechanisms remain unclear. Chemotherapy for CRC is challenging because of the development of drug resistance. In this study, we examined the antiproliferative activity of LCC in human colorectal carcinoma HCT116 cells, oxaliplatin (Ox) sensitive and Ox-resistant HCT116 cells (HCT116- OxR). LCC significantly and selectively inhibited the growth of HCT116 and HCT116-OxR cells. An in vitro kinase assay showed that LCC inhibited the kinase activities of EGFR and AKT. Molecular docking simulations using AutoDock Vina indicated that LCC could be in ATP-binding pockets. Decreased phosphorylation of EGFR and AKT was observed in the LCC-treated cells. In addition, LCC induced cell cycle arrest by modulating the expression of cell cycle regulators p21, p27, cyclin B1, and cdc2. LCC treatment induced ROS generation in CRC cells, and the ROS induction was accompanied by the phosphorylation of JNK and p38 kinases. Moreover, LCC dysregulated mitochondrial membrane potential (MMP), and the disruption of MMP resulted in the release of cytochrome c into the cytoplasm and activation of caspases to execute apoptosis. Overall, LCC showed anticancer activity against both Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, inducing ROS generation and disrupting MMP. Thus, LCC may be potential therapeutic agents for the treatment of Ox-resistant CRC cells.
( Seung-on Lee ),( Ah-won Kwak ),( Mee-hyun Lee ),( Ji-hye Seo ),( Seung-sik Cho ),( Goo Yoon ),( Jung-il Chae ),( Sang Hoon Joo ),( Jung-hyun Shim ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.12
Picropodophyllotoxin (PPT), an epimer of podophyllotoxin, is derived from the roots of Podophyllum hexandrum and exerts various biological effects, including anti-proliferation activity. However, the effect of PPT on colorectal cancer cells and the associated cellular mechanisms have not been studied. In the present study, we explored the anticancer activity of PPT and its underlying mechanisms in HCT116 cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to monitor cell viability. Flow cytometry was used to evaluate cell cycle distribution, the induction of apoptosis, the level of reactive oxygen species (ROS), assess the mitochondrial membrane potential (Δψm), and multi-caspase activity. Western blot assays were performed to detect the expression of cell cycle regulatory proteins, apoptosis-related proteins, and p38 MAPK (mitogen-activated protein kinase). We found that PPT induced apoptosis, cell cycle arrest at the G1 phase, and ROS in the HCT116 cell line. In addition, PPT enhanced the phosphorylation of p38 MAPK, which regulates apoptosis and PPT-induced apoptosis. The phosphorylation of p38 MAPK was inhibited by an antioxidant agent (N-acetyl-L-cysteine, NAC) and a p38 inhibitor (SB203580). PPT induced depolarization of the mitochondrial inner membrane and caspase-dependent apoptosis, which was attenuated by exposure to Z-VAD-FMK. Overall, these data indicate that PPT induced G1 arrest and apoptosis via ROS generation and activation of the p38 MAPK signaling pathway.