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학생들의 식품알레르기 유병률 및 학교급식 식품알레르기 표시제에 대한 인식
이아현 ( Ah Hyun Lee ),김규언 ( Kyu Earn Kim ),이경은 ( Kyung Eun Lee ),김성희 ( Seong Hui Kim ),왕태환 ( Tae Whan Wang ),김경원 ( Kyung Won Kim ),곽동경 ( Tong Kyung Kwak ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3
Purpose: Prevalence of food allergy and perceptions on food allergen labeling in school foodservice among elementary, middle, and high school students were investigated in Korea. Methods: A total of 1,000 elementary, middle, and high schools were selected in 16 cities and provinces of Korea and students attending the schools were surveyed using a questionnaire modified from the Korean International Study of Asthma and Allergies in Childhood questionnaire in July 2012. Responses from 27,679 students were used for data analysis. Results: The ratio of the students who had experienced food allergy was 12.6%; 7.6% of the responding students had food allergy reactions last 12 months and 6.8% of the students had been diagnosed for food allergy by doctors. Eggs, milk, peach, and crabs were the most frequent allergenic foods for the elementary school 1st graders, 5th graders, middle, and high school students, respectively, who had experienced food allergy last 12 months. The students with food allergy read menus more frequently and were more interest in food allergen labeling in school foodservice than their counterparts. Both of the student groups with and without food allergy perceived food allergen labeling important for the students with food allergy and their parents. Conclusion: The prevalence of food allergy and major allergenic foods varied by school years. The Korean students had positive perception on allergic food labeling in school foodservice. An effective food allergen labeling system for school foodservice should be developed and implemented that reflects prevalence, symptoms, and food allergens among Korean students. (Allergy Asthma Respir Dis 2013;1:227-234)
원영화 ( Won Young Hwa ),김지혜 ( Kim Ji Hye ),정은희 ( Jung Eun Hee ),곽은아 ( Kwak Eun Ah ),양윤정 ( Yang Yun Jung ),신순자 ( Shin Soon Ja ),김연희 ( Kim Yeon Hee ),김정혜 ( Kim Jeong Hye ) 병원간호사회 2017 임상간호연구 Vol.23 No.3
Purpose: The purpose of this study was to investigate the effect of customer experience management on nursing service satisfaction of cancer patients and their intent to revisit the hospital and also to identify empathy ability of oncology nurses. Methods: Participants were 376 cancer patients and 190 oncology nurses from a tertiary hospital in Korea. Cancer patients' satisfaction with nursing care and intent to continue using the hospital were measured and empathy of oncology nurses was measured using Empathy Construct Rating Scale. Data were analyzed using descriptive statistics, x<sup>2</sup> test, t-test, one-way ANOVA and stepwise multiple regression analysis. Results: Patient satisfaction with nursing care and intent to continue using the hospital were higher in patients who received the customer experience management program than those who did not. Oncology nurses' ability to empathize was high. Clinical career, participate in customer experience management and education level together explained 20% of variance in empathy ability of oncology nurses. Conclusion: Findings from this study confirm that customer experience management affects patient satisfaction with nursing service and intent to continue using the hospital. Further research is necessary to reaffirm the empathy ability of the oncology nurses and to identify the related various factors.
학생들의 식품알레르기 유병률 및 학교급식 식품알레르기 표시제에 대한 인식
이아현 ( Ah Hyun Lee ),김규언 ( Kyu Earn Kim ),이경은 ( Kyung Eun Lee ),김성희 ( Seong Hui Kim ),왕태환 ( Tae Whan Wang ),김경원 ( Kyung Won Kim ),곽동경 ( Tong Kyung Kwak ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3
Purpose: Prevalence of food allergy and perceptions on food allergen labeling in school foodservice among elementary, middle, and high school students were investigated in Korea. Methods: A total of 1,000 elementary, middle, and high schools were selected in 16 cities and provinces of Korea and students attending the schools were surveyed using a questionnaire modified from the Korean International Study of Asthma and Allergies in Childhood questionnaire in July 2012. Responses from 27,679 students were used for data analysis. Results: The ratio of the students who had experienced food allergy was 12.6%; 7.6% of the responding students had food allergy reactions last 12 months and 6.8% of the students had been diagnosed for food allergy by doctors. Eggs, milk, peach, and crabs were the most frequent allergenic foods for the elementary school 1st graders, 5th graders, middle, and high school students, respectively, who had experienced food allergy last 12 months. The students with food allergy read menus more frequently and were more interest in food allergen labeling in school foodservice than their counterparts. Both of the student groups with and without food allergy perceived food allergen labeling important for the students with food allergy and their parents. Conclusion: The prevalence of food allergy and major allergenic foods varied by school years. The Korean students had positive perception on allergic food labeling in school foodservice. An effective food allergen labeling system for school foodservice should be developed and implemented that reflects prevalence, symptoms, and food allergens among Korean students. (Allergy Asthma Respir Dis 2013;1:227-234)
구강편평세포암종 세포에서 감초 유래 Liquiritigenin의 항증식, 세포주기 정지 및 세포사멸 유도
곽아원(Ah-Won Kwak),윤구(Goo Yoon),채정일(Jung-Il Chae),심정현(Jung-Hyun Shim) 한국생명과학회 2019 생명과학회지 Vol.29 No.3
Liquiritigenin (LG)은 licorice 뿌리에서 분리된 chiral flavonoid이다. LG는 항산화, 항암 및 항염증 효과를 포함하여 다양한 생물학적 활성을 가지고 있다. 구강편평세포암종에서 LG의 항암 활성은 아직 밝혀지지 않았다. 본 연구에서는 구강편평상피암 세포(HN22)에서 LG의 항암 효능을 시험하였다. HN22 세포에 LG를 처리하여 MTT분석으로 세포 생존율을 평가하였으며, Annecin V/7-Aminactinomycin D 염색, 세포주기 및 Multi-caspase 활성을 Muse™ cell Analyzer로 분석하여 세포사멸 유도를 확인하였다. 분석결과, 구강편평상피암 HN22 세포에 LG를 처리시 G2/M 세포주기 정지를 일으켰으며, Western blotting 통하여 cyclin B1 및 CDC2 발현 감소와 p27 발현증가를 확인하였다. LG는 활성산소종의 생성을 유발하고, CCAAT/enhancer-binding protein homologous protein(CHOP) 및 78-kDa glucose regulated protein (GRP78)의 발현을 농도의존적으로 유도하였다. HN22 세포에 LG의 처리는 미토콘드리아 막전위의 손실(△Ψm)을 일으켰다. LG를 처리한 HN22 세포의 단백질 분석결과 apoptotic protease activating factor-1 (Apaf-1), cleaved Poly (ADP-Ribose) Polymerase (C-PARP) 및 Bax의 발현을 증가함을 확인하였다. 따라서 우리의 결과는 LG이 구강편평상피암 세포의 세포사멸을 유도하여 항암제 역할을 할 수 있는 천연 화합물임을 시사한다. Liquiritigenin (LG) is a chiral flavonoid isolated from the roots of licorice. It exhibits multiple biological activities including anti-oxidant, anti-cancer, and anti-inflammatory effects. In particular though, the anti-cancer activity of LG in oral squamous cell carcinoma has yet to be elucidated, and LG-induced apoptosis in oral squamous cell carcinoma remains poorly understood. In the present study, we tested the role of LG in inducing apoptosis in oral squamous cell carcinoma cells. LG treatment of HN22 cells resulted in a dose-dependent inhibition of cell viability as detected by a 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide assay. The induction of apoptosis in terms of Annexin V/7-Aminoactinomycin D staining, sub-G1 population, and multi-caspase activity were assessed with a Muse<SUP>TM</SUP> Cell Analyzer. Flow cytometric analysis revealed that LG treatment resulted in G2/M arrest in cell cycle progression and downregulation of cyclin B1 and CDC2 expression in a concentrationdependent manner. It also resulted in significant upregulation of p27. In addition, LG was seen to trigger the generation of reactive oxygen species and induce CCAAT/enhancer-binding protein homologous protein and 78-kDa glucose-regulated protein in concentration-dependent upregulation. The LG treatment of HN22 cells led to a loss of mitochondrial membrane potential (△Ψm); it also reduced the levels of anti-apoptotic protein and increased the expression of apoptotic protease activating factor-1, cleaved poly (ADP-ribose)polymerase and Bax. Overall, our results indicate that the pro-apoptotic effects of LG in HN22 cells depend on the activation of both intrinsic and extrinsic signaling pathways. Thus, our results suggest that LG constitutes a natural compound with a potential role as an anti-tumor agent in oral squamous cell carcinoma.
( Taek Jong Kwak ),( Yun Hee Chang ),( Young Ah Shin ),( Jung Min Shin ),( Hyeong Rae Kim ),( Bomi Won ),( Min Youl Chang ),( Sang Hwha Lee ),( Hyun Kyung Jung ),( Chang Deok Kim ),( Jeung Hoon Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Human skin pigmentation is regulated by various factors such as genetic, environmental, and endocrine factors. Among these factors, genetic factor is one of the most potent determinants in skin pigmentation phenotype and has polygenic quantitative traits. Objectives: We investigated the genetic factors influencing UV-induced skin pigmentation in Korean women. Methods: We carried out a multistage genome-wide association study after exposure to UV in Korean women and examined the effect of selected gene on melanogensis in normal human epidermal melanocytes. Results: In an initial discovery stage, meta-analysis of two GWA studies of 500K single nucleotide polymorphisms on 97 Korean women identified 9 SNPs as loci highly associated with tanning ability. We further genotyped these SNPs in an independent replication study. We found that a novel SNP in the intron of WWOX gene yielded highly significant replicated associations with skin tanning ability. To understand the functional consequences of this locus, we investigated the role of WWOX in human melanocytes and inhibition of WWOX expression significantly increased the expression and activity of tyrosinase in human melanocytes. Conclusion: Our results suggest that genetic variants in intronic region such as SNP in WWOX could be determinant of an individual’s UV-induced tanning ability. WWOX gene represents a new candidate gene to study the molecular basis of an individual’s UV-induced tanning ability.