한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

폴리프로필렌 섬유보강 콘크리트(PFRC)의 역학적 특성 및 내구성에 관한 실험적 연구

박승범,김부일,윤준석 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

The result of an experimental study on the mechanical properties and durability of polypropylene fiber reinforced concrete are presented in this paper. This study has been performed to obtain the properties of PFRC such as strength toughness and durability. The test variables are fiber content fiber types, W/C ratio. PFRC shows the highest strength when the polypropylene fiber content is about 0.2% in concrete, flexural toughness of PFRC was increased remarkably as polypropylene fiber contents were increased to 2.0 vol.%. Also, freeze-thaw resistance and carbonation were somewhat more improved than plain concrete.

생보사 약관대출 수요에 대한 계량분석적 연구

박상범,마승렬 한국보험학회 2003 保險學會誌 Vol.64 No.-

약관에 보험계약자가 보험증권을 담보로 보험자에 대하여 해지환급금의 범위 내에서 대부를 청구할 수 있도록 구정하고 있는 것이 약관대출이다. 약관대출은 계약자에게는 긴급자금원 등이 될 수 있다. 반면 보험자에게는 자금운용의 한 수단이 될 수 있으나 실제로 현금흐름을 왜곡시킬 수 있다. 따라서 약관대출 수요를 파악하는 것은 투자 등 자금운용에 매우 중요하다고 하겠다. 본 연구에서는 약관대출 수요를 결정짓는 변수에 대한 연구를 시행하였으며 특히 IMF구제금융 요청으로 시작된 경제침체기를 전후하여 각각의 결과를 비교하여 보았다. 결과는 전체적으로 실업률, 물가상승률 그리고 계약준비금이 영향을 미치는 것으로 나타나고 있다. IMF사태 이전에는 계약준비금만이 약관대출에 영향을 주는 것으로 나타나고 IMF이후에는 실업률과 물가상승률이 주요변수임을 보여주고 있다. Policy loans can cause a form of disintermediation and distortion of cash flow for life insurers. Also, when investment market is booming, policy loans impose opportunity cost to life insurers. This study investigates policy loan demands for the years 1991.7∼2002.6, which encompasses period of the IMF shock. The results show that overall unemployment rate and inflation arte are main factors influencing policy loan demands. Before IMF period, policy reserve is the only main factor while after IMF period unemployment rate and inflation rate are the factors that are related to policy loan demands.

構造用 流動化 콘크리트의 長期變形 特性에 關한 硏究 : 크리프 및 건조수축 변형을 중심으로

박승범,이보성,임창덕 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.1

In order to discuss the properties of Superplasticized Concrete for Civil engineering structure at long terms, this report carried out the experiment that Superplasticized concrete compare with control concrete of Compressive Strtength, Drying-Shrinkage, Creep deformation and Creep recovery as follow condition ; ① Kinds of superplasticizer(Naphthalene, Melamine, Lignin base), ② Stress eovel(15%, 30%), ③ Curing Condition (moisture, air) As a results, Superplasticized Concrete has a good results in comp. strength more than 20%, in drying-shrinkage less than 15%, in creep deformation less than 11% of control concrete and creep recovery are also less than control concrete in 28 days. There are some difference in property between superplasticizers, but It has good results to reduce the drying-shrinkage and creep deformation using the proper superplasticizer and its dosage.

다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

高性能 流動化劑를 添加한 시멘트 페이스트의 레오로지 特性에 대한 實驗的 硏究

朴承範,高潤錫 忠南大學校 産業技術硏究所 1987 산업기술연구논문집 Vol.2 No.1

Recently flowing concrete admixture called superplasticizers have come into common use for the purpose of improving the workability of fresh concrete thus making flowing concrete, and it also used to allow a very high significant water reduction resulting in high-strength concrete, even at low levels of admixture addition. In order to consider the workability of concrete, it is necessary to evaluate the characteristics of fresh concrete. However it is still true that a full understanding of the behaviour of fresh concrete will be attainable only when it can be based on a full understanding of the behaviour of cement paste. In principle the rheological properties of any system should be predictable from a detailed knowledge of its constituents and their interrelationships, but that cannot yet done much more in domestic for ever relatively simple system.

유리纖維 補强 콘크리트 流動 特性에 관한 硏究

朴承範,任昌悳,尹義植 忠南大學校 産業技術硏究所 1989 산업기술연구논문집 Vol.4 No.1

Concrete is an excellent structural material, but it has many problems due to brittle behavior, weak resistance in tension, flexibility and toughness. In order to improve these problems, usually fiber reinforced concrete is used. But in the case of GFRC insufficient workability is caused by using glass fiber and there is lack of studying on it. This report of the following concrete of GFRC was experimented by the different W/C, S/A, glass fiber contents and maximum size of Aggregates. The results of this study is as follows; 1) Optimum S/A ratio is 0.6 at the glass fiber contents of from 0.25% to 0.75% in GFRC, but it cannot be obtained optimum S/A ratio at over 0.75. 2) Even though increasing the W/C ratio, we can get more slump, but slump is much more influenced by fiber contents in GFRC rather than increasing the W/C ratio. 3) Workability of GFRC is much more influenced by fiber contents than fiber length. 4) Workability of GFRC is a little improved by the bigger maximum size of aggregates.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.