http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Sangmin,Jung, Seulhee,Koo, Heebeom,Na, Jin Hee,Yoon, Hong Yeol,Shim, Man Kyu,Park, Jooho,Kim, Jong-Ho,Lee, Seulki,Pomper, Martin G.,Kwon, Ick Chan,Ahn, Cheol-Hee,Kim, Kwangmeyung IPC Science and Technology Press 2017 Biomaterials Vol.148 No.-
<P><B>Abstract</B></P> <P>Herein, we developed nano-sized metabolic precursors (Nano-MPs) for new tumor-targeting strategy to overcome the intrinsic limitations of biological ligands such as the limited number of biological receptors and the heterogeneity in tumor tissues. We conjugated the azide group-containing metabolic precursors, triacetylated <I>N</I>-azidoacetyl-<SMALL> <I>D</I> </SMALL>-mannosamine to generation 4 poly(amidoamine) dendrimer backbone. The nano-sized dendrimer of Nano-MPs could generate azide groups on the surface of tumor cells homogeneously regardless of cell types via metabolic glycoengineering. Importantly, these exogenously generated ‘artificial chemical receptors’ containing azide groups could be used for bioorthogonal click chemistry, regardless of phenotypes of different tumor cells. Furthermore, in tumor-bearing mice models, Nano-MPs could be mainly localized at the target tumor tissues by the enhanced permeation and retention (EPR) effect, and they successfully generated azide groups on tumor cells <I>in vivo</I> after an intravenous injection. Finally, we showed that these azide groups on tumor tissues could be used as ‘artificial chemical receptors’ that were conjugated to bioorthogonal chemical group-containing liposomes via <I>in vivo</I> click chemistry in heterogeneous tumor-bearing mice. Therefore, overall results demonstrated that our nano-sized metabolic precursors could be extensively applied to new alternative tumor-targeting technique for molecular imaging and drug delivery system, regardless of the phenotype of heterogeneous tumor cells.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
First satellite tracking of a free-ranging spotted seal (Phoca largha) from the Baengnyeongdo Island
Hyun Woo Kim,Namgyu Uh,Seulhee Lee 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.11
The spotted seal (Phoca largha) in the Yellow Sea has declined due to poaching and habitat destruction. To aid conservation efforts, Argos satellite tracking were used to monitor the movements of a free ranging spotted seal around Baengnyeongdo Island. The satellite-transmitting tag successfully attached to the seal provided 1,556 location data collected during 107 days. The seal mostly moved between two haul-out sites, Yeonbong Rock and Mulbeom Rock. From October 6th to December 12th, the seal stayed within a 7 km radius of Yeonbong Rock. However, as the signal was lost, it was not possible to identify when the seal started to migrate from Baengnyeongdo Island to winter breeding area. This study provide understanding into the habitat preferences and movement patterns of spotted seals around Baengnyeongdo Island, contributing to the conservation and management of this species. Further research with more individuals and different age groups is essential to understand their habitat preference and develop effective conservation measures for the spotted seal population in the Yellow Sea.
김현우 ( Hyun Woo Kim ),이슬희 ( Seulhee Lee ),손호선 ( Hawsun Sohn ) 한국수산과학회(구 한국수산학회) 2021 한국수산과학회지 Vol.54 No.2
There are six species of pinnipeds in Korean waters. Because of the lack of research on pinnipeds, it has been difficult to obtain ecological information on each species. All six species have been designated as endangered species, marine protected species, or national monuments by the government, depending on historical records. In this study, the current status of pinnipeds in Korea was investigated through reviewing the literature, and sighting and bycatch records, with the intention of providing new information for the review of the six species. Spotted seals and northern fur seals are well known inhabitants of Korea. The southern part of the East Sea is thought to be the margin of the distribution of Steller sea lions. Sightings of ribbon seals and ringed seals were not confirmed in Korean waters. Sea lions have not been seen since their last sighting on Dokdo in 1951 and are thought to have become extinct after that. It is necessary to delist undistributed or extinct species in Korea from the marine protected species list.
강화 섬유의 분산도가 SiC<sub>f</sub>/SiC 복합소재의 기계적 강도에 미치는 영향
최지범,김수현,이슬희,한인섭,방형준,김세영,성영훈,Ji Beom Choi,Soo-Hyun Kim,Seulhee Lee,In-Sub Han,Hyung-Joon Bang,Seyoung Kim,Young-Hoon Seong 한국복합재료학회 2023 Composites research Vol.36 No.3
This paper investigates the impact of fiber dispersion on the internal structure and mechanical strength of SiC<sub>f</sub>/SiC composites manufactured using spread SiC fibers. The fiber volume ratio of the specimen to which spread SiC fiber was applied decreased by 9%p compared to the non-spread specimen, and the resin slurry impregnated between the fibers more smoothly, resulting in minimal matrix porosity. In order to compare the fiber dispersion of each specimen, a method was proposed to quantify and evaluate the separation distance between fibers in composite materials. The results showed that the distance between fibers in the spread specimen increased by 2.23 ㎛ compared to the non-spread specimen, with a significant 42.6% increase in the distance between fiber surfaces. Furthermore, the 3pt bending test demonstrated a 49.3% higher flexural strength in the spread specimen, accompanied by a more uniform deviation in test data. These findings highlight the significant influence of SiC fiber dispersion on achieving uniform densification of the SiC<sub>f</sub>/SiC matrix and increasing mechanical strength.