Concurrent Chemoradiation Therapy in Stage III Non-small Cell Lung Cancer

김인아(In Ah Kim),최일봉(Ihl Bhong Choi),강기문(Ki Mun Kang),장지영(Jie Young Jang),문한림(Han Lim Mun),송정섭(Jung Sub Song),이선희(Sun Hee Lee),곽문섭(Mun Sub Kuak),신경섭(Kyung Sub Shinn) 대한방사선종양학회 1997 Radiation Oncology Journal Vol.15 No.1

목 적 : 국소진행된 III기 비소세포성 폐암에서 방사선감작제로서의 저용량 Cisplatin과 방사선 동시병합요법의 효과를 알아보고자하여, 관해율, 전체생존율, 무병생존율 및 치료에 따른 부작용을 방사선 단독치료군과 후향적으로 비교분석하였다. 대상 및 방법 : 1992년 4월부터 1994년 3월까지 32명의 III기 비소세포성 폐암환자(IIIa 12명, IIIb 20명)가 항암제 및 방사선동시병합요법을 받았다. 방사선치료는 3000cGy/ 10회를 2주간에 걸쳐 시행한 뒤 3주후에 2500cGy/ 10회를 추가하였으며, 방사선감작제로 cis platin 6mg/m2를 매일 방사선치료 전에 정맥주사하였다. 추적관찰기간은 13개월에서 48개월로 중간값은 24개월이었다. 방사선단독치료군 32명(IIIa 13명, IIIb 19명)은 매일 170- 200cGy씩 총 5580- 7000cGy (중간값 5960cGy) 치료받았으며, 추적관찰기간은 36개월에서 105개월로 중간값은 62개월이었다. 결 과 : cis platin- 방사선동시요법군이 방사선 단독치료군에 비해 유의하게 높은완전반응률(18.8% vs . 5.6%)및 낮은 조사야내 재발율(25% vs . 47%)을 나타내었다. 2년 전체생존율은 Cisplatin- 방사선동시요법군이 17%, 방사선단독치료군이 9.4%로 유의한 차이는 보이지 않았다.국소재발 없는 2년 무병생존율(16.5% vs. 5.3%) 및 원격전이 없는 2년 무병생존율(17% vs. 4.6%)도 두군간에 유의한 차이를 보이지 않았다. 그러나 Karnofsky performance scale 80 이상인 환자군만을 대상으로 분석한 결과, cisplatin- 방사선동시요법군이 방사선단독치료군에 비해 유의하게 높은 2년 전체생존율을 보였다(62.5% vs. 15.6%). 전체생존율에 영향을 미치는 예후인자로 cisplatin- 방사선동시요법군에 있어서는 performance status 및 조직학적 진단유형(상피세포암 vs. 비상피세포암)으로 나타났고, 방사선단독치료군에 있어서는 performance status 및 병기(IIIa vs. IIIb)로 나타났다. 치료에 따른 급성부작용으로 RTOG/ECOG grade 2 이상의 오심, 구토는 cisplatin- 방사선동시요법군이 방사선단독치료군 (22% vs. 6%)에 비해 유의하게 높은 빈도를 나타내었다. Gra de 2 이상의 혈액학적 독성은 Cis platin- 방사선동시요법군에서 방사선단독치료군에 비해 높은 빈도를 나타내었다(25% vs. 15.6%). 방사선단독치료군에 비해 cis platin- 방사선동시요법군에서, RTOG/ECOG Grade 2 이상의 폐독성의 빈도(31% vs. 19%)나 WHO Grade 3 이상의 폐섬유화의 빈도(38% vs. 25%)의 유의한 증가는 관찰되지 않았다. 방사선치료부위의 면적이 200cm2 이상이었던 경우, 두군 모두에서 폐독성 빈도의 유의한 증가를 보였다. 결 론 : cisplatin- 방사선동시병합요법이 방사선단독치료군에 비해 높은 국소제어율을 나타내었으나, 전체생존율이나 무병생존율의 유의한 증가는 보이지 않았다. KPS 80이상인 환자군에 있어서는 cisplatin- 방사선동시요법군이 방사선단독군에 비해 높은 전체생존율을 보였다. cisplatin- 방사선동시병합요법군에서 급성부작용이 증가되는 경향을 보였으나, 방사선에 의한 폐독성의 유의한 증가는 관찰되지 않았다. cisplatin- 방사선동시병합요법군이 방사선단독치료군에 비해 1년 이내에 조기사망율이 높은 반면, 2년이상 장기생존율이 높은 경향을 보여, 이러한 환자군에 대한 장기적인 추적조사를 통해 생존율에 대한 본 치료의 영향을 좀더 명확하게 평가할 수 있을것으로 기대되며, 향후 치료효과를 증가시키기위해 large fraction size의 split course RT 대신 continuous course의 conventional RT 혹은 hyperfractionated RT와 Cisplatin의 동시병합요법 등이 고려되어야할 것으로 사료된다. Purpose : This study was tried to evaluate the potential be nefits of concurrent chemoradiation therapy (low dose daily cisplatin combined with split course radiation therapy) compared with conventional radiation thera py alone in stage III non- small cell lung cancer. The end points of analyses were responserate , overalls urvival, survival without locoregional failure , survival without distant metastasis , prognostic factors affecting survival and treatment related toxicities. Materials and Methods : Between April 1992 and March 1994, 32 patients who had stage III non-small cell lung cancer were treated with concurrent chemoradiation therapy. Radiation therapy for 2 weeks (300cGy given 10 times up to 3000cGy) followed by a 3 weeks rest period and then radiation therapy for 2 more weeks (250cGy given 10 times up to 2500cGy) was combined with 6mg/M2 of cisplatin. Follow-up period ranged from 13 months to 48 months with median of 24 months . Historical control group consisted of 32 patients who had stage III non-small cell lung cancer were received conventionally fractionated (daily 170- 200cGy) radiation therapy a lone. Total radiation dose ranged from 5580cGy to 7000cGy with median of 5940cGy. Follow-up period ranged from 36 months to 105 months with median of 62 months . Results : Complete reponse rate was higher in chemoradiation therapy (CRT) group than radiation therapy (RT) group (18.8% vs. 6.3%). CRT group showed lower in-field failure rate compared with RT group(25% vs. 47%). The overall survival rate had no significant differences in between CRT group and RT group(17.5% vs. 9.4% at 2 years). The survival without locoregional failure (16.5% vs. 5.3% at 2 years) and survival without distant metastas is (17% vs. 4.6% at 2 years) also had no significant differences . In subgroup analyses for patients with good performance status (Karnofsky performance scale 80), CRT group showed significantly higher overall survival rate compared with RT group (62.5% vs. 15.6% at 2 years). The prognostic factors affecting survival rate were performance status and pathologic subtype (squamous cell cancer vs. nonsquamous cell cancer) in CRT group. In RT alone group, performance status and stage (IIIa vs IIIb) were identified as a prognostic factors . RTOG/EORTC grade 2-3 nausea and vomiting(22% vs. 6%) and bone marrow toxicities (25% vs. 15.6%) were significantly higher in CRT group compared with RT alone group. The incidence of RTOG/EORTC grade 3-4 pulmona ry toxicity had no significant differences in between CRT group and RT group (16% vs. 6%). The incidence of WHO grade 3-4 pulmonary fibrosis also had no significant differences in both group(38% vs . 25%). In analyses for relationship of field size and pulmonary toxicity, the patients who treated with field size beyond 200cm2 had s ignificantly higher rates of pulmonary toxicities. Conclusion : The CRT group showed significantly higher local control rate than RT group. There were no significant differences of survival rate in between two groups. The subgroup of patients who had good performa nce status showed higher overall survival rate in CRT group than RT group. In spite of higher incidence of acute toxicities with concurrent chemoradiation therapy, the survival gain in subgroup of patients with good pe rformance status were encouraging. CRT group showed higher rate of early death within 1 year, higher 2 year survival rate compared with RT group. The refore, to evaluate the accurate effect on survival of concurrent chemoradiation therapy, systematic follow-up for long term survivors are needed.

입내 분산형 Al₂O₃/Ag 나노복합체의 제조와 특성

천승호,한인섭,히데오 아와지,Cheon, Sung-Ho,Han, In-Sub,Awaji, Hideo 한국세라믹학회 2007 한국세라믹학회지 Vol.44 No.4

Alumina/silver ($Al_2O_3/Ag$) nanocomposites with Ag content up to 9 vol% were prepared from nanopowder by soaking method using ${\gamma}-Al_2O_3$ of needle type and spark plasma sintering (SPS). The mechanical properties of specimens were investigated three-point flexural strength and toughness as a function of the Ag contents. The maximum flexural strength of the alumina/silver nanocomposite was 850 MPa for the 1 vol% composite, and also higher than monolith alumina as about 800 MPa at 3, 5, and 7 vol% Ag contents. Fracture toughness by single edged V-notch beam (SEVNB) was $4.05MPa{\cdot}m^{1/2}$ for the 3 vol% composite and maintained about $4.00MPa{\cdot}m^{1/2}$ at 5, and 7 vol% Ag content. Microstructure of fracture surface for each fracture specimens was observed. Due to the inhibition effect of alumina grain growth, the average grain size of nanocomposites depends on the content of Ag nano particles. The fracture morphology of nanocomposite with dislocation (sub-grain boundary) by silver nano-particles of second phases in the alumina matrix also showed transgranular fracture-mode compare with intergranular of monolith alumina. Thermal conductivity of specimens at room temperature was about 40 W/mK for the 1 vol% Ag content.

Characterization of OsJAC1 which is responding to different types of ionizing radiation

In jung Jung,Jung Eun Hwang,Sung Min Han,Hong-Il Choi,Soon-Jae Kwon,Jin-Baek Kim,Si-Yong Kang,Dong Sub Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Ionizing radiation affects gene expression from plant genomes. To monitor the genome-wide transcriptional changes induced by three types of ionizing radiation, we used the rice RNA sequencing to identify genes that are up- or down-regulated by gamma rays (GAs), proton (PRs) and ion beams (IBs). The Oryza sativa jacalin-like lectin domain containing proteins (OsJAC1) gene was highly induced by GAs, PRs and IBs. OsJAC1 was selected based on the expression patterns of a genome-wide dataset of RNA sequencing. Many jacalin-related lectin genes have been shown to be associated with disease resistance, biotic and abiotic stress signaling. Therefore, we studied its expression pattern in response to different abiotic stress and phytohormone treatments. The expression patterns of OsJAC1 under two different abiotic stress conditions (salt and heat stress) and phytohormones (salicylic acid and methyl jasmonate) were examined. The transcripts of OsJAC1 were significantly induced in response to abiotic stress conditions, including salt and heat treatments. In addition, it was induced in response to the salicylic acid and methyl jasmonate treatments, respectively. To investigate the sub-cellular localization of OsJAC1, the gene was expressed as a fusion protein tagged with GFP, in tobacco leaf epidermis and examined under confocal microscope. The OsJAC1 was clearly localized at the nucleus. These results provide critical insights into the molecular functions of the rice jacalin-like lectin domain containing proteins as receptors of external signals.

사파이어의 Fe³^+ -center에 대한 ESR 연구

한찬수,황인섭 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.2

An electron spin resonance study of the Fe3+-center in Sapphire has been carried out at room temperature employing the JEOL JE-TE100 X-band spectrometer. The spin Hamiltonian parameters of the center are determined from the measurements using the least-squares method. The sample was prepared from a synthetic corundum doped with iron and titanium, which was grown in the Korean Research Institute of Chemical Technology in Taedok Science Town. It is found that the c-axis is made an angle of about 63˚ with the growing axis of the crystal. All 190 experimental resonance points are used to fit the ESR parameters, the data are well consistent with our calculations with the parameters. There are still unidentified ESR signals in the sample.

Low Level RF Control System Development for the PEFP Proton Accelerator

Han-Sung Kim,Hyeok-Jung Kwon,In-Seok Hong,Kyung-Tae Seol,Yong-Sub Cho,Young-Gi Song 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.I

For the Proton Engineering Frontier Project (PEFP) proton accelerator, the RF amplitude and the phase stability requirements of the accelerating field are within 1 \% and 1 degree, respectively. As a prototype of the low level radio frequency (LLRF) system, a simple digital proportional integral (PI) control system based on a commercial field programmable gate array (FPGA) board is designed and tested. The main features are a sampling rate of 40 MHz, which is four times higher than the down-converted cavity signal frequency, a digital in-phase and quadrature detection, and a simple proportional-integral feedback algorithm. A simulation study to determine the optimum gain is performed by using MATLAB and a state-space model of the RF cavity system. In the test with a dummy cavity, the field amplitude and phase are maintained within 1 \% and 1 degree with an intentionally applied perturbation of 10 \% in the field amplitude and 12 degrees in the field phase. In addition, the feedback control system improves the shot-to-shot stability by an order of magnitude compared with an open loop control

진로탐색 검사의 구조모형 타당화 연구

송인섭(Song In sub),한윤영(Han Yun Young) 한국영재교육학회 2006 영재와 영재교육 Vol.5 No.2

  본 연구는 중학생용 진로탐색 검사를 개발하고, 그 타당성을 검증하는데 목적이 있다. 관련 문헌과 기존에 개발된 진로검사의 구성요인을 검토하여 자아개념, 진로성숙, 직업인성, 직업선호 4가지 구성요인을 진로탐색의 구성요인으로 가정하였다. 378개의 예비검사 문항을 161명의 중학생들에게 실시하였다. 탐색적 요인분석 결과에 근거하여 378문항을 246개로 축소하여 본검사 문항을 구성하였다. 본검사에는 1587명의 학생들을 대상으로 이루어졌다. 확인적 타당화 과정에 의해 3개 문항이 삭제되고 최종 243문항으로 이루어진 중학생용 진로탐색 검사가 개발되었다. 진로탐색 구조모형의 적합도 분석을 통해 진로탐색의 위계구조를 확인하였다. 경쟁모형들의 적합도 지수를 통해 진로탐색에 대한 최적모형을 평가해 본 결과, 상대적합도 지수인 NFI, TLI, CFI 가 .90이상으로 잘 부합된 것으로 나타났으며 RMSEA를 기준으로 평가한 결과 2단계 모형이 가장 적합한 모형으로 경험적으로 증명되어 진로탐색 구인의 이론적 구조가 위계적 모형임을 확인하였다. 또한 교차타당화를 통해서 모형의 일반화를 확인할 수 있었다.   The purpose of this study ons to develop career exploration scale for Korea middle-school students and to test construct validation through covariance structure analysis. As to research the constructed factors, which to develop career exploration scale we reviewed related documents and inventories, then defined the concept of career exploration and the theological constructive factors. The were included in 4 components of self-concept, career maturity, vocational character, vocational preference for career exploration accordingly in 26 sub-components. 191 middle school students were analysed through 378 items at pilot test. Based on factor analysis, 378 items was reduced into 246 items which were selected to final test items. 1587 students were conducted final test. Through confirmatory factor analysis, 3 item was deleted, finally the test of career exploration scale for Korean middle students, which on consisted 243 items, Through analyzing validations of career exploration structure model, we confirmed hypothetical structure of career exploration and branch structure of psychological career exploration.<BR>  As a result of covariance structure analysis(AMOS), we confirmed 2nd order construct model of career exploration was the gest adequate through the indices of best fit(TLE, NFI, CFI>.90, RMSEA=.112). In addition, generalizability of this model was confirmed through cross-validation testing which showed that this model was fitted in a corss-validation samples.

액상 Ni/Si/Co 침투에 의한 반응결합 TiC 복합체의 치밀화

한인섭,우상국,배강,홍기석,서두원,정윤중,Han, In-Sub,Woo, Sang-Kuk,Bai, Kang,Hong, Ki-Suk,Seo, Doo-Won,Chung, Yoon-Jung 한국세라믹학회 1998 한국세라믹학회지 Vol.35 No.10

The reaction-bonded TiC-Ni/Si/Co composites were prepared by the melt infiltration of Co, Si, and Ni me-tal into the TiC preforms. The miocrostructure reaction composition and mechanical properties were in-vestigated. In the case of the melt infiltrated with Co and Ni TiC grain shape was changed from angular to spherical shape with the average grain size of ∼5$\mu\textrm{m}$. In the case of the melt infiltrated with Co/Si or Ni/Si, Si was reacted with TiC particles and formed SiC particles. The bending strength of both specimens which have atomic ratio of 3 were 710 MPa and 515 MPa respectively. In the case of the melt infiltrated with Ni/Si/Co,. nonstoichiometric TiC was formed and its bending strength decreased to 420 MPa.

공공조직 성과관리의 한계와 과제

한인섭 朝鮮大學校 社會科學硏究所 2007 社會科學硏究 Vol.28 No.1

Zr-V-Mn-Ni계 라브스상 합금의 미세 구조와 전기 화학적 특성

정치규(Chi Gyu Jeong),한동수(Dong Soo Han),정원섭(Won Sub Chung),김인곤(In Gon Kim),김원백(Won Baek Kim) 한국수소및신에너지학회 1997 한국수소 및 신에너지학회논문집 Vol.8 No.3

ZrV_0.1Mn_0.7Ni_1.2 alloy ingot (bulk alloy) made by the arc melting was found to be consisting of mostly of ZrV_0.2Mn_0.98Ni_1.04 matrix alloy and ZrV_0.01Mn_0.13Ni_1.2 2nd phase alloy. The former alloy had the form of the C15 type Laves alloy structure and the latter one had the intermetallic compound structure of Zr₉sNi₁₁. In order to investigate the effect of these two phases on the electrochemical charge-discharge characteristics of bulk ZrV_0.1Mn_0.7Ni_1.2 alloy, the matrix and the 2nd phase alloys were fabricated separately by arc melting method and their electrochemical characteristics were studied and compared with the bulk alloy. It was found that the discharge capacity was the lowest of 160 mAh/g in the 2nd phase alloy. The matrix alloy exhibited 200 mAh/g. Both were lower than that of the bulk alloy of 250 mAh/g. The matrix and the bulk alloys showed a similar properties in the activation stage, the high rate dischargeability and the self discharge characteristics. Also a signigicant capacity decrease was observed after activation in both alloys. Whereas the 2nd phase alloy showed the very different characteristics. This alloy was found to be difficult to activate. However the capacity was remained constant after the activation. Also the self discharge rate was seen to be better than those of the matrix and the bulk alloys.

Organic carbon distribution and cycling in the Quercus glauca forest at Gotjawal wetland, Jeju Island, Korea

Han, Young-Sub,Lee, Eung-Pill,Park, Jae-Hoon,Lee, Seung-Yeon,Lee, Soo-In,You, Young-Han The Ecological Society of Korea 2018 Journal of Ecology and Environment Vol.42 No.5

Background: This study was conducted from March 2011 to February 2013 in order to evaluate the ecosystem value by examining the organic carbon distribution and cycling in the Quercus glauca forest, evergreen oak community at Seonheul-Gotjawal, Jeju Island. Results: The amount of organic carbon distribution was $124.5ton\;C\;ha^{-1}$ in 2011 and $132.63ton\;C\;ha^{-1}$ in 2012 for aboveground biomass. And it was $31.13ton\;C\;ha^{-1}$ in 2011 and $33.16ton\;C\;ha^{-1}$ in 2012 for belowground biomass. In total, the amount of organic carbon distribution in plants was 155.63 and $165.79ton\;C\;ha^{-1}$ in 2011 and 2012, respectively. In 2011 and 2012 respectively, the amount of organic carbon distribution was 3.61 and $6.39ton\;C\;ha^{-1}$ in the forest floor and it was 78.89 and $100.71ton\;C\;ha^{-1}$ in the soil. As shown, most carbon was distributed in plants. Overall, the amount of organic carbon distribution of the Q. glauca forest was $238.13ton\;C\;ha^{-1}$ in 2011 and $272.89ton\;C\;ha^{-1}$ in 2012. In 2011, the amount of organic carbon fixed in plants through photosynthesis (NPP) was $14.22ton\;C\;ha^{-1}\;year^{-1}$ and the amount of carbon emission of soil respiration was $16.77ton\;C\;ha^{-1}\;year^{-1}$. The net ecosystem production (NEP) absorbed by the Q. glauca forest from the atmosphere was $5ton\;C\;ha^{-1}\;year^{-1}$. Conclusions: The carbon storage value based on such organic carbon distribution was estimated about $23.81mil\;won\;ha^{-1}$ in 2011 and $27.29mil\;won\;ha^{-1}$ in 2012, showing an annual increment of carbon storage value by $3.48mil\;won\;ha^{-1}$. The carbon absorption value based on such NEP was estimated about $500,000won\;ha^{-1}\;year^{-1}$.