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Seoyoung Jang,Jungmin Woo 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Long-acting injectable (LAI) antipsychotics are useful in the treatments for schizophrenic patients with poor adherence due to their maintaining feature of therapeutic plasma level without daily administrations. However, their long-lasting property can cause complicated problems such as a long-lasting side effect. We report a patient who experienced LAI-induced extrapyramidal symptoms (EPSs) for 5 months after a single injection. During that period, every trial to ameliorate this condition turned out to be a failure. The 3-month formulation of paliperidone palmitate is now close at hand. We have to be aware of possible long-lasting adverse events and confirm the tolerability to LAI before use.
장서영(Seoyoung Jang),임효덕(Hyo-Deog Rim),김경민(Kyungmin Kim),김병수(Byung-Soo Kim),우정민(Jungmin Woo) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.3
Following the development of human immunodeficiency virus (HIV) treatments, the mean lifespan of patients with an HIV infection has increased to a level comparable to the general population. Patients receiving HIV treatment can achieve viral suppression and perform routine activities without the risk of infection transmission. Recently, the quality of life (QoL) and mental health of patients are becoming the primary outcomes in HIV treatment. The objective of this review was to investigate psychiatric disorders in patients with an HIV infection and available treatment programs. A search for clinical studies and scientific publications was performed. Patients with an HIV infection had a higher prevalence of psychiatric disorders than the general population. The psychopathological factors in HIV infection included neurobiological changes of infection, side-effects of medications, negative social perception, and unresolved intrapsychic conflicts. Severe and unmanaged psychiatric disorders with HIV infection negatively impacted HIV infection transmission and treatment adherence. However, psychiatric treatment programs and referrals to a psychiatric professional were found to be insufficient in most countries. This review revealed a need for psychiatric interventions in clinical practice to improve patients’ mental health and HIV treatment adherence. Psychiatric interventions integrated with conventional HIV treatment can be efficacious to achieve this goal. In addition, clinicians need to investigate and recognize HIV-related stigma as the relationship between patients and clinicians has a significant role in the patient’s treatment adherence.
코티졸, Dehydroepiandrosterone Sulphate와 우울증상 심각도와의 상관성
장서영(Seoyoung Jang),서민수(Min-Soo Seo),우정민(Jungmin Woo) 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.2
Objectives:Cortisol and dehydroepiandrosterone sulfate(DHEAS) are neuroactive steroids related mood disorder as well as stress response. The purposes of this study are to examine the correlations between cortisol, DHEAS and severity of depressive symptoms and to evaluate the possibility of cortisol and DHEAS as biomarkers for depression. Methods:A total of 60 participants who had no history of psychiatric disease were recruited. We assessed the severity of depressive symptoms using the Beck Depression Inventory(BDI) and the Hamilton Depression Rating Scale(HAMD). The blood samples were collected between 12 PM to 14 PM. We applied an ELISA to measure the level of cortisol and DHEAS. Results:The depressive group showed higher cortisol level(Base on BDI : 13.64±7.91 ug/dL, p<0.001 ; Base on HAMD: 14.14±8.34 ug/dL, p<0.001). Cortisol level showed positive correlation with the severity of depressive symptoms based on BDI (r=0.572 ; p<0.01) and HAMD(r=0.638 ; p<0.01). DHEAS level significantly correlated with BDI score (r=0.398 ; p<0.01) but not with HAMD score. Conclusion:These findings suggest that cortisol and DHEAS may have a role as biomarkers for evaluating depression. DHEAS was associated with only one side of two scales. This may suggest the level of steroid hormone is different depending on specific depressive symptoms.
Attachment Insecurity and Stigma as Predictors of Depression and Anxiety in People Living With HIV
Kim Kyungmin,Jang Seoyoung,Rim Hyo-Deog,Kim Shin-Woo,Chang Hyun-ha,Woo Jungmin 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.5
Objective The purpose of this study was to examine whether attachment insecurity, stigma, and certain demographic and medical factors predict depression and anxiety in people living with HIV (PLWH).Methods Participants were 147 PLWH who visited the outpatient infection clinic in Kyungpook National University Hospital (KNUH; Daegu, South Korea) between June 2020 and January 2021. We measured HIV-related stigma, attachment anxiety and avoidance, depressive symptoms, and anxiety symptoms.Results Logistic regression analysis showed that unemployment, longer time receiving antiretroviral therapy, higher attachment avoidance, and higher attachment anxiety were significant predictors of depression. Results also showed that longer time receiving antiretroviral therapy, higher attachment anxiety, and concern with public attitudes were significant predictors of anxiety.Conclusion In addition to education to reduce public stigma, interventions to reduce PLWH’s self-stigma should continue. We suggest attachment-based psychotherapy as an effective intervention to improve PLWH’s mental health.
이재희 ( Jaehui Lee ),김민영 ( Minyoung Kim ),김서영 ( Seoyoung Kim ),남건희 ( Gunhee Nam ),박상원 ( Sangwon Park ),송도형 ( Dohyeong Song ),이윤정 ( Yunjeong Lee ),우승민 ( Seungmin Woo ),하유신 ( Yushin Ha ) 한국농업기계학회 2020 한국농업기계학회 학술발표논문집 Vol.25 No.2
최근 이상기후로 인해 봄철 낮과 밤의 기온차가 커지면서 동해 피해를 입는 농장이 늘어나고 있다. 현재 동해 피해를 줄이기 위해 페인트 도포와 보온재 피복을 통한 방법을 사용하는데, 국내 농가의 평균 재배 주수인 375 그루에 달하는 재배면적에서 각각의 나무에 수작업으로 이루어지고 있어 과도한 노동력을 필요로 하고 있다. 본 연구는 수작업으로 이루어지는 페인트 도포 작업을 펌프를 이용한 노즐 분사로 자동화함으로써 농민들의 노동력과 경영비 절감 및 작업 효율을 증대시키기 위한 선행연구로서 페인트 자동 도포장치를 설계하였다. 개발품은 개폐 가능한 집게와 분사노즐이 존재하는 분사부, 상하이동이 가능한 상하제어부, 운행을 위한 주행부 세부분으로 나누어 설계 하였다. 먼저 분사부는 집게의 개폐를 위한 서보모터와 노즐로 구성하였다. 서보모터를 통한 기어 회전으로 집게개폐 동작이 구현되며 AutoCAD와 Inventor 프로그램을 이용하여 분석한 결과 무게 1.5kg이 적정한 것으로 나타났다. 또한 기어의 효율, 안전계수를 적용하여 토크는 36kgf·cm로 분석되었다. 노즐은 시뮬레이션을 통하여 최소 73도의 분사각이 필요한 것으로 분석되었으며 Sejin 타입의 노즐을 적용하였다. 유량은 이동거리 80cm, 페인트량 0.05L, 희석변환계수 1.1과 최대속도 5cm/s에 필요한 최대 유량이 0.2075L/min로 분석되었으며 이를 바탕으로 펌프를 선정하고, 노즐과 연결함으로서 페인트공급이 가능하게 하였다. 상하제어부는 액추에이터 모터의 회전속도와 방향을 제어함으로써 상하운동이 가능하도록 설계하였다. 간편한 조작을 위하여 볼스크류 방식의 액추에이터를 고려하였고, 도포작업범위 80cm를 최대 5cm/s의 속도로 움직이는 설정값에 따라 선정하였다. 마지막으로 주행부는 페인트통, 펌프, 배터리로 구성된 파트로 적재량과 배치 및 무게중심을 고려하여 설계하였다. 주행부와 상하제어부 연결을 위하여 원형 회전판을 적용하였고, 손잡이 부분에는 조작을 위한 스위치를 설치하였다. 다양한 설계요인을 고려하여 설계된 본 개발품을 동해방지를 위한 페인트 도포에 적용하면 작업 능률을 크게 향상시킬 수 있으며 노동력 절감 및 작업시간의 단축을 이룰 수 있을 것이다. 추후 설계된 장치의 액추에이터 허용 모멘트를 고려한 보완과정을 거쳐서 분사량과 자동제어 방식을 수정하여 시제품을 제작하고 현장실험을 통한 작업능률 분석 및 수정 보완을 진행할 계획이다.