갑상선암의 고용량 방사성옥소 치료교육

유선희,김현미,Yoo, Seon-Hee,Kim, Hyeon-Mi 대한핵의학기술학회 2008 핵의학 기술 Vol.12 No.1

방사성요오드 치료를 받는 갑상선암 환자의 삶의 질 변화와 영향요인

유선희(Yoo, Seon Hee),최스미(Choi-Kwon, Smi) 한국간호과학회 2013 Journal of Korean Academy of Nursing Vol.43 No.6

Purpose: To investigate changes in Quality of life (QOL) and related factors in patients with thyroid cancer undergoing Radioactive Iodine remnant ablation (RAI). Methods: Data were collected longitudinally 3 times for 6 months (2 weeks post-surgery, post RAI, 3 months post RAI) in a hospital located in Seoul. Questionnaires were used to measure levels of physical symptoms, anxiety, depression, and QOL. Ninety-eight patients with thyroid cancer who had RAI were included in the analysis. Data were analyzed using SPSS (18.0). Results: Findings for the three data collection times respectfully were: mean scores for physical symptoms, 0.53, 1.21 and 0.62, patients with depression, 47%, 36.7% and 37.7%, patients with anxiety, 18.4 %, 19.4% and 20.4%, mean scores for QOL, 7.06, 7.01 and 7.28. QOL score was highest 3 months post RAI (p=.031). In the stepwise multiple regression analysis, depression and fatigue were predicting factors for low QOL at all data collection times. Dysponia was a predicting factor for low QOL post RAI and 3 months post RAI. Conclusion: To increase QOL, it is necessary to provide information in advance regarding physical & psychological symptoms and to develop nursing intervention programs to decrease depression and fatigue.

유치원 지도서에 나타난 유아환경교육 관련 내용 분석

유선희(Yoo Seon-Hee),성은영(Sung Eun-Young),김은심(Kim Eun-Shim) 한국열린유아교육학회 2010 열린유아교육연구 Vol.15 No.2

본 연구의 목적은 2009년에 발행된 유치원 지도서의 환경교육 관련 내용들이 2007년 개정 유치원 교육과정에서 제시한 환경교육 관련 방향들을 제대로 반영하고 있는지에 대해 살펴봄으로써 적절한 유아 환경교육의 방향을 제시하기 위한 기초자료를 제공하는 데에 있다. 분석대상은 교육과학기술부에서 2009년에 발행한 ‘유치원 지도서’ 총 13권 중 ‘총론’과 ‘종일반’을 제외한 나머지 11권이다. 환경교육 관련 개념을 분석하기 위한 분석준거는 최석진 외(1999)가 제시한 환경교육 관련 영역 11가지와 그에 따른 내용이다. 이들 분석 준거에 의하여 유치원 교육과정의 생활영역, 유치원 지도서의 각 생활주제, 연령, 활동유형별 환경교육관련 내용의 빈도와 백분율을 산출하여 분석하고 해석하였다. The Purpose of this study was to furnish basic materials for developing a program of environmental education(EE) of kindergarten according to the contents of EE appeared in the Guiding Materials for Kindergarten Educational Activities. The study analyzed the Guiding Materials for Kindergarten Educational Activities published in 2009. Also, that was for using the way of finding the standards about the EE content area. The EE content area consisted of 11 categories. Eleven Content areas of EE, namely natural environment, artificial environment, population, industrialization, natural resources, pollution, environmental conservation, environmental sanitation, environment ethics, environmentally sound and sustainable development(ESSD), and daily life as a consumer, were analyzed by qualitative methods(frequency and percentage). The findings of the study were described in each life area, each educational subject, each age and each activity type of the guiding materials for kindergarten educational activities. From the study, it was found that they were not well balanced. According to the result, balanced EE in content areas is needed at the kindergarten. The environmental education contents should be systematically presented in the guiding materials for kindergarten educational activities.

그림책에 나타난 유치원 이미지 분석

유선희(Yoo, Seon hee),김은심(Kim, Eun sim) 한국유아교육·보육복지학회 2010 유아교육·보육복지연구 Vol.14 No.3

본 연구의 목적은 그림책에 나타난 유치원의 이미지를 분석하여 유치원에 대한 긍정적인 이미지 부각시키기 위한 기초자료를 제공하는 것이다. 이를 위하여 선행연구를 중심으로 분석범주를 설정하여 장면(scene)별로. 글과 그림 텍스트를 양적.질적으로 분석하였다. 그 결과, 첫째, 그림책에 나타난 유치원의 이미지에서 물리적 환경은 대부분의 그림책에서 실제 유치원의 환경과 유사하였으나 일부에서는 학교의 물리적 환경과 혼용되었다. 둘째, 인적 환경에서 교사는 남성보다 여성에 치중되었으며, 전문적인 역할보다 단순한 전달자의 역할을 보였고 부모는 유치원 생활에 참여하거나 유아를 지원하는 형태로 등장하였다. 또래는 지원과 갈등의 관계로 나타났으며, 갈등은 이야기의 마무리부분에서 모두 해소되는 것으로 나타났다. 셋째, 유치원의 다양한 교육적 경험은 특별한 날의 경험보다 일과 중 경험이 많이 나타났으며 특히, 자유선택활동과 대.소집단활동에 치중되어 나타나는 경향을 보였다. 이러한 연구 결과는 유아를 대상으로 하는 그림책에서 유치원을 묘사할 때 좀 더 사실적이고 현실적으로 제시해야 함을 시사하며, 교사와 부모는 유아에게 사실적이고 긍정적인 유치원 이미지를 전달하고 유아가 유치원에 입학하기 전과 유치원 생활에서 느낄 수 있는 감정을 공감해야 함을 시사한다. The purpose of this study is analyzing the images and stories about young children, physical and human environment of kindergarten and educational experience of young children in kindergarten which appear in picture books and finding out basic data which highlight images of kindergarten positively. The results are as follows: Firstly, The physical environment of kindergarten is similar to real one, but fixed blackboard, desks and chairs which are used in elementary school are mixed. Secondly, teachers mainly perform as both teaching staffs and guardians, more female than male teachers are described, and the role of delivering knowledge and regulations is emphasized rather than professional one among the roles of teacher's. Thirdly, the image of parents mainly acts as both physical and emotional support while the image of peer group as support and conflict. Finally, free play is the most frequent educational activity among which young children experience in kindergarten.

TSH, FT4 검사의 Two-point Calibration Curve 적용의 유용성 평가

박혜미,유선희,이선호,김년옥,Park, Hye-Mi,Yoo, Seon-Hee,Lee, Seon-Ho,Kim, Nyun-Ok 대한핵의학기술학회 2016 핵의학 기술 Vol.20 No.2

Purpose The ASAN Medical Center, Nuclear Medicine performs TSH (Thyroid stimulating hormone) and FT4 (Free Thyroxine) tests 8 times per day. Accordingly, 70 ~ 80 kit tubes are consumed every day for the measurements and the time consumed for reagent dispensing averages over 170 seconds, where the TAT (turnaround time) may be effected when the number of test samples is larger than expected. Therefore, the following test was conducted with the purpose to reduce the number of kit tubes consumed, and reduce the time for reagent dispensing. Materials and Methods The test is based on applying the same reagent for tests where the number of samples is 30 or less. The test for TSH was conducted 9 times from July $1^{st}$ 2015 to July $10^{th}$ 2015. The test for FT4 was conducted 4 times from June $18^{th}$ 2015 to June $22^{nd}$, 2015. Standard Solution No.2 (0.153 uU/mL) and No.5 (4.96 uU/mL) was selected as the two-point standards for the TSH test, and Standard Solution No.3 (0.777 ng/dL) and No.4 (2.044 ng/dL) was selected as the two-point standards for the FT4 test. 38 test samples were subject to correlation analysis. Results For TSH, the result of the normal test shows ranges of 0.20 ~ 0.37 uU/mL for Control1, 0.53 ~ 0.71 uU/mL for Control2, and 6.77 ~ 7.94uU/mL for Control3, while the result of two-point calibration curve test shows ranges of 0.18 ~ 0.27 uU/mL for Control1, 0.53 ~ 0.71 uU/mL for Control2, and 7.30 ~ 8.52 uU/mL for Control3. For FT4, the result of the normal test shows ranges of 0.85 ~ 0.94 ng/dL for Control1 and 4.23 ~ 4.57 ng/dL for Control2, while the result of two-point calibration curve test shows ranges of 0.61 ~ 0.75 ng/dL for Control1 and 3.88 ~ 5.71 ng/dL for Control2. For TSH, the CV% of the normal test for Control1, Control2 and Control3 are 10.5, 3.3 and 3.6 respectively, while the CV% of the two-point calibration curve test for Control1 and Control1 are 12.4, 8.2 and 5.1 respectively. The result shows an outstanding correlation of TSH: y = 0.9985x - 0.0459 $R^2=0.9986$. For FT4, the CV% of the normal test for Control1 and Control2 are 0.70 and 0.71 respectively, while the CV% of the two-point calibration curve test for Control1 and Control1 are 8.7 and 16.2 respectively. The result shows an outstanding correlation of FT4: y = 1.2674x - 0.1133 $R^2=0.9824$. Conclusion The two-point calibration curve can be efficiently applied for TSH in cases where the number of test samples is not large, since the number of samples to be re-tested increases when the result is abnormal from the calibration curve. The two-point calibration curve test should not be applied for FT4 where the results do not consistently comply with the quality assessment range. Depending on how the two-point calibration curve is applied, up to 5 test tubes can be conserved per test, and the reduced time for reagent dispensing is anticipated to have a positive effect on the TAT (turnaround time).

The lived experience of ethical dilemma of ICU nurses

Sung-Hee Ko(고성희),Seon-Hee Yoo(유선희),Young-Ju Yun(윤영주),Sung-Hee Lee(이성희) 질적연구학회 2006 질적연구학회 학술대회 자료집 Vol.2006 No.-

Cr-51 EDTA GFR 검사 결과의 분석 및 의의

임수연,문형호,유선희,조시만,Lim, Soo-Yeon,Moon, Hyoung-Ho,Yoo, Seon-Hee,Cho, Shee-Man 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.1

Purpose: Correct estimation of Glomerular filtration rate (GFR) is very important for an accurate clinical assessment of the kidney function. This study compares four GFR markers, a serum creatinine-based estimation using MDRD formula, Cystatin-C, Cr-51 EDTA 2 samples and 6 samples. Materials and Methods: Serum creatinine concentrations, Cystatin-C serum concentrations and Cr-51 EDTA clearance are measured in 43 patients who received or donated kidney. Results: The correlation coefficient between serum based estimated GFR (MDRD) and Cr-51 EDTA 6 samples was 0.817 (p<0.01). The correlation coefficient between Cystatin-C based GFR and EDTA 6 samples was 0.7322 (p<0.01). Regression analysis showed a statistically significant correlation between Cr-51 EDTA 2 samples and 6 samples (r=0.971, p<0.01). Mean value and ${\pm}2SD$ for the difference between Cr-51 EDTA 2 samples and 6 samples were 4.7 mL/min and ${\pm}9.3$ respectively. Conclusions: The estimation of two samples Cr-51 EDTA showed that the method can be simplified by reducing blood samples without losing its high accuracy.

주제와 통합된 Dalcroze 유리드믹스 음악활동이 유아의 음악능력과 창의성에 미치는 효과

김선의(Kim, Seon-Eui),유선희(Yoo, Seon-Hee) 한국변형영유아교육학회 2009 변형영유아교육연구 Vol.3 No.2

본 연구는 주제와 통합된 Dalcroze 유리드믹스 음악활동이 유아의 음악능력과 창의성에 미치는 영향이 어떠한가를 알아보고자 실시하였다. 연구대상은 만 5세 유아 40명으로 7주간 14회 동안 실험집단에는 주제와 통합된 Dalcroze 유리드믹스 음악활동을 실시하고, 비교집단은 주제에 따른 음악활동이 실시되었다. 유아의 음악능력은 Loten과 Walley(1979)의 Recording Skill Development in Music의 음악능력발달 검사를 수정하여 사용하였으며, 창의력 수준을 알아보기 위하여 전경원(2000)의 K-CCTYC 유아 종합 창의성 검사를 사용하였다. 수집된 결과는 t-검증을 통해 실험집단과 비교집단 간의 차이를 분석하였고 연구결과 실험집단이 비교집단보다 음악능력과 창의성에서 유의한 차이가 나타났다. The purpose of this study is to develop the Dalcroze Eurhythmics musical activities integrated with themes. After testing to 5-year-old child, we could see how this development effected to children’s music ability and creativity, and also could see the possibility to the field of early childhood education. To verify the educational effects of the Dalcroze Eurhythmics music activities integrated with themes, I tested music ability and creativity to children, used SPSS 14.0 statistic program, and analyzed the average and the standard deviation about the growth of the two group’s before and after testing with the ‘t-test’. The testing results of this study can be summarized as follows. First, the children who attended the Dalcroze Eurhythmics music activities integrated with themes have higher music ability than comparison group. Second, the children who attended the Dalcroze Eurhythmics music activities integrated with themes have higher creativity than comparison group. Through the study, the teaching method of letting research and move themselves are more useful rather than teaching the activity-centered music education such as singing a real life subjected song, playing an instrument, and listening music, or teaching without relation with theme when we teach the music concept focusing on special music program.

Plasma renin activity 검사의 검체 보관 방법이 방사면역 측정법 결과에 미치는 영향에 대한 고찰

최진주,백송란,유선희,이선호,Choe, Jin-joo,Back, Song-ran,Yoo, Seon-hee,Lee, Sun-ho 대한핵의학기술학회 2021 핵의학 기술 Vol.25 No.1

PRA 검사는 치료 가능한 고혈압 질환 중 하나인 일차성 알도스테론증의 선별 진단에 이용되는 검사 중 하나이다. 혈장의 레닌은 체외에서 변형이 쉬운 물질이며 온도 변화에 민감한 것으로 알려져 있다. 본 연구에서는 검체의 보관온도와 해동온도에 차이를 두어 각각의 결과 차이를 비교 분석하고, PRA 검사의 정확한 결과 보고를 위한 치침의 마련과 재현성을 높일 수 있는 방안을 마련하고자 하였다. 본원에 의뢰된 PRA 검체 43건에 대하여 냉동보관 혈장 분리 자검체와 냉장보관 EDTA tube의 혈장을 재검사 실시하였다. 본검사를 기준으로 회귀분석과 bland-altman plot, 백분율을 비교하여 결과를 분석하였다. 또한, 해동온도에 따른 결과 비교를 위하여 PRA 검체 13건에 대하여 각각 실온해동과 냉장해동을 실시하였다. 실험을 마친 뒤, 다시 얼리고 2차 실온해동과 냉장해동을 실시하여 본검사를 기준으로 결과를 회귀분석하였다. 혈장 분리된 자검체 재검사를 시행한 결과는 y = 1.2048x + 1.046(R=0.8501, n=43)이며, 냉장보관 EDTA tube의 혈장으로 재검사한 결과는 y = 1.0594x + 0.1365 (R=0.9966, n=41)였다. Bland-altman plot에서 본실험과 차이에 대한 평균이 EDTA tube 혈장 재검사한 결과가 0.24, 냉동보관 자검체 재검사한 결과가 1.4로 냉장 보관 EDTA tube의 혈장이 높은 상관관계를 나타내었다. 해동온도에 차이를 두고 비교실험 한 결과, 1차 실온해동한 결과보다 2차 실온해동한 결과의 평균 백분율이 증가한 것으로 나타났다. 동일하게, 1차 냉장해동 결과보다 2차 냉장해동 결과의 평균 백분율이 증가하였다. 본 연구를 통해 PRA 검체의 보관 방법과 해동 온도에 따른 결과변화를 비교 분석한 결과, 냉장 보관된 원검체 EDTA tube 혈장의 재검사 결과가 더 높은 상관관계를 나타내었다. 또한, 해동 시 온도에 상관없이 혈장분리 자검체의 반복적인 얼림과 녹임이 PRA 결과에 영향을 미치는 것으로 나타났다. 따라서 PRA의 재검사 시에는 냉장 보관 중인 원검체 EDTA tube에서 혈장을 다시 채취하여 검사하는 것이 검사 결과의 오차를 줄이고 재현성을 높일 수 있을 것으로 사료된다. Purpose Plasma renin activity (PRA) test is important for the diagnosis of primary aldosteronism. PRA is an easily deformed substance in vitro and affected by temperature changes. Laboratory of ASAN medical center has consistently found that there was a difference between the initial and re-experimental results. We compared and analyzed the differences in PRA test results according to the sample storage status. Materials and Methods The measurement of PRA was performed by using the radioimmunoassay. From August to September 2020, 43 PRA re-test samples were tested with different sample storage condition. The first group was re-examined by freezing the plasma-separated samples at -18℃, and the second group was re-examined with refrigerated EDTA sample. Also, additional tests were conducted on 13 PRA samples to verify the effect on thawing temperature differences in plasma-separated samples. The same samples were divided into two parts and stored frozen at -18℃, respectively, and thawing samples in room temperature and those in refrigerator were were conducted. Each result was compared and analyzed based on the initial experimental results. Results The results of re-examination after frozen storing plasma separation samples showed a lower correlation than the results of re-examination with EDTA plasma samples in refrigerator. When calculating the percentage based on the initial test results, the average percentage of each was 404.9% and 133.8%. The correlation coefficient was also R=0.8501 and R=0.9966, respectively, showing a higher correlation between plasma in the refrigerated sample EDTA tube. In comparison experiments with differences in thawing temperature, average percentage of the results of initial test and room temperature thawing was 94.3% and the average percentage of the results of refrigerated thawing was 88.0%. After again freezing the sample, the average percentage of the second room temperature thawing result is 107.5%, and the second refrigerated thawing group is 112.7%. Both groups showed an increase from first thawing. Conclusion A comparative analysis of retesting according to differences in sample storage methods in PRA tests showed a higher correlation between the results of retesting of the refrigerated EDTA plasma. And repeated freezing and melting of plasma separation samples, regardless of temperature during defrosting, has been shown to affect results. Therefore, retest of PRA should re-collect plasma from original EDTA plasma to increase reproducibility.

Cortisol, $25OHD_3$ 추출 후 원심 분리시 온도가 검사결과에 미치는 영향

김외정,천준홍,유선희,조시만,Kim, Whe-Jung,Cheon, Jun-Hong,Yoo, Seon-Hee,Cho, Shee-Man 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.3

Purpose: We use the centrifugation of refrigeration state in separation of blood serum, Anti-ds-DNA, Vitamin $B_{12}$/Folate and GAD-Ab assay. However, Cortisol urine and 25-Hydroxyvitamin $D_3$ ($25OHD_3$) are conducted centrifuge at room temperature. This is troublesome that change centrifugation temperature into room temperature due to using of most assays at cold temperature. Therefore when using centrifuge after extraction of Cortisol urine and $25OHD_3$, we conducted researches on effect of the centrifugation temperature in assay results. Materials and Methods: In Cortisol urine, add dichloromethane 1.0 mL in urine $500\;{\mu}L$, mix for 15 minutes, and then centrifuge for 8 minutes at 2600rpm. In $25OHD_3$ add acetonitrile 0.5 mL in serum $200\;{\mu}L$, and then centrifuge for 8 minutes at 2600rpm. Those experiments were conducted centrifuge at room temperature and $4^{\circ}C$. And experiments conducted immediately after centrifugation at $4^{\circ}C$ and standing for 20 minutes after centrifugation $4^{\circ}C$. Results: In Cortisol urine, room temperature result in 1.93, 2.18, 2.43, 9.45, 14.2 (${\mu}g/dL$). Experiments of performing immediately after centrifuge at $4^{\circ}C$ result in 1.8, 2.0, 2.3, 8.1, 13.7 (${\mu}g/dL$). Experiments of performing after 20 minutes result in 2.1, 2.1, 2.7, 9.95, 14.35 (${\mu}g/dL$). On the other hand, the $25OHD_3$ tests conducted at room temperature result in 7.13, 26.6, 35.8, 48.2, 74.8 (ng/dL). Experiments were conducted immediately by pipetting after $4^{\circ}C$ centrifugation result in 7.53, 30.9, 40.3, 61.5, 89.1 (ng/dL) as results are higher than experiments at room temperature. The experiments that conducted centrifuge at $4^{\circ}C$ and then left at room temperature for 20 minutes result in 7.40, 32.4, 41.3, 51.6, 85.6 (ng/dL). Conclusions: Experiments were conducted by using centrifuge at $4^{\circ}C$ are higher or lower than room temperature. The differences between results of standing for 20 minutes after centrifuge at $4^{\circ}C$ and those of centrifuge at room temperature are less than conducting immediately. It is concerned that experiments conducted immediately after centrifuge at $4^{\circ}C$ are incorrect, because tubes become dim due to temperature differences between $4^{\circ}C$ and room temperature. Therefore, it is desirable to centrifuge at room temperature as manual and we should pipet promptly without stopping.