Evaluation of bio-compatibility for new bio-material in use of corneal therapies

문형호,조익준,신정휴,여형수,조영낭,박연주,김진아,장하영,강길태,최재준,박철용,이병한,최우성,현병화 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08

절름발이

문형호 한국외국어대학 학도호국단 1970 외대 Vol.5 No.1

하얀 죽음을 위하여

문형호 한국외국어대학교 무역학과 1968 무역논집 Vol.2 No.-

時間雜談

문형호 한국외국어대학교 무역학과 1969 무역논집 Vol.3 No.-

췌장암으로 인해 발생한 고칼슘혈증 (초)

문형호,박보라,신성준,김경수 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

China's Current Position in the North Korean Nuclear Crisis and the Basic Directions of China's Policies

문형호 한양대학교 아태지역연구센터 2003 중소연구 Vol.27 No.3

Clinicopathological Characteristics of Asymptomatic Young Patients with Gastric Cancer Detected during a Health Checkup

문형호,강현우,고성준,김지원,신철민 대한소화기학회 2019 대한소화기학회지 Vol.74 No.5

Background/Aims: The Korean National Cancer Screening Program recommends biennial gastric cancer screening for patients aged ≥40 years. This study compared the characteristics of asymptomatic young gastric cancer patients aged <40 years, whose cancer was detected during a health checkup (screening group), with those whose disease was detected because of symptoms (diagnostic group). Methods: Data were collected retrospectively from 84 subjects who underwent a gastroduodenoscopy before the age of 40 years and who were diagnosed with gastric cancer from January 2006 to February 2017 in three tertiary centers in Korea. The clinicopathological characteristics, including age, sex, stage, location, pathology, and survival, were compared according to the purpose of endoscopy (screening group, n=23 vs. diagnostic group, n=61). Results: The median age of the screening group was higher than that of the diagnostic group (37 vs. 35 years, p=0.027), as was the proportion of early gastric cancer cases (78.3% vs. 29.5%, p<0.01), curative endoscopic treatment or operation rate (95.7% vs. 52.5%, p<0.01), and the overall survival (p<0.01). Poorly differentiated or signet ring cell carcinoma was less common in the screening group than in the diagnostic group (56.5% vs. 83.6%, p=0.006). The sex ratio, smoking status, family history of gastric cancer, Helicobacter pylori infection status, and tumor location were similar in the two groups. Conclusions: Screening gastroduodenoscopy may enable the early detection of gastric cancer and prolong survival in patients <40 years of age.

급성신손상으로 인해 발생한 dabigatran 독성

문형호 ( Hyoung Ho Moon ),이승은 ( Seung Eun Lee ),오동준 ( Dong Jun Oh ),조희범 ( Hee Bum Jo ),권기환 ( Ki Hwan Kwon ),김윤진 ( Yoon Jin Kim ),김경수 ( Kyung Soo Kim ),신성준 ( Sung Joon Shin ) 대한임상독성학회 2014 대한임상독성학회지 Vol.12 No.2

Dabigatran is the first oral direct thrombin inhibitor approved by the US Food and Drug Administration (FDA) for prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Because dabigatran is excreted mainly by the kidneys, serum levels of dabigatran can be elevated to a supratherapeutic range in patients with renal failure, predisposing to emergent bleeding. We describe the case of a 66-year-old man taking dabigatran 150 mg twice daily for atrial fibrillation and cerebral infarction who presented with hematochezia and disseminated intravascular coagulation. Laboratory evaluation showed a hemoglobin level of 6.3 g/dL, platelets of 138,000/mm3, activated partial thromboplastin time (aPTT) of 10?s, and an international normalized ratio (INR) of 8.17. Colonoscopy showed a bleeding anal fissure. Hemostasis was provided by hemoclips and packed red blood cells and fresh frozen plasma were transfused. Since then, there was no further hematochezia, however, bleeding including oral mucosal bleeding, hematuria, and intravenous site bleeding persisted. At presentation, his serum creatinine was 4.96 mg/dL (baseline creatinine, 0.9 mg/dL). Dabigatran toxicity secondary to acute kidney injury was presumed. Because acute kidney injury of unknown cause was progressing after admission, he was treated with hemodialysis. Fresh frozen plasma transfusion was provided with hemodialysis. At 15 days from admission, there was no further bleeding, and laboratory values, including hemoglobin, partial thromboplastin time, and prothrombin time were normalized. He was discharged without bleeding. After 2 months, he undergoes dialysis three times per week and no recurrence of bleeding has been observed.

이자율이 물가상승율과 산출량에 미치는 비선형적 효과의 측정에 관한 연구

문형호 ( Hyeong Ho Mun ),김태환 ( Tae Hwan Kim ),나승호 ( Seung Ho Nah ) 명지대학교 금융지식연구소 2014 금융지식연구 Vol.12 No.2

경제학자들은 일반적으로 물가의 변동에 따른 이자율의 반응에 관심이 많은 반면, 중앙은 행은 그것의 역관계 (즉, 이자율의 변동에 따른 물가의 반응)에 더욱 큰 관심이 있다. 본 논문에서는 중앙은행의 관점에서 후자의 문제를 LSTVAR(Logistic Smooth Transition Vector AutoRegression) 모형을 사용하여 분석한다. 한국 데이터에 이 모형이 적용된 사례는 본 논문이 최초이며 매우 흥미로운 실증분석 결과들을 도출하였다. 가장 기본적인 결과는 이자율이 변동할 때 물가의 반응이 매우 비선형적이라는 것이다. 이러한 비선형적 반응의 함의는 중요하다. 왜냐하면, 한국은행이 시장이 기대하지 못한 이자율의 인상폭을 0.25%p로 하지 않고 그 것의 두 배인 0.50%p로 결정할 때 물가가 단순히 두 배로 감소하는 것이 아니라 두 배 이상으로 감소할 수 있기 때문이다. 또한 한국은행이 이자율을 0.25%p 인상하는 방안과 0.25%p인하하는 방안을 생각할 때, 물가의 반응이 대칭적이지 않다. 즉, 0.25%p 인상할 때 물가가 하락하는 정도가 0.25%p 인하할 때 물가가 상승하는 정도보다 더욱 크다는 함의를 가지게 되는 것이다. 결론적으로, 본 논문에서 발견된 실증적 결과들은 한국은행의 금융통화위원회에서 이자율결정을 할 때 유용한 정보로 사용될 수 있다고 판단된다. While economists are interested in the reaction of the interest rate to changes in the inflation rate, central bankers are usually more interested in the reverse causal relationship, i.e., the response of inflation (and output) to a change in the official interest rate as administrated by the central bank. We investigate the reverse causal relationship in Korea by employing the LSTVAR model proposed by Weise (1999). We have found strong evidence in favor of nonlinearity. As a result, we discovered various types of asymmetric effects of the interest rate on inflation and output. An asymmetric effect of monetary shocks of different sizes was uncovered, which implies that when the unexpected change in the official rate is doubled (i.e. from 0.25%p to 0.5%p), its effect on inflation and output is likely to be more than doubled. However, this finding is upheld only when the economy is in recession. The opposite result, in which the effect is smaller, is supported when the economy is expanding. Regarding the other asymmetric effect of monetary shocks with different signs, we found that central banks can expect that increasing the official rate by some certain amount (e.g. 0.25%p) is likely to have much larger effect on inflation and output than decreasing the rate by the same amount (e.g. -0.25%p) regardless of the state of the economy.

젊은 성인 환자와 노인 환자에서 호기말 산소 농도 감시에 의한 사전 산소 투여

박진우,문형호,정순호,최영균,김영재,신치만,박주열 인제대학교 1999 仁濟醫學 Vol.20 No.1S

마취 유도시 발생할 수 있는 무호흡으로 인한 저산소증의 위험성을 감소시키기 위하여 사전 산소 투여가 중요시되어 왔다. 본 연구는 호기말 산소 농도의 감시를 통해 폐내 탈질소화 정도를 간접 측정함으로써 보다 객관적이고 유용한 사전산소 투여의 지표로 이용될 수 있는가를 알아보고자 하였다. 호기말 산소 농도가 97%에 도달하는 평균 시간은 젊은 성인 환자군에서 2.29(±0.46)분, 노인 환자군에서 2.46(±0.44)분으로 양군 모두에서 3분 이내로 측정되었고 양군간에 통계학적으로 유의한 차이가 없었다. 무호흡 후 말초 산소포화도가 100%에서 95%까지 감소하는데 걸리는 시간은 두 군 모두에서 7분 정도가 소요되었다. 따라서 사전 산소 투여시 호기말 산소 농도의 감시가 젊은 성인 환자뿐만 아니라 노인 환자에서도 사전산소 투여의 유용한 지표가 될 수 있으며 일반적으로 3분 정도의 사전 산소 투여로 충분한 폐내 탈질소화를 예상할 수 있을 것이다. Administration of 100% oxygen before a "rapid-sequ ence" induction of anesthesia is recommended to prevent hypoxemia during induction. Recently, end-tidal fractional oxygen concentration(FEO2) monitoring has been favoured to determine the end point for preoxygenation. we hale compared the time taken to achieve this end point and the safe duration of apnea after induction of anesthesia following preoxygenation in elderly patients and young adults. Sixty patients were randomly selected and divided into two groups : 30 young adult patients(20∼50 yrs, Group 1) and 30 elderly patients(60∼75 years, Group 2). The oxygen flow was set to 10 L/min and patients were instructed to breathe normally after four-maximal breathing. As soon as the patient achieved an FEO2 of 0.9, anesthesia was induced with 2.5% thiopental(4mg/kg), succinylcholine(1.5mg/kg) and the trachea was intubated. Ventilation was not assisted until the patient's peripheral oxygen saturation(SPO2) fell to 95%. This period was described as the 'safe duration of apnea'. We compared the times taken for SPO2 to decrease to 95% between both groups. Except for two patients whom an appreciable leak around the mask was detected in and one patient who was in poor general state, all of the subjects achieved an FEO2 of 0.9 within 3 min: 2.29±0.46 min in Group 1, 2.46±0.44 min in Group 2. The times taken to reach an FEO2 of 0.9 were similar in both groups, The safe duration of apnea was found to be 6.98±1.59 min in Group 1 and 6.95 ±1.94 min in Group 2. This difference is not statistically significant. End-tidal fractional oxygen concentration monitoring is a reliable guide for adequate preoxygenation in not only young adults but also elderly patients. Most patients reached an FEO2of 0.9 in under 3 min of preoxygenation. Hence if FEO2 monitoring is not assailable, about 3 min preoxygenation with 10 L/min flow of oxygen seems to be adequate in the pa clients without cardiopulmonary dysfunction.