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Periventricular white matter hyperintensities and the risk of dementia: a CREDOS study
Kim, Sangha,Choi, Seong Hye,Lee, Young Min,Kim, Min Ji,Kim, Young Don,Kim, Jin Young,Park, Jin Hong,Myung, Woojae,Na, Hae Ri,Han, Hyun Jeong,Shim, Yong S.,Kim, Jong Hun,Yoon, Soo Jin,Kim, Sang Yun,Kim Cambridge University Press 2015 INTERNATIONAL PSYCHOGERIATRICS - Vol.27 No.12
<B>ABSTRACT</B><B>Background:</B><P>Cerebral white matter hyperintensities (WMH) are prevalent incident findings on brain MRI scans among elderly people and have been consistently implicated in cognitive dysfunction. However, differential roles of WMH by region in cognitive function are still unclear. The aim of this study was to ascertain the differential role of regional WMH in predicting progression from mild cognitive impairment (MCI) to different subtypes of dementia.</P><B>Methods:</B><P>Participants were recruited from the Clinical Research Center for Dementia of South Korea (CREDOS) study. A total of 622 participants with MCI diagnoses at baseline and follow-up evaluations were included for the analysis. Initial MRI scans were rated for WMH on a visual rating scale developed for the CREDOS. Differential effects of regional WMH in predicting incident dementia were evaluated using the Cox proportional hazards model.</P><B>Results:</B><P>Of the 622 participants with MCI at baseline, 139 patients (22.3%) converted to all-cause dementia over a median of 14.3 (range 6.0-36.5) months. Severe periventricular WMH (PWMH) predicted incident all-cause dementia (Hazard ratio (HR) 2.22; 95% confidence interval (CI) 1.43-3.43) and Alzheimer's disease (AD) (HR 1.86; 95% CI 1.12-3.07). Subcortical vascular dementia (SVD) was predicted by both PWMH (HR 16.14; 95% CI 1.97-132.06) and DWMH (HR 8.77; 95% CI 1.77-43.49) in more severe form (≥ 10 mm).</P><B>Conclusions:</B><P>WMH differentially predict dementia by region and severity. Our findings suggest that PWMH may play an independent role in the pathogenesis of dementia, especially in AD.</P>
김진영(Jinyoung Kim),김상하(Sangha Kim),명우재(Woojae Myung),강효신(Hyo Shin Kang),나덕렬(Duk L. Na),김성윤(Seong Yoon Kim),이재홍(Jae-Hong Lee),한설희(Seol-Heui Han),최성혜(Seong Hye Choi),김상윤(Sang Yun Kim),김도관(Doh Kwan Kim) 대한노인정신의학회 2014 노인정신의학 Vol.18 No.2
Objective:Patients with mild cognitive impairment (MCI) are at high risk for dementia. Excessive alcohol consumption is known to adversely affect cognitive function. This study aimed to investigate the relationship between alcohol consumption and the risk for dementia in a cohort of MCI patients. Methods:Participants (n=416) with (MCI) who met Petersen’s criteria were recruited from a nationwide, prospective cohort study of dementia and were followed for a median of 17.52 months (range 5.4-63.48). Alcohol consumption was evaluated at baseline. Results:One hundred twenty seven individuals (30.5%) developed incident dementia (115 Alzheimer disease) during follow-up. Patients with current alcohol consumption at baseline had a higher rate of progression to Alzheimer’s dementia than those without current alcohol consumption (hazard ratio 1.61 ; 95% confidence interval 1.03 to 2.53). Conclusion:Alcohol consumption may increase the risk of progression to Alzheimer’s dementia in patients with MCI.
Kim Seong-Ju,Lee Sangha,Han Hyojin,Jung Jaeoh,Yang Su-Jin,Shin Yunmi 대한의학회 2021 Journal of Korean medical science Vol.36 No.25
Background: Coronavirus disease 2019 (COVID-19) is different from previous disasters in that it continues to the present and has affected all aspects of family life. During epidemics, psychosocial support is not less important than infection control. During COVID-19-related school closures, prolonged partial closures of schools could have detrimental social and health consequences for children and may increase the burden on the family. Based on a community sample in Korea, this study identified parental concerns, children's media usage, other various factors and examined whether parental stress level or depression were positively associated with problem behaviors, media exposure, and sleep problems of the primary school children during school closure under COVID-19. Methods: Participants were 217 parents residing in Suwon, South Korea, who had primary school children and responded to a web-based questionnaire on parental concerns from school closure under COVID-19, subjective stress, depression, whether having received mental health services, and family characteristics; children's sleep patterns, problem behaviors, media usage during the online-only class period, and changes in activity level following the pandemic. Results: During school closure, children gained body weight, spent less time in physical activities and more in media usage. Besides online learning content (97.2%), YouTube was highly used content (87.6%), and games followed (78.3%). Parental subjective stress index was highly associated with parental depression (Pearson correlation 0.439, P < 0.001), children's sleep problems (0.283, P < 0.001), tablet time (0.171, P = 0.012) and behavior problems (0.413, P < 0.001). Parental depression was associated with children's sleep problems (0.355, P < 0.001), TV time (0.153, P = 0.024), tablet time (0.159, P = 0.019), and behavior problems (0.524, P < 0.001). Parents who previously received mental services seemed to be more concerned about the problems their children already have getting worse because of COVID-19 than the disease itself. Children's sleep problem was associated with tablet (0.172, P = 0.011) and smartphone time (0.298, P < 0.001), but not its frequency. Conclusion: During COVID-19-related school closures, many parents and children had various difficulties relating to mental health. Ongoing monitoring of mental health of highrisk groups and multiple support systems may need to be expanded to cover those parents having difficulty in caring for their children.
차량 쏠림 민감도 분석을 이용한 쏠림 개선에 관한 연구
노승진(Seungjin Noh),한성제(Sungje Han),황준효(Junhwyo Hwang),김상진(Sangjin Kim),이철훈(Chulhoon Lee),김우신(Woosin Kim),신상하(Sangha Shin),최진호(Jinjo Choi),장진희(Jinhee Jang),김인동(Indong Kim) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
Vehicle pull is one of the most important problem on the vehicle quality from customers. To understand the vehicle pull, this paper describes vehicle pull phenomenon by considering causing factors of conicity and PRAT, vehicle factors of wheel alignment, and the external environment factor of road slope and weight. Those factors must be analyzed to improve the vehicle pull tendency. Therefore, by using Pull sensitivity analysis, vehicle pull simulation which makes it possible to consider the effect of passenger and road slope, PRAT, conicity and wheel alignment, is applied to evaluate and Steering Wheel Torque.
오미화,황희성,Boram Chung,박현동,Sangha Han,Sun Moon Kang,Jun-Sang Ham,김현욱,Kuk-Hwan Seol,장애라,정규열 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.2
This report outlines the development of a rapid, simple, and sensitive detection system for pathogenic bacteria using a capillary electrophoresis-based, single strand conformation polymorphism (CE-SSCP) combined with PCR. We demonstrate that this method, used with primers targeting the V4 region of the16S rRNA gene, is capable of the simultaneous detection of 10 microbes that could be associated with foodborne illness, caused by animal-derived foods: Salmonella enterica,Listeria monocytogenes, Escherichia coli O157:H7, Campylobacter jejuni, Staphylococcus aureus, Bacillus cereus,Clostridium perfringens, Yersinia enterocolitica, Vibrio parahaemolyticus, and Enterobacter sakazakii. The traditional detection techniques are time-consuming and labor-intensive, due to the necessary task of separate cultivation of each target species. As such, the CE-SSCP-PCR method, that we have developed, has the potential to diagnose pathogens rapidly,unlike the traditional technique, in order to prevent foodborne illness in a much more efficient manner.
양정삼(Jeongsam Yang),한순홍(Soonhung Han),최영(Young Chi),박상호(Sangha Park),이명우(Myungwoo Lee) 한국자동차공학회 2001 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2001 No.5_2
To develop automobiles, engineers involved in a new car project team use various kinds of CAD systems according to specific requirements. For example, engineers in Hyundai Automotive are using Pro/Designer for the style design of a car, CATIA to design parts and assemblies, ANSYS for FEM analysis, and Pro/Engineer to design engines. Because they use different CAD systems, they have difficulty in cooperative design. Data, which contains errors, is transferred between CAD systems. It is difficult to find out such errors in a large CAD model. An evaluation method for CAD models has been developed. The developed diagnosis tool analyses a STEP or IGES file form a CAD system, and produces quantitative error report. It has been applied it to several actual car data.<br/> <br/>
소규모 가공경영체 떡류의 생산과정에 따른 미생물학적 품질조사를 위한 모니터링
한상하,김경준,변계환,김덕현,최송이,하상도,Han, Sangha,Kim, Kyeongjun,Byun, Kye-Hwan,Kim, Duk-Hyun,Choi, Song-yi,Ha, Sang-do 한국식품위생안전성학회 2021 한국식품위생안전성학회지 Vol.36 No.5
편의식 소비가 증가하는 식문화가 정착되면서 쌀의 소비형태가 전통적인 쌀밥에서 편의식 가공제품 형태로 변화되면서 떡류는 훌륭한 대체재로 자리 잡아가고 있다. 하지만 대부분의 떡은 소규모의 영세한 업체에서 제조되고 있으며 구입 후 별도의 조리과정 없이 그대로 섭취하므로 떡의 미생물학적 안전성에 대한 우려가 증가되는 추세이다. 따라서 본 연구는 떡류에서 발생하는 미생물학적 안전성을 개선하고자 소규모 업체의 떡류, 생산 환경 및 작업자의 미생물 오염도를 조사하였다. 3가지 떡(가래떡, 인절미, 경단)을 선정하여 원료, 제조공정 및 제조환경에 대한 미생물 오염도를 측정한 결과, 6가지 원재료에서 일반세균 3.76-4.48, 대장균군 2.21-4.14, B. cereus 1.02-1.15 log CFU/g 수준으로 검출되었고, E. coli는 검출되지 않았다. 떡의 제조공정별 오염도 분석결과, 세척과정 후 원재료의 일반세균, 대장균군 및 B. cereus의 오염도가 감소하였지만 불림, 분쇄공정에서 다시 증가하였고, 증자 후에는 3종류의 떡에서 모두 검출한계 이하의 수준을 보였다. 그러나 증자 이후 성형 및 냉각과정을 거치면서 오염도가 다시 증가하여 이 과정에서 냉각수 및 성형떡의 고물관리에 대한 주의를 시사하였다. 떡의 제조환경에 대한 미생물학적 오염도 분석결과, 쌀 분쇄기 및 떡고물 작업환경에 대한 오염 수준이 높게 나타났으며, 성형기에서도 일반세균, 대장균 및 B. cereus가 검출되어 작업환경에서의 기구 및 제조설비 관리가 필요하였다. 제조설비 및 환경에서의 오염은 원재료와의 교차오염을 일으킬 수 있으므로 체계적인 세척 및 소독 등으로 미생물학적 위해를 감소시켜야 할 것으로 사료된다. The purpose of this study was to evaluate the microbial contamination level of Korean traditional rice cakes (Garaetteok, Injeolmi, Gyeongdan), as well as manufacturing environment of small-sized businesses in Korea. The contamination levels of total aerobic bacteria, coliforms, and Bacillus cereus in raw materials were 3.76-4.48, 2.21-4.14, and 1.02-1.15 log CFU/g respectively. On the other hand, Escherichia coli was not found. It has been found that the contamination level of total aerobic bacteria, coliforms, and B. cereus in the raw material decreased after the washing process, but it increased again during the soaking and grinding process. However, after the steaming stage, the contamination level increased again during the molding and cooling process, suggesting the need to take cautions in managing cooling water and molded rice cakes in the process. These results suggest that the safe management of cooling water and taking cautions in the drying process after steaming of rice cakes are necessary for controlling cross-contamination. No E. coli was detected during the manufacturing process involving all tested rice cakes. The microbial contamination level of manufacturing environment such as rice grinder and rice cake forming machine was high. Therefore, in terms of food safety strategy, it is necessary to consider introducing systematic cleansing and disinfection procedure to processing equipment and environment for the sake of reducing microbiological risks.
Woojae Myung,JinHong Park,SookYoung Woo,Seonwoo Kim,SangHa Kim,JaeWon Chung,HyoShin Kang,ShinnWon Lim,Junbae Choi,Duk L. Na,SeongYoon Kim,JaeHong Lee,SeolHeui Han,SeongHye Choi,SangYun Kim,Bernard J. 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-Extrapyramidal signs (EPS) are common in patients with mild cognitive impairment (MCI). However, few studies have assessed the effect of EPS on the clinical course of MCI. We aimed to evaluate whether patients with EPS show more frequent progression from MCI to Alzheimer’s disease (AD) and to other types of dementia. Methods-Participants (n=882) with MCI were recruited, and were followed for up to 5 years. The EPS positive group was defined by the presence of at least one EPS based on a focused neurologic examination at baseline. Results-A total of 234 converted to dementia during the follow-up period. The risk of progression to AD was lower in the patients with EPS after adjusting for potential confounders [hazard ratio (HR)=0.70, 95% confidence interval (CI)=0.53-0.93, p=0.01]. In contrast, the patients with EPS had a six-fold elevated risk of progression to dementia other than AD (HR=6.33, 95%CI=2.30–17.39, p<0.001). Conclusion-EPS in patients with MCI is a strong risk factor for progression of MCI to non-Alzheimer dementia. The careful neurologic examination for EPS in patients with MCI can yield important clinical information for prognosis.
경도인지장애에서 추체외로 증상과 영역별 인지기능 저하 :A Clinical Research Center for Dementia of South Korea (CREDOS) Study
박진홍(Jin Hong Park),명우재(Woojae Myung),최준배(Junbae Choi),김상하(Sangha Kim),강효신(Hyo Shin Kang),나덕렬(Duk L. Na),김성윤(Seong Yoon Kim),이재홍(Jae-Hong Lee),한설희(Seol-Heui Han),최성혜(Seong Hye Choi),김상윤(SangYun Kim),김도 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2
Objective:This study investigated the association between extrapyramidal signs (EPS) and five cognitive sub-domains in a large number of patients with mild cognitive impairment (MCI). Methods:Our analyses considered 1,943 patients with MCI drawn from the nationwide Clinical Research of Dementia of South Korea study. EPS were defined as presence in patients with at least 1 of 11 operationally specified features. We assessed five cognitive sub-domains : attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuro-psychological Screening Battery-Dementia version. The associations of EPS with each cognitive sub-domain were analyzed with a multiple linear regression model after controlling for confounding factors : sex, age, education years, diabetes, hypertension, sever-ity of global function, depressive symptoms, and white matter hyperintensities (WMH). Results:138 MCI patients (7.1%) had EPS. This group had more global cognitive deterioration and severe WMH. MCI pa-tients with EPS showed lower performance compared to those without EPS in 3 cognitive sub-domains: attention (p=0.05), vi-suospatial function (p=0.02), and frontal/executive function (p<0.0001). The language sub-domain and the memory sub-domain did not differ between the EPS positive and the EPS negative groups. Conclusion:EPS in MCI are associated with greater cognitive impairment in specific functional sub-domains rather than with global greater cognitive deterioration.