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Kim, Dong Hwan (Dennis),Lee, Seung-Tae,Won, Hong-Hee,Kim, Seonwoo,Kim, Min-Ji,Kim, Hee-Jin,Kim, Sun-Hee,Kim, Jong-Won,Kim, Hyeoung-Joon,Kim, Yeo-Kyeoung,Sohn, Sang Kyun,Moon, Joon Ho,Jung, Chul Won,Li American Society of Hematology 2011 Blood Vol.117 No.25
<B>Abstract</B><P>In the current study, we identified 2 genetic markers for susceptibility to chronic myeloid leukemia (CML) using a genome-wide analysis. A total of 2744 subjects (671 cases and 2073 controls) were included, with 202 Korean CML patients and 497 control subjects enrolled as a discovery set. Significant findings in the discovery set were validated in a second Korean set of 237 patients and 1000 control subjects and in an additional Canadian cohort of European descent, including 232 patients and 576 control subjects. Analysis revealed significant associations of 2 candidate loci, 6q25.1 and 17p11.1, with CML susceptibility, with the lowest combined P values of 2.4 × 10−6 and 1.3 × 10−12, respectively. Candidate genes in those regions include RMND1, AKAP12, ZBTB2, and WSB1. The locus 6q25.1 was validated in both Korean and European cohorts, whereas 17p11.1 was validated only in the Korean cohort. These findings suggest that genetic variants of 6q25.1 and 17p11.1 may predispose one to the development of CML.</P>
Relative impact of amyloid-β, lacunes, and downstream imaging markers on cognitive trajectories
Kim, Hee Jin,Yang, Jin Ju,Kwon, Hunki,Kim, Changsoo,Lee, Jong Min,Chun, Phillip,Kim, Yeo Jin,Jung, Na-Yeon,Chin, Juhee,Kim, Seonwoo,Woo, Sook-young,Choe, Yearn Seong,Lee, Kyung-Han,Kim, Sung Tae,Kim, Oxford University Press 2016 Brain Vol.139 No.9
<P>Amyloid-beta deposition and cerebral small vessel disease are major contributors to age-related cognitive decline. In a longitudinal study of mild cognitive impairment, Kim et al. show that amyloid-beta and lacunes have differing effects on cognitive trajectories. Amyloid-beta has a greater impact on memory, and lacune number on frontal-executive function.Amyloid-beta and cerebral small vessel disease are the two major causes of cognitive impairment in the elderly. However, the underlying mechanisms responsible for precisely how amyloid-beta and cerebral small vessel disease affect cognitive impairment remain unclear. We investigated the effects of amyloid-beta and lacunes on downstream imaging markers including structural network and cortical thickness, further analysing their relative impact on cognitive trajectories. We prospectively recruited a pool of 117 mild cognitive impairment patients (45 amnestic type and 72 subcortical vascular type), from which 83 patients received annual follow-up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and 87 patients received a second Pittsburgh compound B positron emission tomography analysis. Structural networks based on diffusion tensor imaging and cortical thickness were analysed. We used linear mixed effect regression models to evaluate the effects of imaging markers on cognitive decline. Time-varying Pittsburgh compound B uptake was associated with temporoparietal thinning, which correlated with memory decline (verbal memory test, unstandardized beta = -0.79, P < 0.001; visual memory test, unstandardized beta = -2.84, P = 0.009). Time-varying lacune number was associated with the degree of frontoparietal network disruption or thinning, which further affected frontal-executive function decline (Digit span backward test, unstandardized beta = -0.05, P = 0.002; Stroop colour test, unstandardized beta = -0.94, P = 0.008). Of the multiple imaging markers analysed, Pittsburgh compound B uptake and the number of lacunes had the greatest association with memory decline and frontal-executive function decline, respectively: Time-varying Pittsburgh compound B uptake (standardized beta = -0.25, P = 0.010) showed the strongest effect on visual memory test, followed by time-varying temporoparietal thickness (standardized beta = 0.21, P = 0.010) and time-varying nodal efficiency (standardized beta = 0.17, P = 0.024). Time-varying lacune number (standardized beta = -0.25, P = 0.014) showed the strongest effect on time-varying digit span backward test followed by time-varying nodal efficiency (standardized beta = 0.17, P = 0.021). Finally, time-varying lacune number (beta = -0.22, P = 0.034) showed the strongest effect on time-varying Stroop colour test followed by time-varying frontal thickness (standardized beta = 0.19, P = 0.026). Our multimodal imaging analyses suggest that cognitive trajectories related to amyloid-beta and lacunes have distinct paths, and that amyloid-beta or lacunes have greatest impact on cognitive decline. Our results provide rationale for the targeting of amyloid-beta and lacunes in therapeutic strategies aimed at ameliorating cognitive decline.</P>
Kim, Ji-Yeon,Im, Seock-Ah,Jung, Kyung Hae,Ro, Jungsil,Sohn, Joohyuk,Kim, Jee Hyun,Park, Yeon Hee,Kim, Tae-Yong,Kim, Sung-Bae,Lee, Keun Seok,Kim, Gun Min,Kim, Se Hyun,Kim, Seonwoo,Ahn, Jin Seok,Lee, Ky Elsevier 2018 European journal of cancer Vol.103 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>We investigated the efficacy and safety of fulvestrant plus goserelin (F + G) versus anastrozole plus goserelin (A + G) in comparison with goserelin (G) alone in premenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), tamoxifen-pretreated metastatic breast cancer (MBC).</P> <P><B>Patients and methods</B></P> <P>In this multicentre, open-label, randomised phase II study, premenopausal women aged ≥18 years with HR+, HER2–, tamoxifen-pretreated MBC were randomly assigned (1:1:1) to F + G, A + G or G alone. The primary end-point was time to progression (TTP). Secondary end-points included overall survival, overall response rate, clinical benefit rate and toxicity.</P> <P><B>Results</B></P> <P>Of 138 eligible patients, 44 were randomly assigned to receive F + G, 47 to A + G and 47 to G alone. The median follow-up duration was 32.2 months (interquartile range: 23.69–40.86) and the median age was 43.0 years (range 23.0–55.0). The median TTP was 16.3 months (95% confidence interval [CI] 7.5–25.1) for F + G, 14.5 months (95% CI 11.0–18.0) for A + G and 13.5 months (95% CI 10.3–16.8) for G alone. Compared with G alone, the hazard ratios were 0.608 for F + G (95% CI, 0.370–0.998; p = 0.049) and 0.982 for A + G (95% CI, 0.624–1.546; p = 0.937). In terms of visceral metastasis, a stratification factor, there were no TTP differences according to treatment arm. Grade III or IV toxicities were rarely observed. Of the common adverse events, grade I arthralgia and joint stiffness were more frequently observed in the F + G than in the A + G or G-alone groups (p < 0.05, respectively).</P> <P><B>Conclusions</B></P> <P>F + G provides a promising new option for the treatment of premenopausal women with HR+, HER2-, tamoxifen-pretreated MBC.</P> <P><B>Trial registration</B></P> <P>ClinicalTrials.gov number NCT01266213 and Korean Cancer Study Group (KCSG) Breast cancer protocol number BR10-04.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In premenopausal women with hormone receptor-positive metastatic breast cancer, hormone treatment similar to that used in postmenopausal women is the standard treatment option after tamoxifen treatment failure. </LI> <LI> In this study, fulvestrant plus goserelin (G) has better clinical outcome than G alone in premenopausal women, especially those younger than 40 years. </LI> <LI> Aromatase inhibitor with G is not superior to G alone in tamoxifen-pretreated premenopausal women. </LI> </UL> </P>
Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing
Kim, Jangho,Bae, Won-Gyu,Kim, Yeon Ju,Seonwoo, Hoon,Choung, Han-Wool,Jang, Kyoung-Je,Park, Sunho,Kim, Bog Hee,Kim, Hong-Nam,Choi, Kyoung Soon,Kim, Myung-Sun,Choung, Pill-Hoon,Choung, Yun-Hoon,Chung, J Wiley (John WileySons) 2017 Advanced healthcare materials Vol.6 No.19
Kim, Byung-Tae,Lee, Kyung Soo,Shim, Sung Shine,Choi, Joon Young,Kwon, O Jung,Kim, Hojoong,Shim, Young Mog,Kim, Jhingook,Kim, Seonwoo Radiological Society of North America 2006 Radiology Vol.241 No.2
<P>Purpose: To prospectively evaluate the sensitivity and specificity of integrated fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) (PET/CT) for the preoperative diagnosis of mediastinal nodal metastasis in stage T1 non-small cell lung cancer (NSCLC), with surgical and histologic results as reference standards. Materials and Methods: Institutional review board approval and informed consent were obtained. From June 2003 to February 2005, 150 patients (89 men and 61 women; mean age, 59 years) with stage T1 NSCLC at stand-alone CT underwent integrated PET/CT and surgical staging. Two observers (one radiologist and one nuclear medicine physician) evaluated prospectively and in consensus the mediastinal nodes by analyzing both PET (functional) and CT (anatomic) images. Nodal stages were determined by using the American Joint Committee on Cancer staging system and surgical and histologic findings as the reference standard. Statistical evaluation of malignant lymph nodes was performed on per-nodal-station and per-person bases. Results: A total of 568 mediastinal nodal stations were evaluated. Nodes were positive for malignancy in 34 (23%) of 150 patients and 55 (10%) of 568 nodal stations. For depiction of malignant nodes, the respective sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of integrated PET/CT were 42% (23 of 55), 100% (513 of 513), 100% (23 of 23), 94% (513 of 545), and 94% (536 of 568) on per-nodal-station basis and 47% (16 of 34), 100% (116 of 116), 100% (16 of 16), 87% (116 of 134), and 88% (132 of 150) on a per-patient basis. Conclusion: Integrated FDG PET/CT provides high specificity and positive predictive value of mediastinal nodal staging in stage T1 NSCLC, although the sensitivity is low. (c) RSNA, 2006.</P>
Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds
Kim, Yeo Jin,Kim, Hee Jin,Park, Jae-Hyun,Kim, Seonwoo,Woo, Sook-Young,Kwak, Ki-Chang,Lee, Jong Min,Jung, Na-Yeon,Kim, Jae Seung,Choe, Yearn Seong,Lee, Kyung-Han,Moon, Seung Hwan,Lee, Jae-Hong,Kim, Yun Ovid Technologies (Wolters Kluwer) - American Acad 2016 Neurology Vol.87 No.15
<P>Conclusions: Our findings suggest that amyloid-related pathology and hCSVD have synergistic effects on the progression of lobar microbleeds, providing new clinical insight into the interaction between amyloid burden and hCSVD on CMB progression and cognitive decline with implications for developing effective prevention strategies.</P>
Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer’s Disease
Hyeran Kim,YoungAh Kwon,InnSook Ahn,Sangha Kim,Seonwoo Kim,Sangmee Ahn Jo,DohKwan Kim 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
Objective-Biological markers for Alzheimer’s disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than the onset of clinical manifestations in AD. Methods-We examined the lymphocyte expression of cell cycle proteins in AD patients, dementia controls (DC), and normal controls (NC). One-hundred seventeen subjects (36 AD, 31 DC, and 50 NC) were recruited. The cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were measured in peripheral lymphocytes. Cell cycle protein expression in the three groups was compared after adjusting for age and sex. Results-The levels of cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were significantly higher in AD patients than in the NC subjects. The DC group manifested intermediate levels of cell cycle proteins compared with the AD patients and the NC subjects. The present study indicates that cell cycle proteins are upregulated in the peripheral lymphocytes of AD patients. Conclusion-Cell cycle dysregulation in peripheral lymphocytes may present a promising starting point for identifying peripheral biomarkers of AD.
KBIMS 건축 및 구조 부재 라이브러리 및 IFC 속성명 변환 방법 개발
김선우 ( Kim Seonwoo ),김선중 ( Kim Sunjung ),김홍현 ( Kim Honghyun ),배기우 ( Bae Kiwoo ) 한국건축시공학회 2020 한국건축시공학회지 Vol.20 No.6
본 연구는 KBIMS가 적용된 건축 및 구조 부재 형상과 속성데이터가 포함된 BIM 라이브러리를 구축하는 방법과, 속성데이터 변환 과정의 문제를 해결하여 KBIMS IFC 파일로 변환하는 방법을 제시한다. 프로젝트에서 다양한 BIM 도구가 활용되어짐에도 불구하고 라이브러리 연구에 특정 도구가 주로 활용되었는데 본 연구에서는 클라우드 기반 데이터베이스 통합플랫폼에 포함된 카티아V6를 활용하여 주요 12개 카테고리, 총 793개의 건축 및 부재 형상 및 수치 라이브러리를 개발했다. KBIMS IFC 속성 입력 과정에서 데이터 타입과 특수문자 속성명으로 인한 데이터베이스 입력 제한을 파악하였다. 입력 가능한 데이터 타입을 찾아 입력하고, 아스키코드를 활용한 특수문자 속성명 대체 입력 방법을 개발했다. 변환기 프로토타입을 개발하여 추출된 IFC 파일을 KBIMS 원래 속성명이 포함된 IFC 파일로 변환하고 시범모델을 활용하여 검증하였다. 본 연구 결과는 실제 프로젝트에서 KBIMS 적용시 BIM 도구의 선택의 폭을 넓히고, 프로젝트 데이터 호환문제를 줄이는데 도움을 줄 것이다. 마지막으로 KBIMS 라이브러리의 지속적인 활용을 위해서는 관련 조직 간의 유지 관리 방안에 대한 논의가 필요하다. This research introduces the method of developing Korea BIM standard (KBIMS) architectural and structural element library and the methodology of converting KBIMS IFC property names with special characters. Diverse BIM tools are utilizing in project, however BIM library researches lack diversity on BIM tool selection. This research described the method to generate twelve categories and seven hundred and ninety-three elements library containing geometrical and numerical data in CATIA V6. KBIMS has its special property data naming systems which was the challenge inputting to ENOVIA IFC database. Three mapping methods for special naming characters had been developed and the ASCII code method was applied. In addition, the convertor prototype had been developed for searching and replacing the ASCII codes into the original KBIMS IFC property names. The methodology was verified by exporting 2,443 entities without data loss in the sample model conversion test. This research would provide a wider choice of BIM tool selection for applying KBIMS. Furthermore, the research would help on the reduction of data interoperability issues in projects. The developed library would be open to the public, however the continuous update and maintenance would be necessary.