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Yeon Joo Lee,Il Hwan Oh,Hee Jun Baek,Chang Hwa Lee,Sang Sun Lee 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.2
BACKGROUND/OBJECTIVES: Vitamin D deficiency is common in hemodialysis patients. The aim of this study was to identify whether or not sun exposure and dietary vitamin D intake have effects on serum 25-hydroxyvitamin D (25(OH)D) status in hemodialysis (HD) patients. The objective was to identify the main determinants of serum vitamin D status in the study subjects. SUBJECTS/METHODS: A cross-sectional study of 47 HD patients (19 males and 28 females) was performed. We assessed serum 25(OH)D and 1,25(OH)2D levels between August and September 2012 and analyzed the prevalence of vitamin D deficiency in HD patients. To evaluate the determinants of serum 25(OH)D levels, we surveyed dietary vitamin D intake, degree of sun exposure, and outdoor activities. To compare biological variables, serum 25(OH)D was stratified as below 15 ng/ml or above 15 ng/ml. RESULTS: Mean 25(OH)D and 1,25(OH)2D levels were 13.5 ± 5.8 ng/ml and 20.6 ± 11.8 pg/ml, respectively. The proportions of serum 25(OH)D deficiency (< 15 ng/ml), insufficiency (15-< 30 ng/ml), and sufficiency (≥ 30 ng/ml) in subjects were 72.4%, 23.4%, and 4.3%, respectively. Prevalence of vitamin D deficiency in female patients was 78.6%, whereas that in males was 63.2% (P = 0.046). Vitamin D intake and sun exposure time were not significantly different between the two stratified serum 25(OH)D levels. Dietary intake of vitamin D did not contribute to increased serum 25(OH)D levels in HD patients. The main effective factors affecting serum 25(OH)D status were found to be the sun exposure and active outdoor exercise. CONCLUSIONS: Hypovitaminosis D is common in HD patients and is higher in females than in males. Sun exposure is the most important determinant of serum 25(OH)D status in HD patients.
Oh, So Yeon,Shin, Sang Won,Koh, Su-Jin,Bae, Sang Byung,Chang, Hyun,Kim, Jung Han,Kim, Hyo Jung,Hong, Young Seon,Park, Keon Uk,Park, Jeanno,Lee, Kyung Hee,Lee, Na Ri,Lee, Jung Lim,Jang, Joung Soon,Hong Springer Berlin Heidelberg 2017 SUPPORTIVE CARE IN CANCER Vol.25 No.12
<P><B>Purpose</B></P><P>Neuropathic cancer pain (NCP) is a common and potentially debilitating symptom in cancer patients. We investigated the prevalence of NCP, as well as its management and association with QOL.</P><P><B>Methods</B></P><P>Cancer patients with pain ≥1 on the visual analogue scale (VAS) were surveyed with the Douleur Neuropathique (DN4) questionnaire, the Brief Pain Inventory-Short Form (BPI-SF), and the EuroQOL five dimensions (EQ-5D) questionnaire. The associations between NCP and pain severity or NCP and QOL, while controlling for variables relevant to QOL, were then analyzed.</P><P><B>Results</B></P><P>A total of 2003 patients were enrolled in this survey; the prevalence of NCP was 36.0% (<I>n</I> = 722, 95% CI, 32.5–39.5). We found that NCP in cancer patients was closely correlated to a higher pain severity (BPI-SF; 4.96 ± 1.94 versus 4.24 ± 2.02, <I>p</I> < 0.001), and in patients with NCP, pain more severely interfered with daily living, as compared to those without NCP (BPI-SF; 4.86 ± 2.71 versus 4.41 ± 2.87, <I>p</I> < 0.001). Patients with NCP also had worse QOL than those without NCP, as measured by EQ-5D index score (0.47 ± 0.30 vs. 0.51 ± 0.30, <I>p</I> = 0.005), and this was confirmed using multivariate analysis (<I>p</I> < 0.001), even after controlling for other variables such as age, sex, disease stage, cancer duration, radiotherapy, chemotherapy, and comorbidities. Importantly, adjuvant analgesics were used in less than half of patients with NCP (<I>n</I> = 358, 46.4%).</P><P><B>Conclusions</B></P><P>We found that NCP in cancer patients was significantly associated with a worsened QOL, and current management is inadequate. Therefore, future research aimed at developing improved strategies for management of NCP is required.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00520-017-3806-5) contains supplementary material, which is available to authorized users.</P>
Oh, Chang Taek,Park, Jong Il,Jung, Yi Ra,Joo, Yeon Ah,Shin, Dong Ha,Cho, Hyoung Joo,Ahn, Soo Mi,Lim, Young-Ho,Park, Chae Kyu,Hwang, Jae Sung The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.4
Korean Red Ginseng (KRG) has been reported to exert anticancer, anti-oxidant, and anti-inflammatory effects. However, there has been no report on the effect of KRG on skin pigmentation. In this study, we investigated the inhibitory effect of KRG on melanocyte proliferation. KRG extract (KRGE) at different concentrations had no effect on melanin synthesis in melan-A melanocytes. Saponin of KRG (SKRG) inhibited melanin content to 80% of the control at 100 ppm. Keratinocyte-derived factors induced by UV-irradiation were reported to stimulate melanogenesis, differentiation, proliferation, and dendrite formation. In this study, treatment of melan-A melanocytes with conditioned media from UV-irradiated SP-1 keratinocytes increased melanocyte proliferation. When UV-irradiated SP-1 keratinocytes were treated with KRGE or SKRG, the increase of melanocyte proliferation by the conditioned media was blocked. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was produced and released from UV-irradiated keratinocytes. This factor has been reported to be involved in regulating the proliferation and differentiation of epidermal melanocytes. In this study, GM-CSF was significantly increased in SP-1 keratinocytes by UVB irradiation ($30mJ/cm^2$), and the proliferation of melan-A melanocytes increased significantly by GM-CSF treatment. In addition, the proliferative effect of keratinocyte-conditioned media on melan-A melanocytes was blocked by anti-GM-CSF treatment. KRGE or SKRG treatment decreased the expression of GM-CSF in SP-1 keratinocytes induced by UVB irradiation. These results demonstrate that UV irradiation induced GM-CSF expression in keratinocytes and KRGE or SKRG inhibited its expression. Therefore, KRG could be a good candidate for regulating UV-induced melanocyte proliferation.
A New Rice Variety Adaptable to Direct Seeding with Lodging Tolerance, "Nonghobyeo"
Sang Jong Lim,Un Sang Yeo,No Bong Park,Byeong Geun Oh,Sae Jun Yang,Ho Yeong Kim,Heung Gu Hwang,You Cheon Song,Do Yeon Kwak,Jong Rae Kang,Woon Goo Ha,Jeom Sik Lee,Soon Chul Kim 한국육종학회 2003 한국육종학회지 Vol.35 No.1
Nonghobyeo', was derived from a mutant of Milyang 95, by pure line selection method, which was developed from the single cross between Chukei 1016 and Milyang 79, by the rice breeding team of National Yeongnam Agricultural Experiment Station (NYAES) in 19
Analysis of the width ratio and wear rate of maxillary anterior teeth in the Korean population
Yeon-Ah Oh,Hong-So Yang,Sang-Won Park,Hyun-Pil Lim,Kwi-Dug Yun,Chan Park 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.2
PURPOSE. The purpose of this study was to compare the width ratio of maxillary anterior teeth according to age in the Korean population and to evaluate the maxillary central incisor width-to-length (W/L) ratio, given differences in age and gender. MATERIALS AND METHODS. Ninety-three Korean adults were divided into 3 groups (n = 31) by age. Group I was 20 - 39 years old, Group II was 40 - 59 years old, and Group III was over 60 years of age. After taking an impression and a cast model of the maxillary arch, the anterior teeth width ratio and central incisor W/L ratio were calculated from standard digital images of the cast models using a graph paper with a digital single lens reflex (DSLR) camera. The calculated ratios were compared among all groups and central incisor W/L ratio were analyzed according to age and gender. All comparative data were statistically analyzed with one-sample t-tests, one-way ANOVAs with Tukey tests, and independent t-tests. RESULTS. No significant differences in maxillary anterior teeth ratios were found among the age groups. The maxillary central incisor W/L ratios in Group III were the greatest and were significantly higher than those in the other groups. The central incisor W/L ratio of men was higher than that of women in Group II. CONCLUSION. Maxillary anterior teeth width ratios were similar in all age groups in the Korean population. The maxillary central incisor was observed as worn teeth in the group over 60 years of age, and a significant difference between genders was found in 40 to 50 year olds.
Oh, Young-Ho,Jang, Hyeong Bin,Im, Suk,Song, Myoung Jong,Kim, So-Yeon,Park, Sung-Woo,Chi, Dae Yoon,Song, Choong Eui,Lee, Sungyul Royal Society of Chemistry 2011 Organic & Biomolecular Chemistry Vol.9 No.2
<P>In the catalysis of S<SUB>N</SUB>2 fluorination reactions, the ionic liquid anion plays a key role as a Lewis base by binding to the counterion Cs<SUP>+</SUP> and thereby reducing the retarding Coulombic influence of Cs<SUP>+</SUP> on the nucleophile F<SUP>−</SUP>. The reaction rates also depend critically on the structures of ionic liquid cation, for example, n-butyl imidazolium gives no S<SUB>N</SUB>2 products, whereas n-butylmethyl imidazolium works well. The origin of the observed phenomenal synergetic effects by the ionic liquid [mim-<SUP><I>t</I></SUP>OH][OMs], in which <I>t</I>-butanol is bonded covalently to the cation [mim], is that the <I>t</I>-butanol moiety binds to the leaving group of the substrate, moderating the retarding interactions between the acidic hydrogen and F<SUP>−</SUP>. This work is a significant step toward designing and engineering solvents for promoting specific chemical reactions.</P> <P>Graphic Abstract</P><P>Ionic liquid is demonstrated to be a tailor-made solvent system for specific chemical reactions. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0ob00426j'> </P>
PCR-based allele specific markers for bacterial blight resistance gene in rice.
Yeon-Jae Hur,Jong-Hee Lee,Ji-Ung Jeung,Ji-Yoon Lee,Jun-Hyun Cho,Hyun-Jin Park,You-Chun Song,Myung-Gyu Oh,Un-Sang Yeo,Choon-Woo Lee,Min-Hee Nam 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
The use of functional markers, it is expected to make direct identification about genetic diversity at DNA level and overcome the problem of recombination /linkage. These markers can be used to identify interesting alleles in a breeding program and indirectly select for the trait, saving money, time and labor. Bacterial blight of rice caused by Xanthomonas oryzaepv. Oryzae is a destructive disease in rice production worldwide. No bactericide is effective to control the bacterial blight disease yet. Xa3, which is a gene conferring resistance to BB of the rice plant has been previously characterized by map-based cloning. We have cloned and sequenced the Xa3/xa3 gene in Korean cultivar, Hwayoung, Ilmi and Goun with gene specific primers. Our work detected polymorphisms and PCR-based allele specific SNP markers were developed. Susceptible or resistant individuals from an F2 population developed from across between Milyang244 and Ilmi, Korean germplasms and near isogenic lines carrying BB resistance genes were screened with allele specific markers. We found that the genotype completely matched their phenotype to BB using ASP-primers. These markers could be effective to marker-assisted selection for the Xa3 gene in rice breeding programs.