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Retrospective study for determining recommended resection margin of neurofibroma
( Byeong Geun Park ),( Jae Yeong Jeong ),( Haneul Oh ),( Tae Jun Park ),( Il-hwan Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Cutaneous neurofibroma (CNF) is a common benign tumor. Surgical intervention is currently the best treatment option for the cosmetically disfiguring appearance. Presently, there are a few guidelines for determining adequate surgical margins in literature. Objectives: This study aims to evaluate the resection margin of CNF and correlation between size of CNF and recommended margin. CNF is difficult to determine the margin visually. Therefore, study based on the size and histological findings of neurofibroma are needed to determine the resection margin. Methods: From January 2016 to July 2020 were 52 cases of CNF identified in the database of the Dept. of Dermatology at Korea University Ansan Hospital. Lesions were removed surgically with a margin of 3 mm from the clinical delineation. Tumor invasion was evaluated through histopathologic evaluation. Results: Among the 52 cases of CNF, 24 cases (46%) had a size of 1cm or more and 28 cases (54%) had a size of 1cm or less. 44 lesions (85%) were completely removed without involvement of the margin. Among the 8 cases of incompletely resected CNF, 3 cases involved both side of margin and 5 cases involved one side of margin. Interestingly, none of the cases of CNFs smaller than 1cm were incompletely resected. Conclusion: In this study, we found that CNF size should be considered when determining the resection margin. For CNFs <1cm in diameter, 3mm resection margins are mostly adequate; but for larger CNFs, greater margins are required.
Oh, Yulin,Lim, Ju Won,Kim, Jae Geun,Wang, Huan,Kang, Byung-Hyun,Park, Young Wook,Kim, Heejun,Jang, Yu Jin,Kim, Jihyeon,Kim, Dong Ha,Ju, Byeong-Kwon American Chemical Society 2016 ACS NANO Vol.10 No.11
<P>In this study, we demonstrate a viable and promising optical engineering technique enabling the development of high-performance plasmonic organic photovoltaic devices. Laser interference lithography was explored to fabricate metal nanodot (MND) arrays with elaborately controlled dot size as well as periodicity, allowing spectral overlap between the absorption range of the active layers and the surface plasmon band of MND arrays. MND arrays with,-,91 nm dot size and similar to 202 nm periodicity embedded in a poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) hole transport layer remarkably enhanced the average power conversion efficiency (PCE) from 7.52% up 10.11%, representing one the highest PCE and degree of enhancement (similar to 34.4%) levels compared to the pristine device among plasmonic organic photovoltaics reported to date. The plasmonic enhancement mechanism was investigated by both optical and electrical analyses using finite difference time domain simulation and conductive atomic force microscopy studies.</P>
Transcriptome Profiling of Two Ornamental and Medicinal <i>Papaver</i> Herbs
Oh, Jaehyeon,Shin, Younhee,Ha, In Jin,Lee, Min Young,Lee, Seok-Geun,Kang, Byeong-Chul,Kyeong, Dongsoo,Kim, Dowan MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10
<P>The <I>Papaver</I> spp. (<I>Papaver rhoeas</I> (Corn poppy) and <I>Papaver nudicaule</I> (Iceland poppy)) genera are ornamental and medicinal plants that are used for the isolation of alkaloid drugs. In this study, we generated 700 Mb of transcriptome sequences with the PacBio platform. They were assembled into 120,926 contigs, and 1185 (82.2%) of the benchmarking universal single-copy orthologs (BUSCO) core genes were completely present in our assembled transcriptome. Furthermore, using 128 Gb of Illumina sequences, the transcript expression was assessed at three stages of <I>Papaver</I> plant development (30, 60, and 90 days), from which we identified 137 differentially expressed transcripts. Furthermore, three co-occurrence heat maps are generated from 51 different plant genomes along with the <I>Papaver</I> transcriptome, i.e., secondary metabolite biosynthesis, isoquinoline alkaloid biosynthesis (BIA) pathway, and cytochrome. Sixty-nine transcripts in the BIA pathway along with 22 different alkaloids (quantified with LC-QTOF-MS/MS) were mapped into the BIA KEGG map (map00950). Finally, we identified 39 full-length cytochrome transcripts and compared them with other genomes. Collectively, this transcriptome data, along with the expression and quantitative metabolite profiles, provides an initial recording of secondary metabolites and their expression related to <I>Papaver</I> plant development. Moreover, these profiles could help to further detail the functional characterization of the various secondary metabolite biosynthesis and <I>Papaver</I> plant development associated problems.</P>
Effects of Cofactor Stepwise Feeding for Amino Alcohol Production Using Whole-Cell Conversion
Byeong-Wook LEE,Haeng-Geun CHA,Youjung KONG,Yubin JEON,HyeJi JIN,Kyungjae YU,Hee Taek KIM,Jeong Chan JOO,Seung-Oh SEO,Yung-Hun YANG,Sang-Kyu JUNG,See-Hyoung PARK,Kyungmoon PARK 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4
Jeon, Byeong-Gyun,Kumar, B Mohana,Kang, Eun-Ju,Maeng, Geun-Ho,Lee, Yeon-Mi,Hah, Young-Sool,Ock, Sun-A,Kwack, Dae-Oh,Park, Bong-Wook,Rho, Gyu-Jin Potamitis Press 2011 Anticancer research Vol.31 No.12
<P>We investigated the effects of sodium meta-arsenite (NaAsO(2)) on human cancer cells (MDA-MB-231, MCF-7 and U-87 MG), dental papilla tissue stem cells (DPSCs) and somatic cells [MRC-5 fetal fibroblasts and adult muscle cells (MCs)] by examining telomeric properties, endogenous reverse transcriptase (RT) activity and the expression of tumorigenesis-linked genes. Half maximal inhibitory concentration (IC(50)) values were higher in DPSCs and MCs, possessing longer telomere lengths when compared to cancer cells. Levels of telomerase and RT activity, and the expression of protein 53 (p53), B-cell lymphoma 2 (BCL2), nuclear factor kappa-light-chain-enhancer of activated B-cells (NFκB), transforming growth factor beta (TGFβ) and vascular endothelial growth factor (VEGF) were significantly lower in cancer cells following sodium meta-arsenite treatment, whereas the effect was absent or marginally detected in DPSCs and somatic cells. Collectively, sodium meta-arsenite effectively induced cellular cytotoxicity by inhibiting telomerase and RT activity, and down-regulating transcript levels in cancer cells with shorter telomere lengths, whereas more tolerance was evident in DPSCs and somatic cells possessing longer telomere lengths.</P>