피씨비(PCB) 中毒에 미치는 프라센타(Placenta)의 效果

洪思澳,李香雨,鄭相允 成均館大學校 1983 論文集 Vol.33 No.-

This study was undertaken to investigate the effects of placenta on the toxicity of KC-400 in rabbits. Rabbits were treated with 800㎎ of KC-400 in 2㎖ olive oil via IP injection intermittently day after day for a week and were successively administered with 2㎖ of the placenta extracts via I. V. injection twice a day after day as well as with the placenta extracts with 50 ㎎ of vitamin C as well. The results obtained in this experiment were as follows: 1. When the experimental animals were treated with human placenta, there wasn't any alteration of the hematochemical indicators such as RBC, WBC, Hgb, Het, serum Cholesterol, s-GOT, s-GPT, serum Alkaline Phosphatase and Total lipids in serum. 2. According to the experiment of PCB poisoning, while s-C, s-GPT, s-ALP, and s-TL were increased, RBC, WBC, Hgb and Het were decreased during the experimental periods respectively. 3. The placenta extracts normalized the hematochemical indicators of the PCB poisoned animals after one day treated by the placenta extracts. 4. The combined treatment with the placenta extracts and vitamin C was the same effect as the single placenta treatment only; they were not significant in the t-test. 5. The placenta extracts inhibited the serum tyrosinase activity of the rabbits which was induced by PCB in vivo and in vitro respectively. By the combined treatment with the placenta extracts and vitamin C, the activity of tyrosinase was remarkably inhibited in comparison with the single treatment with the placenta alone.

Reactivity-Selectivity Relationship in the Nucleophilic Substitution Reactions of Methyl para-substituted Benzenesulfonates

이억석,홍승연,전윤탁 경성대학교 1985 부산수산대학 논문집 Vol.6 No.2

The substitution reactions of methyl para-substituted benzenesulfonates with nucleophils such as methanol, pyridine and sodium methoxide in methanol at 30℃ were investigated by conductometry and spectrometry in order to understand the reactivityselectivity relationship. The Hammett plot of kinetic data showed ρ values of 1.29, 1.18, 1.04 for the nucleophilic substitution reaction with methanol, pyridine and methoxide, respectively. Taking ρvalues as a selectivity parameter of the nucleophiles and considering the results with a series of nucleophiles showing the increase of reactivity in that order, there seems to be an inverse relationship between reactivity and selectivity.

천연두 백신 접종 후 발생된 급성 심근염 1예

박옥성,김종환,이광욱,윤성훈,강동구,이승욱,조상기 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Acute myocarditis complicating coronary vasospasm after smallpox vaccination is very rare complication that can be generally developed within less than 30 days after vaccination. Clinically and biochemically, this disorder is often mimic and highly suggestive of acute myocardial infarction. We report 21 years old man that had a history of a smallpox vaccination 3 weeks ago and prodromal symptoms(fever, malaise etc) a few days ago. hIe visited to our hospital because of abrupt onset of severe substernal chest pain, dyspnea and diaphoresis. At admission, electrocardiography was ST elevation in lead Ⅰ, aVL, V4, V5, and V6. The CK-MB level was 68 U/L, LDH level was 760 U/L, Troponin-Ⅰ was 24.64 ng/㎖, and Troponin-T was positive. 2D-echocardiograpy was normal left ventricular function, Clinically we presumed this disorder as acute myocardial infarction and we promptly performed the coronary angiography and revealed focal spasm in distal left coronary artery territory without critical stenosis in both coronary arteries. We diagnosed this disorder as coronary vasospam complicating acute myocarditis that is different with acute myocardial infarction, and we prescribed nitroglycerin and nifedipine. After discharge, he is now well without any symptoms and has been following up monthly at our outward department for 6 months.

표면곡률을 이용한 물체의 형상특징추출

조동욱,김지영,박웅규,윤상균,이성석,김태우 西原大學校 1992 西原大學 論文集 Vol.29 No.-

In this paper, a new shape feature extraction method of the objects using surface curvatures is described. First, the values of the H & K are calculated from range data as given input. Then objects are assigned in the form of 8 primitives by the signs of the H & K values. But existing methods have the difficulties with the complex object. Therefore, We propose the method for the complex primitives such as cone ridge and cone valley. Finally, the effectiveness of this paper is demonstrated by several experiment.

해안선을 따라 이동하는 켈빈파의 회전수조 모형 실험

蘇鮮變,金明煥,許相旭,李惠眞,梁潤實 공주대학교 기초과학연구소 2000 自然科學硏究 Vol.9 No.-

켈빈파란 회전계의 북반구에서 육지를 오른쪽에 두고 해안선을 따라 이동하는 파이다. 이 켈빈파를 가시화하기 위해 밀도차를 갖는 두 층의 유체를 만들고 경계면에 생기는 내부캘빈파를 가시화하여 변화를 관찰하였다. 지금까지는 해안가에서 나타나는 밀물과 썰물을 단순히 달의 인력으로 인한 조석으로만 생각했었는데, 본 실험을 통하여 그것이 지구자전의 영향을 받아 회전하는 조석파임을 알게되었다. Kenvin wave moves along the shoreline from the Northern hemisphere of rotating system in right of the land. Yeu observe s veriety for the visibity of it, we make two layers to have divergence of density, then it is visible the interior of Kelvin wave in a boundary plane. You thought simply the ebb and flow of the tide that they was the tidal movement to be due to the gravitation of the moon on the shore. But we know that Kelvin wave is rotating tide wave affected by revolution of the earth.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

Experimental Study of Ginkgo-Chunghyul-dan on Anti-oxidant, Anti-platelet Aggregation, and Anti-hyperlipidemic Activity

Yun, Sang-Pil,Bae, Hyung-Sup,Park, Seong-Uk,Jung, Woo-Sang,Moon, Sang-Kwan,Park, Jung-Mi,Ko, Chang-Nam,Cho, Ki-Ho,Kim, Young-Suk The Society of Korean Medicine 2008 대한한의학회지 Vol.29 No.5

Objectives :Ginkgo-Chunghyul-dan (GCHD) is newly developed herbal medicine to prevent and treat stroke. In this study, we investigated whether the GCHD had antioxidant activity and anti-platelet aggregation effect in vitro and hypolipidemic activities in vivo. Methods :Anti-oxidant activity of GCHD was measured using the Blois method, anti-platelet effect of GCHD was assessed by the Born method, and hypolipidemic activities of GCHD were evaluated in corn oil- or Triton WR-1339-induced and cholesterol-fed rats. Results :GCHD showed anti-oxidant activity in the study inhibiting the formation of 1-diphenyl-2-picrylhydrazyl radicals and xanthine oxidase activity. GCHD had anti-platelet aggregation activity. GCHD significantly lowered total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in high cholesterol diet and Triton WR-1339 induced model TG in corn oil-induced model. GCHD had no acute toxicity at a single dosage. Conclusion : These results suggest that GCHD has the potential to treat hyperlipidemia and stroke.

Anti-hypertensive Effect of Chunghyul-dan(Qingxue-dan) on Stroke Patients with Essential Hypertension

Yun, Sang-Pil,Jung, Woo-Sang,Park, Scong-Uk,Moon, Sang-Kwan,Ko, Chang-Nam,Cho, Ki-Ho,Kim, Young-Suk,Bac, Hyung-sup EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Hypertension is one of the modifiable risk factors for stroke. Lowering blood pressure is helpful for primary and secondary prevention of stroke. This study is aimed to assess the efficacy of Chunghyul-dan on stroke patients with stage I hypertension using 24 hours ambulatory blood pressure monitoring (24ABPM). Forty hospitalized stroke patients with stage I hypertension were included in the study and they were randomly assigned into two groups: group A was treated with Chunghyul-dan 1200 ㎎ once a day for 2 weeks, while group B was not. Twelve subjects were dropped out because of unexpected early discharge or data error, thus the remaining 28 subjects were included in the final analysis (15 in group A and 13 in group B). Blood pressure was monitored every 30 minutes for 24 hours at baseline and 2 weeks after medication. Blood pressure, pulse rate, trough/peak ratio (TPR) [the value calculated by dividing the blood pressure change at trough (22 to 24 hours after drug intake) by the change at peak (2 adjacent hours with a maximal blood pressure reduction between the second and eighth hour after drug intake)] and smoothness index (SI) (the value calculated as the ratio between the average of the 24 hours, treatment-induced blood pressure changes and its standard deviation) were compared to assess the efficacy of Chunghyul-dan. To assess the safety of Chunghyul-dan, any adverse effects during medication period were monitored. There was no significant difference in the baseline assessment between the two groups. Systolic blood pressure was lower in group A than in group B (141.37 ± 8.96 mmHg versus 132.28 ±9.46 mmHg, P=0.03), while diastolic blood pressure and pulse rate had no significant difference between the two groups. Systolic TPR and SI was 0.87 and 1.04 in group A, respectively. This suggests that Chunghyul-dan have antihypertensive effect on stroke patients with stage 1 hypertension.??

Changes in Goat productivity and Economical Efficiency at Feeding Systems by Castrated Growing Korean Native Goat(Capra hircus coreanae)

Yun, Yeong-Sik,Seong, Hye-Jin,Zhang, Qi-Man,Chung, Sang-Uk,Lee, Ga-Eul,Jang, Se-Young,Lee, Jin-wook,Lee, Sang-Hoon,Moon, Sang-Ho The Korean Society of Grassland and Forage Science 2018 한국초지조사료학회지 Vol.38 No.3

This study was conducted to determine grazing intensity of growing Korean native goats(Capra hircus coreanae) on mountainous pasture. It was carried out to obtain basic information for improvement of mountainous pasture management and establishing feeding system of Korean native goat. A total of 20 goats were grouped by feeding systems [A mountainous pasture grazing group (Concentrated feed of 1.5% body weight, treatment 1, T1, n=10) and a barn feeding group (TMR, treatment 2, T2), n=10] to conduct study from April to September. The average forage productivity of the mountain pasture was $500.9{\pm}61.41kg/ha$. The average dry matter intake in T1 was 0.64 and the calculated grazing intensity was 21 head/ha. In productivity, when the two treatments(T1, T2) were compared, the dry matter intake was about two to three times the difference. The average daily gain per day during the experiment was 63.3 in the mountain pasture and 120 g in barn feeding. When grazing, considering mountainous pasture productivity it is necessary to increase the productivity through proper feeding. The feed costs of black goats raised by grazing on the grassland in the same period showed an average 75% reduction compared to barn feeding. As a result of this study, it can be expected that a considerable reduction of feed costs can be expected in the breeding of Korean native black goat using the mountain pasture.

Hwangryunhaedogtang (Huanglianjiedutang) Treatment for Pathological Laughter after Stroke and Importance of Patterns Identification : A Preliminary Study

Yun, Sang Pil,Jung, Woo Sang,Park, Sung Uk,Moon, Sang Kwan,Park, Jung Mi,Ko, Chang Nam,Cho, Ki Ho,Kim, Young Suk,Bae, Hyung Sup WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

This study was to test the importance of patterns identification (PI) and the effectiveness of Hwangryunhaedogtang (Huanglianjiedutang) (HT) treatment for patients with post stroke pathological laughter (PL). Fourteen subjects were enrolled. Eight subjects diagnosed with Yang Excess patterns (YEP) were assigned into group A and 6 subjects who had no YEP to group B. HT was administrated 3 times a day for 14 days to both groups. The duration of PL at one time. the frequency of PL in a day, and pathological laughter scale (PLS) were the primary outcome measures. Barthel index (BI) was the secondary outcome measure. The duration and the frequency of PL in group A were significantly decreased from 10.88 ± 4.67 to 6.63 ± 4.07 sec and from 6.38 ± 2.72 to 3.00 ± 1.77 times. respectively (p = 0.01) after 14 days administration of HI. PLS in group A was also significantly lowered from 9.13 ± 1.73 to 4.75 ± 0.71 points (p = 0.01). However, significant differences were not observed in BI in group A and in the primary and secondary outcome measures in group H. The duration and the frequency ofPL and PLS were more markedly reduced in group A than in group B(p = 0.01. 0.02, and < O.O1, respectively), These results suggested that HT could be effective on subjects with post stroke PL diagnosed as YEP and PI, that prescription of herbal medications to such patients should be considered.