Oxametallaborane 및 Metallacarborane과 Phenyl Carbene 반응에 대한 반응성과 반응메카니즘

성대동,이용희,심경옥 동아대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.17 No.1

거대고리 뭉치 붕소화합물 중 산소원자를 포함하는 oxametallaborane과 탄소원자를 포함하는 metallacaborane을 이용하여 새로운 metallacarborane을 합성할 수 있는 방법을 알아보고 [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10]과 [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H12]를 합성한 후 이들에 phenyl diazomethane을 반응시켰다. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10]과 phenyl diazomethane의 반응생성물은 예상과는 달리 cis-및 trans-stilbene과 trans, trans-benzaldehyde azine이었다. 카르벤의 이량화 반응은 [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10]의 촉매 작용에 의해 촉진 되었다. Oxametallaborane의 Pt-원자에 있는 d-오비탈이 카르벤의 삼중항 상태의 T1과 T2전자상태를 안정화 시켰다. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H12]와 phenyl diazomethane의 반응생성 oxametallaborane의 결과와 유사하였고 동시에 미량의 C-카르벤 삽입 반응생성물이 생성되었다. Metallacaborane의 탄소 원자궤도함수인 SOMO와 phenyl diazomethane의 LUMO가 반응하여 분자궤도함수 에너지를 낮추는데 기여하였다. The reaction mechanism and a new synthetic method using oxametallaborane and metallacarborane compounds are investigated. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10] and [9,9-(PMe2Ph)2-arachno-9,6-PtCB8H12] are synthesized then, reacted with phenyl diazomethane to find out a new synthetic method corresponding to the metallacarborane cage compound. Unexpectedly cis- and trans-stilbene and trans, trans-benzaldehyde azine are produced from the reaction of [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10] with phenyl diazomethane. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10] is operated as a kind of catalyst to yield dimerization product of carbene. The d-orbital in Pt-atom of oxametallaborane stabilizes the two triplet states of carbene, T1 and T2. A similar reaction products are produced from the reaction of [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H12] with phenyl diazomethane and a trace amount of a new product is also produced such as C-carbene insertion reaction product simultaneously. The molecular orbital energy is lowered by the SOMO energy of metallacarborane and the LUMO energy of phenyl carbene.

다이아몬드상 카본 박막의 레이저공정 변수에 따른 상변이와 내마모성 특성변화

심경석,차금환,이상렬,김대은 연세대학교 산업기술연구소 1999 논문집 Vol.31 No.2

Diamond-like carbon(DLC) thin films have been fabricated by pulsed laser deposition method with various deposition parameters. The characterization of fabricated thin films was performed depending on the deposition parameters. As the kinetic energy provided by deposition temperature and the laser energy density were increased, the film showed graphite properties. Structural properties of the films were investigated by Raman spectroscopy. The growth energy should be optimized to fabricate high quality DLC thin films. DLC films showed high hardness and their friction coefficients were measured to be about 0.2 regardless of the load of the ball pin.

연령적 추이로 본 체굴절도 측정에 관한 연구

이상대,심동원,김원식 대한스포츠의학회 1995 대한스포츠의학회지 Vol.13 No.1

We investigated the body flexibility in adult (age : 41-66), an age group which are susceptible to so called adult disease, and analyzed the measured data according to age. 1) ◁표 삽입▷(원문을 참조하세요) 2) Rate of decrease in body flexibility according to age, The Mean values of forward and backward body flexibility in the subjects in their 3rd decade were 14.0±2.59 and 36.1±4.54Cm, rerpectively. Ageing to the prime of life was associated with a decrease in the flexibility (forward flexibility : 13.0±1.59Cm, backward flexibility: 27.5±5.22㎝). In the age group over 60, the forward and backward flexibility were measured to be 11.1±1.99 and 24.7±2.18㎝, respectively.

흰쥐 척수손상 후 운동회복 양식의 도식적 분석

김상수,김하용,심대무,송하헌,차상도,김종환 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.1

Objectives : To understand the motor recovery pattern after spinal cord injury, We designed the quantitative measuring method of locomotion recovery using computerized motion analysis combined with video recordings. Materials and Methods : Using computerized motion analysis technique, locomotions of the 10 cord-hemisected Sprague-Dawley rats on the treadmill were graphically analyzed. Patterns of foot trajectories were plotted on two dimensions before and after unilateral spinal cord hemisecion at T7 level. Result : Immediately following dorsal hemisection, patterns of foot trajectories altered dramatically. Walking speed, stride length and height of hindfoot movements were markedly reduced. Coordination of left and right hindlimb was also disrupted. Although the lesions were unilateral, locomotor behavior was distrubed bilaterally. However, by six weeks, stride length and coordination of hindlimbs returned to near normal but vertical movement of the hindlimb recovered very little. Forelimb-hindlimb coordination was also initially disrupted but partially returned within three weeks. Conclusion : Computerized motion analysis is a sensitive technique for the detection of minor motor deficits following nerve injuries.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

식물성 식품중 총플라보노이드 함량과 생리활성 탐색

이종미,손은심,오상석,한대석 한국식생활문화학회 2001 韓國食生活文化學會誌 Vol.16 No.5

The contents of total flavonoids, total antioxidant status and superoxide scavenger activity of edible plants were measured. Among twenty one samples of leafy vegetables and teas, mugwort (Artemesia capillaris) and green teas gave high total flavonoids contents, 48.2㎎/g sample and 44.7㎎/g sample, respectively. The highest concentration of total flavonoids among eighty nine samples analyzed was 52.1㎎/g sample from propolis. When samples were tested for total antioxidant status, a kind of groundsel showed the highest Total Antioxidant Status(TAS) value, 13.4 mM among leafy vegetables and teas and green tea gave high TAS value, 11.84 mM. On the other hand, purslane gave the lowest TAS value, 0.01 mM. The superoxide scavenge activity was measured from the extracts of all edible plants. The superoxide scavenge activity of polygonatum (81.1%) and chrysantemum (78.5%) were the highest among leafy vegetables, teas and medicinal plants. On the other hand, ginseng, poria, cassiae semen and dioscoreae rhizoma showed no superoxide scavenge activities.

실업계 고등학생의 직업기초능력 향상을 위한 문제중심학습(PBL)의 효과

박동열,이성덕,김종오,조경희,강경심,박윤희,김대영 한국농업교육학회 2006 농업교육과 인적자원개발 Vol.38 No.4

21세기 지식기반사회는 전문지식뿐만 아니라 효율적인 직무 수행에 필요한 의사소통능력, 문제해결능력, 자기관리능력 및 직업의식 등의 직업기초능력이 강조되고 있다. 직업기초능력은 생의 어느 한 시기에 갑자기 이루어지거나 완성되는 l회적인 것이 아니라 개인의 생애단계에 따라 변화하고 발달하는 것이며 취업자뿐만 아니라 진학자에게도 잠재적으로 매우 중요한 요소이므로 실업계 고등학생의 직업기초능력 향상은 중요한 현안이라 할 수 있다. 이 연구는 여러 교수학습유형 중 실업계 고등학생의 직업기초능력 향상에 타당하리라 사료되는 문제 중심학습 모형(Problem-based learning model)을 선정, 이에 기초한 전문교과 수업을 실시하여 실업계 고등학생의 직업기초능력 향상에 기여할 수 있는지 실증적으로 분석하고자 하였다. 연구 목적 달성을 위해 「대학생의 직업기초능력 유형 검사도구(박동열, 2005)」를 실업계 고등학교 전문가 협의회를 통해 수정ㆍ보완, 이를 활용하여 실업계 고등학생의 직업기초능력을 파악하고, 문제중심학습 모형에 따른 실제 전문교과 수업을 통한 실업계 고등학생의 직업기초능력 향상 정도를 알아보기 위하여 농업계열, 공업계열, 상업계열, 가사ㆍ실업계열 4명의 현직 교사가 문제중심학습 수업 매뉴얼에 따라 실제 수업에 적용 하고 그 결과를 분석하였다. 연구 결과 문제중심학습 모형이 실업계 고등학생의 수업만족도에 긍정적인 영향을 끼쳤으며, 문제중심학습 모형에 따른 전문교과 수업을 통해 실업계 고등학생의 모든 영역의 직업기초능력(문제해결 및 발표 능력, 기술활용능력, 자원활용능력, 수리능력, 조직이해능력, 대인관계능력, 자기관리능력)이 향상되었음을 실증적으로 알 수 있었다. The purpose of this research was to analyze the fitness of problem-based learning(PBL) for improving the core competencies of vocational high school students. This study examined the core competencies of vocational high school students by using the advised BARS test for vocational high school. And in order to examine the effectiveness of the courses based on PBL, 4 teachers had taught the designed courses by PBL method during the regular class in vocational high school : agricultural; technical; commercial, home economic high schools. The major findings in this study were as follows: 1) The courses based on PBL had an positive effect on the class satisfaction of vocational High school students. 2) We found out that the courses based on PBL have a positive effect on improving vocational key competencies of Vocational High school students.

거점공간조직에 따른 중심지 개발 패턴에 관한 연구

김태만,강상훈,김대성,심우갑 대한건축학회 2004 대한건축학회논문집 Vol.20 No.9

This study is to analyze 'anchor system' strategies in CBD. We selected five cases of new town development with 'anchor's and urban axises in 19808, two Korean new towns(Bundang and Ilsan) and three Japanese towns(Tokyo Waterfront City, Minatomirai21 and Makuhari New City) Though all the cases utilized anchors and urban axises In a CBD, they have shown different patterns of anchor distribution In new towns such as Bundang, Ilsan and Tokyo Waterfront City, those anchors are decentralized, while In the other cases, Minatomirai21 and Makuhari New City, anchors are centralized In the CBD Those anchors such as convention center, exhibition hall and business sectors are mostly determined by public corporations and developed as development-leading facilities In Korean cases, those facilities sometimes failed to follow original Intention of master plan or located apart from urban axises On the other hand, Japanese anchors, centered on urban axises, show more systematic patterns of CBD development than those In Korea.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.