R&D Status of High-current Accelerators at IFP

J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61

High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.

Cluster Analysis of 12 Chinese Native Chicken Populations Using Microsatellite Markers

Chen, G.H.,Wu, X.S.,Wang, D.Q.,Qin, J.,Wu, S.L.,Zhou, Q.L.,Xie, F.,Cheng, R.,Xu, Q.,Liu, B.,Zhang, X.Y.,Olowofeso, O. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.8

The genomes of Chinese native chicken populations were screened using microsatellites as molecular markers. A total of, 528 individuals comprisede12 Chinese native chicken populations were typed for 7 microsatellite markers covering 5 linkage groups and genetic variations and genetic distances were also determined. In the 7 microsatellite loci, the number of alleles ranged from 2 to 7 per locus and the mean number of alleles was 4.6 per locus. By using fuzzy cluster, 12 Chinese native chicken populations were divided into three clusters. The first cluster comprised Taihe Silkies, Henan Game Chicken, Langshan Chicken, Dagu Chicken, Xiaoshan Chicken, Beijing Fatty Chicken and Luyuan Chicken. The second cluster included Chahua Chicken, Tibetan Chicken, Xianju Chicken and Baier Chicken. Gushi Chicken formed a separate cluster and demonstrated a long distance when comparing with other chicken populations.

Coronary Atherosclerosis T₁-Weighed Characterization With Integrated Anatomical Reference

Xie, Y.,Kim, Y.J.,Pang, J.,Kim, J.S.,Yang, Q.,Wei, J.,Nguyen, C.T.,Deng, Z.,Choi, B.W.,Fan, Z.,Bairey Merz, C.N.,Shah, P.K.,Berman, D.S.,Chang, H.J.,Li, D. Elsevier Science B.V. Amsterdam 2017 JACC CARDIOVASCULAR IMAGING Vol.10 No.6

Objectives: The aim of this work is the development of coronary atherosclerosis T<SUB>1</SUB>-weighted characterization with integrated anatomical reference (CATCH) technique and the validation by comparison with high-risk plaque features (HRPF) observed on intracoronary optical coherence tomography (OCT) and invasive coronary angiography. Background: T<SUB>1</SUB>-weighted cardiac magnetic resonance with or without contrast media has been used for characterizing coronary atherosclerosis showing promising prognostic value. Several limitations include: 1) coverage is limited to proximal coronary segments; 2) spatial resolution is low and often anisotropic; and 3) a separate magnetic resonance angiography acquisition is needed to localize lesions. Methods: CATCH acquired dark-blood T<SUB>1</SUB>-weighted images and bright-blood anatomical reference images in an interleaved fashion. Retrospective motion correction with 100% respiratory gating efficiency was achieved. Reference control subjects (n = 13) completed both pre- and post-contrast scans. Stable angina patients (n = 30) completed pre-contrast scans, among whom 26 eligible patients also completed post-contrast scans. After cardiac magnetic resonance, eligible patients (n = 22) underwent invasive coronary angiography and OCT for the interrogation of coronary atherosclerosis. OCT images were assessed and scored for HRPF (lipid-richness, macrophages, cholesterol crystals, and microvessels) by 2 experienced analysts blinded to magnetic resonance results. Results: Per-subject analysis showed none of the 13 reference control subjects had coronary hyperintensive plaques (CHIP) in either pre-contrast or post-contrast CATCH. Five patients had CHIP on pre-contrast CATCH and 5 patients had CHIP on post-contrast CATCH. Patients with CHIP had greater lipid abnormality than those without. Per-segment analysis showed elevated pre- and post-contrast plaque to myocardium signal ratio in the lesions with HRPF versus those without. Positive correlation was observed between plaque to myocardium signal ratio and OCT HRPF scoring. CHIP on pre-contrast CATCH were associated with significantly higher stenosis level than non-CHIP on invasive coronary angiography. Conclusions: CATCH provided accelerated whole heart coronary plaque characterization with simultaneously acquired anatomical reference. CHIP detected by CATCH showed positive association with high-risk plaque features on invasive imaging studies.

Preparation of Nd-doped manganese-zinc-ferrite/polyaniline composite materials

Yan, S. F.,Xie, Y.,Liu, J. M.,Pan, J. F.,Yu, Y. F.,Shi, L.,Zhang, K.,Lai, Q.,Liu, F. M.,Gao, Y. H.,Ling, Y. Informa UK (TaylorFrancis) 2014 Materials research innovations Vol.18 No.2

Coordination polymer nanospheres: Preparation, upconversion properties and cytotoxicity study

Zhong, S.,Ji, Y.,Xie, Q.,Wang, L.,Li, Y.,Jeong, J.H. North-Holland 2013 Materials Letters Vol. No.

Coordination polymer (CP) nanospheres with diameters of 100-200nm have been successfully synthesized via a simple solvothermal approach employing glycol both as solvent and ligand in the presence of asparagine. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), inductive coupled plasma (ICP), thermogravimetric (TG) and differential thermal (DTA) analysis were used to characterize the products. Upconversion emission centering at about 676nm is realized in the coordination polymer spheres when excited with 980nm laser. Cytotoxicity study reveals that the coordination polymer nanospheres are biocompatible.

Tl2Ba2CaCu2O8 Thin Films on MgO and Sapphire Substrates

X.J. Zhao,S.L. Yan,C. Zhang,E. Chen,L. Fang,L. Ji,Q.L. Xie,S. Li,T.G. Zhou,X. Zhang,X. Zuo,Y.G. Li 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I

High quality Tl2Ba2CaCu2O8(Tl-2212) films were grown on MgO and sapphire substrates with CeO2 buffer layers. The CeO2 buffer layers were prepared by using an in-situ process with RF magnetron sputtering. The Tl-2212 thin films were then fabricated in a two-step process: deposition of the Tl-containing precursor film and low-temperature post-thallination of the precursor film. The resulting Tl-2212 films showed an excellent biaxial texture. The superconducting transition temperatures, Tc’s, of the films on MgO and sapphire were 103.4 and 104.2 K, respectively. The critical current densities Jc at 77 K and zero magnetic field were as high as 2.37 × 106 A/cm2 for the film on MgO and 1.76 × 106 A/cm2 on sapphire. A surface resistance of 725 μ at 10 GHz and 77 K was obtained in the Tl-2212 film on CeO2 buffered sapphire.

High Sustained Virologic Response with Daclatasvir plus Asunaprevir in HCV GT-1b Chinese, Korean and Taiwanese without Baseline NS5A Polymorphisms

( F. Mcphee ),( L. Wei ),( Q. Xie ),( Y. Suzuki ),( J. Toyota ),( Y. Karino ),( K. Chayama ),( Y. Kawakami ),( M. L. Yu ),( S. H. Ahn ),( N. Zhou ),( H. Kumada ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Daclatasvir (DCV) plus asunaprevir (ASV) has demonstrated highsustained virologic response (SVR) in HCV genotype (GT-)1b infection.NS5A-Y93H and NS5A-L31 resistance-associated polymorphisms(RAPs) to DCV are known to impact DCV+ASV response in GT-1b-infectedJapanese. The effect of RAPs on SVR at posttreatment week12 (SVR12) to DCV+ASV was explored in mainland Chinese, Korean,and Taiwanese.Methods: Pooled data from 2 studies of DCV (60 mg daily) + ASV(100 mg capsule, twice-daily) for 24 weeks in GT-1b-infected interferon/ribavirin-naive and -experienced patients from mainland China,Korea, and Taiwan. Similar Japanese data (4 studies; n=445) werepooled for comparison. SVR12 with versus without baseline Y93Hand/or L31 RAPs was compared by age (<65 vs ≥65 years), cirrhosisstatus, and baseline HCV-RNA.Results: SVR12 and baseline NS5A sequences were available for 282patients (126 mainland Chinese [45%〕, 80 Koreans [28%〕, 76Taiwanese [27%〕). NS5A-Y93H and/or -L31 RAPs were observed pretreatmentin 8% mainland Chinese, 14% Korean, and 18%Taiwanese patients, compared with 19% in Japanese. SVR12 in allnon-Japanese patients is shown (Figure); rates were broadly similarbetween countries and with Japanese data (Japanese: 96% overallwithout RAPs, 41% with RAPs). Responses were lower among patientswith baseline RAPs. By contrast, SVR12 in patients without RAPs washigh (92-100%), irrespective of cirrhosis, age, or baseline HCV-RNA.Conclusions: At least 95% of HCV GT-1b-infected patients from mainlandChina, Korea or Taiwan without baseline NS5A-Y93H or -L31polymorphisms who had HCV-RNA ≤7 log10 IU/mL achieved SVR12on DCV+ASV, regardless of cirrhosis status and age.

Wind effects on a large cantilevered flat roof: loading characteristics and strategy of reduction

J. Y. Fu,Q. S. Li,Z. N. Xie 한국풍공학회 2005 Wind and Structures, An International Journal (WAS Vol.8 No.5

Wind effects on a large cantilevered flat roof: loading characteristics and strategy of reduction

Fu, J.Y.,Li, Q.S.,Xie, Z.N. Techno-Press 2005 Wind and Structures, An International Journal (WAS Vol.8 No.5

Mean and extreme pressure distributions on a large cantilevered flat roof model are measured in a boundary layer wind tunnel. The largest peak suction values are observed from pressure taps beneath conical "delta-wing type" corner vortices that occur for oblique winds, then the characteristics and causes of the local peak suctions are discussed in detail. Power spectra of fluctuating wind pressures measured from some typical taps located at the roof edges under different wind directions are presented, and coherence functions of fluctuating pressures are also obtained. Based on these results, it is verified that the peak suctions are highly correlated with the conical vortices. Furthermore, according to the characteristics of wind loads on the roof, an aerodynamic solution to minimize the peak suctions by venting the leading edges and the corners of the roof is recommended. The experimental results show that the suggested strategy can effectively control the generation of the conical vortices and make a reduction of 50% in mean pressures and 25% in extreme local pressures at wind sensitive locations on the roof.

Optical Nanostructures Fabricated by SU-8 based Nanoimprint Lithography

R. Liu,B.-R. Lu,S.-Q. Xie,J. Wan,Z. Shu,X.-P. Qu,Y. Chen 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3

The high resolution low-cost and high-volume nano-pattering capability of the nanoimprint lithography (NIL) and the high optical transmittance of SU-8 in the infrared, the visible and the near-UV light ranges have enabled us to apply the SU-8 based NIL to produce various optical nanostructures. We fabricated dielectric and metallic gratings of various groove density (1000 – 5000 lines/mm) in a relatively large area (10 mm × 10 mm) and planar chiral photonic meta-material structure in SU-8 with periods of both 600 nm and 4 μm. We also designed and successfully fabricated distributed Bragg reflectors (DBRs) with Si/SiO2/SU8/air structures Optical measurements of the SU-8 based nanostructures showed good optical performance and interesting properties, and the experimental data agree reasonably well with simulation results. The high resolution low-cost and high-volume nano-pattering capability of the nanoimprint lithography (NIL) and the high optical transmittance of SU-8 in the infrared, the visible and the near-UV light ranges have enabled us to apply the SU-8 based NIL to produce various optical nanostructures. We fabricated dielectric and metallic gratings of various groove density (1000 – 5000 lines/mm) in a relatively large area (10 mm × 10 mm) and planar chiral photonic meta-material structure in SU-8 with periods of both 600 nm and 4 μm. We also designed and successfully fabricated distributed Bragg reflectors (DBRs) with Si/SiO2/SU8/air structures Optical measurements of the SU-8 based nanostructures showed good optical performance and interesting properties, and the experimental data agree reasonably well with simulation results.