Parametric analysis and torsion design charts for axially restrained RC beams

Luís F.A. Bernardo,Cátia S.B. Taborda,Jorge M.R. Gama 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.55 No.1

This article presents a theoretical parametric analysis on the ultimate torsional behaviour of axially restrained reinforced concrete (RC) beams. This analysis is performed by using a computing procedure based on a modification of the Variable Angle Truss Model. This computing procedure was previously developed to account for the influence of the longitudinal compressive stress state due to the axial restraint conditions provided by the connections of the beams to other structural members. The presented parametric study aims to check the influence of some important variable studies, namely: torsional reinforcement ratio, compressive concrete strength and axial restraint level. From the results of this parametric study, nonlinear regression analyses are performed and some design charts are proposed. Such charts allow to correct the resistance torque of RC beams (rectangular sections with small height to width ratios) to account for the favorable influence of the axial restraint.

Effective torsional strength of axially restricted RC beams

Cátia S.B. Taborda,Luís F.A. Bernardo,Jorge M.R. Gama 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.67 No.5

In a previous study, design charts where proposed to help the torsional design of axially restricted reinforced concrete (RC) beams with squared cross section. In this article, new design charts are proposed to cover RC beams with rectangular cross section. The influence of the height to width ratio of the cross section on the behavior of RC beams under torsion is firstly shown by using theoretical and experimental results. Next, the effective torsional strength of a reference RC beam is computed for several values and combinations of the study variables, namely: height to width ratio of the cross section, concrete compressive strength, torsional reinforcement ratio and level of the axial restraint. To compute the torsional strength, the modified Variable Angle Truss Model for axially restricted RC beams is used. Then, an extensive parametric analysis based on multivariable and nonlinear correlation analysis is performed to obtain nonlinear regression equations which allow to build the new design charts. These charts allow to correct the torsional strength in order to consider the favourable influence of the compressive axial stress that arises from the axial restraint.

Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer

Daniel Addison,Patrick R. Lawler,Hamed Emami,Sumbal A. Janjua,,Pedro V. Staziaki,Travis R. Hallett,Orla Hennessy,Hang Lee,Bálint Szilveszter,Michael Lu,Negar Mousavi,Matthew G. Nayor,Francesca N. Dell 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.1

Background and Purpose Interventions to reduce the risk for cerebrovascular events (CVE; stroke and transient ischemic attack [TIA]) after radiotherapy (RT) for head and neck cancer (HNCA) are needed. Among broad populations, statins reduce CVEs; however, whether statins reduce CVEs after RT for HNCA is unclear. Therefore, we aimed to test whether incidental statin use at the time of RT is associated with a lower rate of CVEs after RT for HNCA. Methods From an institutional database we identified all consecutive subjects treated with neck RT from 2002 to 2012 for HNCA. Data collection and event adjudication was performed by blinded teams. The primary outcome was a composite of ischemic stroke and TIA. The secondary outcome was ischemic stroke. The association between statin use and events was determined using Cox proportional hazard models after adjustment for traditional and RT-specific risk factors. Results The final cohort consisted of 1,011 patients (59±13 years, 30% female, 44% hypertension) with 288 (28%) on statins. Over a median follow-up of 3.4 years (interquartile range, 0.1 to 14) there were 102 CVEs (89 ischemic strokes and 13 TIAs) with 17 in statin users versus 85 in nonstatins users. In a multivariable model containing known predictors of CVE, statins were associated with a reduction in the combination of stroke and TIA (hazard ratio [HR], 0.4; 95% confidence interval [CI], 0.2 to 0.8; P=0.01) and ischemic stroke alone (HR, 0.4; 95% CI, 0.2 to 0.8; P=0.01). Conclusions Incidental statin use at the time of RT for HNCA is associated with a lower risk of stroke or TIA.

Evaluation of mango saponin in broilers: effects on growth performance, carcass characteristics, meat quality and plasma biochemical indices

Y.N. Zhang,J. Wang,B. Qi,S.G. Wu,H.R. Chen,H.Y. Luo,D.J. Yin,F.J. Lu,H.J. Zhang,G.H. Qi 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.8

Objective: The objective of the present study was to determine whether mango saponin (MS) could be used as a feed additive in broiler chicks by evaluating growth performance, carcass characteristics, meat quality, and plasma biochemical indices. Methods: A total of 216 1-d-old Arbor Acres male broiler chicks were randomly assigned into three dietary treatments supplemented with 0 (control), 0.14% (MS 0.14%), or 0.28% (MS 0.28%) MS. Each treatment had six replicates (cages) with 12 chicks each. The feeding trial lasted for six weeks. Results: Compared with the control, dietary supplemented with 0.14% or 0.28% MS increased average daily weight gain of chicks in the grower (22 to 42 d) and the whole (1 to 42 d) phases, and the final body weight of chicks on d 42 was higher in MS supplemented groups (p<0.05). Lower L45 min* (lightness) and L24 h* values, lower b24 h* (yellowness) value, and higher a45 min* (redness) and a24 h* values of the breast muscle were observed in chicks fed with 0.28% MS on d 42 (p<0.05). The total antioxidant capacity in plasma increased in MS 0.14% group on d 21 (p<0.001). Lower contents of plasma total cholesterol and triglyceride were observed in chicks fed with 0.28% MS on d 21 and d 42, whereas the group supplemented with 0.14% MS only decreased plasma triglyceride content on d 21 (p<0.05). The glucose content in plasma decreased in MS 0.28% group on d 42 (p<0.001). Conclusion: Overall, MS could be used as a feed additive in broiler chicks, and the supplemental level of 0.28% MS in diet could improve growth performance, meat quality, and plasma lipid metabolism in broiler chicks.

Determination of N* amplitudes from associated strangeness production in p+p collisions

Mü,nzer, R.,Fabbietti, L.,Epple, E.,Lu, S.,Klose, P.,Hauenstein, F.,Herrmann, N.,Grzonka, D.,Leifels, Y.,Maggiora, M.,Pleiner, D.,Ramstein, B.,Ritman, J.,Roderburg, E.,Salabura, P.,Sarantsev, A.,B North-Holland Pub. Co 2018 Physics letters. Section B Vol.785 No.-

<P><B>Abstract</B></P> <P>We present the first determination of the energy-dependent amplitudes of N<SUP>⁎</SUP> resonances extracted from their decay in KΛ pairs in p+p → <SUP> pK + </SUP> Λ reactions. A combined Partial Wave Analysis of seven data samples with exclusively reconstructed p+p → <SUP> pK + </SUP> Λ events measured by the COSY-TOF, DISTO, FOPI and HADES Collaborations in fixed target experiments at kinetic energies between 2.14 to 3.5 GeV is used to determine the amplitude of the resonant and non-resonant contributions into the associated strangeness final state. The contribution of seven N<SUP>⁎</SUP> resonances with masses between 1650 MeV/c<SUP>2</SUP> and 1900 MeV/c<SUP>2</SUP> for an excess energy between 0 and 600 MeV has been considered. The Σ–p cusp and final state interactions for the p–Λ channel are also included as coherent contributions in the PWA. The N<SUP>⁎</SUP> contribution is found to be dominant with respect to the phase space emission of the pK Λ + final state at all energies demonstrating the important role played by both N<SUP>⁎</SUP> and interference effects in hadron–hadron collisions.</P>

SπRIT: A time-projection chamber for symmetry-energy studies

Shane, R.,McIntosh, A.B.,Isobe, T.,Lynch, W.G.,Baba, H.,Barney, J.,Chajecki, Z.,Chartier, M.,Estee, J.,Famiano, M.,Hong, B.,Ieki, K.,Jhang, G.,Lemmon, R.,Lu, F.,Murakami, T.,Nakatsuka, N.,Nishimura, M Elsevier 2015 Nuclear Instruments & Methods in Physics Research. Vol.784 No.-

<P><B>Abstract</B></P> <P>A time-projection chamber (TPC) called the SAMURAI Pion-Reconstruction and Ion-Tracker (SπRIT) has recently been constructed at Michigan State University as part of an international effort to constrain the symmetry-energy term in the nuclear Equation of State (EoS). The SπRIT TPC will be used in conjunction with the SAMURAI spectrometer at the Radioactive Isotope Beam Factory (RIBF) at RIKEN to measure yield ratios for pions and other light isospin multiplets produced in central collisions of neutron-rich heavy ions, such as <SUP>132</SUP>Sn+<SUP>124</SUP>Sn. The SπRIT TPC can function both as a TPC detector and as an active target. It has a vertical drift length of 50cm, parallel to the magnetic field. Gas multiplication is achieved through the use of a multi-wire anode plane. Image charges, produced in the 12096 pads, are read out with the recently developed Generic Electronics for TPCs.</P>

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription

Guthridge, Joel M.,Lu, R.,Sun, H.,Sun, C.,Wiley, Graham B.,Dominguez, N.,Macwana, Susan R.,Lessard, Christopher J.,Kim-Howard, X.,Cobb, Beth L.,Kaufman, Kenneth M.,Kelly, Jennifer A.,Langefeld, Carl D University of Chicago Press [etc.] 2014 American journal of human genetics Vol.94 No.4

Efforts to identify lupus-associated causal variants in the FAM167A/BLK locus on 8p21 are hampered by highly associated noncausal variants. In this report, we used a trans-population mapping and sequencing strategy to identify a common variant (rs922483) in the proximal BLK promoter and a tri-allelic variant (rs1382568) in the upstream alternative BLK promoter as putative causal variants for association with systemic lupus erythematosus. The risk allele (T) at rs922483 reduced proximal promoter activity and modulated alternative promoter usage. Allelic differences at rs1382568 resulted in altered promoter activity in B progenitor cell lines. Thus, our results demonstrated that both lupus-associated functional variants contribute to the autoimmune disease association by modulating transcription of BLK in B cells and thus potentially altering immune responses.

Optical Nanostructures Fabricated by SU-8 based Nanoimprint Lithography

R. Liu,B.-R. Lu,S.-Q. Xie,J. Wan,Z. Shu,X.-P. Qu,Y. Chen 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3

The high resolution low-cost and high-volume nano-pattering capability of the nanoimprint lithography (NIL) and the high optical transmittance of SU-8 in the infrared, the visible and the near-UV light ranges have enabled us to apply the SU-8 based NIL to produce various optical nanostructures. We fabricated dielectric and metallic gratings of various groove density (1000 – 5000 lines/mm) in a relatively large area (10 mm × 10 mm) and planar chiral photonic meta-material structure in SU-8 with periods of both 600 nm and 4 μm. We also designed and successfully fabricated distributed Bragg reflectors (DBRs) with Si/SiO2/SU8/air structures Optical measurements of the SU-8 based nanostructures showed good optical performance and interesting properties, and the experimental data agree reasonably well with simulation results. The high resolution low-cost and high-volume nano-pattering capability of the nanoimprint lithography (NIL) and the high optical transmittance of SU-8 in the infrared, the visible and the near-UV light ranges have enabled us to apply the SU-8 based NIL to produce various optical nanostructures. We fabricated dielectric and metallic gratings of various groove density (1000 – 5000 lines/mm) in a relatively large area (10 mm × 10 mm) and planar chiral photonic meta-material structure in SU-8 with periods of both 600 nm and 4 μm. We also designed and successfully fabricated distributed Bragg reflectors (DBRs) with Si/SiO2/SU8/air structures Optical measurements of the SU-8 based nanostructures showed good optical performance and interesting properties, and the experimental data agree reasonably well with simulation results.

Emergence of room-temperature ferroelectricity at reduced dimensions

Lee, D.,Lu, H.,Gu, Y.,Choi, S.-Y.,Li, S.-D.,Ryu, S.,Paudel, T. R.,Song, K.,Mikheev, E.,Lee, S.,Stemmer, S.,Tenne, D. A.,Oh, S. H.,Tsymbal, E. Y.,Wu, X.,Chen, L.-Q.,Gruverman, A.,Eom, C. B. American Association for the Advancement of Scienc 2015 Science Vol.349 No.6254

<P><B>Thinning films induces ferroelectricity</B></P><P>Thin ferroelectric films are needed in computers and medical devices. However, traditional ferroelectric films typically become less and less polarized the thinner the films become. Instead of using a good ferroelectric and making it thinner, Lee <I>et al.</I> started with SrTiO<SUP>3</SUP>, which in its bulk form is not ferroelectric. This material does have naturally occurring nanosized polarized regions. and when the thickness of the SrTiO<SUB>3</SUB> films reaches the typical size of these regions, the whole film aligns and becomes ferroelectric.</P><P><I>Science</I>, this issue p. 1314</P><P>The enhancement of the functional properties of materials at reduced dimensions is crucial for continuous advancements in nanoelectronic applications. Here, we report that the scale reduction leads to the emergence of an important functional property, ferroelectricity, challenging the long-standing notion that ferroelectricity is inevitably suppressed at the scale of a few nanometers. A combination of theoretical calculations, electrical measurements, and structural analyses provides evidence of room-temperature ferroelectricity in strain-free epitaxial nanometer-thick films of otherwise nonferroelectric strontium titanate (SrTiO<SUB>3</SUB>). We show that electrically induced alignment of naturally existing polar nanoregions is responsible for the appearance of a stable net ferroelectric polarization in these films. This finding can be useful for the development of low-dimensional material systems with enhanced functional properties relevant to emerging nanoelectronic devices.</P>

Strategies for shotgun identification of integral membrane proteins by tandem mass spectrometry

Lu, Bingwen,McClatchy, Daniel B.,Kim, Jin Young,Yates III, John R. WILEY-VCH Verlag 2008 Proteomics Vol.8 No.19

<P>Integral membrane proteins (IMPs) are difficult to identify, mainly for two reasons: the hydrophobicity of IMPs and their low abundance. Sample preparation is a key component in the large-scale identification of IMPs. In this review, we survey strategies for shotgun identification of IMPs by MS/MS. We will discuss enrichment, solubilization, separation, and digestion of IMPs, and data analysis for membrane proteomics.</P>