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( Wen Qian Wei ),( Fang Qi Liu ),( Lei Liu ),( Zuo Feng Li ),( Xiao Yan Zhang ),( Fan Jiang ),( Qu Shi ),( Xiao Yan Zhou ),( Wei Qi Sheng ),( San Jun Cai ),( Xuan Li ),( Ye Xu ),( Peng Nan ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.5
Hereditary non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant inheritance syndrome. HNPCC is the most common hereditary variant of colorectal cancer (CRC), which accounts for 2-5% CRCs, mainly due to hMLH1 and hMSH2 mutations that impair DNA repair functions. Our study aimed to identify the patterns of hMSH2 and hMLH1 mutations in Chinese HNPCC patients. Ninety-eight unrelated families from China meeting Amsterdam or Bethesda criteria were included in our study. Germline mutations in MLH1 and MSH2 genes, located in the exons and the splice-site junctions, were screened in the 98 probands by direct sequencing. Eleven mutations were found in ten patients (11%), with six in MLH1 (54.5%) and five in MSH2 (45.5%) genes. One patient had mutations in both MLH1 and MSH2 genes. Three novel mutations in MLH1 gene (c.157_160delGAGG, c.2157dupT and c.-64G>T) were found for the first time, and one suspected hotspot in MSH2 (c.1168C>T) was revealed. [BMB reports 2011; 44(5): 317-322]
Xu, Ling,Dai, Wei-Qi,Xu, Xuan-Fu,Wang, Fan,He, Lei,Guo, Chuan-Yong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Backgrounds: To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide (MTg-AMOs) on proliferation and migration of human gastric cancer cells. Methods: Single anti-microRNA antisense oligonucleotides (AMOs) and MTg-AMOs for miR-221, 21, and 106a were designed and transfected into SGC7901, a gastric cancer cell line, to target the activity of these miRNAs. Their expression was analyzed using stem-loop RT-PCR and effects of MTg-AMOs on human gastric cancer cells were determined using the following two assay methods: CCK8 for cell proliferation and transwells for migration. Results: In the CCK-8 cell proliferation assay, $0.6{\mu}mol/L$ was selected as the preferred concentration of MTg-AMOs and incubation time was 72 hours. Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs (P = 0.014, 0.024; 0.038, respectively). Migration activity was also clearly decreased as compared to those in randomized and blank control groups ($28{\pm}4$ Vs $54{\pm}3$, P <0.01; $28{\pm}4$ Vs $59{\pm}4$, P < 0.01). Conclusions: MTg-AMOs can specifically inhibit the expression of multiple miRNAs, and effectively antagonize proliferation and migration of gastric cancer cells promoted by oncomirs.
Preparation and properties of Joule thermal effect self-healing polyurethane
Xu Qi,Liu Yang,Chen Yu,Zhang Zhaoyang,Wei Yan Yan 한국탄소학회 2022 Carbon Letters Vol.32 No.1
Carbon nanotubes (CNTs) were added into the self-healing polyurethane materials as conductive filler, the mass fraction of carbon nanotubes was adjusted, and 1% polyaniline was doped. The conductive self-healing polyurethane composites with different carbon nanotubes content (PU)-1/3/5/8/10 were prepared, and analyzed and tested. The result shows that the permeability threshold value of the composite material is 8wt%, and the comprehensive performance of the composite material PU-8 is the best; the resistance of PU-8 is 1278Ω, PU-8P has a resistance of 1400Ω; using an infrared camera, it can be seen that the material can reach 143.3 °C under the DC current of 0.1A, reaching the temperature condition when the material is repaired; the swelling test shows that the PU-8P equilibrium swelling rate is 177%, the gel content is 52.67%, and there is no dissolution in dimethyl sulfoxide. Solvent stability is better than PU-8;DSC test shows that the glass transition temperature of the soft segment of PU-8P is 43 °C, and the glass transition temperature of the hard segment is − 55 °C, which is not much different from that of PU-8; TG test shows that the epitaxial starting temperature of PU-8P is 365 °C; the observation photo is magnified by a stereo microscope at ten times and the PU-8P sample is cut of in the middle at room temperature, applying a constant voltage of 30 V, the cracks disappeared. The material cracks realized self-healing with electricity, and the repair efficiency reached 20.5%.
Wei Zhu,Jiahong Liu,Kuanxiang Shi,Fei Qi,Huiping Shen,Zhu Xu,Zhilong Ma 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9
This paper proposes a three degree-of-freedoms (DOFs) cable-driven parallel robot (CDPR), which is actuated by three groups of parallel cables and tensioned by an elastic telescopic rod with a passive spring. Firstly, the architecture of the robot is briefly illustrated with emphasis on the three parallelogram arrangements of the cables and composition of elastic telescopic rod structure. This robot has larger workspace and greater tension than previous under-constrained CDPRs. Secondly, the kinematic and dynamic models of the robot are established. On this basis, the parameters of the spring installed in the telescopic rod are optimized and determined considering both the acceleration and cable force through using the differential evolution (DE) algorithm. Thirdly, dynamic stability analysis of the robot under impulsive disturbances is performed according to the Gauss principle of least constraint (GPLC). The results of a simulation case show that this robot has better dynamic stability in comparison with conventional under-constraint CDPR because of the presence of the elastic telescopic rod. The measurement results in the workspace are obtained through dynamic simulation. Finally, the experiments are performed based on numerical simulation. The feasibility of the CDPR is verified via the experiments and simulations.
Study on Precision Grinding of Screw Rotors using CBN Wheel
Wei, Jing,Zhang, Qi,Xu, ZheZhu,Lyu, Sung-Ki 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.5
With increasing demands for high-speed and high-precision machining technology, CBN shape grinding is an effective means in the field of precision machining for screw rotors. Aiming at the high precision machining of screw rotors, a mathematical model for the axial profiles of the CBN wheel for machining screw rotors is developed based on theory of gear engagement. Small electroplated CBN wheel is firstly used to grinding screw rotors. Taking the backlash of screw rotors and the coating thickness of CBN layer into consideration, the modification of the base body of the wheel shape is introduced into the design of CBN wheel. For reducing the tooth profile errors of screw rotors induced by mounting errors and wears of CBN wheel, a mathematical model of the error analyses is established and the influence curves of the profile errors affected by mounting errors and radius error of grinding wheel are proposed. The electroplated CBN wheels for the screw rotors are made to verify the validity and effectiveness of the presented method and the machining experiments were performed. Results of this study reveals that the method proposed in this paper can be used as the precision grinding of screw rotors.
Xu Zhang,Zeyong Wei,Yuancheng Fan,Limei Qi 한국물리학회 2017 Current Applied Physics Vol.17 No.6
A reflective metamaterial polarization transformer (RMPT) is proposed with closed fish-scale structure for high efficient cross-polarization reflection. The maximum efficiency of cross-polarization reflection for normal incidence is 97.2%. The RMPT maintains good performance for incident angles up to 25, and the RMPT is not restricted to a specific polarization state of the incident wave. Furthermore, the designed RMPT shows excellent structural tunability by optimizing the structural parameters, which makes it userfriendly.
Chuan-Wei Zhang,Fang-Yi Li,Jianfeng Li,Qi Xie,Jie Xu,An-Fu Guo,Cheng-Zhao Wang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.3
Starch-based biomass composites were prepared with starch and plant fiber. In order to improve the properties of the compos ites, oxidized starches (OS) were prepared using hydroxyl peroxide as oxidizer, then glycerol was added into OS as plasticizer to produce thermoplastic oxidized starches (TPOS). Crystal structure, hydrogen bonds of TPOS were researched to gain comprehensive views on the mechanism of the property differences between the starch-based composites with native starch, OS and TPOS. The changes of crystal structure were analyzed by X-ray diffraction analysis. Starch intermolecular hydroxyl changes were investigated using the method of infrared spectrum analysis. It was found that the new hydrogen bonds were formed between the plasticizer, oxidizer and starch, and the starch intermolecular bonding force was weakened. The structure of starch crystallization was destructed in TPOS. Differential scanning calorimetry showed that cross reaction with oxidization and plasticization changed the crystal structure, glass transition process was not observed in TPOS. The tensile and compressive strengths of composite based on TPOS were improved greatly and mechanical properties were not weakened obviously with water content increased. All the results indicated that TPOS could improve the properties of starch-based composites.