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- 저자 : Qi Yao (검색결과 80 건)
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Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.
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THE IMPACT OF TOURISM DESTINATION IMAGE AND TOURISTS’ SELF-CONCEPT CONGRUITY ON INTENTION TO VISIT
Qi Yao,Dan Zhang,Guoqun Fu 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
This paper selects Xi'an and Suzhou as the research objects, uses the methods of questionnaire and situational simulated method to discuss the impact of tourists' perceived destination image and self-concept congruity on intention to visit, and the moderating effect of self-construal (independent / interdependent). The Study I found the following results: the tourists' perceived destination image and self-concept congruity as well as the self-concept congruity dimensions (actual self-concept congruity, ideal self-concept congruity, social self-concept congruity, ideal social self-concept congruity) have a significant positive effect on intention to visit; the impact of ideal self-concept congruity is greater than that of actual self-concept congruity; the impact of ideal social self-concept congruity is greater than that of social self-concept congruity; and the ideal self-concept congruity has strongest impact on intention to visit. The Study II found out that: self-construal has moderating effect on this impact; the higher the actual self-concept congruity perceived by the tourists of independent self-construal, the greater the intention to visit; the higher the social self-concept congruity perceived by the tourists of interdependent self-construal, the greater the intention to visit. The research conclusion has certain reference value for building of tourism destination image, understanding of the tourism decision-making of the tourists and formulation and implementation of marketing strategies of relevant departments and enterprises.
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Qi Fei-Yan,Zhu Zhou-Hai,Li Meng,Guan Ying,Peng Qi-Yuan,Lu She-Ming,Liu Zhi-Hua,Wang Ming-Feng,Miao Ming-Ming,Chen Zhang-Yu,Li Xue-Mei,Bai Jie,Yao Jian-Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.11
Background: Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear. Objective: This study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population. Methods: The haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293. Results: Significant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X2 = 4.611, 1 df, p = 0.032) and strong cigarette smoke flavor intensity preference (X2 = 4.5383, 1 df, p = 0.033) in participants. Furthermore, in the in vitro cellular calcium assay, total particle matter (TPM), N-formylnornicotine and cotinine, existing in cigarette smoke, activated TAS2R38-PAV but not TAS2R38-AVI-transfected cells. Conclusion: Our data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.
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Yao-Dong Wu,Qi-Qi Wang,Meng Wang,Hany M. Elsheikha,Xin Yang,Min Hu,Xing-Quan Zhu,Min-Jun Xu 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.2
Haemonchosis remains a significant problem in small ruminants. In this study, the assay of recombinase polymerase amplification (RPA) combined with the lateral flow strip (LFS-RPA) was established for the rapid detection of Haemonchus contortus in goat feces. The assay used primers and a probe targeting a specific sequence in the ITS-2 gene. We compared the performance of the LFS-RPA assay to a PCR assay. The LFS-RPA had a detection limit of 10 fg DNA, which was 10 times less compared to the lowest detection limit obtained by PCR. Out of 24 goat fecal samples, LFS-RPA assay detected H. contortus DNA with 95.8% sensitivity, compared to PCR, 79.1% sensitivity. LFS-RPA assay did not detect DNA from other related helminth species and demonstrated an adequate tolerance to inhibitors present in the goat feces. Taken together, our results suggest that LFS-RPA assay had a high diagnostic accuracy for the rapid detection of H. contortus and merits further evaluation.
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SERVICE TYPE AND CUSTOMER PRIVACY CONCERNS AFFECT ROBOT ADOPTION INTENTIONS
Qi Yao,Chao Hu,Wenkai Zhou 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
The proliferation of service robots has led to a growing concern about the impact of these technological advancements on privacy. Despite the development, quantitative research on the influence mechanism of privacy concerns on service robot adoption intentions is still limited. This research explores the influencing mechanism and boundary conditions of the interaction effect between customer privacy concerns and service type on customers’ service robot adoption intentions.
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BtPDR: Bluetooth and PDR-Based Indoor Fusion Localization Using Smartphones
( Yingbiao Yao ),( Qiaojing Bao ),( Qi Han ),( Ruili Yao ),( Xiaorong Xu ),( Junrong Yan ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.8
This paper presents a Bluetooth and pedestrian dead reckoning (PDR)-based indoor fusion localization approach (BtPDR) using smartphones. A Bluetooth and PDR-based indoor fusion localization approach can localize the initial position of a smartphone with the received signal strength (RSS) of Bluetooth. While a smartphone is moving, BtPDR can track its position by fusing the localization results of PDR and Bluetooth RSS. In addition, BtPDR can adaptively modify the parameters of PDR. The contributions of BtPDR include: a Bluetooth RSS-based Probabilistic Voting (BRPV) localization mechanism, a probabilistic voting-based Bluetooth RSS and PDR fusion method, and a heuristic search approach for reducing the complexity of BRPV. The experiment results in a real scene show that the average positioning error is < 2m, which is considered adequate for indoor location-based service applications. Moreover, compared to the traditional PDR method, BtPDR improves the location accuracy by 42.6%, on average. Compared to state-of-the-art Wireless Local Area Network (WLAN) fingerprint + PDR-based fusion indoor localization approaches, BtPDR has better positioning accuracy and does not need the same offline workload as a fingerprint algorithm.
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Qi Dong,Dan Zu,Lingqiang Kong,Sunfang Chen,Jun Yao,Jiawei Lin,Lei Lu,Bing Wu,Bin Fang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3
Background: Hydrogels loaded with antimicrobial agents have been widely used for treating infected wound defects. However, hydrogels derived from a porcine dermal extracellular matrix (PADM), containing silver nanoparticles (AgNPs), have not yet been studied. Therefore, we investigated the therapeutic effect of an AgNP-impregnated PADM (AgNP–PADM) hydrogel on the treatment of infected wounds. Methods: An AgNP–PADM hydrogel was synthesized by embedding AgNPs into a PADM hydrogel. We examined the porosity, moisture retention, degradation, antibacterial properties, cytotoxicity, antioxidant properties, and ability of the PADM and AgNP–PADM hydrogels to treat infected wounds in animals. Results: The PADM and AgNP–PADM hydrogels were pH sensitive, which made them flow dynamically and solidify under acidic and neutral conditions, respectively. The hydrogels also exhibited porous network structures, satisfactory moisture retention, and slow degradation. Additionally, the AgNP–PADM hydrogel showed a slow and sustained release of AgNPs for at least 7 days without the particle size changing. Thus, the AgNPs exhibited adequate antibacterial ability, negligible toxicity, and antioxidant properties in vitro. Moreover, the AgNP–PADM hydrogel promoted angiogenesis and healed infected skin defects in vivo. Conclusions: The AgNP–PADM hydrogel is a promising bioderived antibacterial material for clinical application to infected wound dressings
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Migraine Susceptibility Genes in Han Chinese of Fujian Province
Qi-fang Lin,Zi-chun Chen,Xian-guo Fu,Jing Yang,Luo-yuan Cao,Long-teng Yao,Yong-tong Xin,Gen-bin Huang 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.1
Background and Purpose Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population. Methods This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction—restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients. Results The frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05). Conclusions Our findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.
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