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RISS 인기검색어
- 검색키워드
- 저자 : Luo-yuan Cao (검색결과 3 건)
- 무료
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XPC 939A>C and 499C>T Polymorphisms and Skin Cancer Risk: a Meta-analysis
Ji, Geng,Lin, Yuan,Cao, Song-Yu,Li, Luo-Zhu,Chen, Xin-Long,Sun, Bu-Mei,Chen, Chuan-Jun,Ma, Hong-Xia Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.
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Commutation Torque Ripple Suppression in Three Phase Brushless DC Motor Using Open-end Winding
Qi Huang,Ling Luo,Yuan Zhang,Jichao Cao 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.8
Three phase brushless DC motor has the characteristics of high power density, simple structure and excellent speed regulation performance, which is widely used in the field of electric drive. Open-end winding brushless DC motor has no neutral point, and each phase winding is electrically isolated, which can realize the independent control of each phase winding. Compared with Y-connected brushless DC motor, the open-end winding brushless DC motor has a wider range of speed regulation under the same voltage, and has certain fault-tolerant performance, which is suitable for the application of low voltage and large current. Compared with the multiphase fault-tolerant motor, open-end winding brushless DC motor has simpler structure and higher winding utilization rate. However, the open-end winding brushless DC motor still has torque ripple, among which the cogging torque is related to the motor body structure, while commutation torque ripple is affected by the mutual inductance ofthe winding and the current freewheeling loop. The commutation process of the open-winding brushless DC motor is analyzed, and it is concluded that the current change rates of the turn-off phase and turn-on phase are equal under the ideal back electromotive force(back-EMF), which can ensure that the non-commutation phase current and the electromagnetic torque kept constant. The overlapping commutation with phase current closed-loop method is proposed to suppress the commutation torque ripple of open-end winding BLDC motor, and the applied voltage on turn-off phase and delayed time of turn-off phase in overlapping commutation are derived, the sliding mode observer is used to calculate the electromagnetic torque. MATLAB simulation and experimental results verify the effectiveness of this method.
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Migraine Susceptibility Genes in Han Chinese of Fujian Province
Qi-fang Lin,Zi-chun Chen,Xian-guo Fu,Jing Yang,Luo-yuan Cao,Long-teng Yao,Yong-tong Xin,Gen-bin Huang 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.1
Background and Purpose Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population. Methods This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction—restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients. Results The frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05). Conclusions Our findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.
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