Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

Variation of Bird community and Habitat use after Developing Hangang river Ecological Learning Center

Paik, In-Hwan,Jin, Seon-Deok,Jeon, Byung-Seon,Yu, Jae-Pyoung,Park, Chi-Young,Paek, Woon-Kee national science museum of korea 2010 Journal of Korean nature Vol.3 No.4

The Hangang (Han River) Ecological Learning Center is a river ecosystem park which was completed in December of 2002. The river ecosystem park was created based on the understanding of the problems of standard park-formed river which centers around convenient facilities instead of on the wish to accentuate the innate unique characteristics of a river. Therefore, the study was conducted in order to analyze the changes and habitation usage of the avifauna in the Hangang Ecological Learning Center to provide basic information for the improvement of bird species diversity in an ecosystem park. The study was conducted in July and October of both 2003 and 2005 to study the avian colonies of the same time period, and the habitat usage of four different areas were examined. Main dominant species includes species which preferred waterside and grassland, and 2005 showed higher levels of species, bird count and number of migratory birds. Furthermore, among the four regions used as habitats, the confluence region showed the highest level of increase, and this is predicted to have caused by the shallow depth of the confluence and the stability of the waterside plant colonies.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

악성림프종 환자에서 복합화학요법으로 유발된 백혈구 감소증에 대한 인형 재조합 과립구 집락형성-촉진인자(rhG-CSF: Neutrogin)의 효과

박성규,전진우,기신영,유병우,김홍수,백승호,원종호,홍대식,박희숙 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Clinical effects of rhG-CSF were investigated in 17 patients receiving chemotherapy for non-Hodgkin's lymphoma. Patients were given G-CSF 2㎍/㎏/day after 2nd cycle chemotherapy for least 14 consecutive days, and clinical and laboratory results were compared to results of the first cycle. Treatment with G-CSF resulted in increase of mean WBC count(952.9±152.2㎜³vs 1882.4±350.4/㎜³) and neutrophil count(212.9±53.0/㎜³vs 841.5±238.0/㎜³), reduced the duration of leukocytopenic days(12.4±1.3 days vs 5.5±1.0 days, WBC count less than 4000/㎜³) and neutropenic days(4.5±0.9 days vs 2.3±0.7 days, neutrophil count less than 500/㎜³), and reduced the duration of neutropenic fever(5.8±1.1 days vs 0.9±0.5 days). The side effects of G-CSF were not so significant. These results demonstrated that G-CSF is safe and useful for the treatment of neutropenia induced by anticancer chemotherapy of non-Hodgkin's lymphoma and reducing the incidence of febrile periods and duration of antibiotic administration.

림프부종 치료프로그램이 림프부종이 있는 말기 암 환자의 사지둘레와 신체증상에 미치는 영향

박명희,허수진,최은미,정유니 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was performed to investigate the effects of lymphedema treatment program on extremities circumference and physical symptoms in terminal cancer patients with lymphedema. Method: The subject was 13 patients diagnosed with lymphedema and admitted to C Hospital, hospice unit from March 1 to August 31, 2004. The effects of treatment were evaluated by measuring extremities circumferernce and by assessing physical symptons. Data were analyzed by using repeated measures ANOVA, Scheffé multiple comparisons. Result: The results were as follows: Extremities circumference was reduced significantly 30.8cm after last treatment compared with 33.4cm pre-treatment. Physical sysptom, 'heaviness' was improved significantly 4.2 after last treatment compared with 7.8 pre-treatment and difficulty to mobility was improved significantly 4.5 after last treatment compared with 7.4 pre-treatment. Conclusion: These findings indicate that lymphedema treatment program could be an effective nursing intervention for reducing extremities circumference and improving physical symptoms in terminal cancer patient.

포도재배용 봉지제조 기술개발 : 종이의 구조적 특성이 광 투과에 미치는 영향

유병철,이진호,이장호,박종문 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

양방향 요소제거법을 이용한 신뢰성 기반 최적설계

유진식,박재용,황승민,임민규,오영규,한석영 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This research presents a Reliability-Based Topology Optimization (RBTO) using Bi-directional Evolutionary Structural Optimization (BESO). An actual design involves uncertain conditions such as material property, operational load and dimensional variation. Deterministic Topology Optimization (DTO) is obtained without considering of uncertainties related to the uncertainty parameters. However, RBTO involves evaluation of probabilistic constraints, which can be done in two different ways, the reliability index approach (RIA) and the performance measure approach (PMA). The reliability index approach (RIA) and the performance measure approach (PMA) are adopted to evaluate the probabilistic constraints. In order to apply the BESO method to the RBTO, sensitivity number is defined as the change in the reliability index due to the addition or the removal of the ith element. In the BESO, a mesh-independency filter using nodal variables is used to remove the checkerboard patterns. The optimal topologies of RIA and PMA are obtained very similarly. It is shown that RBTO based on BESO can be effectively applied from the presented examples.

Triazole계 건묘육성제 처리가 '삼복꿀' 수박의 유묘생장에 미치는 영향

박유진,강봉화,정기윤,이정명 경희대학교식량자원개발연구소 2006 硏究論文集 Vol.25 No.-

수박의 시설재배 육묘 시 일조량이 부족하여 도장, 과번무가 필연적으로 발생하므로 이에 대한 생장억제물질의 이용도 폭넓게 실용화되고 있다. 본 실험은 수박 품종 중 가장 대표적으로 재배되는 삼복꿀 품종을 접목묘와 무접목묘로 나누어 triazole계 건묘육성제의 처리 방법, 처리 회수, 처리 농도에 따른 반응성을 비교하였는데 공시 물질로는 triazole계 살균제로 국내에 등록된 빈나리(diniconazole)와 Bonzi(paclobutrazol)을 유묘에 살포와 토양주입 처리하였다. 빈나리의 경우 토양주입처리보다 살포처리가 더 효과적이었고 Bonzi는 두 처리 수준 모두에서 강한 왜화 효과를 나타냈다. 처리 회수에 따른 반응성은 1회 처리만으로 충분하였으며 2회 처리는 왜화 효과가 지나치게 강하게 나타났다. 이러한 경향은 무접목묘나 접목묘에서 거의 유사하였다. 건묘육성제의 종류로는 농도조절만 적합하다면 어느 것이라도 소정의 건묘육성 효과를 거둘 수 있었는데 빈나리는 본엽 3~4매시 25 mg·L^(-1) 수준으로, 그리고 Bonzi는 5 mg·L^(-1) 수준으로 엽면살포하는 것이 가장 적절하였다. Use of commercial plug seedlings has been markedly increased in recent years with development of mechanized production systems. However, plug seedlings are prone to overgrow because of the short period maintaining the healthy seedling character when grown in small-volume cell. The triazole bioregulators are registered primarily as fungicides, even though some of them have been used as plant bioregulators due to the remarkable growth inhibitory effects. Spray treatments of diniconazole and paclobutrazol suppressed growth of watermelon seedlings especially when treated at earlier stages. The higher the treatment concentration, the stronger the growth retarding effect, in general. Foliar spray of diniconazole at 25 mg·L^(-1) was recommended for proper growth suppression in both grafted and non-grafted watermelon seedlings, while soil injection method was less effective. On the other hand, paclobutrazol at 5 mg·L^(-1) was effective in spray treatment and 25 mg·L^(-1) for soil treatment.

한국형 노인주거개발을 위한 이론적 고찰

박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.