관상동맥 시술 도중 발생한 좌주간부 관상동맥 박리에 대한 스텐트 삽입 치료의 단장기 임상 결과 : acute and long-term results

이세환,이승환,홍명기,김영학,이철환,한기훈,송종민,강덕현,송재관,김재중,박성욱,박승정 대한내과학회 2004 대한내과학회지 Vol.66 No.6

목적 : 심도자 사용 시술과 관련된 좌주간부 관상동맥박리에 대한 적절한 치료는 아직 확실히 정립되지 않은 상태이다. 이에 본 연구는 좌주간부 관상동맥 박리에 대한 스텐트 삽입술의 단장기 임상결과를 후향적으로 분석하였다. 방법 : 좌주간부 관상동맥 박리에 대한 치료로 즉각적인 스텐트 삽입술을 시행하는 것이 안전하고 효과적인 방법임을 가설하였고, 이러한 즉각적인 스텐트 삽입을 시행한 10명의 환자를 대상으로 단장기적 임상경과를 의무기록 고찰과 전화 면담을 통해서 평가하였다. 결과 : 전체 환자 모두 처음부터 좌주간부 관상동맥에 유의한 협착을 가진 환자는 없었으며, 8명의 환자는 심도자의 조작으로 인한 박리가 발생한 경우였고(진단적 혈관 조영술 중에 3명, 유도 도자 조작 중에 5명), 나머지 2명은 다른 병변에 스텐트 삽입시술을 하는 중에 박리가 발생하였다. 이 10명의 환자에서 모두 즉각적인 스텐트 삽입술이 시행되었고, 4명의 환자에서 시술 도중 혈압 저하로 Intra-aortic Ballon Pump (IABP)를 장착하였다. 모든 환자에서 성공적으로 스텐트가 삽입되었고, 병원내 사망은 1명도 없었다. 6개월 추적 관상동맥 조영술은 8명의 환자에서 시행되었다. 혈관 조영상의 재협착(직경 협착 50% 이상)은 8명 모두에게서 관찰되지 않았으며, 퇴원 후 평균 31±25개월의 추적관찰 결과 주요 심장사건은 1건도 발생하지 않았다. 결론 : 비록 대상 환자가 적은 연구였지만 좌주간부 관상동맥 박리에 대한 스텐트 삽입술은 기술적으로 안전하고 빠르게 시행 할 수 있으며, 훌륭한 단장기적인 치료 효과를 보여준다. Background : The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter-based procedure remains uncertain. We retrospectively analyzed the acute and long-term results of bail-out stenting for LMCA dissection. Methods : In cases with significant LMCA dissection occurring during catheter-based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome. We evaluated the acute and long-term results of bail-out stenting for LMCA dissection occurring during catheter-bases procedure in 1- patients. Results : Initially, there was significant stenosis of LMCA segment in these patients. Catheter-induced dissection occurred in 8 patients (during diagnostic angiography in 3 patients and guiding catheter manipulation in 5 patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail-out stenting LMCA dissection was performed in a total of 10 patients. In 4 patients, hypotension developed and intra-aortic balloon pump was placed during procedure. Stents were successfully deployed in all patients. There was no in-hospital mortality. Six-month angiographic follow-up was performed in 8 patients. Angiographic restenosis(diameter stenosis 50%) was not observed in all patients at follow-up study. During a mean follow-up of 31±25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization). Conclusion : Bail-out LMCA stenting is technically feasible, and showed good acute and long-term results in a small series of patients.

엉겅퀴(Cirsium japonicum var. ussuriense KITAMURA)의 조직배양에 의한 식물체의 재분화

강호종,박상현,박기관,김재환 진주산업대학교 1993 論文集 Vol.32 No.-

To examine proper part and medium in in-vitro culture shoot formation of in-vitro Crisium japonicum var. ussurinese KITAMURA, the test was carried out. The results are as follow: The wsa good in differentiation of the plant on the medium was good in MS+BA 10.0+Ki 10.0㎎/ℓ. In the results of formation and roots formation, proper medium was MS+Ki 0.1/ℓ. The case of MS+Ki 0.1㎎/ℓ was much no of shoots, ratio of roots, no of roots, also was good on growth.

Expression Profiles of Retinoblastoma Protein and p27Kip1 According to HER2 Amplification Status in Primary Breast Cancer

신재호,Sung-Jin Park,Hyun-Jin Cho,Geumhee Gwak,Byung-Noe Bae,Ki Whan Kim,Hong-Yong Kim2,Kyeongmee Park,Sehwan Han 한국유방암학회 2009 Journal of breast cancer Vol.12 No.1

Purpose: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to investigate whether retinoblastoma protein (pRB) and p27Kip1 were differently expressed according to the HER2 amplification status in human breast cancer. Methods: HER2 amplification was assayed by fluorescence in situ hybridization and the expression of cell cycle regulators were assayed by immunohistochemistry on 153 consecutive invasive breast cancers. The proliferative activity of breast cancer was analyzed according to the HER2 amplification and cell cycle protein expression status. Results: HER2 amplification was observed in 39 (25.5%) of 153 breast cancers. In the HER2 amplified breast cancers, the pRB expression was significantly increased (p=0.011) whereas there was no significant relationship between HER2 amplification and p27Kip1 expression. There was an inverse correlation between pRB expression and Ki-67 labeling index in the HER2 amplified breast cancers (p=0.036). In contrast, Ki67 labeling index was significantly decreased as p27Kip1 expression increased in HER2 non-amplified breast cancers (p=0.028). In HER2 non-amplified breast cancers, we could not observe any association between the pRB expression and Ki67 labeling index. Conclusion: The proliferation of the breast cancers was associated with pRB expression in HER2 amplified tumors whereas it was associated with p27Kip1 expression in HER2 non-amplified tumors. The results of the current study indicate that the cell proliferative activity of the breast cancer is under different growth signal pathways according to HER2 amplification status.

로케트 工學에 관한 硏究 : 第1報 : 亞音速 亂流流動에서 飛行翼模型의 剝離現象 Ⅰst Report : Separation of Airfoils in Subsonic Turbulent Flow

朴煥奎,金鍾一,金鎭興,李茂錫,朴吉文,鄭洛奎,李行男,李東起 조선대학교 동력자원연구소 1984 動力資源硏究所誌 Vol.6 No.2

Separation, pressure and velocity distributions were studied fully developed two dimensinonal, incompressible flow over a flat airfoil in subsonic wind tunnel. Velocity and turbulence were measured with a two channel constant temperature hot wire anemometer and pressure with a pitot tube and pressure tranducer system. The experimental results were obtained as follow: (1) Turbulent intensity of shear layer just outside the separation point is considered to affect the size of separation bubble. (2) Static pressure coefficient is separated into three regions according to its value change. (3) Separation point is varied with the change of attack angle. (4) Velocity distributions and boundary layers normal to airfoil surface are changed as variation of attack angle of airfoil.

천이금속 표면에서의 수소의 동력학 : 수소의 화학 흡착, 방출, 확산에 관하여

손기수,박동수,최상돈,김석환,김영주 慶北大學校 物理化學硏究所 1986 硏究論文集 Vol.7 No.-

S.M. Ko, L.D. Schmidt 등에 의하여 제시된 표면의 bulk내의 원자, 진공 근처 표면에서의 분자의 존재, 그리고 T. Engel, U. Kuipers 등에 의해서 제시된 진공과 bulk 사이에서의 분자와 원자간의 상호 변환 가설을 합쳐 진공과 접한 표면의 단 원자층에 화학흡수층을 설정하여 새로운 model을 만들었고, 이 model에 의하여 표면과 bulk 및 진공 사이에 일어나는 모든 과정 즉 표면과 bulk 사이의 difussion과 adsorption, 화학 흡수층에서 분자가 dissociation 과정을 거쳐 표면에 adsorption 되거나, recombination 과정을 거쳐 분자로 desorption 하는 과정등을 모두 설명할 수 있는 결과를 얻었다. 나아가서 평형 상태하의 표면 fraction과 화학 흡수층내의 분자의 시간분포, desorption하는 분자들의 시간 분포함수를 얻었다. 온도에 대해 peak amplitude와 log(θ/1-θ)의 값을 얻어서 실험치와 비교했으며, 수소원자의 desorption fraction을 얻었다. Proposing a new model which includes two states model and chemisorption layer right above the surface atomic layer which interrelates the atoms in bulk and the molecules in vacuum, the diffusion from the surface to bulk, adsorption on surface from chemisorption layer and desorption from chemisorption layer are explained. We also get the distribution of molecules versus time at the chemisorption layer, log(θ/1-θ), and atomic peak amplitude on surface versus the reciprocal temperature on equilibrium condition. These results are turned out to be good results. Furthermore by the use of above results, we derive the desorbing fraction as a linear function of inverse temperature.

태풍 Vera 통과시 남해에서의 파랑추정

전기천,강시환,박광순,김상익 경남대학교 환경문제연구소 1990 환경연구 Vol.12 No.-

최근 한반도를 통과했던 태풍 중 그 규모가 커서 海上에서 발생된 颱風波浪에 의해 특히 남해안 지역에 큰 재해를 준 1986년 태풍 Vera(8613)호 통과시에 南海의 거문도와 거제도 海上에서 동시에 태풍파랑을 관측하였다. 관측된 태풍파랑의 재현을 위하여 유럽의 북해를 대상으로 최근 연구개발된 Hybrid Parametric Wave Model(HYPA)을 적용하여 Vera 통과시의 파랑분포를 수치적으로 계산하였으며, 그 계산결과를 관측치와 비교하였다. 또한 태풍파랑의 추정에 주로 사용되어온 Wilson모델의 결과와도 비교하여으며, HYPA모델의 결과가 Wilson모델에 비해 훨씬 관측된 파랑자료에 근접함을 보였다. 따라서 본 연구를 통해서 한반도 근해상에서 발생되는 태풍파랑의 예측과 추정에 있어 HYPA모델에 매우 정확함을 보여주었다. During the passage of Typhoon Vera(8613) which causes the heavy natural disasters, especially, on the southern coast of Korea, waves were simultaneously measured at two different locations of the South Sea, that is, near to the Geomun and the Geoje Islands. In order to reproduce the measured typhoen-waves, Hybrid Parameteric Wave Model(HYPA) which has been developed for the North Sea was adopted to calculate numerically the waves generated by the Typhoon Vera. The model results were jilter-compared with the measured waves, and also with the results of Wilson model which has been widely used for the hindcast of typhoon-waves. HYPA's results show in the closer ageement with the measured waves than those of Wilson's. Based on these comparisons, HYPA model can be used for more accurate forecast and hindcast of typhoon-waves in Korean Seas.

천이금속 표면에서의 수소 흡입의 동력학 : 수소흡착, 방출과 확산에 관하여

손기수,박동수,최상돈,김석환,배준규 慶北大學校 物理化學硏究所 1986 硏究論文集 Vol.7 No.-

천이금속(Nb) 표면에 수소의 두 상태는 R.J. Smith에 의해 암시되어 왔다. 우리는 이것을 받아들여 천이금속 표면에 두 개의 상태를 가정하여 몇 개의 경우의 potential barrier에 관해 charging과 degassing 조건하에서 수소원자의 fraction의 시간에 대한 변화율을 얻었다. 그리고 수소의 표면 fraction θ에 대해 온도와 log(θ/1-θ)의 비와 peak amplitude를 구하여 R.J. Smith팀의 실험결과와 비교했으며 그것을 이용해서 온도에 관한 desorption rate를 얻었다. It was known by R.J. Smith that there are two kinds of surface states on transition metal(Nb) surfaces. Furthermore for all metals desorption energy is larger than the solution energy. Here we present a model for hydrogen absorption of metal surfaces and then obtained the time rates of hydrogen charging and degassing on metal surfaces for few limiting cases. We also get log(θ/1-θ) versus the reciprocal temperature and peak amplitude of surface fraction versus the temperature, turned out to be good agreement with experiments. Finally we get the desorption fraction of hydrogen atom.

탈지 환원유에서 Bifidobacterium longum의 호기성 고농도 배양에 관한 연구

구동환,하상우,조수현,박기문,김동운,강국희 성균관대학교 생명과학자원연구소 1997 生命資源科學硏究 Vol.4 No.1

The objectives of this study were to investigate the optimal condition for growth and highly concenterated culture of Bifidobacterium longum (Bif longum). The effects of additives were compared with titratable acidity and viable cell counts, and 10% reconstituted skim milk (no additive) was used as a control. Correlation coefficient for the growth of Bif. longun between CO_2 anaerobic jar method and overalaid medium method was R=0.99. When 1% Bif. longurn was inoculated on 12%, 14%, and 16% reconstituted skim-milk, viable cell counts were 8.60, 8.89, and 8.93 Log CFU/ml, respectively. When Lactose, Glucose, Glucosamine, Fructose, Peptone, N-acethyl-D-glucosamine, D-galactose, and liver extract were added to 16% reconstituted skim-milk, the viable cell counts were 8.61, 9.05, 9.15, 9.24, 8.82, 9.75, 9.17, and 9.64 Log CFU/ml, respectively. Therefore, D-galactose, liver extract, and N-acethyl-D-glucosamine were selected as final additives. When Bif longum was inoculated on Fermentor-I (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% D-galactose and 0.5% liver extract), Fermentor-II (16% reconstituted skim milk containing 0.190% yeast extract, 0.590% N-acethyl-D-glucosamine and 0.5% liver extract), Batch culture-I (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% D-galactose and 0.5% liver extract), and Batch culture-II (16% reconstituted skim milk containing 0.1% yeast extract, 0.5% N-acethyl-D-glucosamine and 0.5% liver extract), viable cell counts were 10.46, 9.37, 9.03, and 8.83 Log CFU/ml, respectively. Although liver extract was the important additive for the highly concentrated culture of Bif. longum in this study, it caused serious off-flavor when liver extract-1 (contained cell mass) was added to Fermentor culture. However, flavor was improved when liver extract-2 which was removed cell mass, was used instead of liver extract-1. Addition of 2% liver extract-II and 1% D-galactose had the similar effect with addition of 0.5% Liver extract-I and 0.5% D-galactose on the growth of Bif. longum.

Fenitrothion의 생체내 분포 및 잔류성에 관하여

이상기,인상환,박윤식,정영호,구기서 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

建築工業敎育科 敎育改善에 관한 硏究 : 敎育課程을 中心으로 Focused on the development of curriculum

李昌甲,朴萬植,延吉煥,崔武革,李基男 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

Due to the radical change of society and the technological innovation, it is inevitable to rearrange the educational objective of the Department of Architectural Engineering Education and to reorganize the curriculum responding to the objective. In this study, all the current curricula of architectural institutions have been analized to identify problems, and the educational objective of the department of architectural engineering education have been established based on the objective of the College of Industrial Education. As the result of the above studies, the model curriculum for the major subjects have been developed in order to have following characteristics. 1. The required subjects were limited to the basic fields in order to cover the education in the technical high school. 2. The elective subjects were organized into three fields, namely, architecture, structural engineering, and building materials and construction to meet the diversified demands to a possible maximum extent.