한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

대전에서 연중 태양광선의 UVA와 UVB양에 대한 조사 (예비보고)

박장규,김경훈,이우재,서기범 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Ultraviolet A(355 nm) and ultraviolet B(290 nm) doses were measured at Taejon from March to September, 1993, on four different weather conditions(clear, relatively clear, relatively cloudy and cloudy). And the results were compared with the doses of Kongju area measured in 1985. The followings were the summary of the findings. 1. UVA(1.98± 0.35 × 10 exp(-3) w/㎠) and UVB(17.62+ 5.72 X 10 exp(-6) w/㎠ doses were peak at noon on clear weather. 2. Average doses of UVA(2.36±0.70 × exp(-3) w/㎠) and UVB(24.28±8.83 × exp(-3) w/㎠) were peak at noon in August on clear weather. 3. The doses of UVA and UVB were influenced by yellow sand, fog and other pollutants. 4. The doses of UVA on clear weather in Daejoen were lower than Kongju about 40%, in contrast those of UVB were not different in statistical values.

궤환선형화와 LMI기법을 통한 PMSM의 H₂/H∞제어에 관한 연구

장우영,박승규 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

The purpose fo this paper is to obtain the mixed H₂/H∞controller for the PMSM which is nonlinear system. The mixed H₂/H∞control problem of the nonlinear system requires the coupled Hamitonian-Jacobi-Isaacs equations. And it is not easy to obtain the solutions. So we change this problem to the LMI(Linear Matrix Inequality) condition by using feedback linearization.

HgCdTe광다이오드에서 고정전하와 계면전하가 터널링 전류에 미치는 영향

박장우 순천대학교 공업기술연구소 1995 工業技術硏究所論文集 Vol.9 No.-

In this paper, we investigate the contribution of the fixed charge in passivation layer and the HgCdTe/passivation layer interface charge to the current-voltage characteristics of HgCdTe photodiode. If there is the assumption that these charges serve as a gate of the gate-controlled diode, it can be expected that they change a depletion width and an electric field of n^+-p junction. Because the changed junction field has and effect on the tunneling current, which is sensitively dependent on electic filed, the total current, after all, is influenced by these charges, In this paper, the modeling method of these charge contribution to the current-voltage characteristics and the results are presented. The method and results proposed in this paper can't exactly describe experimental results but may be helpful in understanding the effect of these charge on the electic characteristics of the device.

만성질환자에서 인풀루엔자 예방 접종의 효능 분석 : 후향적 환자-대조군 연구

박승철,정희진,손장욱,최선주,엄중식,우흥정,천병철,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.4

목적: 인플루엔자는 예방접종을 통하여 효과적으로 예방이 가능한 대표적인 호흡기 감염질환이다. 미국이나 국내의 인플루엔자 예방접종 지침에서 고령인구(50세 또는 65세 이상)와 그 외의 만성질환자들을 인플루엔자 예방접종의 일차 대상자로 정하고 있다. 그러나 국내에서는 아직까지 만성질환자들에서의 인플루엔자 백신의 효능평가에 대한 연구결과가 없는 실정이며 국내에서의 만성질환의 분포가 외국의 그것과 일치하지 않기 때문에 본 연구에서는 국내 만성질환자들에서 인플루엔자 예방접종과 연관된 병원입원율의 차이를 비교해 보고자 하였다. 재료 및 방법 : 1999년 11월-2000년 3월(5개월간) 서울 소재 2개 대학병원에 입원한 만성질환자중 발열과 호흡기 증상이 있어 인플루엔자 또는 인플루엔자양 질환이 의심되거나 그로인한 만성질환의 악화로 추정되는 환자군과 이를 배제한 대조군을 중심으로 혈중 인플루엔자 항체가를 조사하였고 인플루엔자 백신접종력을 조사하였다. 결과의 해석은 로지스틱 회귀분석을 이용하였다. 결과 : 만성질환자를 대상으로한 환자 대조군 연구에서 2개 대학병원에서 1년간 조사한 결과 항체 검사에 기준하여 최종적으로 환자군 64명, 대조군 117명이 포함되었다. 환자군에서는 대부분이 호흡기질환(253%)과 심혈관계질환(313%)였던 반면에 대조군은 암(466%)이 가장 많았고 심혈관계질환과 호흡기계질환은 각각 134%, 60%로 낮았다. 또한 두군간에는 예방접종의 경력에서 통계적으로 유의한 차이를 보였으며 이때의 비차비(OR)은 0328로서 인플루엔자 예방접종의 입원 예방효능은 672%이었다. 결론 : 만성질환자, 특히 만성 심폐질환들에서의 인플루엔자 예방접종은 불필요한 입원을 줄이는 효과가 관찰되었다. 따라서 의료인들은 고위험군의 환자들에 대하여 인플루엔자 에방접종을 적극적으로 권장하고 실천하여야 하겠다. Background : Influenza is one of the preventable respiratory disease by annual vaccination. Elderly people and patients with chronic medical disease are the primary target for influenza vaccination according to ACIP (Advisory Committee on Immunization). This study was done to determine whether influenza vaccination affects hospitalization due to influenza like illness or it's related complications among chronic ill patients. Materials and methods : Retrospective, case-control study was conducted for 5 months (Nov. 1999-Mar. 2000). Physicians from two-university hospitals in Korea were instructed to collect clinical data, sera from subjects presenting with a flu-like illness or flu-related exacerbation in patients with chronic underlying diseases. We compared the vaccination history of case patients with control. Logistic regression analysis was used to calculate the odd ratio and efficacy of influenza vaccination. Results : Hospitalization due to ILI (influenza like illness) or it's related complications were observed more frequently in patients with chronic lung disease (25.3%) and chronic cardiac disease (31.3%) compared to others. Influenza vaccination resulted in fewer hospitalization with ILI or ILI-related acute exacerbation of underlying disease in chronic ill patients (adjusted odd ratio, 0.328 [CI, 0.14 to 0.73]) during influenza seasons. Conclusion : For patients with chronic disease, influenza vaccination is associated with substantial health benefit including fewer hospitalization. Health care providers should take advantage of all opportunities to immunize these high-risk patients.

낮은 Crossover 왜곡을 갖는 Class-AB 출력단의 설계

박장우 順天大學校 1999 論文集 Vol.18 No.1

Power efficiency in the power amplifier is important. To obtain high power efficiency in the power amplifier, push-pull amplifier utilizing class-B operation has been usually used. Class-B amplifier has the high power efficiency but shows the distortion in output signal. It's distortion can be improved using the class-A amplifier, which has low power efficiency. To overcome the drawbacks of above two amplifiers, class-AB amplifier has been adapted. That is, the class-AB output amplifier shows the low crossover distortion and relatively high power efficiency. In this paper, class-AB output stage is designed, which can be used in the general purpose opamp. The output stage is designed to reduce the crossover distortion and to operate in full supply voltage range, which is needed to efficiently utilize the supply voltage. The designed output stage can be operating at 3V or below and shows the output voltage swing of 2.8V at 1㏀ load resistance and 1.5V at 100Ω

화학 이론의 전통 과학적 연구

박서영,정원우,방경곤,김용수,문장수,이우붕 慶北大學校 師範大學 科學敎育硏究所 2007 科學敎育硏究誌 Vol.31 No.-

According to the system of the oriental traditional science, everything has to be harmony and interact with one another. The fundamental notions of the traditional natural philosophy are "do(doctrine)", "taegeuk(the great absolute)", "yin-yang," "five primary substance", "four events", and "eight signs for divination". Taegeuk, especially, explains the formation and the death of all things in the universe through circulation of yin-yang, and shows the balance of nature and universe. Yin-yang, relative ideas produces four events, and four events also is divided into the eight signs for divination. 'four events', 'eight signs for divination' like 'yin-yang' indicates the cycle of nature. The essential notions of the traditional science are not different from those of modern chemistry. Taegeuk which is the origin of all things in the universe means the situation of harmony and balance through ceaseless circulation and connotes dynamic equilibrium on neutralization that chemical reaction get to. A number of opponent concepts such as acid-base, oxidation-reduction, atomic nucleus-electron are given an explanation by ying-yang(the positive and negative) that reaches Taegeuk through chemical bonding or reaction over simple antagonistic relationship. 'Yin-yang', 'four-events', 'eight signs for divination' do not imply a substance or a phenomenon in itself but the properties of them. That is why it is possible to see into various chemical concepts like a relative strength of acid-base, groups of periodic table with traditional scientific philosophy. We have regretfully neglected studies in traditional science. It is time to perform the concrete work connecting theory of traditional science with that of modern science for advisable appreciating of traditional science. Moreover, It is necessary to do research and development of educational programs or teaching-learning materials using the traditional science properly. 동양 과학 철학이나 자연 철학은 태극,음양오행,사상팔괘를 이용해 우주 만물의 운동과 자연의 순환을 설명하는데 있어 그 학문적 우수성을 부인할 수 없으나 현대의 화학식이나 수식이 현상을 미시적 관점에서 구체적으로 설명할 수 있는 것과는 달리 전통 과학이론은 거시적 관점에서 그 전체적 흐름만을 나타낸다는 한계를 가지고 있다. 그럼에도 불구하고 태극,음양오행 그리고 사상팔괘론을 중심으로 한 전통 과학 이론은 현대인들에게 과학에 대한 새로운 시각을 제공함으로써 무분별하고 비윤리적인 과학 기술 활용으로 인한 전 지구적인 문제들을 해결하는데 있어 핵심적인 역할을 수행함은 물론 오늘날의 한국 과학이 한 걸음더 전진하는데 이바지 할 수 있을 것이다. 그러므로 서구 중심의 기존의 과학문명에만 머무를 것이 아니라 동양의 전통 과학 철학을 연구하여 민족의 과학 체계를 수립하고 과학의 토착화를 이루어야 한다. 이를 성공적으로 수행하기 위해서는 전통 과학과 현대 과학 사이에 다리를 놓는 구체적인 작업이 본격적으로 진행되어야 한다. 기본적인 화학 개념들을 전통 과학적 관점에서 재해석 하는 것은 물론이고 더 나아가 전통 과학의 이론을 이용하여 화학 반응 과정을 구체적으로 설명하려는 시도가 필요할 것이다.

자극성 물질이 첩포시험 결과에 미치는 영향에 대한 연구

박장규,이우재,김경훈,서기범,이증훈 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

We studied the effects of irritants on the positive patch test sites in 6 volunteers. We firstly performed the patch test with 2, 4, 6, 8, 10% sodium lauryl sulfate on the back of 22 volunteers. Allergens (thimerosal, mercury ammonium chloride) were applied in duplicate, and 24 hours later they were removed and sodium lauryl sulfate was applied for a further 24hours to one set of patches. Response of allergen alone were measured at 24 hours, 48 hours, 72 hours, 120hours, 140hours and the degree of inflammation of the other site(allergen + irritant) was graded 30 minutes, 24, 48 and 72 hours later according to International Contact Dermatitis Research Group. The results were as follows 1. Twenty volunteers(90.9%) showed irritation sign on the patch sites with 6% sodium lauryl sulfate. 2. In the results of patch test in 6 cases with positive allergen sites, 5 cases showed the similar results with those of previous patch test (reproducibility = 83 %) 3. When we assessed the patch test results according to ICDRG, the results of patch tests after application with irritants on previous positive allergen slites did not show stronger responses than those of positive allergen alone 4. The results of patch test after application with irritants on previous negative allergen did not show erythema. It seems that the effect irritant application of lower concentration than irritant dose not influence the response to the allergen concentration than to cause erythema, on the response of allergen