Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

후두적출자의 의사소통 태도

강수균,박선희,백은아,이현혜,최경희,강은희,박은실 대구대학교 특수교육재활과학연구소 2005 특수교육재활과학연구 Vol.44 No.3

본 연구는 후두적출자의 주된 발성방법과 후두적출 경과 시기에 따른 의사소통 태도를 살펴보고자 하였다. 연구의 대상은 성인 남자 55명으로 후두암으로 인한 후두적출자들로 구성되었다. 이들에게 실시한 의사소통 태도 설문지는 Erickson의 의사소통 태도 척도-수정판(Modified Erickson Scale of Communication Attitudes: S-24)을 본 연구에 맞게 수정 보완하여 사용하였다. 본 연구의 결과는 첫째, 주된 발성방법에 따라서는 인공후두기 사용자와 식도발성자간의 의사소통 태도에 차이가 없었다. 둘째, 후두적출 경과 시기에 따라 10년 초과된 후두적출자들과 10년 이하의 후두 적출자들 간의 의사소통 태도에 차이가 없었다. 그러므로 이들의 의사소통 태도의 긍정적 태도를 증가시키기 위하여 다양한 방법을 활용하고 습득하여 이들의 의사소통 능력을 빠르게 재습득 하여 긍정적인 의사소통 능력을 가질 수 있도록 해야 한다. The purpose of this study was to determine laryngectomee's communication attitude. 55 laryngectomees, who were in the range of 40 years old to 80 years old participated in the study. Communication attitude measurements were taken by S-24(Modified Erickson Scale of Communication Attitudes). The results showed as follows: First, score of laryngectomees with artificial larynx and esophageal speakers were no significant. Second, score of laryngectomees with over 10 years after latyngectomy and 10 years after latyngectomy were no significant.

암환자가 지각한 사회적지지, 희망과 삶의 질과의 관계

태영숙,강은실,이명화,박금자 고신대학교 전인간호과학연구소 2002 전인간호과학연구 학술모음집 Vol.- No.-

The Relationship among Percieved Social Support, Hope and Quality of Life of Cancer Patients Tae, Young Sook. Kong, Eun Sil. Lee, Myung Hwa. Park, Geum Ja The purpose of this study was to investigate the relationship among percieved social support, hope and Quality of life of the cancer patients and to gain the baseline data for development of nursing intervention program for promoting quality of life in cancer patients. The design of this study was a cross sectional correlational survey. The subjects were 220 out and in-cancer patients in 5 general hospitals in Pusan The data were collected from July 2 to August 1,2001. The instruments were the Percieved social support scale(16 items, 5 point scale) had developed by Tae(1986), Hope scale(12 items, 4point scale) developed by Nowotny(1989) and Quality of life scale(31 items, 10 point scale) developed by Tae et. al(2000). The data was analyzed by the SPSS/PC+ program using frequency & percentage, item mean & standard deviation, t-test, ANOVA & Scheffe test, Pearson's correlation coefficient. The results of this study was as follows : 1) The item mean score of quality of life was 6.05±1.16 (range 0-10) .The heighest score of subarea of the quality of life was the spiritual wellbeing area (7.09±1.63) and the lowest score was social wellbeing area(5.53±1.65). The mean score of perceived social support was 52.65±10.32 (최고 1, 최저 80). The mean score of family support was32.71±6.66 (range 1- 40) and the mean score of medical team support was 19.93±5.95 (range 1- 40). The mean score of Hope was 37.02±5.64 (range 1-48). 2) There were statistically significant difference in the score of quality of life according to the life effect of religion (F=3.97, p=0.00), treatment method(F=2.94, p=0.01), area of diagnosis (F=3.48, p=0.01), stage of disease (F=13.74, p= 0.00). 3) There was significant correlation between perceived social support(r=0.44, p= 0.000 ; family support: r=0.334, p=0.000, medical support; r=0.395, p=0.000), hope(r=0.563, p= 0.000) and quality of life. In conclusion, there was a significant relationship among perceived social support, hope and quality of life. Therefore perceived social support, hope intervention programs should be developed to improve the quality of life in cancer patients.

연쇄알구균 감염에 의한 급성 인후염 후 반응성 관절염 1예

박은하,도연실,양정채,강미라,서현주,정숙인,손준성,기현균,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

연쇄알구균에 의한 급성 인후염 후 발생한 반응성 관절염은 급성 류마티스열의 개정된 진단기준을 충족하지 못하면서, 지속적 혹은 재발성의 비이동성 관절염과 발열, 홍반성 결절, 일시적 간기능 이상 등을 보이면서 심장염과 무도증을 드물게 동반하는 질환이다. 따라서, 발열을 동반한 급성 관절염 환자에서 감별해야 할 질환 중의 하나이며, 심근염 예방을 위한 페니실린 요법의 적응증 및 기간에 대해서는 아직 이론이 많은 상황으로, 보다 광범위한 연구가 필요하다. 저자들은 연쇄알구균에 의한 급성 인후염 1주 후에 발생한 하지의 다발성 비이동성 관절염과 함께 결절홍반 및 일시적 간기능 이상을 보인 환자에서 PSRA로 진단하고 비스테로이드성 항염증제 및 스테로이드로 성공적인 치료를 하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Poststreptococcal reactive arthritis (PSRA) is associated with recent streptococcal infections. However, PSRA is distinct from acute rheumatic fever by its clinical manifestations: non-migrating arthritis, erythema nodosum or erythema multiforme, and transient elevation of serum transaminases. We experienced a 33-year-old man who presented with fever, arthritis of both knees and ankles, and erythema nodosums on extensor surfaces of lower legs which developed 6 days after the onset of pharyngitis symptoms. Blood and urine cultures were negative. Throat culture was negative for group A β-hemolytic streptococcus. The ASO titers increased up to 2080 IU/mL in sequential monitoring. The result of bone scan was compatible to arthritis of both knees and ankles. There were no signs or symptom of carditis. He showed clinical improvement with anti-inflammatory drugs (naproxen 1,000 mg/day and prednisolone 7.5 mg/d). PSRA should be included in the differential diagnosis of patients presenting with arthritis combined with fever.

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

여름철에 스타킹과 양말 착용시의 생리적 반응 및 착용감

박은실,류현혜,성수광 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

The purpose of this study was to obtain the basic data for designing the physiologically comfortable stocking. The study investigated physiological responses and wearing sensation of healty female adults in twenties in wearing support type stocking and socks according to ambient temperature and humidity in summer. The various factors, such as rectal temperature, skin temperature, body weight loss, blood pressure pulse rate, wearing sensation were statistically analyzed according to the warm temperature ambient condition and ensemble of clothes. The results were as follows : 1. Mean skin temperature showed significant differences with ambient temperature and clothes. In the low humidity and temperature, mean skin temperature was highest in support stocking in order high supporting stocking 〉socks. In the high humidity and temperature, no significant difference on ensemble of clothes was indicated at the end of exercise. 2. Under the certain ambient humidity, mean skin temperature increased in proportion to the increasa of ambient temperature in all ensemble of clothes under the certain ambient temperature, 70% RH higher mean skin temperature was indicated without relation to ensemble of clothes in high temperature. 3. Maximum blood pressure showed significant differences with the increase or decrease of ambient temperature. But, minimum blood pressure increased according to the decreased of ambient temperature. Pluse rate increased in proportion to the increase of ambient temperature during exercise. 4. Comfort showed 0.1% of significant differences with ambient temperature, clothes and time. Phychological responces showed 'very hot' 'very uncomfortable' as exercise and ambient temperature op up. Under the high humidity and temperature, high humudaty and temperature, high support stocking was most comfortable.

초등교사의 직무만족도와 직무성취도에 영향을 미치는 변인에 대한 분석

박은실,김의철,박영신 이화여자대학교 교육과학연구소 2007 교육과학연구 Vol.38 No.3

The purpose of this study is to analyze factors that influence job satisfactionand occupational achievement of elementary school teachers, focusing specificallyon the mediating role played by social support and self-efficacy. A total of 355elementary school teachers, who are participating in teachers' training program,completed a questionnaire developed by Park and Kim(2005). The results showthat self-efficacy is an important predictor of occupational achievement. Specially,teachers' efficacy, self-regulation efficacy and social efficacy influenced teachers' occupational achievement. Social support received from administrators andcolleagues increases job satisfaction. 이 연구의 주된 목적은 초등교사의 직무만족도와 직무성취도에 영향을 미치는 변인을 탐색하는 데 있다. 이 연구에서는 특별히 사회적 지원과 자기효능감이 초등교사의직무만족도와 직무성취도에 어떠한 영향을 미치는지를 체계적으로 분석하고자 한다. 분석대상은 연수에 참여한 초등교사 355명이었다. 질문지는 박영신과 김의철(2005)에의해 제작되었으며 분석 결과는 다음과 같다. 첫째, 초등교사의 직무성취도는 교사효능감, 자기조절 효능감, 사회성효능감에 의한 설명력이 가장 높으므로, 자기효능감은직무성취도를 결정하는 가장 핵심적인 변인임이 확인되었다. 둘째, 초등교사의 직무만족도는 학교관리자로부터의 사회적 지원에 의해 가장 영향을 받았으며, 또한 동료 교사로부터의 사회적 지원도 의미 있는 변인으로 포함되었다.

구체적 조작 활동을 통한 길이의 양감 형성에 관한 연구

박계순,정은실 진주교육대학교 과학교육연구소 2000 科學敎育硏究 Vol.26 No.-

The purpose of this study was to develop the program of concrete operational activity for the formation of quantitative-sense of length and to use it to teaching and learning activity, to create the environment for students' measuring length through concrete operatioanl activity and to investigate the effects of concrete operational activity on the formation of quantitative-sense of length. The subjects were 80(40 in an experimental group, 40 in a control group) students attending the 2nd grade of an elementary school in Chinju city. The major findings of this study were as follows. First, the results of the test in the domain of a unit, comparison, measuring, estimation, sum and difference of length showed that the two groups had a significant difference (p <0.05) only in the domain of estimation. Second, creating the environment for the students' measurement was helpful to develop estimation skill. Third, students formed quantitative-sense of length in the process of their own learning-plan and estimation activities. Fourth, students' ability of gathering and using useful materials for the estimation was improved by their own learning and co-operated learning. Fifth, homework for the estimation was also helpful to their attaining to the goals of learning. Sixth, the ability using mathematical knowledge in everyday life was improved naturally through developing estimation skills.

서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

정맥내 주사로 인한 정맥염 발생의 다기관 공동 역학 조사 : 서울, 경기도 6개 종합병원을 대상으로:Focused on 6 hospitals in Seoul or Gyonggi-do, Korea

최정실,박은숙,진혜영,정선영,박미라,김정은,김금순 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.2